IL40585A - Blood sugar-sinking sulphonylaminopyrimidines,processes for their preparation and pharmaceutical compositions containing the same - Google Patents
Blood sugar-sinking sulphonylaminopyrimidines,processes for their preparation and pharmaceutical compositions containing the sameInfo
- Publication number
- IL40585A IL40585A IL40585A IL4058572A IL40585A IL 40585 A IL40585 A IL 40585A IL 40585 A IL40585 A IL 40585A IL 4058572 A IL4058572 A IL 4058572A IL 40585 A IL40585 A IL 40585A
- Authority
- IL
- Israel
- Prior art keywords
- sulphonamide
- compound
- pyrimidinyl
- ethyl
- benzene
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title claims abstract 3
- 238000000034 method Methods 0.000 title claims 8
- 239000008280 blood Substances 0.000 title 1
- 210000004369 blood Anatomy 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims abstract 20
- 229940124530 sulfonamide Drugs 0.000 claims abstract 5
- 125000000217 alkyl group Chemical group 0.000 claims abstract 4
- 125000004432 carbon atom Chemical group C* 0.000 claims abstract 4
- 150000003839 salts Chemical class 0.000 claims abstract 4
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims abstract 3
- 239000002253 acid Substances 0.000 claims abstract 3
- 125000003545 alkoxy group Chemical group 0.000 claims abstract 3
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims abstract 3
- 229910052760 oxygen Inorganic materials 0.000 claims abstract 3
- 239000001301 oxygen Substances 0.000 claims abstract 3
- FDDDEECHVMSUSB-UHFFFAOYSA-N sulfanilamide Chemical compound NC1=CC=C(S(N)(=O)=O)C=C1 FDDDEECHVMSUSB-UHFFFAOYSA-N 0.000 claims abstract 3
- CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical compound C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 claims abstract 2
- 239000005864 Sulphur Substances 0.000 claims abstract 2
- 125000004183 alkoxy alkyl group Chemical group 0.000 claims abstract 2
- 125000005083 alkoxyalkoxy group Chemical group 0.000 claims abstract 2
- 229910052799 carbon Inorganic materials 0.000 claims abstract 2
- 125000000000 cycloalkoxy group Chemical group 0.000 claims abstract 2
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 claims abstract 2
- 239000003937 drug carrier Substances 0.000 claims abstract 2
- 229910052736 halogen Inorganic materials 0.000 claims abstract 2
- 239000007788 liquid Substances 0.000 claims abstract 2
- 239000008024 pharmaceutical diluent Substances 0.000 claims abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims abstract 2
- 239000007787 solid Substances 0.000 claims abstract 2
- -1 bicyclic radical Chemical class 0.000 claims 8
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 3
- SLRMQYXOBQWXCR-UHFFFAOYSA-N 2154-56-5 Chemical compound [CH2]C1=CC=CC=C1 SLRMQYXOBQWXCR-UHFFFAOYSA-N 0.000 claims 1
- CHJJGSNFBQVOTG-UHFFFAOYSA-N N-methyl-guanidine Natural products CNC(N)=N CHJJGSNFBQVOTG-UHFFFAOYSA-N 0.000 claims 1
- 125000004450 alkenylene group Chemical group 0.000 claims 1
- 125000004414 alkyl thio group Chemical group 0.000 claims 1
- 125000002947 alkylene group Chemical group 0.000 claims 1
- ZRALSGWEFCBTJO-UHFFFAOYSA-N anhydrous guanidine Natural products NC(N)=N ZRALSGWEFCBTJO-UHFFFAOYSA-N 0.000 claims 1
- 125000004210 cyclohexylmethyl group Chemical group [H]C([H])(*)C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 claims 1
- SWSQBOPZIKWTGO-UHFFFAOYSA-N dimethylaminoamidine Natural products CN(C)C(N)=N SWSQBOPZIKWTGO-UHFFFAOYSA-N 0.000 claims 1
- 125000004185 ester group Chemical group 0.000 claims 1
- 125000006351 ethylthiomethyl group Chemical group [H]C([H])([H])C([H])([H])SC([H])([H])* 0.000 claims 1
- 150000002367 halogens Chemical class 0.000 claims 1
- ORTFAQDWJHRMNX-UHFFFAOYSA-N hydroxidooxidocarbon(.) Chemical compound O[C]=O ORTFAQDWJHRMNX-UHFFFAOYSA-N 0.000 claims 1
- 125000004356 hydroxy functional group Chemical group O* 0.000 claims 1
- 150000007529 inorganic bases Chemical class 0.000 claims 1
- 125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 claims 1
- 150000007530 organic bases Chemical class 0.000 claims 1
- ICFJFFQQTFMIBG-UHFFFAOYSA-N phenformin Chemical class NC(=N)NC(=N)NCCC1=CC=CC=C1 ICFJFFQQTFMIBG-UHFFFAOYSA-N 0.000 claims 1
- 150000003230 pyrimidines Chemical class 0.000 claims 1
- 125000000714 pyrimidinyl group Chemical group 0.000 claims 1
- 229910052717 sulfur Chemical group 0.000 claims 1
- 239000011593 sulfur Chemical group 0.000 claims 1
- DQGBPFUIAYFOLA-UHFFFAOYSA-N 2-(sulfonylamino)pyrimidine Chemical class O=S(=O)=NC1=NC=CC=N1 DQGBPFUIAYFOLA-UHFFFAOYSA-N 0.000 abstract 2
- 125000005843 halogen group Chemical group 0.000 abstract 2
- FYSNRJHAOHDILO-UHFFFAOYSA-N thionyl chloride Chemical compound ClS(Cl)=O FYSNRJHAOHDILO-UHFFFAOYSA-N 0.000 abstract 2
- DWUGGYMHKCSQFR-UHFFFAOYSA-N 5-methoxy-2-methyl-2,3-dihydro-1-benzofuran-7-carbonyl chloride Chemical compound COC1=CC2=C(OC(C2)C)C(=C1)C(=O)Cl DWUGGYMHKCSQFR-UHFFFAOYSA-N 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- DHKHKXVYLBGOIT-UHFFFAOYSA-N acetaldehyde Diethyl Acetal Natural products CCOC(C)OCC DHKHKXVYLBGOIT-UHFFFAOYSA-N 0.000 abstract 1
- 125000002777 acetyl group Chemical class [H]C([H])([H])C(*)=O 0.000 abstract 1
- 230000003178 anti-diabetic effect Effects 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 125000002619 bicyclic group Chemical group 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 150000002081 enamines Chemical class 0.000 abstract 1
- 150000002366 halogen compounds Chemical class 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 230000003647 oxidation Effects 0.000 abstract 1
- 238000007254 oxidation reaction Methods 0.000 abstract 1
- 238000010992 reflux Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/69—Benzenesulfonamido-pyrimidines
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19712152230 DE2152230A1 (de) | 1971-10-20 | 1971-10-20 | Blutzuckersenkende sulfonylaminopyrimidine und verfahren zu deren herstellung |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL40585A0 IL40585A0 (en) | 1972-12-29 |
| IL40585A true IL40585A (en) | 1976-04-30 |
Family
ID=5822885
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL40585A IL40585A (en) | 1971-10-20 | 1972-10-16 | Blood sugar-sinking sulphonylaminopyrimidines,processes for their preparation and pharmaceutical compositions containing the same |
Country Status (21)
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS59186969A (ja) * | 1983-04-08 | 1984-10-23 | Yoshitomi Pharmaceut Ind Ltd | ベンゾフラン−およびベンゾピランカルボキサミド誘導体 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1670168C3 (de) * | 1966-11-29 | 1975-04-10 | Boehringer Mannheim Gmbh, 6800 Mannheim | 2-Benzolsulfonamido-4-methyl-5alkyl-pyrimidine und Verfahren zu ihrer Herstellung |
| DE1670282B2 (de) * | 1967-10-24 | 1977-02-24 | Antidiabetisch wirksame hydrindensulfonylamino-pyrimidine sowie verfahren zu deren herstellung | |
| DE2022746A1 (de) * | 1970-05-09 | 1971-12-02 | Bochringer Mannheim Gmbh | Blutzuckersenkende Sulfonylaminopyrimidine und Verfahren zu deren Herstellung |
-
1971
- 1971-10-20 DE DE19712152230 patent/DE2152230A1/de active Pending
-
1972
- 1972-10-11 US US00296744A patent/US3849417A/en not_active Expired - Lifetime
- 1972-10-13 CS CS427*[A patent/CS161959B2/cs unknown
- 1972-10-13 BG BG023371A patent/BG20368A3/xx unknown
- 1972-10-13 BG BG021615A patent/BG20366A3/xx unknown
- 1972-10-13 CS CS6936A patent/CS161958B2/cs unknown
- 1972-10-13 BG BG023369A patent/BG20798A3/xx unknown
- 1972-10-13 BG BG023370A patent/BG20367A3/xx unknown
- 1972-10-13 CS CS428*[A patent/CS161960B2/cs unknown
- 1972-10-13 CS CS429*[A patent/CS161961B2/cs unknown
- 1972-10-16 IL IL40585A patent/IL40585A/en unknown
- 1972-10-16 AR AR244646A patent/AR197007A1/es active
- 1972-10-16 GB GB4760872A patent/GB1346705A/en not_active Expired
- 1972-10-17 DK DK512472AA patent/DK130297B/da unknown
- 1972-10-17 CH CH272276A patent/CH578559A5/xx not_active IP Right Cessation
- 1972-10-17 NL NL7214010A patent/NL7214010A/xx not_active Application Discontinuation
- 1972-10-17 CH CH272476A patent/CH578560A5/xx not_active IP Right Cessation
- 1972-10-17 CH CH272376A patent/CH591476A5/xx not_active IP Right Cessation
- 1972-10-17 CH CH1513772A patent/CH578558A5/xx not_active IP Right Cessation
- 1972-10-18 FR FR7236850A patent/FR2157878B1/fr not_active Expired
- 1972-10-18 DD DD166307A patent/DD101153A5/xx unknown
- 1972-10-18 ZA ZA727443A patent/ZA727443B/xx unknown
- 1972-10-19 AT AT00305/74A patent/AT319957B/de not_active IP Right Cessation
- 1972-10-19 RO RO7280266A patent/RO68648A/ro unknown
- 1972-10-19 PL PL1972175421A patent/PL92394B1/pl unknown
- 1972-10-19 SU SU1839306A patent/SU556726A3/ru active
- 1972-10-19 PL PL1972175423A patent/PL92392B1/pl unknown
- 1972-10-19 AT AT00306/74A patent/AT319958B/de not_active IP Right Cessation
- 1972-10-19 PL PL1972175422A patent/PL92393B1/pl unknown
- 1972-10-19 RO RO7280264A patent/RO68646A/ro unknown
- 1972-10-19 ES ES407775A patent/ES407775A1/es not_active Expired
- 1972-10-19 PL PL1972158370A patent/PL83610B1/pl unknown
- 1972-10-19 AT AT00309/74A patent/AT319959B/de not_active IP Right Cessation
- 1972-10-19 RO RO7280265A patent/RO68647A/ro unknown
- 1972-10-19 CA CA154,566A patent/CA985682A/en not_active Expired
- 1972-10-19 NO NO3756/72A patent/NO136842C/no unknown
- 1972-10-19 AT AT896572A patent/AT319954B/de not_active IP Right Cessation
- 1972-10-20 JP JP47105135A patent/JPS5125032B2/ja not_active Expired
-
1973
- 1973-07-23 AR AR249221A patent/AR197050A1/es active
- 1973-07-23 AR AR249220A patent/AR197049A1/es active
- 1973-07-23 AR AR249219A patent/AR202900A1/es active
- 1973-12-28 SU SU1985248A patent/SU553931A3/ru active
- 1973-12-29 SU SU1982651A patent/SU499807A3/ru active
- 1973-12-29 SU SU7301982650A patent/SU576934A3/ru active
-
1975
- 1975-10-19 RO RO7272570A patent/RO74822A/ro unknown
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