IL41668A - N-Transformed History of Dihydropyridine, Their Manufacture, and Pharmaceutical Preparations Containing Them - Google Patents

N-Transformed History of Dihydropyridine, Their Manufacture, and Pharmaceutical Preparations Containing Them

Info

Publication number
IL41668A
IL41668A IL7341668A IL4166873A IL41668A IL 41668 A IL41668 A IL 41668A IL 7341668 A IL7341668 A IL 7341668A IL 4166873 A IL4166873 A IL 4166873A IL 41668 A IL41668 A IL 41668A
Authority
IL
Israel
Prior art keywords
ester
acid
general formula
ethyl
dihydropyridine
Prior art date
Application number
IL7341668A
Other languages
English (en)
Hebrew (he)
Other versions
IL41668A0 (en
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag filed Critical Bayer Ag
Publication of IL41668A0 publication Critical patent/IL41668A0/xx
Publication of IL41668A publication Critical patent/IL41668A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pulmonology (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
IL7341668A 1972-03-06 1973-03-02 N-Transformed History of Dihydropyridine, Their Manufacture, and Pharmaceutical Preparations Containing Them IL41668A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE2210672A DE2210672C3 (de) 1972-03-06 1972-03-06 N-substituierte unsymmetrische 1 ^-Dihydropyridin-S^-dicarbonsäureester, Verfahren zu ihrer Herstellung sowie ihre Verwendung als Arzneimittel

Publications (2)

Publication Number Publication Date
IL41668A0 IL41668A0 (en) 1973-05-31
IL41668A true IL41668A (en) 1977-02-28

Family

ID=5838025

Family Applications (1)

Application Number Title Priority Date Filing Date
IL7341668A IL41668A (en) 1972-03-06 1973-03-02 N-Transformed History of Dihydropyridine, Their Manufacture, and Pharmaceutical Preparations Containing Them

Country Status (25)

Country Link
US (1) US3883540A (fr)
JP (1) JPS5626657B2 (fr)
KR (1) KR780000010B1 (fr)
AT (1) AT324335B (fr)
AU (1) AU468879B2 (fr)
BE (1) BE796274A (fr)
BG (2) BG20351A3 (fr)
CA (1) CA1045138A (fr)
CH (2) CH579049A5 (fr)
CS (2) CS173649B2 (fr)
DD (1) DD107456A5 (fr)
DE (1) DE2210672C3 (fr)
DK (1) DK136900C (fr)
ES (2) ES412319A1 (fr)
FR (1) FR2183674B1 (fr)
GB (1) GB1384031A (fr)
HU (1) HU164867B (fr)
IE (1) IE37366B1 (fr)
IL (1) IL41668A (fr)
LU (1) LU67146A1 (fr)
NL (1) NL7303135A (fr)
PL (2) PL92117B1 (fr)
RO (2) RO62798A (fr)
SU (6) SU464111A3 (fr)
ZA (1) ZA731500B (fr)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4031104A (en) * 1972-04-18 1977-06-21 Bayer Aktiengesellschaft 1,4-Dihydropyridine carboxylic acid esters
US3974278A (en) * 1973-07-12 1976-08-10 Bayer Aktiengesellschaft 1,4-Dihydropyridine esters
CH607848A5 (fr) * 1974-06-04 1978-11-30 Bayer Ag
FR2320750A1 (fr) * 1975-08-12 1977-03-11 Hexachimie Dihydro-1,4 pyridines et leur application therapeutique
US4466972A (en) * 1977-06-20 1984-08-21 Sandoz Ltd. Benzoxadiazoles and benzothiadiazoles, their preparation and pharmaceutical compositions containing them
SU798099A1 (ru) * 1978-03-06 1981-01-23 Ордена Трудового Красного Знамениинститут Органического Синтезаан Латвийской Ccp 1-Бензил-2,6-диметил-4-о-или-M-НиТРОфЕНил-3,5-диэТОКСиКАРбОНил- 1,4-дигидРОпиРидиНы, пРО Вл ющиЕКОРОНАРОдилАТиРующую АКТиВНОСТь
SE429652B (sv) * 1978-06-30 1983-09-19 Haessle Ab 2.6-dimetyl-4-(2.3-diklorfenyl)-1.4-dihydropyridin-3.5-dikarboxylsyra-3-metylester-5-etylester
DE2847236A1 (de) * 1978-10-31 1980-05-14 Bayer Ag Neue dihydropyridine mit substituierten estergruppierungen, mehrer verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
US4497808A (en) * 1981-12-30 1985-02-05 Ciba-Geigy Corporation N-Oxide compounds useful in the treatment of cardiovascular ailments
DE3208628A1 (de) * 1982-03-10 1983-09-22 Bayer Ag, 5090 Leverkusen Neue verbindungen, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
IL68604A0 (en) * 1982-05-21 1983-09-30 Haessle Ab Processes for preparing therapeutically active dihydropyridines and intermediates for the processes
DE3312283A1 (de) * 1983-04-05 1984-10-18 Bayer Ag, 5090 Leverkusen Verfahren zur herstellung von unsymmetrischen 1,4-dihydropyridincarbonsaeureestern
US5237089A (en) * 1986-02-07 1993-08-17 Basf Aktiengesellschaft Nitro or amino substituted phenylalkyl or phenylalkenyl carboxylic acid derivatives
DE3724399A1 (de) * 1987-07-23 1989-02-02 Basf Ag Phenylalkenylcarbonsaeuren und deren ester
EP0330470A3 (fr) * 1988-02-24 1992-01-02 Ajinomoto Co., Inc. Dérivés de 1,4-dihydropyridine utiles contre les cellules tumorales
US5216172A (en) * 1988-02-24 1993-06-01 Ajinomoto Co., Inc. 1,4-dihydropyridine-4-aryl-2,6-dimethyl-3,5-dicarboxylates useful as agents against drug resistant tumor cells
DE4011695A1 (de) * 1990-04-11 1991-10-17 Bayer Ag Verwendung von n-alkylierten 1,4-dihydropyridindicarbonsaeureestern als arzneimittel, neue verbindungen und verfahren zu ihrer herstellung
DE4125271A1 (de) * 1991-07-31 1993-02-11 Bayer Ag Neue n-alkylierte 1,4-dihydropyridindicarbonsaeureester
DE4133257A1 (de) * 1991-10-08 1993-04-15 Bayer Ag N-methyl-nimodipin, verfahren zu seiner herstellung und seine verwendung als zerebraltherapeutikum
EP1554572B1 (fr) 2001-07-25 2009-10-14 Raptor Pharmaceutical Inc. Compositions et procedes de modulation du transport a travers la barriere hematho-encephalique
EP3827747A1 (fr) 2005-04-28 2021-06-02 Otsuka Pharmaceutical Co., Ltd. Système pharma-informatique
EP2063905B1 (fr) 2006-09-18 2014-07-30 Raptor Pharmaceutical Inc Traitement des troubles hépatiques par l'administration de conjugués de protéine associée au récepteur (rap)
NZ616673A (en) 2009-02-20 2014-08-29 To Bbb Holding B V Glutathione-based drug delivery system
ES2942923T3 (es) 2009-05-06 2023-06-07 Laboratory Skin Care Inc Composiciones de administración dérmica que comprenden complejos de agente activo-partículas de fosfato de calcio y métodos de uso de las mismas
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates
US10258498B2 (en) * 2011-11-24 2019-04-16 Richter Gedeon Nyrt. 1,4-dihydropyridine derivatives with Hsp modulating activity
JP7411994B2 (ja) 2020-03-19 2024-01-12 昌史 星野 腰枕および腰枕セット

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2359329A (en) * 1943-06-18 1944-10-03 Burroughs Wellcome Co Quinoline substituted dihydropyridines
DE2013431C3 (de) * 1970-03-20 1979-12-20 Bayer Ag, 5090 Leverkusen 4-Azidophenyl-l,4-dihydropyridin-3,5-dicarbonsäureester
DE1963186C3 (de) * 1969-12-17 1979-02-15 Bayer Ag, 5090 Leverkusen Schwefelhaltige 1,4-Dihydropyridin-33-dicarbonsäureester
DE2117572C3 (de) * 1971-04-10 1980-03-20 Bayer Ag, 5090 Leverkusen Unsymmetrische 1,4-Dihydropyridin ^-dicarbonsäureester, Verfahren zu ihrer Herstellung sowie ihre Verwendung als Arzneimittel

Also Published As

Publication number Publication date
DE2210672C3 (de) 1980-03-20
SU464111A3 (ru) 1975-03-15
NL7303135A (fr) 1973-09-10
BG22389A3 (fr) 1977-02-20
ZA731500B (en) 1973-11-28
SU468416A3 (ru) 1975-04-25
FR2183674A1 (fr) 1973-12-21
US3883540A (en) 1975-05-13
DE2210672B2 (de) 1979-07-12
CH578530A5 (fr) 1976-08-13
RO62798A (fr) 1977-11-15
PL89257B1 (fr) 1976-11-30
ES439487A1 (es) 1977-02-01
JPS4899179A (fr) 1973-12-15
BG20351A3 (fr) 1975-11-05
HU164867B (fr) 1974-05-28
ES412319A1 (es) 1976-05-01
KR780000010B1 (en) 1978-03-04
IE37366B1 (en) 1977-07-06
BE796274A (fr) 1973-09-05
CS173649B2 (fr) 1977-02-28
CH579049A5 (fr) 1976-08-31
IL41668A0 (en) 1973-05-31
PL92117B1 (fr) 1977-03-31
JPS5626657B2 (fr) 1981-06-19
RO63067A (fr) 1978-05-15
AT324335B (de) 1975-08-25
AU5287673A (en) 1975-03-27
IE37366L (en) 1973-09-06
DE2210672A1 (de) 1973-09-20
SU451241A3 (ru) 1974-11-25
AU468879B2 (en) 1975-03-27
SU470958A3 (ru) 1975-05-15
DD107456A5 (fr) 1974-08-05
LU67146A1 (fr) 1973-05-22
FR2183674B1 (fr) 1976-10-22
GB1384031A (en) 1975-02-19
CS173624B2 (fr) 1977-02-28
CA1045138A (fr) 1978-12-26
SU466656A3 (ru) 1975-04-05
DK136900B (da) 1977-12-12
DK136900C (da) 1978-05-22
SU457217A3 (ru) 1975-01-15

Similar Documents

Publication Publication Date Title
IL41668A (en) N-Transformed History of Dihydropyridine, Their Manufacture, and Pharmaceutical Preparations Containing Them
US4849433A (en) The compound, (⃡)1,4-dihydro-2,6-dimethyl-4-(2'-nitrophenyl)-pyridine-3,5-dicarboxylic acid, methyl isobutyl ester, compositions containing same and a method for effecting coronary dilation
US4248873A (en) Nitro-substituted 1,4-dihydropyridines, processes for _their production and their medicinal use
US4551467A (en) Vasodilating cyanoalkyl esters of 1,4-dihydropyridines
US4154839A (en) 2,6-Dimethyl-3-carboxymethoxy-4-(2-nitrophenyl)-5-carbisobutoxy-1,4-dihydropyridine
US4177278A (en) 2-Alkyleneaminodihydropyridines compounds, their production and their medicinal use
IL42458A (en) 1,4-dihydropyridines their production and pharmaceutical compositions containing them
US3708489A (en) Azido-aryl 1,4-dihydropyridines and their production
US3905983A (en) 3,5,6-Tricarboxy- and 2,3,5,6-tetracarboxy-1,4-dihydropyridine derivatives
US4237137A (en) Sila-substituted 1,4-dihydropyridine derivatives and their medicinal use
IE49462B1 (en) New fluorine-containing 1,4-dihydropyridine compounds,their production and their medicinal use
US3946027A (en) 3,5,6-Tricarboxy-4-pyridyl-1,4-dihydropyridine derivatives
EP0197488A2 (fr) Dérivés 1,4-dihydropyridine, leur procédé de préparation, médicament les contenant et leur utilisation
IE51267B1 (en) 1,4-dihydropyridine compounds having different substituents in the 2-position and 6-position,their production,and their medicinal use
US4166855A (en) 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid ester, and its use as a peripheral vasodilator
US3946028A (en) 2,3,5,6-Tetracarboxy-4-pyridyl-1,4-dihydropyridine derivatives
US3943140A (en) 2,3,5,6-Tetracarboxy-1,4-dihydropyridine derivatives
CA1085406A (fr) Isobutylmethyl-1,4-dihydro-2,6-dimethyl-4-(2- nitrophenyl)-3,5-pyridindicarboxylate
US4162321A (en) Sulphur-containing amino-dihydropyridines, and their use as medicants
US4364952A (en) Certain 1,4-dihydro-2,6-dimethyl-3,5-pyridine-dicarboxylates, composition containing same and method of use
IL42933A (en) 2- Alcalamino dihydropyridines, their manufacture and pharmaceutical preparations containing them
IL46593A (en) 2-amino-6-dialkylamino-dihydropyridines their production and pharmaceutical compositions containing them
US4469696A (en) Substituted 2-amino-pyridine derivative compounds, their production and their medicinal use
JPS6256474A (ja) ジヒドロピリジン−２−ヒドロキシアミン類
US4351837A (en) 1,4-Dihydropyridine-3,5-dicarboxylate-4-carboxamide compounds, compositions containing same and method of using same