IL43686A - Process for the production of certain indole derivatives - Google Patents
Process for the production of certain indole derivativesInfo
- Publication number
- IL43686A IL43686A IL43686A IL4368673A IL43686A IL 43686 A IL43686 A IL 43686A IL 43686 A IL43686 A IL 43686A IL 4368673 A IL4368673 A IL 4368673A IL 43686 A IL43686 A IL 43686A
- Authority
- IL
- Israel
- Prior art keywords
- compounds
- general formula
- production
- phch
- nov
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/26—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an acyl radical attached to the ring nitrogen atom
- C07D209/28—1-(4-Chlorobenzoyl)-2-methyl-indolyl-3-acetic acid, substituted in position 5 by an oxygen or nitrogen atom; Esters thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/26—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an acyl radical attached to the ring nitrogen atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Indole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
1417080 Process for benzoylating indoles TROPON GmbH [trading as TROPONWERKE DINKLAGE & CO] 23 Nov 1973 [25 Nov 1972] 54400/73 Heading C2C A process for making compounds of formula wherein R is PhCH 2 - or PhCH 2 O 2 CCH 2 - and X is H, or one or more halogen atoms or functional groups, comprises reacting together in an inert solvent at #100‹ C., the corresponding N-unsubstituted indole and benzoyl chloride, with formation of free HCl. The products may be hydrogenolysed to the corresponding acids, i.e. analogues having otherwise the above structure but containing -CH 2 CO 2 H or -CH 2 CO 2 CH 2 CO 2 H in the 3-position of the indole nucleus.
[GB1417080A]
Claims (4)
1. Process for the production of compounds of the general formula 0 in which R stands for a benzyl radical or the radical
2. -CH2-COOCH2HQ> and X is hydrogen or represents one or more halogen atoms ;,£/ - · ÷- - .-. or functional groups,Imethoxy, nitro or trifluoro-methyl groups, wherein compounds of the general formula 0 •I are condensed with compounds of the general formula in which J? and X have the meaning indicated, at temperatures of at least 100°C in inert solvents, with formation of the operation takes place with exclusion of oxygen and advantageously a stream of oxygen-free inert gas is conducted through the reaction mixture.
3. Process according to claims 1 aid 2, characterised by working at temperatures from 100 to 220°C and advantageously in the range from 170-210°C.
4. Process according to claims 1 to 3, characterised in that in addition moisture and possibly also the action of light are excluded during the reaction.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2257867A DE2257867C2 (en) | 1972-11-25 | 1972-11-25 | Process for the preparation of 1-benzoylindole derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL43686A0 IL43686A0 (en) | 1974-03-14 |
| IL43686A true IL43686A (en) | 1976-10-31 |
Family
ID=5862712
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL43686A IL43686A (en) | 1972-11-25 | 1973-11-23 | Process for the production of certain indole derivatives |
Country Status (25)
| Country | Link |
|---|---|
| JP (1) | JPS5327274B2 (en) |
| AT (1) | AT329552B (en) |
| BE (1) | BE807766A (en) |
| CA (1) | CA1002040A (en) |
| CH (1) | CH593256A5 (en) |
| CS (1) | CS192507B2 (en) |
| DD (1) | DD108292A5 (en) |
| DE (1) | DE2257867C2 (en) |
| DK (1) | DK135944C (en) |
| ES (1) | ES420811A1 (en) |
| FI (1) | FI56832C (en) |
| FR (1) | FR2207915B1 (en) |
| GB (1) | GB1417080A (en) |
| HU (1) | HU167187B (en) |
| IE (1) | IE39146B1 (en) |
| IL (1) | IL43686A (en) |
| LU (1) | LU68847A1 (en) |
| NL (1) | NL173638C (en) |
| NO (1) | NO140185C (en) |
| PL (1) | PL91250B1 (en) |
| RO (1) | RO63986A (en) |
| SE (1) | SE397828B (en) |
| SU (1) | SU498905A3 (en) |
| YU (1) | YU35352B (en) |
| ZA (1) | ZA738957B (en) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS52156862A (en) * | 1976-06-22 | 1977-12-27 | Hisamitsu Pharmaceut Co Inc | Novel indoleacetic acid ester derivatives |
| JPS53163075U (en) * | 1977-05-27 | 1978-12-20 | ||
| DE3206885A1 (en) * | 1982-02-26 | 1983-09-15 | Troponwerke GmbH & Co KG, 5000 Köln | INDOLDER DERIVATIVES, METHOD FOR THEIR PRODUCTION AND THEIR USE AS MEDICINAL PRODUCTS |
| JPS60112760A (en) * | 1983-11-18 | 1985-06-19 | Green Cross Corp:The | Indoleacetic acid derivative and fatty emulsion thereof |
| US7632955B2 (en) | 2001-12-13 | 2009-12-15 | National Health Research Institutes | Indole compounds |
| NO317776B1 (en) | 2003-04-14 | 2004-12-13 | Bodil Korshamn | children Pose |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3483220A (en) * | 1967-05-03 | 1969-12-09 | Merck & Co Inc | Process for preparing 1-aroylindole-3-acetic acid compounds |
-
1972
- 1972-11-25 DE DE2257867A patent/DE2257867C2/en not_active Expired
-
1973
- 1973-11-08 CA CA185,335A patent/CA1002040A/en not_active Expired
- 1973-11-15 YU YU2959/73A patent/YU35352B/en unknown
- 1973-11-20 DK DK625673A patent/DK135944C/en not_active IP Right Cessation
- 1973-11-21 CS CS738010A patent/CS192507B2/en unknown
- 1973-11-22 RO RO7300076742A patent/RO63986A/en unknown
- 1973-11-22 PL PL1973166694A patent/PL91250B1/pl unknown
- 1973-11-23 ZA ZA738957A patent/ZA738957B/en unknown
- 1973-11-23 BE BE138138A patent/BE807766A/en not_active IP Right Cessation
- 1973-11-23 GB GB5440073A patent/GB1417080A/en not_active Expired
- 1973-11-23 NO NO4489/73A patent/NO140185C/en unknown
- 1973-11-23 HU HUTO942A patent/HU167187B/hu unknown
- 1973-11-23 FI FI3611/73A patent/FI56832C/en active
- 1973-11-23 AT AT983473A patent/AT329552B/en not_active IP Right Cessation
- 1973-11-23 LU LU68847A patent/LU68847A1/xx unknown
- 1973-11-23 IL IL43686A patent/IL43686A/en unknown
- 1973-11-23 DD DD174857A patent/DD108292A5/xx unknown
- 1973-11-23 FR FR7341875A patent/FR2207915B1/fr not_active Expired
- 1973-11-23 SE SE7315928A patent/SE397828B/en unknown
- 1973-11-23 SU SU1971581A patent/SU498905A3/en active
- 1973-11-23 CH CH1654873A patent/CH593256A5/xx not_active IP Right Cessation
- 1973-11-23 IE IE2131/73A patent/IE39146B1/en unknown
- 1973-11-24 ES ES420811A patent/ES420811A1/en not_active Expired
- 1973-11-26 JP JP13251673A patent/JPS5327274B2/ja not_active Expired
- 1973-11-26 NL NLAANVRAGE7316146,A patent/NL173638C/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| IE39146L (en) | 1974-05-25 |
| IE39146B1 (en) | 1978-08-16 |
| DE2257867A1 (en) | 1974-06-06 |
| NL7316146A (en) | 1974-05-28 |
| HU167187B (en) | 1975-08-28 |
| AU6278173A (en) | 1975-05-22 |
| ATA983473A (en) | 1975-08-15 |
| ZA738957B (en) | 1974-10-30 |
| CA1002040A (en) | 1976-12-21 |
| JPS4982657A (en) | 1974-08-08 |
| BE807766A (en) | 1974-05-24 |
| DD108292A5 (en) | 1974-09-12 |
| DK135944C (en) | 1977-12-12 |
| SU498905A3 (en) | 1976-01-05 |
| PL91250B1 (en) | 1977-02-28 |
| YU35352B (en) | 1980-12-31 |
| FR2207915B1 (en) | 1978-01-06 |
| IL43686A0 (en) | 1974-03-14 |
| YU295973A (en) | 1980-06-30 |
| FI56832B (en) | 1979-12-31 |
| GB1417080A (en) | 1975-12-10 |
| CS192507B2 (en) | 1979-08-31 |
| NO140185C (en) | 1979-07-18 |
| AT329552B (en) | 1976-05-25 |
| FI56832C (en) | 1980-04-10 |
| DK135944B (en) | 1977-07-18 |
| NO140185B (en) | 1979-04-09 |
| ES420811A1 (en) | 1976-04-16 |
| CH593256A5 (en) | 1977-11-30 |
| NL173638C (en) | 1984-02-16 |
| SE397828B (en) | 1977-11-21 |
| RO63986A (en) | 1978-08-15 |
| JPS5327274B2 (en) | 1978-08-07 |
| FR2207915A1 (en) | 1974-06-21 |
| LU68847A1 (en) | 1974-01-28 |
| DE2257867C2 (en) | 1982-09-23 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Patchett et al. | Studies on hydroxyproline | |
| Lee et al. | Antitumor agents, 107. New cytotoxic 4-alkylamino analogues of 4'-demethyl-epipodophyllotoxin as inhibitors of human DNA topoisomerase II | |
| White et al. | Analogs of firefly luciferin | |
| SE7907812L (en) | PROCEDURE FOR PREPARING CEFEM ASSOCIATIONS | |
| Weider et al. | Oxidative cyclization of unsaturated aminoquinones. Synthesis of quinolinoquinones. Palladium-catalyzed synthesis of pyrroloindoloquinones | |
| JPS58154582A (en) | Novel camptothecin derivative and its preparation | |
| FI880816A0 (en) | Process for the preparation of novel therapeutically useful quinoxaline derivatives | |
| JPS6314783A (en) | Production of 2-halogenated ergorin derivative | |
| US3238224A (en) | Production of 6, 8-dithiooctanoyl amides | |
| Huang et al. | Regioselective synthesis of 2, 3′-biindoles mediated by an NBS-induced homo-coupling of indoles | |
| IL43686A (en) | Process for the production of certain indole derivatives | |
| SE8204312L (en) | PROCEDURE FOR PREPARING 1,4-DIHYDROPYRIDINE DERIVATIVES | |
| US3796723A (en) | Cyclodopa derivatives | |
| Schwarzberg et al. | Photoalkylation of peptides. Visible light-induced conversion of glycine residues into branched. alpha.-amino acids | |
| NO752493L (en) | ||
| Slocum et al. | The preparation of several N-Substituted and N, N-Disubstituted ferrocenesulfonamides | |
| Abd‐Elzaher et al. | Preparation, characterization and biological studies of some novel ferrocenyl compounds | |
| Bartoli et al. | A new approach to the synthesis of 2-substituted indoles: reaction of dimetallated ortho-trimethylsilylmethylanilides with esters | |
| CN110156657B (en) | Synthesis method of 4-aminoindole | |
| IE42372B1 (en) | Ergoline derivatives | |
| GB1455100A (en) | Derivatives of 3,3-bis-4-hydroxyphenyl-2-indolinone and process for the preparation thereof | |
| JPH01249777A (en) | Novel camptothecin derivative and production thereof | |
| JPS62111983A (en) | 12- and 13-bromine-ergorin derivative, its production and therapeutic agent of derangement of atrabilary disease syndrome | |
| Mata et al. | Chemo-and stereoselective reduction of (pivaloyloxy) methyl 6, 6-dihalopenicillanates by trineophyltin hydride: Selective synthesis of 6β-halopenicillanates | |
| GB1505020A (en) | Substituted 2-phenylimino-thiazolines a process for their preparation and their use as ectoparasiticides |