IL320810A - אגוניסטים של פפטיד 1 דמוי גלוקגון - Google Patents
אגוניסטים של פפטיד 1 דמוי גלוקגוןInfo
- Publication number
- IL320810A IL320810A IL320810A IL32081025A IL320810A IL 320810 A IL320810 A IL 320810A IL 320810 A IL320810 A IL 320810A IL 32081025 A IL32081025 A IL 32081025A IL 320810 A IL320810 A IL 320810A
- Authority
- IL
- Israel
- Prior art keywords
- methoxy
- oxetan
- methyl
- carboxylic acid
- ylmethyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Engineering & Computer Science (AREA)
- Child & Adolescent Psychology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202263425751P | 2022-11-16 | 2022-11-16 | |
| PCT/US2023/079720 WO2024107781A1 (en) | 2022-11-16 | 2023-11-15 | Glucagon-like peptide 1 receptor agonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL320810A true IL320810A (he) | 2025-07-01 |
Family
ID=89378473
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL320810A IL320810A (he) | 2022-11-16 | 2023-11-15 | אגוניסטים של פפטיד 1 דמוי גלוקגון |
Country Status (13)
| Country | Link |
|---|---|
| EP (1) | EP4619098A1 (he) |
| JP (1) | JP2025538389A (he) |
| KR (1) | KR20250085816A (he) |
| CN (1) | CN120344520A (he) |
| AU (1) | AU2023379473A1 (he) |
| CL (1) | CL2025001423A1 (he) |
| CO (1) | CO2025005958A2 (he) |
| CR (1) | CR20250178A (he) |
| DO (1) | DOP2025000110A (he) |
| IL (1) | IL320810A (he) |
| JO (1) | JOP20250110A1 (he) |
| MX (1) | MX2025005718A (he) |
| WO (1) | WO2024107781A1 (he) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FI4408840T3 (fi) | 2021-09-27 | 2025-11-04 | Terns Pharmaceuticals Inc | Bentsimidatsolikarboksyylihappoja glp-1r-agonisteina |
| IL312364A (he) | 2021-10-25 | 2024-06-01 | Luehr Gary W | תרכובות כאגוניסטים של glp-1r |
| US12410163B2 (en) | 2022-02-23 | 2025-09-09 | Terns Pharmaceuticals, Inc. | Compounds as GLP-IR agonists |
| WO2024211898A1 (en) | 2023-04-07 | 2024-10-10 | Terns Pharmaceuticals, Inc. | Combination comprising a thrbeta agonist anda glp-1r agonist for use in treating a liver disorder or a cardiometabolic disease |
| AU2024340407A1 (en) | 2023-09-14 | 2026-04-23 | Ascletis Pharma (China) Co., Limited | Glp-1r agonist and therapeutic method thereof |
| WO2025109387A1 (en) | 2023-11-24 | 2025-05-30 | Ascletis Pharma (China) Co., Limited | Glp-1r agonist and therapeutic method thereof |
Family Cites Families (56)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110325530B (zh) | 2016-12-16 | 2022-01-11 | 辉瑞大药厂 | Glp-1受体激动剂及其用途 |
| US10934279B2 (en) | 2018-06-13 | 2021-03-02 | Pfizer Inc. | GLP-1 receptor agonists and uses thereof |
| SG11202011704XA (en) | 2018-06-15 | 2020-12-30 | Pfizer | Glp-1 receptor agonists and uses thereof |
| CU20210042A7 (es) | 2018-11-22 | 2022-01-13 | Qilu Regor Therapeutics Inc | Compuestos agonistas de glp-1r y composiciones farmacéuticas que lo contienen |
| BR112021020335A2 (pt) | 2019-04-12 | 2021-12-14 | Qilu Regor Therapeutics Inc | Agonistas glp-1r e usos dos mesmos |
| TWI751585B (zh) | 2019-06-28 | 2022-01-01 | 美商美國禮來大藥廠 | 類升糖素肽1受體促效劑 |
| WO2021018023A1 (zh) | 2019-08-01 | 2021-02-04 | 济南泰达领创医药技术有限公司 | 小分子glp-1受体调节剂 |
| PE20221040A1 (es) | 2019-10-25 | 2022-06-17 | Gilead Sciences Inc | Compuestos moduladores de glp-1r |
| MA57692B1 (fr) | 2019-11-15 | 2025-04-30 | Ildong Pharmaceutical Co., Ltd. | Agoniste du récepteur glp-1 et son utilisation |
| EP4069686B1 (en) | 2019-12-02 | 2025-01-22 | Hyundai Pharm Co., Ltd. | Glp-1 receptor agonist |
| CA3168543A1 (en) | 2020-01-29 | 2021-08-05 | Gilead Sciences, Inc. | Glp-1r modulating compounds |
| JP7836762B2 (ja) | 2020-02-13 | 2026-03-27 | ガシャーブラム・バイオ・インコーポレイテッド | ヘテロ環ｇｌｐ－１アゴニスト |
| MX2022011349A (es) | 2020-03-18 | 2022-11-10 | Lg Chemical Ltd | Agonista del receptor de glp-1, composición farmacéutica que comprende el mismo, y método para preparar el mismo. |
| TW202144340A (zh) | 2020-04-03 | 2021-12-01 | 大陸商江蘇恆瑞醫藥股份有限公司 | 稠合咪唑類衍生物、其製備方法及其在醫藥上的應用 |
| CN113493447B (zh) | 2020-04-03 | 2024-06-11 | 轩竹(北京)医药科技有限公司 | Glp-1受体激动剂 |
| EP4143183B1 (en) | 2020-04-29 | 2025-10-22 | Gasherbrum Bio, Inc. | Heterocyclic glp-1 agonists |
| EP4155313B1 (en) | 2020-06-04 | 2025-08-27 | Hangzhou Sciwind Biosciences Co., Ltd. | Five-membered heteroaromatic imidazole compound and use thereof |
| EP4166142A4 (en) | 2020-06-10 | 2024-06-26 | Medshine Discovery Inc. | Methyl-substituted benzobisoxazole compound and use thereof |
| CN113801136B (zh) | 2020-06-16 | 2023-04-07 | 江苏恒瑞医药股份有限公司 | 咪唑并杂芳基类衍生物、其制备方法及其在医药上的应用 |
| CN115916772B (zh) | 2020-06-19 | 2025-01-14 | 江苏恒瑞医药股份有限公司 | 6-氧代-3,6-二氢吡啶类衍生物、其制备方法及其在医药上的应用 |
| CN113816948B (zh) | 2020-06-19 | 2023-08-11 | 江苏恒瑞医药股份有限公司 | 稠合咪唑类衍生物、其制备方法及其在医药上的应用 |
| WO2021259309A1 (zh) | 2020-06-24 | 2021-12-30 | 广州市恒诺康医药科技有限公司 | Glp-1受体激动剂及其药物组合物和用途 |
| TW202214622A (zh) | 2020-08-06 | 2022-04-16 | 大陸商上海齊魯銳格醫藥研發有限公司 | Ｇｌｐ－１ｒ促效劑及其用途 |
| WO2022028572A1 (en) | 2020-08-06 | 2022-02-10 | Gasherbrum Bio, Inc. | Heterocyclic glp-1 agonists |
| KR20230074486A (ko) | 2020-08-21 | 2023-05-30 | 테른스 파마슈티칼스, 인크. | Glp-1r 효능제로서의 화합물 |
| CN116406360A (zh) | 2020-08-28 | 2023-07-07 | 加舒布鲁姆生物公司 | 杂环glp-1激动剂 |
| CN119930605A (zh) | 2020-09-01 | 2025-05-06 | 江苏恒瑞医药股份有限公司 | 稠合咪唑类衍生物、其制备方法及其在医药上的应用 |
| WO2022068772A1 (zh) | 2020-09-29 | 2022-04-07 | 深圳信立泰药业股份有限公司 | 一种苯并咪唑类衍生物及其制备方法和医药用途 |
| CN116348464A (zh) | 2020-10-12 | 2023-06-27 | 杭州中美华东制药有限公司 | 苯并咪唑酮类glp-1受体激动剂及其用途 |
| CN116547279A (zh) | 2020-10-13 | 2023-08-04 | 加舒布鲁姆生物公司 | 杂环glp-1激动剂 |
| CN116547278A (zh) | 2020-10-13 | 2023-08-04 | 加舒布鲁姆生物公司 | 杂环glp-1激动剂 |
| CN114478497B (zh) | 2020-11-12 | 2023-10-20 | 杭州中美华东制药有限公司 | 芳基烷基酸类glp-1受体激动剂及其用途 |
| WO2022109182A1 (en) | 2020-11-20 | 2022-05-27 | Gilead Sciences, Inc. | Polyheterocyclic glp-1 r modulating compounds |
| CA3200245A1 (en) | 2020-11-27 | 2022-06-02 | Junjun Wu | Benzimidazole derivative and preparation method therefor and medical use thereof |
| CN114591296A (zh) | 2020-12-02 | 2022-06-07 | 海思科医药集团股份有限公司 | 一种glp-1r激动剂及其在医药上的应用 |
| CN114591308B (zh) | 2020-12-03 | 2024-03-08 | 苏州闻泰医药科技有限公司 | 一类glp-1r受体激动剂化合物及其用途 |
| CN114634510B (zh) | 2020-12-16 | 2025-11-04 | 杭州中美华东制药有限公司 | 咪唑并吡啶衍生物及其用途 |
| AU2021405918A1 (en) | 2020-12-25 | 2023-07-20 | Xizang Haisco Pharmaceutical Co., Ltd. | Five-membered ring derivative and medical use thereof |
| CN114763352A (zh) | 2021-01-15 | 2022-07-19 | 海思科医药集团股份有限公司 | 一种glp-1受体激动剂及其在医药上的应用 |
| CN114805336B (zh) | 2021-01-20 | 2026-04-14 | 江苏恒瑞医药股份有限公司 | 稠合咪唑类化合物、其制备方法及其在医药上的应用 |
| MX2023008854A (es) | 2021-01-28 | 2023-10-17 | Carmot Therapeutics Inc | Agonistas del receptor acoplado a proteinas g (gpcr), composiciones farmaceuticas que los comprenden y metodos para su uso. |
| CN114907351A (zh) | 2021-02-07 | 2022-08-16 | 杭州中美华东制药有限公司 | 三环类glp-1受体激动剂及其用途 |
| WO2022184849A1 (en) | 2021-03-04 | 2022-09-09 | Les Laboratoires Servier | Glp-1r agonists, uses and pharmaceutical compositions thereof |
| EP4304711A1 (en) | 2021-03-11 | 2024-01-17 | Gilead Sciences, Inc. | Glp-1r modulating compounds |
| WO2022192430A1 (en) | 2021-03-11 | 2022-09-15 | Gilead Sciences, Inc. | Glp-1r modulating compounds |
| CN116940561A (zh) | 2021-03-22 | 2023-10-24 | 杭州中美华东制药有限公司 | 噻吩类glp-1受体激动剂及其用途 |
| US20220348564A1 (en) | 2021-03-24 | 2022-11-03 | Eccogene (Shanghai) Co., Ltd. | Phenyl-[1,3]dioxolo[4,5-c]pyridinyl-phenyl-, phenyl-[1,3]dioxolo[4,5-c]pyridinyl-heteroaryl-, or phenyl-(1,3)dioxo[4,5-c]pyridinyl-piperidinyl-methyl-oxetanylmethyl-1h-benzo[d]imidazole-carboxylic acid derivatives and methods of using same |
| JP7772778B2 (ja) | 2021-03-24 | 2025-11-18 | 塩野義製薬株式会社 | 縮合環を有するｇｌｐ－１受容体作動薬を含有する医薬組成物 |
| JP2024514259A (ja) | 2021-04-08 | 2024-03-29 | エルジー・ケム・リミテッド | Ｇｌｐ－１受容体作動薬、それを含む薬学的組成物、およびその製造方法 |
| WO2022219495A1 (en) | 2021-04-12 | 2022-10-20 | Novartis Ag | 2-((4-((s)-2-(4-chloro-2-fluorophenyl)-2-methylbenzo[d][1,3]dioxol-4-yl)piperidin-1-yl)methyl)-1-(((s)-oxetan-2-yl)methyl)-1h-imidazole derivatives as activators of the glp1 receptor for the treatment of obesity |
| PL4271672T3 (pl) | 2021-04-21 | 2026-04-20 | Gilead Sciences, Inc. | Karboksybenzimidazolowe związki modulujące glp-1r |
| PE20232051A1 (es) | 2021-04-21 | 2023-12-27 | Gilead Sciences Inc | Compuestos carboxi-benzimidazol moduladores de glp-1r |
| WO2022228490A1 (zh) | 2021-04-30 | 2022-11-03 | 上海翰森生物医药科技有限公司 | 多环类衍生物调节剂、其制备方法和应用 |
| EP4334304A1 (en) | 2021-05-03 | 2024-03-13 | Carmot Therapeutics, Inc. | Benzimidazoyl glp-1 receptor agonists, pharmaceutical compositions comprising the same, and methods for their use |
| CN113480534B (zh) | 2021-07-23 | 2022-05-13 | 广州必贝特医药股份有限公司 | 苯并咪唑或氮杂苯并咪唑-6-羧酸类化合物及其应用 |
| CN114716423A (zh) | 2022-05-20 | 2022-07-08 | 中国科学院上海药物研究所 | 5,6-二氢-1,2,4-三嗪类化合物及其作为glp-1受体激动剂的药学用途 |
-
2023
- 2023-11-15 EP EP23828849.2A patent/EP4619098A1/en active Pending
- 2023-11-15 KR KR1020257015415A patent/KR20250085816A/ko active Pending
- 2023-11-15 CR CR20250178A patent/CR20250178A/es unknown
- 2023-11-15 AU AU2023379473A patent/AU2023379473A1/en active Pending
- 2023-11-15 JP JP2025528178A patent/JP2025538389A/ja active Pending
- 2023-11-15 CN CN202380079819.9A patent/CN120344520A/zh active Pending
- 2023-11-15 IL IL320810A patent/IL320810A/he unknown
- 2023-11-15 WO PCT/US2023/079720 patent/WO2024107781A1/en not_active Ceased
-
2025
- 2025-05-08 CO CONC2025/0005958A patent/CO2025005958A2/es unknown
- 2025-05-13 CL CL2025001423A patent/CL2025001423A1/es unknown
- 2025-05-13 JO JOJO/P/2025/0110A patent/JOP20250110A1/ar unknown
- 2025-05-14 DO DO2025000110A patent/DOP2025000110A/es unknown
- 2025-05-15 MX MX2025005718A patent/MX2025005718A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| MX2025005718A (es) | 2025-06-02 |
| EP4619098A1 (en) | 2025-09-24 |
| JP2025538389A (ja) | 2025-11-28 |
| WO2024107781A1 (en) | 2024-05-23 |
| AU2023379473A1 (en) | 2025-05-15 |
| CL2025001423A1 (es) | 2025-08-08 |
| DOP2025000110A (es) | 2025-06-15 |
| JOP20250110A1 (ar) | 2025-05-13 |
| CR20250178A (es) | 2025-06-06 |
| CN120344520A (zh) | 2025-07-18 |
| KR20250085816A (ko) | 2025-06-12 |
| CO2025005958A2 (es) | 2025-05-29 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EP4125896B1 (en) | Treatment of type 2 diabetes with 2-[(4-{6-[(4-cyano-2-fluorobenzyl)oxy]pyridin-2-yl} piperidin-1-yl)methyl]-1-[(2s)-oxetan-2-ylmethyl]-1h-benzimidazole-6-carboxylic acid or a pharmaceutically salt thereof | |
| TWI453197B (zh) | 可用作抗菌劑之氟吡啶酮衍生物 | |
| CA2622472C (en) | Dipeptidyl peptidase inhibitors for treating diabetes | |
| US20230373948A1 (en) | Ppar agonists, compounds, pharmaceutical compositions, and methods of use thereof | |
| CA2674436A1 (en) | Amide substituted indazoles as poly(adp-ribose)polymerase (parp) inhibitors | |
| KR20230175328A (ko) | 과혈당증의 치료에 사용하기 위한 헤테로아릴 치환된 베타-히드록시에틸아민 | |
| JP2006518763A5 (he) | ||
| CA2934517C (en) | Fused heterocyclic compounds as ion channel modulators | |
| JP2013519667A (ja) | 新規抗真菌性トリアゾール誘導体 | |
| BRPI0616077A2 (pt) | administração de inibidores de dipeptidil peptidase | |
| TWI749024B (zh) | 化合物及其於降低尿酸位準之用途 | |
| JP5425219B2 (ja) | アミドチアゾール誘導体、その製造方法および使用 | |
| RU2016108753A (ru) | Ингибиторы ферментов | |
| CN101616673A (zh) | 2-[6-(3-氨基-哌啶-1-基)-3-甲基-2,4-二氧代-3,4-二氢-2h-嘧啶-1-基甲基]-4-氟-苄腈的用途 | |
| JP2005526696A5 (he) | ||
| US20240287098A1 (en) | Compositions and methods for treating cancer | |
| RU2003112610A (ru) | Производные пиразола для лечения вирксных заболеваний | |
| EP2781512A1 (en) | Oxadiazole compound and preparation method thereof, pharmaceutical composition and use thereof | |
| WO2011002001A1 (ja) | ピラゾール誘導体とビグアナイド薬との組み合わせ医薬 | |
| JP2010504321A5 (he) | ||
| JP2020532589A (ja) | Ｉｒｅ１阻害のための化合物および組成物 | |
| JP2019511466A (ja) | オレキシン受容体調節因子としてのハロ置換ピペリジン | |
| RU2538964C1 (ru) | Соединение с последовательной арициклической структурой, обладающее активностью ингибирования ацилкофермента а: диацилглицеринацилтрансферазы (dgat1) | |
| JP2010504322A5 (he) | ||
| JP4774995B2 (ja) | アシルアミノチアゾール誘導体を有効成分とする医薬組成物 |