IL43686A - Process for the production of certain indole derivatives - Google Patents
Process for the production of certain indole derivativesInfo
- Publication number
- IL43686A IL43686A IL43686A IL4368673A IL43686A IL 43686 A IL43686 A IL 43686A IL 43686 A IL43686 A IL 43686A IL 4368673 A IL4368673 A IL 4368673A IL 43686 A IL43686 A IL 43686A
- Authority
- IL
- Israel
- Prior art keywords
- compounds
- general formula
- production
- phch
- nov
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims abstract 6
- 150000002475 indoles Chemical class 0.000 title abstract 3
- 229940054051 antipsychotic indole derivative Drugs 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims abstract 4
- 230000015572 biosynthetic process Effects 0.000 claims abstract 2
- 125000000524 functional group Chemical group 0.000 claims abstract 2
- 125000005843 halogen group Chemical group 0.000 claims abstract 2
- 239000012442 inert solvent Substances 0.000 claims abstract 2
- SLRMQYXOBQWXCR-UHFFFAOYSA-N 2154-56-5 Chemical compound [CH2]C1=CC=CC=C1 SLRMQYXOBQWXCR-UHFFFAOYSA-N 0.000 claims 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 1
- 230000007717 exclusion Effects 0.000 claims 1
- 239000001257 hydrogen Substances 0.000 claims 1
- 229910052739 hydrogen Inorganic materials 0.000 claims 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 1
- 239000011261 inert gas Substances 0.000 claims 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 1
- 239000001301 oxygen Substances 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 150000003254 radicals Chemical class 0.000 claims 1
- 239000011541 reaction mixture Substances 0.000 claims 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 1
- 239000002253 acid Substances 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- SIKJAQJRHWYJAI-UHFFFAOYSA-N benzopyrrole Natural products C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 abstract 1
- PASDCCFISLVPSO-UHFFFAOYSA-N benzoyl chloride Chemical compound ClC(=O)C1=CC=CC=C1 PASDCCFISLVPSO-UHFFFAOYSA-N 0.000 abstract 1
- PZOUSPYUWWUPPK-UHFFFAOYSA-N indole Natural products CC1=CC=CC2=C1C=CN2 PZOUSPYUWWUPPK-UHFFFAOYSA-N 0.000 abstract 1
- RKJUIXBNRJVNHR-UHFFFAOYSA-N indolenine Natural products C1=CC=C2CC=NC2=C1 RKJUIXBNRJVNHR-UHFFFAOYSA-N 0.000 abstract 1
- 125000001041 indolyl group Chemical group 0.000 abstract 1
- QVWDCTQRORVHHT-UHFFFAOYSA-N tropone Chemical compound O=C1C=CC=CC=C1 QVWDCTQRORVHHT-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/26—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an acyl radical attached to the ring nitrogen atom
- C07D209/28—1-(4-Chlorobenzoyl)-2-methyl-indolyl-3-acetic acid, substituted in position 5 by an oxygen or nitrogen atom; Esters thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/26—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an acyl radical attached to the ring nitrogen atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Indole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2257867A DE2257867C2 (de) | 1972-11-25 | 1972-11-25 | Verfahren zur Herstellung von 1-Benzoylindol-Derivaten |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL43686A0 IL43686A0 (en) | 1974-03-14 |
| IL43686A true IL43686A (en) | 1976-10-31 |
Family
ID=5862712
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL43686A IL43686A (en) | 1972-11-25 | 1973-11-23 | Process for the production of certain indole derivatives |
Country Status (25)
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS52156862A (en) * | 1976-06-22 | 1977-12-27 | Hisamitsu Pharmaceut Co Inc | Novel indoleacetic acid ester derivatives |
| JPS53163075U (enrdf_load_stackoverflow) * | 1977-05-27 | 1978-12-20 | ||
| DE3206885A1 (de) * | 1982-02-26 | 1983-09-15 | Troponwerke GmbH & Co KG, 5000 Köln | Indolderivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
| JPS60112760A (ja) * | 1983-11-18 | 1985-06-19 | Green Cross Corp:The | インド−ル酢酸誘導体及びその脂肪乳剤 |
| US7632955B2 (en) | 2001-12-13 | 2009-12-15 | National Health Research Institutes | Indole compounds |
| NO317776B1 (no) | 2003-04-14 | 2004-12-13 | Bodil Korshamn | Barnepose |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3483220A (en) * | 1967-05-03 | 1969-12-09 | Merck & Co Inc | Process for preparing 1-aroylindole-3-acetic acid compounds |
-
1972
- 1972-11-25 DE DE2257867A patent/DE2257867C2/de not_active Expired
-
1973
- 1973-11-08 CA CA185,335A patent/CA1002040A/en not_active Expired
- 1973-11-15 YU YU2959/73A patent/YU35352B/xx unknown
- 1973-11-20 DK DK625673A patent/DK135944C/da not_active IP Right Cessation
- 1973-11-21 CS CS738010A patent/CS192507B2/cs unknown
- 1973-11-22 PL PL1973166694A patent/PL91250B1/pl unknown
- 1973-11-22 RO RO7300076742A patent/RO63986A/ro unknown
- 1973-11-23 CH CH1654873A patent/CH593256A5/xx not_active IP Right Cessation
- 1973-11-23 GB GB5440073A patent/GB1417080A/en not_active Expired
- 1973-11-23 NO NO4489/73A patent/NO140185C/no unknown
- 1973-11-23 SE SE7315928A patent/SE397828B/xx unknown
- 1973-11-23 HU HUTO942A patent/HU167187B/hu unknown
- 1973-11-23 FR FR7341875A patent/FR2207915B1/fr not_active Expired
- 1973-11-23 DD DD174857A patent/DD108292A5/xx unknown
- 1973-11-23 LU LU68847A patent/LU68847A1/xx unknown
- 1973-11-23 ZA ZA738957A patent/ZA738957B/xx unknown
- 1973-11-23 AT AT983473A patent/AT329552B/de not_active IP Right Cessation
- 1973-11-23 SU SU1971581A patent/SU498905A3/ru active
- 1973-11-23 BE BE138138A patent/BE807766A/xx not_active IP Right Cessation
- 1973-11-23 IL IL43686A patent/IL43686A/en unknown
- 1973-11-23 FI FI3611/73A patent/FI56832C/fi active
- 1973-11-23 IE IE2131/73A patent/IE39146B1/xx unknown
- 1973-11-24 ES ES420811A patent/ES420811A1/es not_active Expired
- 1973-11-26 JP JP13251673A patent/JPS5327274B2/ja not_active Expired
- 1973-11-26 NL NLAANVRAGE7316146,A patent/NL173638C/xx not_active IP Right Cessation
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