IN2014CN04920A - - Google Patents

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Publication number
IN2014CN04920A
IN2014CN04920A IN4920CHN2014A IN2014CN04920A IN 2014CN04920 A IN2014CN04920 A IN 2014CN04920A IN 4920CHN2014 A IN4920CHN2014 A IN 4920CHN2014A IN 2014CN04920 A IN2014CN04920 A IN 2014CN04920A
Authority
IN
India
Prior art keywords
cells
adult
producing
reprogrammed
differentiated
Prior art date
Application number
Inventor
Scott Noggle
Kevin Eggan
Stephen Chang
Susan L Solomon
Original Assignee
New York Stem Cell Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by New York Stem Cell Foundation filed Critical New York Stem Cell Foundation
Publication of IN2014CN04920A publication Critical patent/IN2014CN04920A/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0696—Artificially induced pluripotent stem cells, e.g. iPS
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/02—Form or structure of the vessel
    • C12M23/04—Flat or tray type, drawers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M35/00—Means for application of stress for stimulating the growth of microorganisms or the generation of fermentation or metabolic products; Means for electroporation or cell fusion
    • C12M35/02—Electrical or electromagnetic means, e.g. for electroporation or for cell fusion
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M35/00—Means for application of stress for stimulating the growth of microorganisms or the generation of fermentation or metabolic products; Means for electroporation or cell fusion
    • C12M35/08—Chemical, biochemical or biological means, e.g. plasma jet, co-culture
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M47/00—Means for after-treatment of the produced biomass or of the fermentation or metabolic products, e.g. storage of biomass
    • C12M47/04—Cell isolation or sorting
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0607—Non-embryonic pluripotent stem cells, e.g. MASC
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/13—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells
    • C12N2506/1307—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells from adult fibroblasts

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Sustainable Development (AREA)
  • Molecular Biology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Transplantation (AREA)
  • Clinical Laboratory Science (AREA)
  • Electromagnetism (AREA)
  • Physics & Mathematics (AREA)
  • Physiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Rheumatology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Analytical Chemistry (AREA)
  • Computer Hardware Design (AREA)

Abstract

The invention provides an automated system for producing induced pluripotent stem cells (iPSCs) from adult somatic cells. Further the system is used for producing differentiated adult cells from stem cells. The invention system is useful for isolating somatic cells from tissue samples producing iPSC lines from adult differentiated cells by reprogramming such cells identifying the pluripotent reprogrammed adult cells among other cells and expanding and screening the identified reprogrammed cells.
IN4920CHN2014 2011-12-01 2012-11-30 IN2014CN04920A (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201161565818P 2011-12-01 2011-12-01
US201161580007P 2011-12-23 2011-12-23
US201261700792P 2012-09-13 2012-09-13
PCT/US2012/067417 WO2013082509A1 (en) 2011-12-01 2012-11-30 Automated system for producing induced pluripotent stem cells or differentiated cells

Publications (1)

Publication Number Publication Date
IN2014CN04920A true IN2014CN04920A (en) 2015-09-18

Family

ID=48536128

Family Applications (1)

Application Number Title Priority Date Filing Date
IN4920CHN2014 IN2014CN04920A (en) 2011-12-01 2012-11-30

Country Status (14)

Country Link
US (4) US10273459B2 (en)
EP (2) EP2785829B1 (en)
JP (1) JP6257520B2 (en)
KR (5) KR20240019378A (en)
CN (2) CN110724636A (en)
AU (4) AU2012345676B2 (en)
BR (2) BR122020005735B1 (en)
CA (2) CA3118842C (en)
DK (1) DK2785829T3 (en)
ES (1) ES2773863T3 (en)
IL (3) IL299477A (en)
IN (1) IN2014CN04920A (en)
WO (1) WO2013082509A1 (en)
ZA (3) ZA201403945B (en)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2773863T3 (en) 2011-12-01 2020-07-15 New York Stem Cell Found Inc Automated system for the production of induced pluripotent stem cells or differentiated cells
US10428309B2 (en) 2011-12-01 2019-10-01 New York Stem Cell Foundation, Inc. Systems and methods for producing stem cells and differentiated cells
US20160130561A1 (en) * 2013-06-13 2016-05-12 The New York Stem Cell Foundation Inc. Pluripotent stem cells derived from non-cryoprotected frozen tissue and methods for making and using the same
WO2014210533A1 (en) * 2013-06-27 2014-12-31 The New York Stem Cell Foundation Improved systems and methods for producing stem cells and differentiated cells
US10202568B2 (en) * 2013-08-12 2019-02-12 Invivosciences Inc. Automated cell culture system and method
WO2016105578A1 (en) * 2014-12-26 2016-06-30 The New York Stem Cell Foundation Improved systems and methods for producing stem cells, differentiated cells, and genetically edited cells
US9828634B2 (en) 2015-01-22 2017-11-28 Regenerative Medical Solutions, Inc. Markers for differentiation of stem cells into differentiated cell populations
CN114717183A (en) 2015-08-31 2022-07-08 爱平世股份有限公司 Pluripotent stem cell production system and method for producing induced pluripotent stem cells
CN105567642B (en) * 2016-02-01 2019-07-12 中国科学院生物物理研究所 A kind of preparation method of xeroderma pitmentosum human pluripotent stem cells
AU2017228466B2 (en) 2016-03-03 2023-05-25 New York Stem Cell Foundation, Inc. Microglia derived from pluripotent stem cells and methods of making and using the same
WO2018015561A1 (en) * 2016-07-21 2018-01-25 Celyad Method and apparatus for automated independent parallel batch-processing of cells
US10354218B2 (en) 2016-08-04 2019-07-16 Fanuc Corporation System and method for iPS cell bank using internet technology
US10373109B2 (en) 2016-08-04 2019-08-06 Fanuc Corporation System and method for iPS cell bank using media
US11259520B2 (en) 2016-08-04 2022-03-01 Fanuc Corporation Stem cell manufacturing system, stem cell information management system, cell transport apparatus, and stem cell frozen storage apparatus
US11542465B2 (en) * 2016-11-18 2023-01-03 New York Stem Cell Foundation, Inc. Microfluidic system and method of use thereof
EP4039792A1 (en) 2017-01-20 2022-08-10 FUJIFILM Corporation Cell culture apparatus and cell culture method
JP6998018B2 (en) * 2017-02-24 2022-01-18 剛士 田邊 Cell processing device, suspension incubator, and method for inducing stem cells
US20190382706A1 (en) * 2017-02-27 2019-12-19 Koji Tanabe Somatic cell production system
WO2018154791A1 (en) 2017-02-27 2018-08-30 剛士 田邊 Cell processing system and cell processing device
CN111094567A (en) * 2017-06-30 2020-05-01 因思科瑞普特公司 Automated cell processing methods, modules, instruments and systems
GB2564437B (en) 2017-07-10 2020-11-04 Univ Brunel Method of testing a gene therapy vector using induced pluripotent stem cells
KR102296580B1 (en) 2017-09-01 2021-09-02 론자 워커스빌 아이엔씨. Automating End-to-End Cell Therapy
CN111372650A (en) * 2017-09-30 2020-07-03 因思科瑞普特公司 Flow-through electroporation apparatus
CN112292445A (en) * 2018-06-13 2021-01-29 富士胶片株式会社 Information processing apparatus, export method, and export program
JP7090337B2 (en) * 2019-03-20 2022-06-24 アイ ピース，インコーポレイテッド Cell processing system and cell processing equipment
JP6530577B1 (en) * 2019-03-20 2019-06-12 剛士 田邊 Cell processing system and cell processing apparatus
JP6530874B1 (en) * 2019-03-20 2019-06-12 剛士 田邊 Cell processing system and cell processing apparatus
AU2020358866A1 (en) * 2019-10-04 2022-06-02 New York Stem Cell Foundation, Inc. Imaging system and method of use thereof
CN115087730A (en) * 2019-11-28 2022-09-20 香港大学 Mesenchymal stromal cells as IPSC-induced reprogramming source
JP2024525159A (en) * 2021-06-17 2024-07-10 ジェネンテック， インコーポレイテッド Automated Cell Culture System
CN114606198A (en) * 2022-03-25 2022-06-10 深圳临研医学有限公司 Osteogenesis imperfecta induced pluripotent stem cell and construction method thereof
WO2024020572A1 (en) 2022-07-22 2024-01-25 New York Stem Cell Foundation, Inc. Methods and compositions for the treatment of ptsd

Family Cites Families (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5843780A (en) 1995-01-20 1998-12-01 Wisconsin Alumni Research Foundation Primate embryonic stem cells
US5994619A (en) 1996-04-01 1999-11-30 University Of Massachusetts, A Public Institution Of Higher Education Of The Commonwealth Of Massachusetts, As Represented By Its Amherst Campus Production of chimeric bovine or porcine animals using cultured inner cell mass cells
US5945577A (en) 1997-01-10 1999-08-31 University Of Massachusetts As Represented By Its Amherst Campus Cloning using donor nuclei from proliferating somatic cells
JP2001512689A (en) 1997-08-11 2001-08-28 カイロン コーポレイション Methods for genetically modifying T cells
US8026096B1 (en) 1998-10-08 2011-09-27 Protein Sciences Corporation In vivo active erythropoietin produced in insect cells
US20110171185A1 (en) * 1999-06-30 2011-07-14 Klimanskaya Irina V Genetically intact induced pluripotent cells or transdifferentiated cells and methods for the production thereof
US6429013B1 (en) 1999-08-19 2002-08-06 Artecel Science, Inc. Use of adipose tissue-derived stromal cells for chondrocyte differentiation and cartilage repair
US6959438B2 (en) 2000-12-06 2005-10-25 Microsoft Corporation Interface and related methods for dynamically generating a filter graph in a development system
US8492140B2 (en) * 2002-04-08 2013-07-23 Octane Biotech Inc. Automated tissue engineering system
EP1445320A1 (en) 2003-02-05 2004-08-11 ARTEMIS Pharmaceuticals GmbH Automated gene-targeting using non-toxic detectable markers
JP2007529515A (en) * 2004-03-19 2007-10-25 サイトリ セラピューティクス インコーポレイテッド Cell carrier containing regenerative cells and cell carrier containment device
US20070238175A1 (en) 2006-04-06 2007-10-11 Chi Alfred L Standardization of processes for culturing primary cells
GB0704406D0 (en) 2007-03-07 2007-04-18 Stem Cell Sciences Uk Ltd Automated culture of stem cells
JP2008307007A (en) 2007-06-15 2008-12-25 Bayer Schering Pharma Ag Human pluripotent stem cell induced from human tissue-originated undifferentiated stem cell after birth
EP3293256B1 (en) * 2007-06-29 2019-05-22 FUJIFILM Cellular Dynamics, Inc. Automated method and apparatus for embryonic stem cell culture
US20100196923A1 (en) * 2007-08-14 2010-08-05 Anthony Atala Pluripotent adult stem cells
WO2010017562A2 (en) 2008-08-08 2010-02-11 Mayo Foundation For Medical Education And Research Induced pluripotent stem cells
WO2010068955A2 (en) * 2008-12-13 2010-06-17 Dna Microarray MICROENVIRONMENT NICHE ASSAY FOR CiPS SCREENING
NO2373784T3 (en) 2008-12-17 2018-03-24
JP6189581B2 (en) * 2009-02-20 2017-08-30 セルラー ダイナミクス インターナショナル， インコーポレイテッド Methods and compositions for stem cell differentiation
WO2010099539A1 (en) 2009-02-27 2010-09-02 Cellular Dynamics International, Inc. Differentiation of pluripotent cells
CN101580816B (en) 2009-04-23 2012-02-29 中国科学院广州生物医药与健康研究院 Novel serum-free culture medium for inducing fast and efficient production of pluripotent stem cells and use method thereof
KR101811235B1 (en) * 2009-06-05 2017-12-21 셀룰러 다이내믹스 인터내셔널, 인코포레이티드 Reprogramming T cells and hematopoietic cells
US20110020814A1 (en) * 2009-06-05 2011-01-27 Ipierian, Inc. Methods and compositions for selection of stem cells
WO2011026222A1 (en) 2009-09-01 2011-03-10 Mcmaster University Transformed human pluripotent stem cells and associated methods
WO2011037301A1 (en) * 2009-09-22 2011-03-31 서울대학교병원 Method for derivation of pluripotent stem cells from adult cells and pluripotent stem cells produced by method
CA3122219A1 (en) 2010-04-16 2011-10-20 The Children's Hospital Corporation Sustained polypeptide expression from synthetic, modified rnas and uses thereof
US20110306516A1 (en) 2010-06-15 2011-12-15 The New York Stem Cell Foundation Methods for producing induced pluripotent stem cells
KR102482184B1 (en) 2010-12-22 2022-12-28 페이트 세러퓨틱스, 인코포레이티드 Cell culture platform for single cell sorting and enhanced reprogramming of iPSCs
EP2481795A1 (en) 2011-01-28 2012-08-01 Universität für Bodenkultur Wien Method of generating induced pluripotent stem cells and differentiated cells
ES2773863T3 (en) * 2011-12-01 2020-07-15 New York Stem Cell Found Inc Automated system for the production of induced pluripotent stem cells or differentiated cells

Also Published As

Publication number Publication date
US20190352613A1 (en) 2019-11-21
CN110724636A (en) 2020-01-24
IL289822A (en) 2022-03-01
KR20210096700A (en) 2021-08-05
US10273459B2 (en) 2019-04-30
ZA201803502B (en) 2022-12-21
DK2785829T3 (en) 2020-01-27
JP6257520B2 (en) 2018-01-10
AU2021212081B2 (en) 2024-02-29
ZA201403945B (en) 2018-08-29
BR112014013152B1 (en) 2021-08-31
AU2012345676B2 (en) 2018-10-04
JP2015502747A (en) 2015-01-29
ES2773863T3 (en) 2020-07-15
AU2012345676A1 (en) 2014-06-19
AU2018286561A1 (en) 2019-01-24
IL299477A (en) 2023-02-01
US20240191203A1 (en) 2024-06-13
CN104080906A (en) 2014-10-01
KR102631374B1 (en) 2024-01-29
EP2785829A4 (en) 2015-04-29
IL232869A0 (en) 2014-07-31
EP2785829B1 (en) 2019-10-16
US20130345094A1 (en) 2013-12-26
EP3653698A1 (en) 2020-05-20
BR112014013152A2 (en) 2017-06-13
KR20220141823A (en) 2022-10-20
EP2785829A1 (en) 2014-10-08
WO2013082509A1 (en) 2013-06-06
IL289822B2 (en) 2023-06-01
ZA202205833B (en) 2024-09-25
AU2021212081A1 (en) 2021-08-26
US10968435B2 (en) 2021-04-06
KR20190124326A (en) 2019-11-04
KR102439238B1 (en) 2022-08-31
CA3118842A1 (en) 2013-06-06
KR20140101393A (en) 2014-08-19
CA2857295C (en) 2021-06-29
US11732242B2 (en) 2023-08-22
US20210332330A1 (en) 2021-10-28
KR102039202B1 (en) 2019-10-31
IL232869B (en) 2022-02-01
BR122020005735B1 (en) 2021-12-28
CA3118842C (en) 2023-12-12
AU2024203546A1 (en) 2024-06-20
KR20240019378A (en) 2024-02-14
CA2857295A1 (en) 2013-06-06

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