DK3653698T3 - Automatiseret system til fremstilling af inducerede pluripotente stamceller eller differentierede celler - Google Patents

Automatiseret system til fremstilling af inducerede pluripotente stamceller eller differentierede celler

Info

Publication number
DK3653698T3
DK3653698T3 DK19203379.3T DK19203379T DK3653698T3 DK 3653698 T3 DK3653698 T3 DK 3653698T3 DK 19203379 T DK19203379 T DK 19203379T DK 3653698 T3 DK3653698 T3 DK 3653698T3
Authority
DK
Denmark
Prior art keywords
production
pluripotent stem
automated system
induced pluripotent
cells
Prior art date
Application number
DK19203379.3T
Other languages
Danish (da)
English (en)
Inventor
Scott Noggle
Kevin Eggan
Stephen Chang
Susan L Solomon
Original Assignee
New York Stem Cell Found Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by New York Stem Cell Found Inc filed Critical New York Stem Cell Found Inc
Application granted granted Critical
Publication of DK3653698T3 publication Critical patent/DK3653698T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/48—Automatic or computerized control
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M21/00—Bioreactors or fermenters specially adapted for specific uses
    • C12M21/08—Bioreactors or fermenters specially adapted for specific uses for producing artificial tissue or for ex-vivo cultivation of tissue
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/02—Form or structure of the vessel
    • C12M23/04—Flat or tray type, drawers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M35/00—Means for application of stress for stimulating the growth of microorganisms or the generation of fermentation or metabolic products; Means for electroporation or cell fusion
    • C12M35/02—Electrical or electromagnetic means, e.g. for electroporation or for cell fusion
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M35/00—Means for application of stress for stimulating the growth of microorganisms or the generation of fermentation or metabolic products; Means for electroporation or cell fusion
    • C12M35/08—Chemical, biochemical or biological means, e.g. plasma jet, co-culture
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M47/00—Means for after-treatment of the produced biomass or of the fermentation or metabolic products, e.g. storage of biomass
    • C12M47/04—Cell isolation or sorting
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0607—Non-embryonic pluripotent stem cells, e.g. MASC
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0696—Artificially induced pluripotent stem cells, e.g. iPS
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/13—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells
    • C12N2506/1307—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells from adult fibroblasts

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Sustainable Development (AREA)
  • Cell Biology (AREA)
  • Molecular Biology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Transplantation (AREA)
  • Clinical Laboratory Science (AREA)
  • Electromagnetism (AREA)
  • Physics & Mathematics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physiology (AREA)
  • Analytical Chemistry (AREA)
  • Computer Hardware Design (AREA)
  • Rheumatology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
DK19203379.3T 2011-12-01 2012-11-30 Automatiseret system til fremstilling af inducerede pluripotente stamceller eller differentierede celler DK3653698T3 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201161565818P 2011-12-01 2011-12-01
US201161580007P 2011-12-23 2011-12-23
US201261700792P 2012-09-13 2012-09-13
EP12852680.3A EP2785829B1 (en) 2011-12-01 2012-11-30 Automated system for producing induced pluripotent stem cells or differentiated cells

Publications (1)

Publication Number Publication Date
DK3653698T3 true DK3653698T3 (da) 2025-07-07

Family

ID=48536128

Family Applications (2)

Application Number Title Priority Date Filing Date
DK19203379.3T DK3653698T3 (da) 2011-12-01 2012-11-30 Automatiseret system til fremstilling af inducerede pluripotente stamceller eller differentierede celler
DK12852680.3T DK2785829T3 (da) 2011-12-01 2012-11-30 Automatiseret system til fremstilling af inducerede pluripotente stamceller eller differentierede celler

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK12852680.3T DK2785829T3 (da) 2011-12-01 2012-11-30 Automatiseret system til fremstilling af inducerede pluripotente stamceller eller differentierede celler

Country Status (14)

Country Link
US (4) US10273459B2 (cg-RX-API-DMAC10.html)
EP (2) EP3653698B1 (cg-RX-API-DMAC10.html)
JP (1) JP6257520B2 (cg-RX-API-DMAC10.html)
KR (6) KR20240019378A (cg-RX-API-DMAC10.html)
CN (2) CN110724636A (cg-RX-API-DMAC10.html)
AU (4) AU2012345676B2 (cg-RX-API-DMAC10.html)
BR (2) BR122020005735B1 (cg-RX-API-DMAC10.html)
CA (2) CA2857295C (cg-RX-API-DMAC10.html)
DK (2) DK3653698T3 (cg-RX-API-DMAC10.html)
ES (2) ES3038941T3 (cg-RX-API-DMAC10.html)
IL (3) IL299477B1 (cg-RX-API-DMAC10.html)
IN (1) IN2014CN04920A (cg-RX-API-DMAC10.html)
WO (1) WO2013082509A1 (cg-RX-API-DMAC10.html)
ZA (3) ZA201403945B (cg-RX-API-DMAC10.html)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013082509A1 (en) 2011-12-01 2013-06-06 The New York Stem Cell Foundation Automated system for producing induced pluripotent stem cells or differentiated cells
US10428309B2 (en) * 2011-12-01 2019-10-01 New York Stem Cell Foundation, Inc. Systems and methods for producing stem cells and differentiated cells
WO2014201412A1 (en) * 2013-06-13 2014-12-18 The New York Stem Cell Foundation Inc. Pluripotent stem cells derived from non-cryoprotected frozen tissue and methods for making and using the same
EP3013941B1 (en) * 2013-06-27 2018-10-31 New York Stem Cell Foundation, Inc. Improved systems and methods for producing stem cells and differentiated cells
EP3033414A4 (en) * 2013-08-12 2017-03-22 Invivosciences Inc. Automated cell culture system and method
US20160222355A1 (en) * 2014-12-26 2016-08-04 New York Stem Cell Foundation, Inc. Systems and methods for producing stem cells differentiated cells, and genetically edited cells
US9828634B2 (en) 2015-01-22 2017-11-28 Regenerative Medical Solutions, Inc. Markers for differentiation of stem cells into differentiated cell populations
CA2996582A1 (en) 2015-08-31 2017-03-09 I Peace, Inc. Pluripotent stem cell manufacturing system and method for producing induced pluripotent stem cells
CN105567642B (zh) * 2016-02-01 2019-07-12 中国科学院生物物理研究所 一种着色性干皮病人多能干细胞的制备方法
CA3016575A1 (en) 2016-03-03 2017-09-08 New York Stem Cell Foundation, Inc. Microglia derived from pluripotent stem cells and methods of making and using the same
CN109923204A (zh) * 2016-07-21 2019-06-21 塞尔艾德 用于细胞的自动化独立并行批量处理的方法和装置
US10354218B2 (en) 2016-08-04 2019-07-16 Fanuc Corporation System and method for iPS cell bank using internet technology
US11259520B2 (en) * 2016-08-04 2022-03-01 Fanuc Corporation Stem cell manufacturing system, stem cell information management system, cell transport apparatus, and stem cell frozen storage apparatus
US10373109B2 (en) 2016-08-04 2019-08-06 Fanuc Corporation System and method for iPS cell bank using media
WO2018094235A1 (en) * 2016-11-18 2018-05-24 New York Stem Cell Foundation, Inc. Microfluidic system and method of use thereof
CN110168067A (zh) 2017-01-20 2019-08-23 富士胶片株式会社 细胞培养装置及细胞培养方法
EP3587556A4 (en) 2017-02-24 2021-04-14 Koji Tanabe CELL TREATMENT DEVICE, SUSPENSION CULTURE VESSEL AND STEM CELL INDUCTION METHOD
JP6530876B2 (ja) * 2017-02-27 2019-06-12 剛士 田邊 細胞処理システム及び細胞処理装置
EP3530727A4 (en) * 2017-02-27 2020-07-08 Koji Tanabe SOMATIC CELL PRODUCTION SYSTEM
MX2019015505A (es) * 2017-06-30 2020-07-28 Inscripta Inc Metodos, modulos, instrumentos y sistemas de procesamiento de celulas automatizados.
GB2564437B (en) 2017-07-10 2020-11-04 Univ Brunel Method of testing a gene therapy vector using induced pluripotent stem cells
KR102546681B1 (ko) 2017-09-01 2023-06-22 론차 콜로그네 게엠베하 엔드-투-엔드 세포 요법의 자동화
US10435713B2 (en) * 2017-09-30 2019-10-08 Inscripta, Inc. Flow through electroporation instrumentation
JPWO2019240008A1 (ja) * 2018-06-13 2021-06-24 富士フイルム株式会社 情報処理装置、導出方法、及び導出プログラム
JP7090337B2 (ja) * 2019-03-20 2022-06-24 アイ ピース,インコーポレイテッド 細胞処理システム及び細胞処理装置
JP6530577B1 (ja) * 2019-03-20 2019-06-12 剛士 田邊 細胞処理システム及び細胞処理装置
JP6530874B1 (ja) * 2019-03-20 2019-06-12 剛士 田邊 細胞処理システム及び細胞処理装置
WO2021067797A1 (en) * 2019-10-04 2021-04-08 New York Stem Cell Foundation, Inc. Imaging system and method of use thereof
CN115087730A (zh) * 2019-11-28 2022-09-20 香港大学 间充质基质细胞作为ipsc诱导的重编程来源
WO2022266661A1 (en) * 2021-06-17 2022-12-22 Genentech, Inc. Automated cell culture system
US12385002B1 (en) * 2022-01-21 2025-08-12 Sahar M. H. Jaffal Automated primary cells' triturator
CN114606198A (zh) * 2022-03-25 2022-06-10 深圳临研医学有限公司 成骨发育不全诱导多能干细胞及其构建方法
WO2024020572A1 (en) 2022-07-22 2024-01-25 New York Stem Cell Foundation, Inc. Methods and compositions for the treatment of ptsd
EP4649500A1 (en) * 2023-01-11 2025-11-19 Regeneron Pharmaceuticals, Inc. Systems and methods for a regulatory-compliant automated assay
JPWO2024228384A1 (cg-RX-API-DMAC10.html) * 2023-04-30 2024-11-07
JP2025064611A (ja) * 2023-10-06 2025-04-17 住友化学株式会社 細胞チップ

Family Cites Families (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5843780A (en) 1995-01-20 1998-12-01 Wisconsin Alumni Research Foundation Primate embryonic stem cells
US5994619A (en) 1996-04-01 1999-11-30 University Of Massachusetts, A Public Institution Of Higher Education Of The Commonwealth Of Massachusetts, As Represented By Its Amherst Campus Production of chimeric bovine or porcine animals using cultured inner cell mass cells
US5945577A (en) 1997-01-10 1999-08-31 University Of Massachusetts As Represented By Its Amherst Campus Cloning using donor nuclei from proliferating somatic cells
JP2001512689A (ja) 1997-08-11 2001-08-28 カイロン コーポレイション T細胞を遺伝子改変するための方法
US8026096B1 (en) 1998-10-08 2011-09-27 Protein Sciences Corporation In vivo active erythropoietin produced in insect cells
US20110171185A1 (en) * 1999-06-30 2011-07-14 Klimanskaya Irina V Genetically intact induced pluripotent cells or transdifferentiated cells and methods for the production thereof
US6429013B1 (en) 1999-08-19 2002-08-06 Artecel Science, Inc. Use of adipose tissue-derived stromal cells for chondrocyte differentiation and cartilage repair
US6959438B2 (en) 2000-12-06 2005-10-25 Microsoft Corporation Interface and related methods for dynamically generating a filter graph in a development system
US8492140B2 (en) * 2002-04-08 2013-07-23 Octane Biotech Inc. Automated tissue engineering system
EP1445320A1 (en) 2003-02-05 2004-08-11 ARTEMIS Pharmaceuticals GmbH Automated gene-targeting using non-toxic detectable markers
EP1743021B1 (en) * 2004-03-19 2014-03-26 Cytori Therapeutics, Inc. Method of preparing regenerative cells on a cell carrier and cell carrier containment device
US20070238175A1 (en) 2006-04-06 2007-10-11 Chi Alfred L Standardization of processes for culturing primary cells
GB0704406D0 (en) 2007-03-07 2007-04-18 Stem Cell Sciences Uk Ltd Automated culture of stem cells
JP2008307007A (ja) 2007-06-15 2008-12-25 Bayer Schering Pharma Ag 出生後のヒト組織由来未分化幹細胞から誘導したヒト多能性幹細胞
AU2008272949B2 (en) * 2007-06-29 2014-05-15 FUJIFILM Cellular Dynamics, Inc. Automated method and apparatus for embryonic stem cell culture
US20100196923A1 (en) * 2007-08-14 2010-08-05 Anthony Atala Pluripotent adult stem cells
WO2009152529A2 (en) 2008-06-13 2009-12-17 Whitehead Institute For Biomedical Research Nine Cambridge Center Programming and reprogramming of cells
EP2315829B1 (en) 2008-08-08 2015-02-11 Mayo Foundation For Medical Education And Research Induced pluripotent stem cells
US20100062534A1 (en) 2008-09-09 2010-03-11 The General Hospital Corporation Inducible lentiviral vectors for reprogramming somatic cells
EP2376626A4 (en) * 2008-12-13 2012-10-17 Dna Microarray MICRO-ENVIRONMENTAL NICHE ASSAY FOR SCREENING OF INDUCED PLURIPOTENT STEM CELLS (CIPS)
SG172160A1 (en) 2008-12-17 2011-07-28 Scripps Research Inst Generation and maintenance of stem cells
EP2398897B1 (en) 2009-02-20 2017-06-28 Cellular Dynamics International, Inc. Methods and compositions for the differentiation of stem cells
CA2753679C (en) 2009-02-27 2021-03-02 Cellular Dynamics International, Inc. Differentiation of pluripotent cells
CN101580816B (zh) 2009-04-23 2012-02-29 中国科学院广州生物医药与健康研究院 诱导多能性干细胞快速高效产生的新型无血清培养基以及使用其的方法
CN105925535A (zh) * 2009-06-05 2016-09-07 细胞动力国际有限公司 重编程t细胞和造血细胞的方法
US20110020814A1 (en) * 2009-06-05 2011-01-27 Ipierian, Inc. Methods and compositions for selection of stem cells
US20120178158A1 (en) 2009-06-23 2012-07-12 The Scripps Research Institute Adult animals generated from induced pluripotent cells
US20120252697A1 (en) * 2009-09-01 2012-10-04 Mcmaster University Transformed human pluripotent stem cells and associated methods
WO2011037301A1 (ko) * 2009-09-22 2011-03-31 서울대학교병원 성체세포로부터 만능줄기세포를 유도하는 방법 및 그 방법에 의해 제조된 만능줄기세포
WO2011130624A2 (en) 2010-04-16 2011-10-20 Immune Disease Institute, Inc. Sustained polypeptide expression from synthetic, modified rnas and uses thereof
US20110306516A1 (en) 2010-06-15 2011-12-15 The New York Stem Cell Foundation Methods for producing induced pluripotent stem cells
US9732319B2 (en) 2010-12-22 2017-08-15 Fate Therapeutics, Inc. Cell culture platform for single cell sorting and enhanced reprogramming of iPSCs
EP2481795A1 (en) 2011-01-28 2012-08-01 Universität für Bodenkultur Wien Method of generating induced pluripotent stem cells and differentiated cells
US10428309B2 (en) 2011-12-01 2019-10-01 New York Stem Cell Foundation, Inc. Systems and methods for producing stem cells and differentiated cells
WO2013082509A1 (en) 2011-12-01 2013-06-06 The New York Stem Cell Foundation Automated system for producing induced pluripotent stem cells or differentiated cells

Also Published As

Publication number Publication date
KR20220141823A (ko) 2022-10-20
CA2857295A1 (en) 2013-06-06
KR20240019378A (ko) 2024-02-14
BR122020005735B1 (pt) 2021-12-28
ZA201803502B (en) 2022-12-21
ES3038941T3 (en) 2025-10-16
US20210332330A1 (en) 2021-10-28
IL289822B2 (en) 2023-06-01
ES2773863T3 (es) 2020-07-15
IL232869A0 (en) 2014-07-31
US12698479B2 (en) 2026-08-04
JP6257520B2 (ja) 2018-01-10
BR112014013152A2 (pt) 2017-06-13
CA2857295C (en) 2021-06-29
IL299477B1 (en) 2026-05-01
IN2014CN04920A (cg-RX-API-DMAC10.html) 2015-09-18
CN104080906A (zh) 2014-10-01
EP2785829A1 (en) 2014-10-08
DK2785829T3 (da) 2020-01-27
CA3118842C (en) 2023-12-12
IL299477A (en) 2023-02-01
AU2024203546A1 (en) 2024-06-20
EP2785829B1 (en) 2019-10-16
CN110724636A (zh) 2020-01-24
IL289822A (en) 2022-03-01
US20130345094A1 (en) 2013-12-26
KR102039202B1 (ko) 2019-10-31
AU2021212081B2 (en) 2024-02-29
ZA201403945B (en) 2018-08-29
JP2015502747A (ja) 2015-01-29
AU2018286561A1 (en) 2019-01-24
US20240191203A1 (en) 2024-06-13
AU2012345676A1 (en) 2014-06-19
CA3118842A1 (en) 2013-06-06
US10968435B2 (en) 2021-04-06
US20190352613A1 (en) 2019-11-21
ZA202205833B (en) 2024-09-25
WO2013082509A1 (en) 2013-06-06
AU2021212081A1 (en) 2021-08-26
US10273459B2 (en) 2019-04-30
EP3653698A1 (en) 2020-05-20
KR102439238B1 (ko) 2022-08-31
EP3653698B1 (en) 2025-04-02
KR102631374B1 (ko) 2024-01-29
US11732242B2 (en) 2023-08-22
KR20190124326A (ko) 2019-11-04
IL232869B (en) 2022-02-01
BR112014013152B1 (pt) 2021-08-31
KR20140101393A (ko) 2014-08-19
KR20260069768A (ko) 2026-05-15
EP2785829A4 (en) 2015-04-29
KR20210096700A (ko) 2021-08-05
AU2012345676B2 (en) 2018-10-04

Similar Documents

Publication Publication Date Title
IL289822A (en) Automated system for producing induced pluripotent stem cells or differentiated cells
IL229879B (en) Culture media for stem cells
DK2658965T3 (da) Fremgangsmåde til fremstilling af inducerede pluripotente stamceller og differentierede celler
DK2882850T3 (da) System for preparation of adipose-derived stem cells
DK3824991T3 (da) Fremgangsmåde til forberedelse af lithiumsulfat
DK2880151T3 (da) Fremgangsmåder til frembringelse af mesenkymale stemceller, som udskiller neurotrofiske faktorer
DK2718404T3 (da) Fremgangsmåde til fremstilling af flydende carbonhydrider
DK2893001T3 (da) Fremgangsmåde til dyrkning af mesenkymale stamceller
DK3543333T3 (da) Fremgangsmåde til screening af alfa-amylaser
DK3050972T3 (da) Fremgangsmåder til fremstilling af eicosapentaensyre i thraustochytrider
EP2681306A4 (en) CELL CULTURE SYSTEM
DK2874506T3 (da) Fremgangsmåde til fremstilling af enzymgranulater
DK2533895T3 (da) Fremgangsmåde til fremstilling af hydrogeneret biodiesel
DK2573571T3 (da) Sporbarhed til automatiseret farvningssystem
DK3050961T3 (da) Fremgangsmåde til forbedring af effektiviteten ved inducering af pluripotente stamceller
DK3064575T3 (da) Fremgangsmåde til differentiering af pluripotent stamcelle induceret fra mesenkymal stamcelle til hepatocyt
SG11201503167XA (en) Method of efficiently establishing induced pluripotent stem cells
DK2802204T3 (da) Modulering af plantebiologi
GB2504996A8 (en) Stem cell culture method
DK3064573T3 (da) Fremgangsmåde til differentiering af pluripotent stamcelle induceret fra mesenkymal stamcelle til neuron
DK3064574T3 (da) Fremgangsmåde til differentiering af pluripotente stamceller induceret fra mesenkymstamceller til chondrocyt
PT2641833T (pt) Um método de ocultação solar
DK2586868T3 (da) Fremgangsmåde og biogasanlæg til fremstilling af biogas
ZA201504388B (en) Method for culturing pluripotent stem cells
DK2727979T3 (da) Fischer-tropsch-fremgangsmåde til fremstilling af carbonhydrider på grundlag af biogas