IL40050A - Compositions for treating microbial infections containing piperidine derivatives - Google Patents
Compositions for treating microbial infections containing piperidine derivativesInfo
- Publication number
- IL40050A IL40050A IL40050A IL4005072A IL40050A IL 40050 A IL40050 A IL 40050A IL 40050 A IL40050 A IL 40050A IL 4005072 A IL4005072 A IL 4005072A IL 40050 A IL40050 A IL 40050A
- Authority
- IL
- Israel
- Prior art keywords
- composition
- potentiator
- pharmaceutical formulation
- compound
- competitor
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title claims 35
- 208000015181 infectious disease Diseases 0.000 title claims 4
- 230000000813 microbial effect Effects 0.000 title claims 3
- 150000003053 piperidines Chemical class 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 15
- 239000003112 inhibitor Substances 0.000 claims 12
- 150000001875 compounds Chemical class 0.000 claims 11
- 125000000217 alkyl group Chemical group 0.000 claims 7
- 238000000034 method Methods 0.000 claims 5
- LDBTVAXGKYIFHO-UHFFFAOYSA-N diaveridine Chemical group C1=C(OC)C(OC)=CC=C1CC1=CN=C(N)N=C1N LDBTVAXGKYIFHO-UHFFFAOYSA-N 0.000 claims 4
- 229950000246 diaveridine Drugs 0.000 claims 4
- 125000005843 halogen group Chemical group 0.000 claims 4
- 125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- -1 2-amino-4-hydroxy-7 ,8-dihydropteridine compound Chemical class 0.000 claims 3
- NHZLNPMOSADWGC-UHFFFAOYSA-N 4-amino-N-(2-quinoxalinyl)benzenesulfonamide Chemical group C1=CC(N)=CC=C1S(=O)(=O)NC1=CN=C(C=CC=C2)C2=N1 NHZLNPMOSADWGC-UHFFFAOYSA-N 0.000 claims 3
- 239000002552 dosage form Substances 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- 244000005700 microbiome Species 0.000 claims 3
- 230000003389 potentiating effect Effects 0.000 claims 3
- CPNGPNLZQNNVQM-UHFFFAOYSA-N pteridine Chemical compound N1=CN=CC2=NC=CN=C21 CPNGPNLZQNNVQM-UHFFFAOYSA-N 0.000 claims 3
- 108010022394 Threonine synthase Proteins 0.000 claims 2
- 229960004050 aminobenzoic acid Drugs 0.000 claims 2
- 239000005557 antagonist Substances 0.000 claims 2
- 125000004432 carbon atom Chemical group C* 0.000 claims 2
- 102000004419 dihydrofolate reductase Human genes 0.000 claims 2
- OZRNSSUDZOLUSN-LBPRGKRZSA-N dihydrofolic acid Chemical compound N=1C=2C(=O)NC(N)=NC=2NCC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OZRNSSUDZOLUSN-LBPRGKRZSA-N 0.000 claims 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 2
- 125000005359 phenoxyalkyl group Chemical group 0.000 claims 2
- 239000002904 solvent Substances 0.000 claims 2
- NFUPHFBYVLJFCU-UHFFFAOYSA-N 2-amino-7,7-diethyl-6-(hydroxymethyl)-1,8-dihydropteridin-4-one Chemical compound NC1=NC(O)=C2N=C(CO)C(CC)(CC)NC2=N1 NFUPHFBYVLJFCU-UHFFFAOYSA-N 0.000 claims 1
- BYIRZDTVVMWWFI-UHFFFAOYSA-N 2h-pteridin-1-ylmethanol Chemical compound C1=CN=C2N(CO)CN=CC2=N1 BYIRZDTVVMWWFI-UHFFFAOYSA-N 0.000 claims 1
- 241000271566 Aves Species 0.000 claims 1
- 241001465754 Metazoa Species 0.000 claims 1
- 108090000526 Papain Proteins 0.000 claims 1
- 239000004365 Protease Substances 0.000 claims 1
- 125000003545 alkoxy group Chemical group 0.000 claims 1
- 125000001246 bromo group Chemical group Br* 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 229940088598 enzyme Drugs 0.000 claims 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 238000001802 infusion Methods 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 230000005764 inhibitory process Effects 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- 231100000053 low toxicity Toxicity 0.000 claims 1
- 210000003205 muscle Anatomy 0.000 claims 1
- 229940055729 papain Drugs 0.000 claims 1
- 235000019834 papain Nutrition 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D475/00—Heterocyclic compounds containing pteridine ring systems
- C07D475/02—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4
- C07D475/04—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4 with a nitrogen atom directly attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/525—Isoalloxazines, e.g. riboflavins, vitamin B2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/63—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/63—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide
- A61K31/635—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide having a heterocyclic ring, e.g. sulfadiazine
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Fodder In General (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB3677471 | 1971-08-05 | ||
| GB3581772A GB1405246A (en) | 1971-08-05 | 1972-08-01 | Potentiated antimicrobial compositions |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL40050A0 IL40050A0 (en) | 1972-10-29 |
| IL40050A true IL40050A (en) | 1976-02-29 |
Family
ID=26262869
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL40050A IL40050A (en) | 1971-08-05 | 1972-08-04 | Compositions for treating microbial infections containing piperidine derivatives |
Country Status (14)
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1454165A (en) * | 1972-08-01 | 1976-10-27 | Wellcome Found | Biologically active compounds and compositions |
| GB1451043A (en) * | 1972-08-01 | 1976-09-29 | Wellcome Found | Biologicylly acitve compounds and compositions |
| GB1469521A (en) * | 1973-01-05 | 1977-04-06 | Wellcome Found | Antimicrobial preparations |
| GB1596044A (en) * | 1977-04-14 | 1981-08-19 | Wellcome Found | Veterinary compositions |
| DK426083A (da) * | 1982-09-20 | 1984-03-21 | Wellcome Found | Pteriner, fremgangsmaader til deres fremstilling samt deres anvendelse |
| JPS63121616U (enrdf_load_stackoverflow) * | 1987-01-30 | 1988-08-08 | ||
| CN113897413A (zh) * | 2021-10-12 | 2022-01-07 | 广州达安基因股份有限公司 | 一种体外诊断试剂防腐剂及其用途 |
-
0
- BE BE787236D patent/BE787236A/xx not_active IP Right Cessation
-
1972
- 1972-08-01 GB GB3581772A patent/GB1405246A/en not_active Expired
- 1972-08-04 SE SE7210162A patent/SE434337B/xx unknown
- 1972-08-04 FR FR7228236A patent/FR2150733B1/fr not_active Expired
- 1972-08-04 IE IE1103/72A patent/IE36867B1/xx unknown
- 1972-08-04 NO NO2781/72A patent/NO139004C/no unknown
- 1972-08-04 JP JP47078240A patent/JPS6036409B2/ja not_active Expired
- 1972-08-04 IT IT52002/72A patent/IT1057861B/it active
- 1972-08-04 DE DE2238536A patent/DE2238536C2/de not_active Expired
- 1972-08-04 IL IL40050A patent/IL40050A/en unknown
- 1972-08-04 NL NL7210719A patent/NL7210719A/xx unknown
- 1972-08-04 HU HUWE464A patent/HU170534B/hu unknown
- 1972-08-04 CS CS5448A patent/CS172956B2/cs unknown
- 1972-08-04 LU LU65857A patent/LU65857A1/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| BE787236A (fr) | 1973-02-05 |
| FR2150733B1 (enrdf_load_stackoverflow) | 1975-06-20 |
| DE2238536A1 (de) | 1973-02-22 |
| NO139004B (no) | 1978-09-11 |
| IE36867L (en) | 1973-02-05 |
| LU65857A1 (enrdf_load_stackoverflow) | 1973-02-01 |
| FR2150733A1 (enrdf_load_stackoverflow) | 1973-04-13 |
| IT1057861B (it) | 1982-03-30 |
| NO139004C (no) | 1978-12-20 |
| NL7210719A (enrdf_load_stackoverflow) | 1973-02-07 |
| DE2238536C2 (de) | 1984-11-29 |
| IE36867B1 (en) | 1977-03-16 |
| GB1405246A (en) | 1975-09-10 |
| JPS6036409B2 (ja) | 1985-08-20 |
| JPS4828610A (enrdf_load_stackoverflow) | 1973-04-16 |
| IL40050A0 (en) | 1972-10-29 |
| HU170534B (enrdf_load_stackoverflow) | 1977-06-28 |
| CS172956B2 (enrdf_load_stackoverflow) | 1977-01-28 |
| SE434337B (sv) | 1984-07-23 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CA2029596C (en) | Medicaments containing r-a-lipoic acid | |
| CA1161362A (en) | Pharmaceutical compositions containing a corticosteroid substance | |
| EP0188821B1 (en) | Stabilized spergualin-containing pharmaceutical compositions having cancer controlling and immunomodulating activity | |
| OA09039A (fr) | Acides 3-alcenyl-1-azabicyclo(3.2.0)hep-2-ene-2carboxyliques | |
| DK0934276T3 (da) | Anthranilinsyrederivater som multiresistensmodulatorer | |
| EP0371731A3 (en) | Quinazolinone derivatives | |
| DE68917023D1 (de) | 3-Pyrrolidinylthio-1-azabicyclo[3.2.0]-hept-2-en-2-carbonsäureverbindungen. | |
| NO810479L (no) | Fremgangsmaate for fremstilling av terapeutisk aktive substituerte imidazolderivater | |
| KR890005124A (ko) | 세펨 화합물 및 이의 제조방법 | |
| NO824062L (no) | Fremgangsmaate for fremstilling av terapeutisk aktive imidazol-derivater. | |
| IL40050A (en) | Compositions for treating microbial infections containing piperidine derivatives | |
| IL41426A (en) | Process for the production of history 3 - amino - benzo - 1, 2, 4, - triazine di N - oxides and pharmaceutical preparations containing such history | |
| RS20050231A (en) | Pyrrole derivatives as antimycobacterial compounds | |
| RU2001126063A (ru) | Производные пиридазин-3-она и содержащие их лекарственные средства | |
| BR0115454A (pt) | Composto de 1-metilcarbapenem ou um sal ou derivado de éster deste farmaceuticamente aceitável, composição farmacêutica, e, uso de um composto ou de um sal ou derivado de éster deste farmaceuticamente aceitável | |
| US3716531A (en) | 5-nitro-furfurylidene antimicrobic agents | |
| JPS6041656A (ja) | 新規アミノ酸誘導体の製法 | |
| JPS61180785A (ja) | 新規な治療用組成物 | |
| US5563149A (en) | Aqueous solutions of pyridone carboxylic acids | |
| EA200600022A1 (ru) | Применение производных бицикло [2.2.1] гептана для приготовления нейропротекторных фармацевтических композиций | |
| ATE34739T1 (de) | Neue 2-pyridin-thiol-derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate. | |
| US4920126A (en) | Barbituric acid derivative and treatment of leukemia and tumors therewith | |
| SU1447283A3 (ru) | Способ получени конденсированных производных @ S-триазина | |
| US3181994A (en) | Analgesic biphenyl acetic acid derivatives | |
| GB1070243A (en) | S-triazolopyrimidones, their preparation and compositions containing them |