IL315355A - Crystalline dipeptides useful in the synthesis of elamipretide - Google Patents
Crystalline dipeptides useful in the synthesis of elamipretideInfo
- Publication number
- IL315355A IL315355A IL315355A IL31535524A IL315355A IL 315355 A IL315355 A IL 315355A IL 315355 A IL315355 A IL 315355A IL 31535524 A IL31535524 A IL 31535524A IL 315355 A IL315355 A IL 315355A
- Authority
- IL
- Israel
- Prior art keywords
- compound
- formula
- suspension
- charge
- crystalline
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06086—Dipeptides with the first amino acid being basic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/20—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06086—Dipeptides with the first amino acid being basic
- C07K5/06095—Arg-amino acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1019—Tetrapeptides with the first amino acid being basic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2299/00—Coordinates from 3D structures of peptides, e.g. proteins or enzymes
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Life Sciences & Earth Sciences (AREA)
- Peptides Or Proteins (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862651430P | 2018-04-02 | 2018-04-02 | |
| PCT/US2019/024617 WO2019195080A1 (en) | 2018-04-02 | 2019-03-28 | Crystalline dipeptides useful in the synthesis of elamipretide |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL315355A true IL315355A (en) | 2024-11-01 |
Family
ID=68101313
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL315355A IL315355A (en) | 2018-04-02 | 2019-03-28 | Crystalline dipeptides useful in the synthesis of elamipretide |
| IL277718A IL277718B2 (en) | 2018-04-02 | 2019-03-28 | Crystalline dipeptides used in the synthesis of almipretide |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL277718A IL277718B2 (en) | 2018-04-02 | 2019-03-28 | Crystalline dipeptides used in the synthesis of almipretide |
Country Status (13)
| Country | Link |
|---|---|
| US (4) | US10975118B2 (https=) |
| EP (2) | EP3774844B1 (https=) |
| JP (2) | JP7350007B2 (https=) |
| KR (2) | KR102753323B1 (https=) |
| CN (2) | CN112292388B (https=) |
| AU (1) | AU2019249121B2 (https=) |
| CA (2) | CA3280578A1 (https=) |
| DK (1) | DK3774844T3 (https=) |
| ES (1) | ES2941266T3 (https=) |
| FI (1) | FI3774844T3 (https=) |
| IL (2) | IL315355A (https=) |
| PT (1) | PT3774844T (https=) |
| WO (1) | WO2019195080A1 (https=) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115160402A (zh) * | 2016-03-11 | 2022-10-11 | 隐形生物治疗公司 | 结晶盐形式 |
| PT3774844T (pt) | 2018-04-02 | 2023-03-28 | Stealth Biotherapeutics Inc | Dipeptídeos cristalinos úteis na síntese de elamipretida |
| CN117881411A (zh) | 2021-06-01 | 2024-04-12 | 艾迪雅生物有限责任公司 | 用于眼部药物的延长释放药物递送系统和使用方法 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4711166B2 (ja) * | 2004-08-03 | 2011-06-29 | 株式会社 液晶先端技術開発センター | 結晶化装置、および結晶化方法 |
| CA3022250A1 (en) * | 2012-12-12 | 2014-06-12 | Ariad Pharmaceuticals, Inc. | Crystalline forms of 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-n-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide mono hydrochloride |
| CN104945453B (zh) * | 2014-03-28 | 2018-06-26 | 江苏天士力帝益药业有限公司 | 吡唑衍生物的多晶型物 |
| WO2016001042A1 (en) | 2014-06-30 | 2016-01-07 | Flamma S.P.A. | Process for the production of d-arginyl-2,6-dimethyl-l-tyrosyl-l-lysyl-l-phenylalaninamide |
| US10633415B2 (en) * | 2015-03-06 | 2020-04-28 | Stealth Biotherapeutics Corp | Processes for preparing pharmaceutically relevant peptides |
| CA3254279A1 (en) * | 2015-06-03 | 2025-03-18 | Triastek, Inc. | PHARMACEUTICAL FORMS AND RELATED USES |
| CN115160402A (zh) * | 2016-03-11 | 2022-10-11 | 隐形生物治疗公司 | 结晶盐形式 |
| CN110087667A (zh) | 2016-08-16 | 2019-08-02 | 隐形生物治疗公司 | Elamipretide的基于N-羧基酸酐的规模合成 |
| CN110914287A (zh) * | 2017-04-05 | 2020-03-24 | 隐形生物治疗公司 | Boc-d-arg-dmt-lys-(boc)-phe-nh2的结晶盐形式 |
| PT3774844T (pt) | 2018-04-02 | 2023-03-28 | Stealth Biotherapeutics Inc | Dipeptídeos cristalinos úteis na síntese de elamipretida |
-
2019
- 2019-03-28 PT PT197814320T patent/PT3774844T/pt unknown
- 2019-03-28 CA CA3280578A patent/CA3280578A1/en active Pending
- 2019-03-28 WO PCT/US2019/024617 patent/WO2019195080A1/en not_active Ceased
- 2019-03-28 JP JP2020554100A patent/JP7350007B2/ja active Active
- 2019-03-28 EP EP19781432.0A patent/EP3774844B1/en active Active
- 2019-03-28 ES ES19781432T patent/ES2941266T3/es active Active
- 2019-03-28 CN CN201980037029.8A patent/CN112292388B/zh active Active
- 2019-03-28 EP EP23156906.2A patent/EP4219523A3/en active Pending
- 2019-03-28 DK DK19781432.0T patent/DK3774844T3/da active
- 2019-03-28 CN CN202410219985.0A patent/CN118206614A/zh active Pending
- 2019-03-28 AU AU2019249121A patent/AU2019249121B2/en active Active
- 2019-03-28 IL IL315355A patent/IL315355A/en unknown
- 2019-03-28 FI FIEP19781432.0T patent/FI3774844T3/fi active
- 2019-03-28 KR KR1020207031595A patent/KR102753323B1/ko active Active
- 2019-03-28 IL IL277718A patent/IL277718B2/en unknown
- 2019-03-28 CA CA3095869A patent/CA3095869C/en active Active
- 2019-03-28 US US16/485,369 patent/US10975118B2/en active Active
- 2019-03-28 KR KR1020257000322A patent/KR20250010134A/ko active Pending
-
2021
- 2021-04-07 US US17/224,353 patent/US11560404B2/en active Active
-
2022
- 2022-12-21 US US18/086,203 patent/US12018094B2/en active Active
-
2023
- 2023-09-12 JP JP2023147376A patent/JP7663642B2/ja active Active
-
2024
- 2024-05-15 US US18/665,100 patent/US20250122238A1/en active Pending
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US20250122238A1 (en) | Crystalline dipeptides useful in the synthesis of elamipretide | |
| WO2016180275A1 (zh) | Ahu-377的制备方法、ahu-377中间体及ahu-377中间体的制备方法 | |
| WO2019026014A1 (en) | METHODS FOR PREPARING LIFITEGRAST AND ITS INTERMEDIATES | |
| CN112272665B (zh) | 制备立他司特的方法 | |
| WO2015110885A1 (en) | A process for preparation of (2s,5r)-6-sulphooxy-7-oxo-2-[((3r)-piperidine-3-carbonyl)-hydrazinocarbonyl]-1,6-diaza-bicyclo[3.2.1] octane | |
| US20240262805A1 (en) | Method for producing compound or pharmaceutically acceptable salt thereof | |
| HK40097695A (en) | Crystalline dipeptides useful in the synthesis of elamipretide | |
| HRP20050039A2 (en) | Crystal forms of olanzapine and processes for their preparation | |
| JP2025501596A (ja) | 酸化型グルタチオン及びその結晶形並びに不純物の調製方法 | |
| HK40045731B (en) | Crystalline dipeptides useful in the synthesis of elamipretide | |
| HK40045731A (en) | Crystalline dipeptides useful in the synthesis of elamipretide | |
| HK40046563A (en) | Crystalline dipeptides useful in the synthesis of elamipretide | |
| CN116265466A (zh) | 调节用途依赖性的电压门控的钠通道的化合物的合成 | |
| JP6336166B2 (ja) | イミダフェナシンの新規中間体、その製造方法及びそれを用いたイミダフェナシンの製造方法 | |
| CN118475589A (zh) | 一种神经激肽-1拮抗剂前药化合物的晶型 | |
| JP4416111B2 (ja) | ２，３−ジアミノピリジン誘導体の製造方法 | |
| HK40046563B (zh) | 用於合成elamipretide的结晶二肽 | |
| CN120665002A (zh) | 一种3-氨基吡咯烷-1-羧酸叔丁酯的制备方法及其应用 | |
| WO2013054273A9 (en) | Process for the preparation of agomelatine | |
| JPH10195075A (ja) | Ｚ−バラシクロビルの製造方法 | |
| IE52967B1 (en) | Chemical process |