IL303270A - The CD45–GATE vehicle activates a protease - Google Patents

The CD45–GATE vehicle activates a protease

Info

Publication number
IL303270A
IL303270A IL303270A IL30327023A IL303270A IL 303270 A IL303270 A IL 303270A IL 303270 A IL303270 A IL 303270A IL 30327023 A IL30327023 A IL 30327023A IL 303270 A IL303270 A IL 303270A
Authority
IL
Israel
Prior art keywords
car
protease
cell
activating
domain
Prior art date
Application number
IL303270A
Other languages
English (en)
Hebrew (he)
Inventor
Shanshan Lang
Blarcom Thomas John Van
Michael Thomas Bethune
Siler Panowski
Nguyen Tan
Yi Zhang
Barbra Johnson Sasu
Zhe Li
Original Assignee
Allogene Therapeutics Inc
Pfizer
Shanshan Lang
Blarcom Thomas John Van
Michael Thomas Bethune
Siler Panowski
Nguyen Tan
Yi Zhang
Barbra Johnson Sasu
Zhe Li
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Allogene Therapeutics Inc, Pfizer, Shanshan Lang, Blarcom Thomas John Van, Michael Thomas Bethune, Siler Panowski, Nguyen Tan, Yi Zhang, Barbra Johnson Sasu, Zhe Li filed Critical Allogene Therapeutics Inc
Publication of IL303270A publication Critical patent/IL303270A/en

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    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
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    • A61K40/15—Natural-killer [NK] cells; Natural-killer T [NKT] cells
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    • C—CHEMISTRY; METALLURGY
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    • C07K16/289—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD45
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    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3076—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells against structure-related tumour-associated moieties
    • C07K16/3092—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells against structure-related tumour-associated moieties against tumour-associated mucins
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
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    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
    • C—CHEMISTRY; METALLURGY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
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    • C—CHEMISTRY; METALLURGY
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    • C07K2319/00—Fusion polypeptide
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    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
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    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/31—Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/50—Fusion polypeptide containing protease site
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  • Peptides Or Proteins (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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IL303270A 2020-12-21 2021-12-21 The CD45–GATE vehicle activates a protease IL303270A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202063128667P 2020-12-21 2020-12-21
US202163289984P 2021-12-15 2021-12-15
PCT/US2021/064615 WO2022140388A1 (en) 2020-12-21 2021-12-21 Protease-activating cd45-gate car

Publications (1)

Publication Number Publication Date
IL303270A true IL303270A (en) 2023-07-01

Family

ID=80823813

Family Applications (1)

Application Number Title Priority Date Filing Date
IL303270A IL303270A (en) 2020-12-21 2021-12-21 The CD45–GATE vehicle activates a protease

Country Status (9)

Country Link
US (1) US12404315B2 (https=)
EP (1) EP4263590A1 (https=)
JP (1) JP2024500189A (https=)
KR (1) KR20230122618A (https=)
AU (2) AU2021409801B2 (https=)
CA (1) CA3201115A1 (https=)
IL (1) IL303270A (https=)
MX (1) MX2023007384A (https=)
WO (1) WO2022140388A1 (https=)

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WO2025038668A1 (en) * 2023-08-14 2025-02-20 Voro Therapeutics, Inc. Therapeutic binding agents that conditionally promote myeloid cell activity against target cells and uses thereof
CN118620078B (zh) * 2024-07-09 2024-11-19 武汉爱博泰克生物科技有限公司 抗人cd45ra蛋白的抗体、抗体偶联物及其应用

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