FI3774844T3 - Elamipretidin synteesissä hyödyllisiä kiteisiä dipeptidejä - Google Patents
Elamipretidin synteesissä hyödyllisiä kiteisiä dipeptidejä Download PDFInfo
- Publication number
- FI3774844T3 FI3774844T3 FIEP19781432.0T FI19781432T FI3774844T3 FI 3774844 T3 FI3774844 T3 FI 3774844T3 FI 19781432 T FI19781432 T FI 19781432T FI 3774844 T3 FI3774844 T3 FI 3774844T3
- Authority
- FI
- Finland
- Prior art keywords
- crystalline form
- xrpd pattern
- characteristic peaks
- theta values
- crystalline
- Prior art date
Links
- SFVLTCAESLKEHH-WKAQUBQDSA-N (2s)-6-amino-2-[[(2s)-2-[[(2r)-2-amino-5-(diaminomethylideneamino)pentanoyl]amino]-3-(4-hydroxy-2,6-dimethylphenyl)propanoyl]amino]-n-[(2s)-1-amino-1-oxo-3-phenylpropan-2-yl]hexanamide Chemical compound CC1=CC(O)=CC(C)=C1C[C@H](NC(=O)[C@H](N)CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(N)=O)CC1=CC=CC=C1 SFVLTCAESLKEHH-WKAQUBQDSA-N 0.000 title 1
- 108010016626 Dipeptides Proteins 0.000 title 1
- 108010033284 arginyl-2,'6'-dimethyltyrosyl-lysyl-phenylalaninamide Proteins 0.000 title 1
- 230000015572 biosynthetic process Effects 0.000 title 1
- 229950009298 elamipretide Drugs 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
- 238000000634 powder X-ray diffraction Methods 0.000 claims 8
- 150000001875 compounds Chemical class 0.000 claims 6
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06086—Dipeptides with the first amino acid being basic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/20—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06086—Dipeptides with the first amino acid being basic
- C07K5/06095—Arg-amino acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1019—Tetrapeptides with the first amino acid being basic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2299/00—Coordinates from 3D structures of peptides, e.g. proteins or enzymes
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Life Sciences & Earth Sciences (AREA)
- Peptides Or Proteins (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862651430P | 2018-04-02 | 2018-04-02 | |
| PCT/US2019/024617 WO2019195080A1 (en) | 2018-04-02 | 2019-03-28 | Crystalline dipeptides useful in the synthesis of elamipretide |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| FI3774844T3 true FI3774844T3 (fi) | 2023-04-04 |
Family
ID=68101313
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FIEP19781432.0T FI3774844T3 (fi) | 2018-04-02 | 2019-03-28 | Elamipretidin synteesissä hyödyllisiä kiteisiä dipeptidejä |
Country Status (13)
| Country | Link |
|---|---|
| US (4) | US10975118B2 (https=) |
| EP (2) | EP3774844B1 (https=) |
| JP (2) | JP7350007B2 (https=) |
| KR (2) | KR102753323B1 (https=) |
| CN (2) | CN112292388B (https=) |
| AU (1) | AU2019249121B2 (https=) |
| CA (2) | CA3280578A1 (https=) |
| DK (1) | DK3774844T3 (https=) |
| ES (1) | ES2941266T3 (https=) |
| FI (1) | FI3774844T3 (https=) |
| IL (2) | IL315355A (https=) |
| PT (1) | PT3774844T (https=) |
| WO (1) | WO2019195080A1 (https=) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115160402A (zh) * | 2016-03-11 | 2022-10-11 | 隐形生物治疗公司 | 结晶盐形式 |
| PT3774844T (pt) | 2018-04-02 | 2023-03-28 | Stealth Biotherapeutics Inc | Dipeptídeos cristalinos úteis na síntese de elamipretida |
| CN117881411A (zh) | 2021-06-01 | 2024-04-12 | 艾迪雅生物有限责任公司 | 用于眼部药物的延长释放药物递送系统和使用方法 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4711166B2 (ja) * | 2004-08-03 | 2011-06-29 | 株式会社 液晶先端技術開発センター | 結晶化装置、および結晶化方法 |
| CA3022250A1 (en) * | 2012-12-12 | 2014-06-12 | Ariad Pharmaceuticals, Inc. | Crystalline forms of 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-n-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide mono hydrochloride |
| CN104945453B (zh) * | 2014-03-28 | 2018-06-26 | 江苏天士力帝益药业有限公司 | 吡唑衍生物的多晶型物 |
| WO2016001042A1 (en) | 2014-06-30 | 2016-01-07 | Flamma S.P.A. | Process for the production of d-arginyl-2,6-dimethyl-l-tyrosyl-l-lysyl-l-phenylalaninamide |
| US10633415B2 (en) * | 2015-03-06 | 2020-04-28 | Stealth Biotherapeutics Corp | Processes for preparing pharmaceutically relevant peptides |
| CA3254279A1 (en) * | 2015-06-03 | 2025-03-18 | Triastek, Inc. | PHARMACEUTICAL FORMS AND RELATED USES |
| CN115160402A (zh) * | 2016-03-11 | 2022-10-11 | 隐形生物治疗公司 | 结晶盐形式 |
| CN110087667A (zh) | 2016-08-16 | 2019-08-02 | 隐形生物治疗公司 | Elamipretide的基于N-羧基酸酐的规模合成 |
| CN110914287A (zh) * | 2017-04-05 | 2020-03-24 | 隐形生物治疗公司 | Boc-d-arg-dmt-lys-(boc)-phe-nh2的结晶盐形式 |
| PT3774844T (pt) | 2018-04-02 | 2023-03-28 | Stealth Biotherapeutics Inc | Dipeptídeos cristalinos úteis na síntese de elamipretida |
-
2019
- 2019-03-28 PT PT197814320T patent/PT3774844T/pt unknown
- 2019-03-28 CA CA3280578A patent/CA3280578A1/en active Pending
- 2019-03-28 WO PCT/US2019/024617 patent/WO2019195080A1/en not_active Ceased
- 2019-03-28 JP JP2020554100A patent/JP7350007B2/ja active Active
- 2019-03-28 EP EP19781432.0A patent/EP3774844B1/en active Active
- 2019-03-28 ES ES19781432T patent/ES2941266T3/es active Active
- 2019-03-28 CN CN201980037029.8A patent/CN112292388B/zh active Active
- 2019-03-28 EP EP23156906.2A patent/EP4219523A3/en active Pending
- 2019-03-28 DK DK19781432.0T patent/DK3774844T3/da active
- 2019-03-28 CN CN202410219985.0A patent/CN118206614A/zh active Pending
- 2019-03-28 AU AU2019249121A patent/AU2019249121B2/en active Active
- 2019-03-28 IL IL315355A patent/IL315355A/en unknown
- 2019-03-28 FI FIEP19781432.0T patent/FI3774844T3/fi active
- 2019-03-28 KR KR1020207031595A patent/KR102753323B1/ko active Active
- 2019-03-28 IL IL277718A patent/IL277718B2/en unknown
- 2019-03-28 CA CA3095869A patent/CA3095869C/en active Active
- 2019-03-28 US US16/485,369 patent/US10975118B2/en active Active
- 2019-03-28 KR KR1020257000322A patent/KR20250010134A/ko active Pending
-
2021
- 2021-04-07 US US17/224,353 patent/US11560404B2/en active Active
-
2022
- 2022-12-21 US US18/086,203 patent/US12018094B2/en active Active
-
2023
- 2023-09-12 JP JP2023147376A patent/JP7663642B2/ja active Active
-
2024
- 2024-05-15 US US18/665,100 patent/US20250122238A1/en active Pending
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