IL299477B1 - Automated system for producing induced pluripotent stem cells or differentiated cells - Google Patents

Automated system for producing induced pluripotent stem cells or differentiated cells

Info

Publication number
IL299477B1
IL299477B1 IL299477A IL29947722A IL299477B1 IL 299477 B1 IL299477 B1 IL 299477B1 IL 299477 A IL299477 A IL 299477A IL 29947722 A IL29947722 A IL 29947722A IL 299477 B1 IL299477 B1 IL 299477B1
Authority
IL
Israel
Prior art keywords
cells
cell
automated
differentiated
unit
Prior art date
Application number
IL299477A
Other languages
English (en)
Hebrew (he)
Other versions
IL299477A (en
Original Assignee
New York Stem Cell Found Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by New York Stem Cell Found Inc filed Critical New York Stem Cell Found Inc
Publication of IL299477A publication Critical patent/IL299477A/en
Publication of IL299477B1 publication Critical patent/IL299477B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/48—Automatic or computerized control
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M21/00—Bioreactors or fermenters specially adapted for specific uses
    • C12M21/08—Bioreactors or fermenters specially adapted for specific uses for producing artificial tissue or for ex-vivo cultivation of tissue
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/02—Form or structure of the vessel
    • C12M23/04—Flat or tray type, drawers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M35/00—Means for application of stress for stimulating the growth of microorganisms or the generation of fermentation or metabolic products; Means for electroporation or cell fusion
    • C12M35/02—Electrical or electromagnetic means, e.g. for electroporation or for cell fusion
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M35/00—Means for application of stress for stimulating the growth of microorganisms or the generation of fermentation or metabolic products; Means for electroporation or cell fusion
    • C12M35/08—Chemical, biochemical or biological means, e.g. plasma jet, co-culture
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M47/00—Means for after-treatment of the produced biomass or of the fermentation or metabolic products, e.g. storage of biomass
    • C12M47/04—Cell isolation or sorting
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0607—Non-embryonic pluripotent stem cells, e.g. MASC
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0696—Artificially induced pluripotent stem cells, e.g. iPS
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/13—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells
    • C12N2506/1307—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells from adult fibroblasts

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Sustainable Development (AREA)
  • Cell Biology (AREA)
  • Molecular Biology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Transplantation (AREA)
  • Clinical Laboratory Science (AREA)
  • Electromagnetism (AREA)
  • Physics & Mathematics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physiology (AREA)
  • Analytical Chemistry (AREA)
  • Computer Hardware Design (AREA)
  • Rheumatology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
IL299477A 2011-12-01 2012-11-30 Automated system for producing induced pluripotent stem cells or differentiated cells IL299477B1 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201161565818P 2011-12-01 2011-12-01
US201161580007P 2011-12-23 2011-12-23
US201261700792P 2012-09-13 2012-09-13
PCT/US2012/067417 WO2013082509A1 (en) 2011-12-01 2012-11-30 Automated system for producing induced pluripotent stem cells or differentiated cells

Publications (2)

Publication Number Publication Date
IL299477A IL299477A (en) 2023-02-01
IL299477B1 true IL299477B1 (en) 2026-05-01

Family

ID=48536128

Family Applications (3)

Application Number Title Priority Date Filing Date
IL299477A IL299477B1 (en) 2011-12-01 2012-11-30 Automated system for producing induced pluripotent stem cells or differentiated cells
IL232869A IL232869B (en) 2011-12-01 2014-05-29 Automated system for producing induced pluripotent stem cells or differentiated cells
IL289822A IL289822B2 (en) 2011-12-01 2022-01-13 An automated system for the production of induced pluripotent stem cells or differentiated cells

Family Applications After (2)

Application Number Title Priority Date Filing Date
IL232869A IL232869B (en) 2011-12-01 2014-05-29 Automated system for producing induced pluripotent stem cells or differentiated cells
IL289822A IL289822B2 (en) 2011-12-01 2022-01-13 An automated system for the production of induced pluripotent stem cells or differentiated cells

Country Status (14)

Country Link
US (4) US10273459B2 (cg-RX-API-DMAC10.html)
EP (2) EP3653698B1 (cg-RX-API-DMAC10.html)
JP (1) JP6257520B2 (cg-RX-API-DMAC10.html)
KR (6) KR20240019378A (cg-RX-API-DMAC10.html)
CN (2) CN110724636A (cg-RX-API-DMAC10.html)
AU (4) AU2012345676B2 (cg-RX-API-DMAC10.html)
BR (2) BR122020005735B1 (cg-RX-API-DMAC10.html)
CA (2) CA2857295C (cg-RX-API-DMAC10.html)
DK (2) DK3653698T3 (cg-RX-API-DMAC10.html)
ES (2) ES3038941T3 (cg-RX-API-DMAC10.html)
IL (3) IL299477B1 (cg-RX-API-DMAC10.html)
IN (1) IN2014CN04920A (cg-RX-API-DMAC10.html)
WO (1) WO2013082509A1 (cg-RX-API-DMAC10.html)
ZA (3) ZA201403945B (cg-RX-API-DMAC10.html)

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KR20220141823A (ko) 2022-10-20
CA2857295A1 (en) 2013-06-06
KR20240019378A (ko) 2024-02-14
BR122020005735B1 (pt) 2021-12-28
ZA201803502B (en) 2022-12-21
ES3038941T3 (en) 2025-10-16
US20210332330A1 (en) 2021-10-28
IL289822B2 (en) 2023-06-01
ES2773863T3 (es) 2020-07-15
IL232869A0 (en) 2014-07-31
US12698479B2 (en) 2026-08-04
JP6257520B2 (ja) 2018-01-10
BR112014013152A2 (pt) 2017-06-13
CA2857295C (en) 2021-06-29
IN2014CN04920A (cg-RX-API-DMAC10.html) 2015-09-18
CN104080906A (zh) 2014-10-01
EP2785829A1 (en) 2014-10-08
DK2785829T3 (da) 2020-01-27
CA3118842C (en) 2023-12-12
IL299477A (en) 2023-02-01
AU2024203546A1 (en) 2024-06-20
EP2785829B1 (en) 2019-10-16
CN110724636A (zh) 2020-01-24
IL289822A (en) 2022-03-01
US20130345094A1 (en) 2013-12-26
KR102039202B1 (ko) 2019-10-31
AU2021212081B2 (en) 2024-02-29
ZA201403945B (en) 2018-08-29
JP2015502747A (ja) 2015-01-29
AU2018286561A1 (en) 2019-01-24
US20240191203A1 (en) 2024-06-13
AU2012345676A1 (en) 2014-06-19
CA3118842A1 (en) 2013-06-06
US10968435B2 (en) 2021-04-06
US20190352613A1 (en) 2019-11-21
ZA202205833B (en) 2024-09-25
WO2013082509A1 (en) 2013-06-06
AU2021212081A1 (en) 2021-08-26
US10273459B2 (en) 2019-04-30
EP3653698A1 (en) 2020-05-20
KR102439238B1 (ko) 2022-08-31
EP3653698B1 (en) 2025-04-02
KR102631374B1 (ko) 2024-01-29
US11732242B2 (en) 2023-08-22
KR20190124326A (ko) 2019-11-04
IL232869B (en) 2022-02-01
DK3653698T3 (da) 2025-07-07
BR112014013152B1 (pt) 2021-08-31
KR20140101393A (ko) 2014-08-19
KR20260069768A (ko) 2026-05-15
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KR20210096700A (ko) 2021-08-05
AU2012345676B2 (en) 2018-10-04

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