SG11202011704XA - Glp-1 receptor agonists and uses thereof - Google Patents
Glp-1 receptor agonists and uses thereofInfo
- Publication number
- SG11202011704XA SG11202011704XA SG11202011704XA SG11202011704XA SG11202011704XA SG 11202011704X A SG11202011704X A SG 11202011704XA SG 11202011704X A SG11202011704X A SG 11202011704XA SG 11202011704X A SG11202011704X A SG 11202011704XA SG 11202011704X A SG11202011704X A SG 11202011704XA
- Authority
- SG
- Singapore
- Prior art keywords
- glp
- receptor agonists
- agonists
- receptor
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4188—1,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
-
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
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- A—HUMAN NECESSITIES
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
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-
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- C07—ORGANIC CHEMISTRY
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- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Ophthalmology & Optometry (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Urology & Nephrology (AREA)
- Immunology (AREA)
- Psychology (AREA)
- Child & Adolescent Psychology (AREA)
- Vascular Medicine (AREA)
- Dermatology (AREA)
- Pulmonology (AREA)
- Pain & Pain Management (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201862685656P | 2018-06-15 | 2018-06-15 | |
PCT/IB2019/054961 WO2019239371A1 (en) | 2018-06-15 | 2019-06-13 | Glp-1 receptor agonists and uses thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11202011704XA true SG11202011704XA (en) | 2020-12-30 |
Family
ID=67766191
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11202011704XA SG11202011704XA (en) | 2018-06-15 | 2019-06-13 | Glp-1 receptor agonists and uses thereof |
Country Status (21)
Country | Link |
---|---|
US (2) | US11858916B2 (en) |
EP (1) | EP3806855B1 (en) |
JP (1) | JP7053900B2 (en) |
KR (1) | KR102538572B1 (en) |
CN (1) | CN112566637B (en) |
AU (1) | AU2019285570B2 (en) |
BR (1) | BR112020024956A2 (en) |
CA (1) | CA3103051C (en) |
DK (1) | DK3806855T5 (en) |
ES (1) | ES2943510T3 (en) |
FI (1) | FI3806855T3 (en) |
HU (1) | HUE061888T2 (en) |
IL (1) | IL279224B2 (en) |
MX (1) | MX2020013624A (en) |
PL (1) | PL3806855T3 (en) |
PT (1) | PT3806855T (en) |
RU (1) | RU2765721C1 (en) |
SG (1) | SG11202011704XA (en) |
SI (1) | SI3806855T1 (en) |
WO (1) | WO2019239371A1 (en) |
ZA (1) | ZA202007304B (en) |
Families Citing this family (56)
Publication number | Priority date | Publication date | Assignee | Title |
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JP2022508203A (en) * | 2018-11-22 | 2022-01-19 | キル・レガー・セラピューティクス・インコーポレーテッド | GLP-1R agonist and its use |
SG11202110825WA (en) * | 2019-04-12 | 2021-10-28 | Qilu Regor Therapeutics Inc | Glp-1r agonists and uses thereof |
US10954221B2 (en) | 2019-04-12 | 2021-03-23 | Qilu Regor Therapeutics Inc. | GLP-1R agonists and uses thereof |
TWI751585B (en) | 2019-06-28 | 2022-01-01 | 美商美國禮來大藥廠 | Glucagon-like peptide 1 receptor agonists |
WO2021018023A1 (en) * | 2019-08-01 | 2021-02-04 | 济南泰达领创医药技术有限公司 | Small molecule glp-1 receptor modulator |
CR20220178A (en) | 2019-10-25 | 2022-06-15 | Gilead Sciences Inc | Glp-1r modulating compounds |
KR20220156535A (en) * | 2020-02-07 | 2022-11-25 | 가셔브룸 바이오, 인크. | Heterocyclic GLP-1 agonists |
WO2021160127A1 (en) * | 2020-02-13 | 2021-08-19 | Gasherbrum Bio, Inc. | Heterocyclic glp-1 agonists |
CN115279750B (en) * | 2020-03-18 | 2024-06-21 | 株式会社Lg化学 | GLP-1 receptor agonist, pharmaceutical composition containing same and preparation method thereof |
US20230203021A1 (en) * | 2020-03-18 | 2023-06-29 | Lg Chem, Ltd. | Glp-1 receptor agonist, pharmaceutical composition comprising same, and method for preparing same |
TW202144340A (en) | 2020-04-03 | 2021-12-01 | 大陸商江蘇恆瑞醫藥股份有限公司 | Fused imidazole derivatives, preparation method and medical use thereof |
CN113493447B (en) * | 2020-04-03 | 2024-06-11 | 轩竹(北京)医药科技有限公司 | GLP-1 receptor agonists |
CN115427404A (en) * | 2020-04-22 | 2022-12-02 | 艾尼莫生物科技公司 | Collagen 1 translation inhibitors and methods of use thereof |
TW202206429A (en) * | 2020-04-29 | 2022-02-16 | 美商迦舒布魯姆生物有限公司 | Heterocyclic glp-1 agonists |
CA3181120C (en) * | 2020-06-04 | 2024-01-02 | Tao Yu | Five-membered heteroaromatic imidazole compound and use thereof |
US20230234968A1 (en) * | 2020-06-10 | 2023-07-27 | Medshine Discovery Inc. | Methyl-substituted benzobisoxazole compound and use thereof |
CN113816948B (en) * | 2020-06-19 | 2023-08-11 | 江苏恒瑞医药股份有限公司 | Condensed imidazole derivative, preparation method and medical application thereof |
WO2021254470A1 (en) * | 2020-06-19 | 2021-12-23 | 江苏恒瑞医药股份有限公司 | 6-oxo-3,6-dihydropyridine derivative, and preparation method therefor and use thereof in medicine |
WO2021259309A1 (en) * | 2020-06-24 | 2021-12-30 | 广州市恒诺康医药科技有限公司 | Glp-1 receptor agonist, and pharmaceutical composition and use thereof |
MX2023001311A (en) | 2020-08-06 | 2023-04-18 | Gasherbrum Bio Inc | Heterocyclic glp-1 agonists. |
EP4199919A1 (en) * | 2020-08-21 | 2023-06-28 | Terns Pharmaceuticals, Inc. | Compounds as glp-1r agonists |
EP4204415A1 (en) | 2020-08-28 | 2023-07-05 | Gasherbrum Bio, Inc. | Heterocyclic glp-1 agonists |
CN115515956B (en) * | 2020-09-29 | 2024-06-25 | 深圳信立泰药业股份有限公司 | Benzimidazole derivative, and preparation method and medical application thereof |
EP4229050A1 (en) * | 2020-10-13 | 2023-08-23 | Gasherbrum Bio, Inc. | Heterocyclic glp-1 agonists |
JP2023546054A (en) * | 2020-10-13 | 2023-11-01 | ガシャーブラム・バイオ・インコーポレイテッド | Heterocyclic GLP-1 agonist |
CA3195264A1 (en) * | 2020-10-14 | 2022-04-21 | Wenge Zhong | Crystal forms of glp-1r agonists and uses thereof |
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CA3200245A1 (en) | 2020-11-27 | 2022-06-02 | Junjun Wu | Benzimidazole derivative and preparation method therefor and medical use thereof |
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JPWO2022202864A1 (en) | 2021-03-24 | 2022-09-29 | ||
WO2022216094A1 (en) * | 2021-04-08 | 2022-10-13 | 주식회사 엘지화학 | Glp-1 receptor agonist, pharmaceutical composition comprising same, and method for preparing same |
US11858918B2 (en) | 2021-04-21 | 2024-01-02 | Gilead Sciences, Inc. | GLP-1R modulating compounds |
AU2022275931A1 (en) | 2021-05-20 | 2023-11-02 | Eli Lilly And Company | Macrocyclic glucagon-like peptide 1 receptor agonists |
CN117715906A (en) * | 2021-07-21 | 2024-03-15 | 和博医药有限公司 | Glucagon-like peptide-1 receptor modulators and uses thereof |
CN113480534B (en) * | 2021-07-23 | 2022-05-13 | 广州必贝特医药股份有限公司 | Benzimidazole or azabenzimidazole-6-carboxylic acid compounds and application thereof |
CN117693504A (en) * | 2021-08-02 | 2024-03-12 | 深圳信立泰药业股份有限公司 | Salt of GLP-1R agonist compound, preparation method and medical application thereof |
IL310400A (en) * | 2021-08-04 | 2024-03-01 | Shanghai Hansoh Biomedical Co Ltd | Cycloalkene derivative regulator, preparation method therefor, and application thereof |
JPWO2023038039A1 (en) | 2021-09-08 | 2023-03-16 | ||
WO2023057414A1 (en) | 2021-10-05 | 2023-04-13 | Astrazeneca Ab | Certain octahydrofuro[3,4- b]pyrazines as glp-1 receptor modulators |
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