CN112292388B - 用于合成elamipretide的结晶二肽 - Google Patents

用于合成elamipretide的结晶二肽 Download PDF

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Publication number
CN112292388B
CN112292388B CN201980037029.8A CN201980037029A CN112292388B CN 112292388 B CN112292388 B CN 112292388B CN 201980037029 A CN201980037029 A CN 201980037029A CN 112292388 B CN112292388 B CN 112292388B
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China
Prior art keywords
crystalline form
compound
elamipretide
crystalline
characteristic peaks
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CN201980037029.8A
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English (en)
Chinese (zh)
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CN112292388A (zh
Inventor
S·M·邓肯
M·P·雷蒙
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Stealth Biotherapeutics Corp
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Stealth Biotherapeutics Corp
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Priority to CN202410219985.0A priority Critical patent/CN118206614A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06086—Dipeptides with the first amino acid being basic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/20—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06086—Dipeptides with the first amino acid being basic
    • C07K5/06095—Arg-amino acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1019—Tetrapeptides with the first amino acid being basic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2299/00—Coordinates from 3D structures of peptides, e.g. proteins or enzymes

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN201980037029.8A 2018-04-02 2019-03-28 用于合成elamipretide的结晶二肽 Active CN112292388B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202410219985.0A CN118206614A (zh) 2018-04-02 2019-03-28 用于合成elamipretide的结晶二肽

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862651430P 2018-04-02 2018-04-02
US62/651430 2018-04-02
PCT/US2019/024617 WO2019195080A1 (en) 2018-04-02 2019-03-28 Crystalline dipeptides useful in the synthesis of elamipretide

Related Child Applications (1)

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CN202410219985.0A Division CN118206614A (zh) 2018-04-02 2019-03-28 用于合成elamipretide的结晶二肽

Publications (2)

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CN112292388A CN112292388A (zh) 2021-01-29
CN112292388B true CN112292388B (zh) 2024-04-19

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CN202410219985.0A Pending CN118206614A (zh) 2018-04-02 2019-03-28 用于合成elamipretide的结晶二肽

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US (4) US10975118B2 (https=)
EP (2) EP3774844B1 (https=)
JP (2) JP7350007B2 (https=)
KR (2) KR102753323B1 (https=)
CN (2) CN112292388B (https=)
AU (1) AU2019249121B2 (https=)
CA (2) CA3280578A1 (https=)
DK (1) DK3774844T3 (https=)
ES (1) ES2941266T3 (https=)
FI (1) FI3774844T3 (https=)
IL (2) IL315355A (https=)
PT (1) PT3774844T (https=)
WO (1) WO2019195080A1 (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115160402A (zh) * 2016-03-11 2022-10-11 隐形生物治疗公司 结晶盐形式
PT3774844T (pt) 2018-04-02 2023-03-28 Stealth Biotherapeutics Inc Dipeptídeos cristalinos úteis na síntese de elamipretida
CN117881411A (zh) 2021-06-01 2024-04-12 艾迪雅生物有限责任公司 用于眼部药物的延长释放药物递送系统和使用方法

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006049480A (ja) * 2004-08-03 2006-02-16 Advanced Lcd Technologies Development Center Co Ltd 結晶化装置、結晶化方法、および位相変調素子
CN104945453A (zh) * 2014-03-28 2015-09-30 苏州汉德景曦新药研发有限公司 吡唑衍生物的多晶型物
CN105188701A (zh) * 2012-12-12 2015-12-23 阿里亚德医药股份有限公司 3-(咪唑并[1，2-b]哒嗪-3-基乙炔基)-4-甲基-n{4-[(4-甲基哌嗪-1-基)甲基]-3-(三氟甲基)苯基}苯甲酰胺和它的单盐酸盐的晶形
WO2016192680A1 (en) * 2015-06-03 2016-12-08 Triastek, Inc. Dosage forms and use thereof
WO2018034901A1 (en) * 2016-08-16 2018-02-22 Stealth Biotherapeutics N-carboxyanhydride-based-scale synthesis of elamipretide

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016001042A1 (en) 2014-06-30 2016-01-07 Flamma S.P.A. Process for the production of d-arginyl-2,6-dimethyl-l-tyrosyl-l-lysyl-l-phenylalaninamide
US10633415B2 (en) * 2015-03-06 2020-04-28 Stealth Biotherapeutics Corp Processes for preparing pharmaceutically relevant peptides
CN115160402A (zh) * 2016-03-11 2022-10-11 隐形生物治疗公司 结晶盐形式
CN110914287A (zh) * 2017-04-05 2020-03-24 隐形生物治疗公司 Boc-d-arg-dmt-lys-(boc)-phe-nh2的结晶盐形式
PT3774844T (pt) 2018-04-02 2023-03-28 Stealth Biotherapeutics Inc Dipeptídeos cristalinos úteis na síntese de elamipretida

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006049480A (ja) * 2004-08-03 2006-02-16 Advanced Lcd Technologies Development Center Co Ltd 結晶化装置、結晶化方法、および位相変調素子
CN105188701A (zh) * 2012-12-12 2015-12-23 阿里亚德医药股份有限公司 3-(咪唑并[1，2-b]哒嗪-3-基乙炔基)-4-甲基-n{4-[(4-甲基哌嗪-1-基)甲基]-3-(三氟甲基)苯基}苯甲酰胺和它的单盐酸盐的晶形
CN104945453A (zh) * 2014-03-28 2015-09-30 苏州汉德景曦新药研发有限公司 吡唑衍生物的多晶型物
WO2016192680A1 (en) * 2015-06-03 2016-12-08 Triastek, Inc. Dosage forms and use thereof
WO2018034901A1 (en) * 2016-08-16 2018-02-22 Stealth Biotherapeutics N-carboxyanhydride-based-scale synthesis of elamipretide

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Org. 715 Polypeptides. Part VII1.1 Variations of the Aspartyl Position in the C-Terminal Tetrapeptide Amide Sequence of the Gastrins;H Gregory ET AL;Inform. Bui 1. Chem. Soc;全文 *
线粒体靶向抗氧化剂SS-31(H-D-Arg-Dmt-Lys-Phe-NH_2)的发现及其研究进展;陈珍;陆丹丹;秦亚娟;厉廷有;;中国新药杂志(12);全文 *

Also Published As

Publication number Publication date
US20250122238A1 (en) 2025-04-17
AU2019249121B2 (en) 2024-05-02
CA3280578A1 (en) 2025-10-30
AU2019249121A1 (en) 2020-11-26
EP3774844A1 (en) 2021-02-17
KR102753323B1 (ko) 2025-01-09
IL315355A (en) 2024-11-01
EP4219523A3 (en) 2023-08-09
IL277718B1 (en) 2024-10-01
ES2941266T3 (es) 2023-05-19
US20200283476A1 (en) 2020-09-10
DK3774844T3 (da) 2023-04-03
KR20210005042A (ko) 2021-01-13
EP4219523A2 (en) 2023-08-02
EP3774844A4 (en) 2021-12-15
US12018094B2 (en) 2024-06-25
JP2021520357A (ja) 2021-08-19
CA3095869C (en) 2025-10-21
CN118206614A (zh) 2024-06-18
JP7663642B2 (ja) 2025-04-16
EP3774844B1 (en) 2023-02-22
JP2023165756A (ja) 2023-11-17
PT3774844T (pt) 2023-03-28
CN112292388A (zh) 2021-01-29
JP7350007B2 (ja) 2023-09-25
KR20250010134A (ko) 2025-01-20
IL277718B2 (en) 2025-02-01
US20210292274A1 (en) 2021-09-23
FI3774844T3 (fi) 2023-04-04
IL277718A (en) 2020-11-30
US11560404B2 (en) 2023-01-24
US10975118B2 (en) 2021-04-13
CA3095869A1 (en) 2019-10-10
WO2019195080A1 (en) 2019-10-10
US20230203093A1 (en) 2023-06-29

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