IL44954A - Oral hygiene products containing alexidine dihydrofluoride - Google Patents
Oral hygiene products containing alexidine dihydrofluorideInfo
- Publication number
- IL44954A IL44954A IL44954A IL4495474A IL44954A IL 44954 A IL44954 A IL 44954A IL 44954 A IL44954 A IL 44954A IL 4495474 A IL4495474 A IL 4495474A IL 44954 A IL44954 A IL 44954A
- Authority
- IL
- Israel
- Prior art keywords
- alexidine
- dihydrofluoride
- oral hygiene
- alexidine dihydrofluoride
- water
- Prior art date
Links
- LFVVNPBBFUSSHL-UHFFFAOYSA-N alexidine Chemical compound CCCCC(CC)CNC(=N)NC(=N)NCCCCCCNC(=N)NC(=N)NCC(CC)CCCC LFVVNPBBFUSSHL-UHFFFAOYSA-N 0.000 title claims abstract description 33
- 229950010221 alexidine Drugs 0.000 title claims abstract description 33
- 239000000203 mixture Substances 0.000 title claims description 24
- 238000009472 formulation Methods 0.000 title description 12
- 208000002925 dental caries Diseases 0.000 claims abstract description 13
- 208000002064 Dental Plaque Diseases 0.000 claims abstract description 7
- 208000028169 periodontal disease Diseases 0.000 claims abstract description 5
- 208000007565 gingivitis Diseases 0.000 claims abstract description 4
- 230000002262 irrigation Effects 0.000 claims description 9
- 238000003973 irrigation Methods 0.000 claims description 9
- 230000002265 prevention Effects 0.000 claims description 7
- 239000004480 active ingredient Substances 0.000 claims description 3
- 239000007788 liquid Substances 0.000 claims 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 16
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 12
- 239000012141 concentrate Substances 0.000 description 8
- 235000008504 concentrate Nutrition 0.000 description 8
- 239000000243 solution Substances 0.000 description 8
- 239000000796 flavoring agent Substances 0.000 description 7
- 235000019634 flavors Nutrition 0.000 description 7
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 6
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 6
- 235000011187 glycerol Nutrition 0.000 description 6
- 239000002324 mouth wash Substances 0.000 description 6
- 239000003921 oil Substances 0.000 description 6
- 238000002360 preparation method Methods 0.000 description 5
- 239000000606 toothpaste Substances 0.000 description 5
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 4
- 239000004354 Hydroxyethyl cellulose Substances 0.000 description 4
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 description 4
- 150000002222 fluorine compounds Chemical class 0.000 description 4
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 description 4
- 229940051866 mouthwash Drugs 0.000 description 4
- GHXZTYHSJHQHIJ-UHFFFAOYSA-N Chlorhexidine Chemical compound C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 GHXZTYHSJHQHIJ-UHFFFAOYSA-N 0.000 description 3
- 229920001214 Polysorbate 60 Polymers 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 239000003795 chemical substances by application Substances 0.000 description 3
- 229960003260 chlorhexidine Drugs 0.000 description 3
- 150000001875 compounds Chemical class 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 229910001506 inorganic fluoride Inorganic materials 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 3
- 239000007787 solid Substances 0.000 description 3
- 238000003756 stirring Methods 0.000 description 3
- 229940034610 toothpaste Drugs 0.000 description 3
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 2
- 208000006558 Dental Calculus Diseases 0.000 description 2
- KRHYYFGTRYWZRS-UHFFFAOYSA-N Fluorane Chemical compound F KRHYYFGTRYWZRS-UHFFFAOYSA-N 0.000 description 2
- 206010044029 Tooth deposit Diseases 0.000 description 2
- 238000010936 aqueous wash Methods 0.000 description 2
- 239000012153 distilled water Substances 0.000 description 2
- 235000019441 ethanol Nutrition 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 239000006072 paste Substances 0.000 description 2
- 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 description 2
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- 239000000600 sorbitol Substances 0.000 description 2
- 235000010356 sorbitol Nutrition 0.000 description 2
- MOMKYJPSVWEWPM-UHFFFAOYSA-N 4-(chloromethyl)-2-(4-methylphenyl)-1,3-thiazole Chemical compound C1=CC(C)=CC=C1C1=NC(CCl)=CS1 MOMKYJPSVWEWPM-UHFFFAOYSA-N 0.000 description 1
- WLDHEUZGFKACJH-ZRUFZDNISA-K Amaranth Chemical compound [Na+].[Na+].[Na+].C12=CC=C(S([O-])(=O)=O)C=C2C=C(S([O-])(=O)=O)C(O)=C1\N=N\C1=CC=C(S([O-])(=O)=O)C2=CC=CC=C12 WLDHEUZGFKACJH-ZRUFZDNISA-K 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
- KRHYYFGTRYWZRS-UHFFFAOYSA-M Fluoride anion Chemical compound [F-] KRHYYFGTRYWZRS-UHFFFAOYSA-M 0.000 description 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 235000012735 amaranth Nutrition 0.000 description 1
- LDDQLRUQCUTJBB-UHFFFAOYSA-N ammonium fluoride Chemical compound [NH4+].[F-] LDDQLRUQCUTJBB-UHFFFAOYSA-N 0.000 description 1
- 239000012736 aqueous medium Substances 0.000 description 1
- 239000008366 buffered solution Substances 0.000 description 1
- JUNWLZAGQLJVLR-UHFFFAOYSA-J calcium diphosphate Chemical compound [Ca+2].[Ca+2].[O-]P([O-])(=O)OP([O-])([O-])=O JUNWLZAGQLJVLR-UHFFFAOYSA-J 0.000 description 1
- 229940043256 calcium pyrophosphate Drugs 0.000 description 1
- 238000009960 carding Methods 0.000 description 1
- 239000002026 chloroform extract Substances 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 210000003298 dental enamel Anatomy 0.000 description 1
- 239000000551 dentifrice Substances 0.000 description 1
- 230000008021 deposition Effects 0.000 description 1
- 235000019821 dicalcium diphosphate Nutrition 0.000 description 1
- 239000003651 drinking water Substances 0.000 description 1
- 235000020188 drinking water Nutrition 0.000 description 1
- 230000009977 dual effect Effects 0.000 description 1
- 239000000706 filtrate Substances 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 150000004673 fluoride salts Chemical class 0.000 description 1
- 229940050410 gluconate Drugs 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 235000014666 liquid concentrate Nutrition 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- -1 monooleate Calcium pyrophosphate Chemical compound 0.000 description 1
- 229920000053 polysorbate 80 Polymers 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 238000009877 rendering Methods 0.000 description 1
- AQMNWCRSESPIJM-UHFFFAOYSA-M sodium metaphosphate Chemical compound [Na+].[O-]P(=O)=O AQMNWCRSESPIJM-UHFFFAOYSA-M 0.000 description 1
- 235000019983 sodium metaphosphate Nutrition 0.000 description 1
- 239000008247 solid mixture Substances 0.000 description 1
- 230000007928 solubilization Effects 0.000 description 1
- 238000005063 solubilization Methods 0.000 description 1
- ANOBYBYXJXCGBS-UHFFFAOYSA-L stannous fluoride Chemical compound F[Sn]F ANOBYBYXJXCGBS-UHFFFAOYSA-L 0.000 description 1
- 229960002799 stannous fluoride Drugs 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/69—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing fluorine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/43—Guanidines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/20—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups containing any of the groups, X being a hetero atom, Y being any atom, e.g. acylguanidines
- C07C279/24—Y being a hetero atom
- C07C279/26—X and Y being nitrogen atoms, i.e. biguanides
- C07C279/265—X and Y being nitrogen atoms, i.e. biguanides containing two or more biguanide groups
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Cosmetics (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US370481A US3887712A (en) | 1973-06-15 | 1973-06-15 | Oral hygiene products |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL44954A0 IL44954A0 (en) | 1974-09-10 |
| IL44954A true IL44954A (en) | 1977-05-31 |
Family
ID=23459843
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL44954A IL44954A (en) | 1973-06-15 | 1974-06-03 | Oral hygiene products containing alexidine dihydrofluoride |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US3887712A (enExample) |
| BE (1) | BE816389A (enExample) |
| CA (1) | CA1029663A (enExample) |
| DE (1) | DE2428227C2 (enExample) |
| FR (1) | FR2233040B1 (enExample) |
| GB (1) | GB1436487A (enExample) |
| IE (1) | IE39303B1 (enExample) |
| IL (1) | IL44954A (enExample) |
| NL (1) | NL7407084A (enExample) |
| PH (1) | PH14569A (enExample) |
| ZA (1) | ZA743812B (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH590659A5 (enExample) * | 1973-01-20 | 1977-08-15 | Blendax Werke Schneider Co | |
| US4291017A (en) * | 1979-11-19 | 1981-09-22 | Dental Concepts, Inc. | Method for limiting adherence of plaque and dental composition therefor |
| US6143281A (en) * | 1987-03-31 | 2000-11-07 | Smithkline Beecham P.L.C. | Dentifrice compositions |
| GB2210265A (en) * | 1987-10-02 | 1989-06-07 | Richardson Vicks Ltd | Dentifrice compositions |
| DE364245T1 (de) * | 1988-10-13 | 1990-08-16 | Beecham Group p.l.c., Brentford, Middlesex | Zahnreinigungsmittel. |
| US5082653A (en) * | 1990-10-31 | 1992-01-21 | Warner-Lambert Company | Anti-plaque compositions comprising a combination of morpholinoamino alcohol and antibiotic |
| US5147632A (en) * | 1990-10-31 | 1992-09-15 | Warner-Lambert Company | Anti-plaque compositions comprising a combination of morpholinoamino alcohol and chelating agent |
| US5039515A (en) * | 1990-11-21 | 1991-08-13 | Korf Patricia K | Mouth cleansing preparation |
| US6610276B2 (en) | 2001-01-12 | 2003-08-26 | Steven A. Melman | Multi-functional dental composition |
| JP3877537B2 (ja) * | 2001-03-07 | 2007-02-07 | 高砂香料工業株式会社 | 口腔用組成物用抗菌剤およびそれを含む口腔用組成物 |
| US20050084551A1 (en) * | 2003-09-26 | 2005-04-21 | Jensen Claude J. | Morinda citrifolia-based oral care compositions and methods |
| US20070138439A1 (en) * | 2005-12-21 | 2007-06-21 | 3M Innovative Properties Company | Denaturant for ethanol |
| US8298516B2 (en) * | 2006-12-22 | 2012-10-30 | Douglas Anderson | Calculus dissolving dental composition and methods for using same |
| CA2853857C (en) | 2011-10-31 | 2022-06-14 | Kane Biotech Inc. | Compositions and methods for preventing and treating oral diseases |
| US11723852B2 (en) | 2011-10-31 | 2023-08-15 | Kane Biotech Inc. | Antimicrobial-antibiofilm compositions and methods of use thereof for personal care products |
| CN106572662A (zh) | 2014-06-27 | 2017-04-19 | 凯恩生物科技有限公司 | 抗微生物‑抗生物膜组合物及其作为个人护理产品的使用方法 |
| CA3027948C (en) | 2015-12-15 | 2023-01-24 | John A. Gontarz | Compositions comprising chlorine dioxide and dianhydrohexitol for the removal of tartar and plaque from teeth |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3413326A (en) * | 1956-10-03 | 1968-11-26 | Gaba Ag | Addition compounds of amino acids and hydrofluoric acid or soluble fluorides,and method of preparing the same |
| US3562385A (en) * | 1968-12-23 | 1971-02-09 | Merck & Co Inc | Dental antiplaque and anticalculus compositions |
| US3758689A (en) * | 1971-03-24 | 1973-09-11 | I Rapfogel | Method of treating periodontal disease |
-
1973
- 1973-06-15 US US370481A patent/US3887712A/en not_active Expired - Lifetime
-
1974
- 1974-05-27 NL NL7407084A patent/NL7407084A/xx not_active Application Discontinuation
- 1974-06-03 PH PH15892A patent/PH14569A/en unknown
- 1974-06-03 IL IL44954A patent/IL44954A/en unknown
- 1974-06-06 IE IE1186/74A patent/IE39303B1/xx unknown
- 1974-06-10 CA CA202,347A patent/CA1029663A/en not_active Expired
- 1974-06-11 DE DE2428227A patent/DE2428227C2/de not_active Expired
- 1974-06-11 GB GB2585674A patent/GB1436487A/en not_active Expired
- 1974-06-13 FR FR7420550A patent/FR2233040B1/fr not_active Expired
- 1974-06-14 BE BE145474A patent/BE816389A/xx not_active IP Right Cessation
- 1974-06-14 ZA ZA00743812A patent/ZA743812B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IL44954A0 (en) | 1974-09-10 |
| GB1436487A (en) | 1976-05-19 |
| PH14569A (en) | 1981-09-24 |
| FR2233040A1 (enExample) | 1975-01-10 |
| BE816389A (fr) | 1974-12-16 |
| CA1029663A (en) | 1978-04-18 |
| NL7407084A (enExample) | 1974-12-17 |
| FR2233040B1 (enExample) | 1977-12-16 |
| DE2428227A1 (de) | 1975-01-09 |
| AU6976474A (en) | 1975-12-04 |
| DE2428227C2 (de) | 1983-12-29 |
| IE39303B1 (en) | 1978-09-13 |
| IE39303L (en) | 1974-12-15 |
| ZA743812B (en) | 1976-01-28 |
| US3887712A (en) | 1975-06-03 |
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