GB1405246A - Potentiated antimicrobial compositions - Google Patents

Potentiated antimicrobial compositions

Info

Publication number
GB1405246A
GB1405246A GB3581772A GB3581772A GB1405246A GB 1405246 A GB1405246 A GB 1405246A GB 3581772 A GB3581772 A GB 3581772A GB 3581772 A GB3581772 A GB 3581772A GB 1405246 A GB1405246 A GB 1405246A
Authority
GB
United Kingdom
Prior art keywords
aug
alkyl
optionally substituted
competitor
specified
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB3581772A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wellcome Foundation Ltd
Original Assignee
Wellcome Foundation Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to BE787236D priority Critical patent/BE787236A/en
Application filed by Wellcome Foundation Ltd filed Critical Wellcome Foundation Ltd
Priority to GB3581772A priority patent/GB1405246A/en
Priority to HUWE464A priority patent/HU170534B/hu
Priority to CS5448A priority patent/CS172956B2/cs
Priority to DE2238536A priority patent/DE2238536C2/en
Priority to NL7210719A priority patent/NL7210719A/xx
Priority to LU65857A priority patent/LU65857A1/xx
Priority to IT52002/72A priority patent/IT1057861B/en
Priority to SE7210162A priority patent/SE434337B/en
Priority to FR7228236A priority patent/FR2150733B1/fr
Priority to JP47078240A priority patent/JPS6036409B2/en
Priority to CA148,837A priority patent/CA1007566A/en
Priority to NO2781/72A priority patent/NO139004C/en
Priority to IE1103/72A priority patent/IE36867B1/en
Priority to IL40050A priority patent/IL40050A/en
Publication of GB1405246A publication Critical patent/GB1405246A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D475/00—Heterocyclic compounds containing pteridine ring systems
    • C07D475/02—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4
    • C07D475/04—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4 with a nitrogen atom directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/525—Isoalloxazines, e.g. riboflavins, vitamin B2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/63—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/63—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide
    • A61K31/635—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide having a heterocyclic ring, e.g. sulfadiazine

Abstract

1405246 Potentiated antibacterial medicines WELLCOME FOUNDATION LTD 4 Aug 1972 [5 Aug 1971 1 Aug 1972] 36774/71 and 35817/72 Heading A5B Antibacterial compositions comprise a competitor of p-aminobenzoic acid or an inhibitor of dihydrofolate reductase, or both, together with a potentiator which is itself a pteridine antagonist (as defined in the specification) and which inhibits the enzyme hydroxymethyldihydropteridine pyrophosphokinase and has a sufficiently low toxicity to a mammalion or arian host. Specified potentiatas are compounds of the formula: wherein R is -alkyl, optionally substituted by a hydroxy group, a halogen atom or by a phenoxy group itself optionally substituted by one or more alkoxy, amino, alkyl or hydroxy groups or halogen atoms and R<SP>1</SP> and R<SP>2</SP> are the same or different and is each alkyl or they form: together a C 4-6 spirocycloalkyl ring system. Specified competitor/inhibitor compounds are various sulphonamides, pyrimethamine, trimethoprim, diaveridine and various derivatives of 2, 4-diamino pyrimidine. The compositions may be put up into conventional forms for oral, parenteral and rectal administration.
GB3581772A 1971-08-05 1972-08-01 Potentiated antimicrobial compositions Expired GB1405246A (en)

Priority Applications (15)

Application Number Priority Date Filing Date Title
BE787236D BE787236A (en) 1971-08-05 POTENTIALIZATION COMPOSITIONS
GB3581772A GB1405246A (en) 1971-08-05 1972-08-01 Potentiated antimicrobial compositions
IT52002/72A IT1057861B (en) 1971-08-05 1972-08-04 COMPOSITION FOR DIAGNOSIS AND TREATMENT OF MICROBIAL INFECTIONS
FR7228236A FR2150733B1 (en) 1971-08-05 1972-08-04
DE2238536A DE2238536C2 (en) 1971-08-05 1972-08-04 Preparations for the treatment of microbial infections
NL7210719A NL7210719A (en) 1971-08-05 1972-08-04
LU65857A LU65857A1 (en) 1971-08-05 1972-08-04
HUWE464A HU170534B (en) 1971-08-05 1972-08-04
SE7210162A SE434337B (en) 1971-08-05 1972-08-04 PROCEDURE FOR PREPARING A PHARMACEUTICAL COMPOSITION WITH SYNERGISTIC PROPERTIES FOR USE IN TREATING INFECTIONS CAUSED BY MICRO-ORGANISMS
CS5448A CS172956B2 (en) 1971-08-05 1972-08-04
JP47078240A JPS6036409B2 (en) 1971-08-05 1972-08-04 Composition for treating microbial infections
CA148,837A CA1007566A (en) 1971-08-05 1972-08-04 Potentiating formulations
NO2781/72A NO139004C (en) 1971-08-05 1972-08-04 PREPARATION FOR TESTING AND DETERMINATION OF PROTOCOL AND BACTERIAL INFECTIONS
IE1103/72A IE36867B1 (en) 1971-08-05 1972-08-04 Potentiated antimicrobial compositions
IL40050A IL40050A (en) 1971-08-05 1972-08-04 Compositions for treating microbial infections containing piperidine derivatives

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB3677471 1971-08-05
GB3581772A GB1405246A (en) 1971-08-05 1972-08-01 Potentiated antimicrobial compositions

Publications (1)

Publication Number Publication Date
GB1405246A true GB1405246A (en) 1975-09-10

Family

ID=26262869

Family Applications (1)

Application Number Title Priority Date Filing Date
GB3581772A Expired GB1405246A (en) 1971-08-05 1972-08-01 Potentiated antimicrobial compositions

Country Status (14)

Country Link
JP (1) JPS6036409B2 (en)
BE (1) BE787236A (en)
CS (1) CS172956B2 (en)
DE (1) DE2238536C2 (en)
FR (1) FR2150733B1 (en)
GB (1) GB1405246A (en)
HU (1) HU170534B (en)
IE (1) IE36867B1 (en)
IL (1) IL40050A (en)
IT (1) IT1057861B (en)
LU (1) LU65857A1 (en)
NL (1) NL7210719A (en)
NO (1) NO139004C (en)
SE (1) SE434337B (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2400218A1 (en) * 1973-01-05 1974-07-18 Wellcome Found PHARMACEUTICAL FORMULATIONS
DE2816064A1 (en) * 1977-04-14 1978-10-19 Wellcome Found VETERINE MEDICAL PREPARATION FOR TREATING BACTERIAL AND PROTOZOE DISEASES IN POULTRY
EP0108890A2 (en) * 1982-09-20 1984-05-23 The Wellcome Foundation Limited Pharmaceutically active pteridine derivatives
CN113897413A (en) * 2021-10-12 2022-01-07 广州达安基因股份有限公司 In-vitro diagnostic reagent preservative and application thereof

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1454165A (en) * 1972-08-01 1976-10-27 Wellcome Found Biologically active compounds and compositions
GB1451043A (en) * 1972-08-01 1976-09-29 Wellcome Found Biologicylly acitve compounds and compositions
JPS63121616U (en) * 1987-01-30 1988-08-08

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2400218A1 (en) * 1973-01-05 1974-07-18 Wellcome Found PHARMACEUTICAL FORMULATIONS
DE2816064A1 (en) * 1977-04-14 1978-10-19 Wellcome Found VETERINE MEDICAL PREPARATION FOR TREATING BACTERIAL AND PROTOZOE DISEASES IN POULTRY
EP0108890A2 (en) * 1982-09-20 1984-05-23 The Wellcome Foundation Limited Pharmaceutically active pteridine derivatives
EP0108890B1 (en) * 1982-09-20 1988-12-07 The Wellcome Foundation Limited Pharmaceutically active pteridine derivatives
CN113897413A (en) * 2021-10-12 2022-01-07 广州达安基因股份有限公司 In-vitro diagnostic reagent preservative and application thereof
WO2023060818A1 (en) * 2021-10-12 2023-04-20 广州达安基因股份有限公司 In-vitro diagnostic reagent preservative and use thereof

Also Published As

Publication number Publication date
LU65857A1 (en) 1973-02-01
IE36867L (en) 1973-02-05
JPS6036409B2 (en) 1985-08-20
FR2150733A1 (en) 1973-04-13
IT1057861B (en) 1982-03-30
CS172956B2 (en) 1977-01-28
IL40050A0 (en) 1972-10-29
DE2238536A1 (en) 1973-02-22
BE787236A (en) 1973-02-05
DE2238536C2 (en) 1984-11-29
NO139004C (en) 1978-12-20
FR2150733B1 (en) 1975-06-20
HU170534B (en) 1977-06-28
SE434337B (en) 1984-07-23
IE36867B1 (en) 1977-03-16
NL7210719A (en) 1973-02-07
IL40050A (en) 1976-02-29
JPS4828610A (en) 1973-04-16
NO139004B (en) 1978-09-11

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PCNP Patent ceased through non-payment of renewal fee