GR69706B - - Google Patents

Info

Publication number
GR69706B
GR69706B GR59823A GR790159823A GR69706B GR 69706 B GR69706 B GR 69706B GR 59823 A GR59823 A GR 59823A GR 790159823 A GR790159823 A GR 790159823A GR 69706 B GR69706 B GR 69706B
Authority
GR
Greece
Application number
GR59823A
Original Assignee
Fisons Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fisons Ltd filed Critical Fisons Ltd
Publication of GR69706B publication Critical patent/GR69706B/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
    • C07D241/38—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
    • C07D241/40—Benzopyrazines
    • C07D241/44—Benzopyrazines with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
GR59823A 1978-08-15 1979-08-13 GR69706B (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB7833431 1978-08-15
GB7848348 1978-12-13

Publications (1)

Publication Number Publication Date
GR69706B true GR69706B (el) 1982-07-09

Family

ID=26268543

Family Applications (1)

Application Number Title Priority Date Filing Date
GR59823A GR69706B (el) 1978-08-15 1979-08-13

Country Status (9)

Country Link
US (1) US4296114A (el)
EP (1) EP0008864A1 (el)
AU (1) AU4985379A (el)
DK (1) DK338379A (el)
FI (1) FI792507A (el)
GR (1) GR69706B (el)
IL (1) IL58038A0 (el)
NO (1) NO792653L (el)
PT (1) PT70064A (el)

Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0030795A3 (en) * 1979-12-06 1981-09-09 Imperial Chemical Industries Plc Quinoxaline derivatives, processes therefor, pharmaceutical compositions, and benzene derivatives
DE3032994A1 (de) * 1980-09-02 1982-04-22 Dr. Karl Thomae Gmbh, 7950 Biberach Neue pyrazino-azepine, deren herstellung und diese sie enthaltende arzneimittel
JPS62198671A (ja) * 1986-02-25 1987-09-02 Toyo Jozo Co Ltd １−置換アルキル１，２−ジヒドロ−２−ピラジノン誘導体
JPS62281878A (ja) * 1986-02-26 1987-12-07 Taisho Pharmaceut Co Ltd アザアントラセン化合物
JPH0678319B2 (ja) * 1986-03-11 1994-10-05 東ソー株式会社 キノキサリノン誘導体
JPS6450868A (en) * 1987-08-21 1989-02-27 Toyo Jozo Kk 1-substituted alkyl-2-oxo-1,2-dihydroquinoxaline derivative
JPH0276860A (ja) * 1987-10-05 1990-03-16 Toyo Jozo Co Ltd ６−置換アルコキシ−２−オキソ−１，２−ジヒドロキノキサリン誘導体
NO179551C (no) * 1987-11-10 1996-10-30 Novo Nordisk As Analogifremgangsmåte for fremstilling av terapeutisk virksomme kinoxalinforbindelser
GB9413975D0 (en) 1994-07-11 1994-08-31 Fujisawa Pharmaceutical Co New heterobicyclic derivatives
AU9049391A (en) * 1990-12-20 1992-07-22 Warner-Lambert Company 2-acylamido derivatives of 3,4-dihydro-3-oxo-quinoxaline having pharmaceutical activity
DE4217952A1 (de) * 1992-05-30 1993-12-02 Basf Ag Chinoxalin-2,3(1H,4H)-dione
FR2696456B1 (fr) * 1992-10-07 1995-01-06 Pf Medicament Dérivés de dihydro-1,2 oxo amino-3 quinoxalines, leur préparation et leur application en thérapeutique.
DE4340045A1 (de) * 1993-11-24 1995-06-01 Basf Ag Neue Chinoxaline und Arzneimittel daraus
US5620978A (en) * 1994-01-03 1997-04-15 State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University And The University Of Oregon, Eugene Oregon 8-aza, 6-aza and 6,8-diaza-1,4-dihydroquinoxaline-2,3-diones and the use thereof as antagonists for the glycine/NMDA receptor
GB2291422A (en) * 1994-07-18 1996-01-24 Fujisawa Pharmaceutical Co 4-phenyl-pyrido[2,3-b]pyrazin-4-ones
FR2731221B1 (fr) * 1995-03-01 1997-05-30 Pf Medicament Nouveaux derives de l'ethyl-1 dihydro-1, 2 oxo-2 methylamino-3 quinoxaline, leur utilisation a titre de medicament et les compositions pharmaceutiques les comprenant
GB9526558D0 (en) * 1995-12-27 1996-02-28 Fujisawa Pharmaceutical Co Heterobicyclic derivatives
ZA973884B (en) * 1996-05-23 1998-11-06 Du Pont Merck Pharma Tetrahydropteridines and pyridylpiperazines for treatment of neurological disorders
EP1380298A3 (en) * 1996-05-23 2004-04-07 Bristol-Myers Squibb Pharma Company Tetrahydropteridines and pyridylpiperazines for treatment of neurological disorders, anorexia, inflammation
US5869487A (en) * 1996-10-24 1999-02-09 Merck & Co., Inc. Pyrido 3,4-B!pyrazines for use as thrombin inhibitors
US6087373A (en) * 1997-09-23 2000-07-11 Merck & Co., Inc. Thrombin inhibitors
TR200200971T2 (tr) * 1998-09-29 2002-06-21 Fujisawa Pharmaceutical Co., Ltd. Piridopirazan bileşiğinin yeni tuzları ve bunların kristalleri.
US6239132B1 (en) 1999-04-23 2001-05-29 Merck & Co., Inc. Thrombin inhibitors
EP1189618A4 (en) 1999-06-04 2002-06-19 Merck & Co Inc thrombin
RU2003135424A (ru) * 2001-05-14 2005-05-20 Бристол-Маерс Сквибб Фарма Компани (Us) Замещенные пиразиноны, пиридины и пиримидины в качестве лигандов кортикотропин высвобождающего фактора
SE0302323D0 (sv) * 2003-08-28 2003-08-28 Astrazeneca Ab Novel compounds
SE0302324D0 (sv) * 2003-08-28 2003-08-28 Astrazeneca Ab Novel compounds
SE0302486D0 (sv) 2003-09-18 2003-09-18 Astrazeneca Ab Novel compounds
JP2007507514A (ja) * 2003-09-30 2007-03-29 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ キノキサリン化合物
CA2543710A1 (en) * 2003-11-03 2005-05-12 Warner-Lambert Company Llc Novel norepinephrine reuptake inhibitors for the treatment of central nervous system disorders
PT1711184E (pt) * 2004-01-06 2007-09-24 Janssen Pharmaceutica Nv ''derivados de ( 3-oxo-3, 4-di-hidro-quinoxalin-2-il-amino)-benzamina e compostos relacionados como inibidores da fosforilase do glicogénio para o tratamento da diabetes e da obesidade''
PA8640801A1 (es) * 2004-08-09 2006-08-03 Warner Lambert Co Nuevos inhibidores de la recaptacion de norepinefrina de quinoxalinona para el tratamiento de trastornos del sistema nervioso central
US7601716B2 (en) * 2006-05-01 2009-10-13 Cephalon, Inc. Pyridopyrazines and derivatives thereof as ALK and c-Met inhibitors
TW200808763A (en) 2006-05-08 2008-02-16 Astrazeneca Ab Novel compounds I
TW200808771A (en) 2006-05-08 2008-02-16 Astrazeneca Ab Novel compounds II
DE102007050673A1 (de) 2007-10-19 2009-04-23 Friedrich-Schiller-Universität Jena Neue Hexaaza-acene und Verfahren zu ihrer Herstellung
CL2008003301A1 (es) 2007-11-06 2009-10-16 Astrazeneca Ab Compuestos derivados de 3,4-dihidropirazina-2-carboxamida, inhibidores de la elastasa de neutrofilos humanos; composiciones farmacéuticas; procesos de preparación de compuestos y composición farmacéutica; y uso en el tratamiento de síndrome de dificultad respiratoria de los adultos, fibrosis quística, cáncer, entre otras.
ES2632964T3 (es) 2008-03-05 2017-09-18 Merck Patent Gmbh Derivados de piridopirazinonas estimuladores de la secreción de insulina, métodos para obtenerlos y uso de los mismos para el tratamiento de la diabetes
PT2250156E (pt) * 2008-03-05 2015-09-09 Merck Patent Gmbh Derivados de pirazinona como estimuladores da secreção de insulina, métodos para a sua obtenção e utilização destes para o tratamento de diabetes
TW201036957A (en) 2009-02-20 2010-10-16 Astrazeneca Ab Novel salt 628
JP5548685B2 (ja) 2009-06-26 2014-07-16 イハラケミカル工業株式会社 ケトマロン酸化合物又はその抱水体の製造法
WO2011039528A1 (en) 2009-10-02 2011-04-07 Astrazeneca Ab 2-pyridone compounds used as inhibitors of neutrophil elastase
JP5921500B2 (ja) 2013-07-19 2016-05-24 イハラケミカル工業株式会社 ケトマロン酸化合物の製造方法
JP6017710B2 (ja) 2014-02-17 2016-11-02 イハラケミカル工業株式会社 流通反応器を用いたケトマロン酸化合物の連続製造方法
EP3394046B1 (en) * 2015-12-24 2022-03-09 The Regents Of The University Of California Cftr regulators and methods of use thereof
US11839616B2 (en) 2017-08-24 2023-12-12 The Regents Of The University Of California Ocular pharmaceutical compositions

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1189552B (de) * 1959-07-03 1965-03-25 Donau Pharmazie Ges M B H Verfahren zur Herstellung von 2-Oxo-1, 2-dihydrochinoxalinen und von deren Salzen und quaternaeren Ammoniumverbindungen
US4077955A (en) * 1977-02-17 1978-03-07 E. R. Squibb & Sons, Inc. Amino derivatives of 1,2,3,4-tetrahydro-2-oxopyrido[2,2-b]-pyrazine carboxylic acids and esters

Also Published As

Publication number Publication date
AU4985379A (en) 1980-02-21
NO792653L (no) 1980-02-18
US4296114A (en) 1981-10-20
IL58038A0 (en) 1979-12-30
PT70064A (en) 1979-09-01
FI792507A (fi) 1980-02-16
DK338379A (da) 1980-02-16
EP0008864A1 (en) 1980-03-19

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