IL43063A - 2-phenoxy-1-imidazolyl-alkan-3-ones their production and pharmaceutical compositions containing them - Google Patents
2-phenoxy-1-imidazolyl-alkan-3-ones their production and pharmaceutical compositions containing themInfo
- Publication number
- IL43063A IL43063A IL43063A IL4306373A IL43063A IL 43063 A IL43063 A IL 43063A IL 43063 A IL43063 A IL 43063A IL 4306373 A IL4306373 A IL 4306373A IL 43063 A IL43063 A IL 43063A
- Authority
- IL
- Israel
- Prior art keywords
- compound according
- compound
- hereinbefore described
- imidazole
- mols
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title claims 4
- 238000004519 manufacturing process Methods 0.000 title claims 3
- 150000001875 compounds Chemical class 0.000 claims abstract 33
- RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 claims abstract 22
- 239000002253 acid Substances 0.000 claims abstract 6
- 239000011230 binding agent Substances 0.000 claims abstract 5
- 150000003839 salts Chemical class 0.000 claims abstract 3
- IWDFHWZHHOSSGR-UHFFFAOYSA-N 1-ethylimidazole Chemical class CCN1C=CN=C1 IWDFHWZHHOSSGR-UHFFFAOYSA-N 0.000 claims abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 claims abstract 2
- 239000001257 hydrogen Substances 0.000 claims abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims abstract 2
- 238000000034 method Methods 0.000 claims 10
- 239000003085 diluting agent Substances 0.000 claims 5
- 239000003814 drug Substances 0.000 claims 4
- 239000004480 active ingredient Substances 0.000 claims 3
- 241001465754 Metazoa Species 0.000 claims 2
- 229910052801 chlorine Inorganic materials 0.000 claims 2
- 239000000460 chlorine Substances 0.000 claims 2
- 125000000468 ketone group Chemical group 0.000 claims 2
- 239000002904 solvent Substances 0.000 claims 2
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical group [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims 1
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 claims 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical group [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 claims 1
- 150000001338 aliphatic hydrocarbons Chemical class 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 150000004945 aromatic hydrocarbons Chemical class 0.000 claims 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 1
- 230000037396 body weight Effects 0.000 claims 1
- 238000009835 boiling Methods 0.000 claims 1
- 125000001246 bromo group Chemical group Br* 0.000 claims 1
- 239000002775 capsule Substances 0.000 claims 1
- 125000004432 carbon atom Chemical group C* 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 125000001309 chloro group Chemical group Cl* 0.000 claims 1
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 1
- 239000012024 dehydrating agents Substances 0.000 claims 1
- 239000008298 dragée Substances 0.000 claims 1
- 229910052731 fluorine Inorganic materials 0.000 claims 1
- 239000011737 fluorine Substances 0.000 claims 1
- 229910052736 halogen Inorganic materials 0.000 claims 1
- 150000002367 halogens Chemical group 0.000 claims 1
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- -1 nitro, phenyl Chemical group 0.000 claims 1
- 150000007524 organic acids Chemical class 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 239000001301 oxygen Substances 0.000 claims 1
- 125000004430 oxygen atom Chemical group O* 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- WSDQIHATCCOMLH-UHFFFAOYSA-N phenyl n-(3,5-dichlorophenyl)carbamate Chemical class ClC1=CC(Cl)=CC(NC(=O)OC=2C=CC=CC=2)=C1 WSDQIHATCCOMLH-UHFFFAOYSA-N 0.000 claims 1
- 239000006187 pill Substances 0.000 claims 1
- 239000003495 polar organic solvent Substances 0.000 claims 1
- 239000002798 polar solvent Substances 0.000 claims 1
- 150000003254 radicals Chemical class 0.000 claims 1
- 239000007787 solid Substances 0.000 claims 1
- 125000001424 substituent group Chemical group 0.000 claims 1
- 239000000829 suppository Substances 0.000 claims 1
- 239000004094 surface-active agent Substances 0.000 claims 1
- 239000003826 tablet Substances 0.000 claims 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims 1
- RAXXELZNTBOGNW-UHFFFAOYSA-O Imidazolium Chemical compound C1=C[NH+]=CN1 RAXXELZNTBOGNW-UHFFFAOYSA-O 0.000 abstract 2
- 239000012458 free base Substances 0.000 abstract 1
- 231100000252 nontoxic Toxicity 0.000 abstract 1
- 230000003000 nontoxic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/63—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
- C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
- C07C45/72—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction of compounds containing >C = O groups with the same or other compounds containing >C = O groups
- C07C45/75—Reactions with formaldehyde
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/20—Unsaturated compounds containing keto groups bound to acyclic carbon atoms
- C07C49/255—Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing ether groups, groups, groups, or groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2242454A DE2242454A1 (de) | 1972-08-29 | 1972-08-29 | 1-aethyl-imidazole, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL43063A0 IL43063A0 (en) | 1973-11-28 |
| IL43063A true IL43063A (en) | 1976-11-30 |
Family
ID=5854889
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL43063A IL43063A (en) | 1972-08-29 | 1973-08-24 | 2-phenoxy-1-imidazolyl-alkan-3-ones their production and pharmaceutical compositions containing them |
Country Status (28)
| Country | Link |
|---|---|
| US (1) | US3940413A (pl) |
| JP (2) | JPS5734250B2 (pl) |
| AR (2) | AR198869A1 (pl) |
| AT (1) | AT324325B (pl) |
| AU (1) | AU471621B2 (pl) |
| BE (1) | BE804092A (pl) |
| CA (1) | CA1026347A (pl) |
| CH (2) | CH605805A5 (pl) |
| DD (1) | DD107037A5 (pl) |
| DE (1) | DE2242454A1 (pl) |
| DK (1) | DK136468C (pl) |
| ES (2) | ES418277A1 (pl) |
| FI (1) | FI57935C (pl) |
| FR (1) | FR2197593B1 (pl) |
| GB (1) | GB1394962A (pl) |
| GT (1) | GT197851542A (pl) |
| HK (1) | HK38578A (pl) |
| HU (1) | HU166356B (pl) |
| IE (1) | IE38139B1 (pl) |
| IL (1) | IL43063A (pl) |
| LU (1) | LU68314A1 (pl) |
| NL (1) | NL7311764A (pl) |
| NO (1) | NO138025C (pl) |
| PL (2) | PL93901B1 (pl) |
| SE (1) | SE403287B (pl) |
| SU (2) | SU501671A3 (pl) |
| YU (2) | YU36015B (pl) |
| ZA (1) | ZA735876B (pl) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL47885A (en) * | 1974-09-23 | 1979-01-31 | Syntex Inc | Imidazole derivatives,their preparation and antifungal and antibacterial compositions containing them |
| DE2455954A1 (de) * | 1974-11-27 | 1976-08-12 | Bayer Ag | Diaryloxy-imidazolyl-o,n-acetale, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel |
| US4675316A (en) * | 1978-03-10 | 1987-06-23 | Rohm And Haas Company | Substituted azoylmethylarylsulfides and derivatives and pesticidal use thereof |
| DE2816818A1 (de) * | 1978-04-18 | 1979-10-31 | Bayer Ag | Optisch aktive 1-aethyl-imidazole, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel |
| DE2846980A1 (de) * | 1978-10-28 | 1980-05-08 | Bayer Ag | 1-ethen-azol-derivate, verfahren zu ihrer herstellung und ihre verwendung als fungizide |
| JPS58139827U (ja) * | 1982-03-15 | 1983-09-20 | 古河電気工業株式会社 | 管路気中ケ−ブル |
| EP0099165A1 (en) * | 1982-03-23 | 1984-01-25 | Imperial Chemical Industries Plc | Triazole and imidazole compounds, process for their preparation and their use as fungicides and plant growth regulators, and intermediates for their synthesis |
| US4584307A (en) * | 1983-08-10 | 1986-04-22 | Pfizer Inc. | Antifungal 2-aryl-2-hydroxy perfluoro-1-(1H-1,2,4-triazol-1-yl) alkanones and alkanols |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3575999A (en) * | 1968-08-19 | 1971-04-20 | Janssen Pharmaceutica Nv | Ketal derivatives of imidazole |
| SU557755A3 (ru) * | 1968-08-19 | 1977-05-05 | Янссен Фармасьютика Н.В. (Фирма) | Способ получени производных имидазола |
| US3658813A (en) * | 1970-01-13 | 1972-04-25 | Janssen Pharmaceutica Nv | 1-(beta-aryl-beta-(r-oxy)-ethyl)-imidazoles |
| DE2037610A1 (de) * | 1970-07-29 | 1972-02-03 | Bayer Ag | Neue alpha-substituierte Benzyl-azole, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| DE2041771C3 (de) * | 1970-08-22 | 1979-07-26 | Bayer Ag, 5090 Leverkusen | derivate |
-
1972
- 1972-08-29 DE DE2242454A patent/DE2242454A1/de not_active Withdrawn
-
1973
- 1973-08-20 US US05/390,042 patent/US3940413A/en not_active Expired - Lifetime
- 1973-08-21 CA CA179,350A patent/CA1026347A/en not_active Expired
- 1973-08-24 IL IL43063A patent/IL43063A/en unknown
- 1973-08-27 CH CH706376A patent/CH605805A5/xx not_active IP Right Cessation
- 1973-08-27 SU SU1962549A patent/SU501671A3/ru active
- 1973-08-27 CH CH1226473A patent/CH580595A5/xx not_active IP Right Cessation
- 1973-08-27 FI FI2669/73A patent/FI57935C/fi active
- 1973-08-27 DD DD173105A patent/DD107037A5/xx unknown
- 1973-08-27 LU LU68314A patent/LU68314A1/xx unknown
- 1973-08-27 NL NL7311764A patent/NL7311764A/xx not_active Application Discontinuation
- 1973-08-28 ES ES418277A patent/ES418277A1/es not_active Expired
- 1973-08-28 AT AT746973A patent/AT324325B/de not_active IP Right Cessation
- 1973-08-28 JP JP9581473A patent/JPS5734250B2/ja not_active Expired
- 1973-08-28 NO NO3391/73A patent/NO138025C/no unknown
- 1973-08-28 SE SE7311669A patent/SE403287B/xx unknown
- 1973-08-28 IE IE1507/73A patent/IE38139B1/xx unknown
- 1973-08-28 AU AU59712/73A patent/AU471621B2/en not_active Expired
- 1973-08-28 ZA ZA735876A patent/ZA735876B/xx unknown
- 1973-08-28 PL PL1973187922A patent/PL93901B1/pl unknown
- 1973-08-28 YU YU2292/73A patent/YU36015B/xx unknown
- 1973-08-28 GB GB4053073A patent/GB1394962A/en not_active Expired
- 1973-08-28 AR AR249800A patent/AR198869A1/es active
- 1973-08-28 JP JP9581373A patent/JPS5735195B2/ja not_active Expired
- 1973-08-28 BE BE134998A patent/BE804092A/xx unknown
- 1973-08-28 DK DK473573A patent/DK136468C/da active
- 1973-08-28 PL PL1973164884A patent/PL90769B1/pl unknown
- 1973-08-29 FR FR7331235A patent/FR2197593B1/fr not_active Expired
- 1973-08-29 HU HUBA2974A patent/HU166356B/hu unknown
-
1974
- 1974-08-27 AR AR255328A patent/AR200221A1/es active
- 1974-10-09 SU SU742066991A patent/SU509225A3/ru active
-
1975
- 1975-11-12 ES ES442554A patent/ES442554A1/es not_active Expired
-
1978
- 1978-04-03 GT GT197851542A patent/GT197851542A/es unknown
- 1978-07-13 HK HK385/78A patent/HK38578A/xx unknown
-
1979
- 1979-11-27 YU YU2912/79A patent/YU35884B/xx unknown
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