IL298086B2 - Bispecific antibodies against plasma kallikrein and factor xii - Google Patents

Bispecific antibodies against plasma kallikrein and factor xii

Info

Publication number
IL298086B2
IL298086B2 IL298086A IL29808622A IL298086B2 IL 298086 B2 IL298086 B2 IL 298086B2 IL 298086 A IL298086 A IL 298086A IL 29808622 A IL29808622 A IL 29808622A IL 298086 B2 IL298086 B2 IL 298086B2
Authority
IL
Israel
Prior art keywords
seq
bispecific antibody
sequence
antibody
polypeptide comprises
Prior art date
Application number
IL298086A
Other languages
English (en)
Hebrew (he)
Other versions
IL298086B1 (en
IL298086A (en
Original Assignee
Takeda Pharmaceuticals Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Pharmaceuticals Co filed Critical Takeda Pharmaceuticals Co
Publication of IL298086A publication Critical patent/IL298086A/en
Publication of IL298086B1 publication Critical patent/IL298086B1/en
Publication of IL298086B2 publication Critical patent/IL298086B2/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/36—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against blood coagulation factors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/51—Complete heavy chain or Fd fragment, i.e. VH + CH1
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/64—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising a combination of variable region and constant region components
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Hematology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
IL298086A 2015-01-02 2015-12-31 Bispecific antibodies against plasma kallikrein and factor xii IL298086B2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201562099236P 2015-01-02 2015-01-02
US201562200363P 2015-08-03 2015-08-03
US201562261609P 2015-12-01 2015-12-01
PCT/US2015/068238 WO2016109774A1 (en) 2015-01-02 2015-12-31 Bispecific antibodies against plasma kallikrein and factor xii

Publications (3)

Publication Number Publication Date
IL298086A IL298086A (en) 2023-01-01
IL298086B1 IL298086B1 (en) 2024-07-01
IL298086B2 true IL298086B2 (en) 2024-11-01

Family

ID=56285069

Family Applications (2)

Application Number Title Priority Date Filing Date
IL298086A IL298086B2 (en) 2015-01-02 2015-12-31 Bispecific antibodies against plasma kallikrein and factor xii
IL253180A IL253180B2 (en) 2015-01-02 2015-12-31 Bispecific antibodies against plasma kallikrein and factor xii

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL253180A IL253180B2 (en) 2015-01-02 2015-12-31 Bispecific antibodies against plasma kallikrein and factor xii

Country Status (13)

Country Link
US (2) US11390687B2 (cg-RX-API-DMAC7.html)
EP (2) EP3240570B1 (cg-RX-API-DMAC7.html)
JP (4) JP6744313B2 (cg-RX-API-DMAC7.html)
KR (2) KR102670705B1 (cg-RX-API-DMAC7.html)
CN (2) CN114316061B (cg-RX-API-DMAC7.html)
AU (2) AU2015373910B2 (cg-RX-API-DMAC7.html)
CA (1) CA2972800A1 (cg-RX-API-DMAC7.html)
CO (1) CO2017007123A2 (cg-RX-API-DMAC7.html)
EA (1) EA201791527A1 (cg-RX-API-DMAC7.html)
IL (2) IL298086B2 (cg-RX-API-DMAC7.html)
MX (2) MX2017008541A (cg-RX-API-DMAC7.html)
NZ (1) NZ771568A (cg-RX-API-DMAC7.html)
WO (1) WO2016109774A1 (cg-RX-API-DMAC7.html)

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IL298086B2 (en) 2015-01-02 2024-11-01 Takeda Pharmaceuticals Co Bispecific antibodies against plasma kallikrein and factor xii
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IL315175A (en) * 2016-09-16 2024-10-01 Takeda Pharmaceuticals Co RNA biomarkers for hereditary angioedema
CA3221995C (en) 2017-02-08 2024-05-28 Dragonfly Therapeutics, Inc. Multi-specific binding proteins for activation of natural killer cells and therapeutic uses thereof to treat cancer
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EP3668893A4 (en) * 2017-08-16 2021-08-04 Dragonfly Therapeutics, Inc. PROTEINS BINDING TO NKG2D, CD16 AND EGFR, HLA-E, CCR4, OR PD-L1
BR112020007405A2 (pt) * 2017-10-18 2020-12-08 Regenxbio Inc. Produtos terapêuticos de anticorpo pós-translacionalmente modificados totalmente humanos
JP7394767B2 (ja) * 2018-01-12 2023-12-08 ジェンザイム・コーポレーション ポリペプチドの定量化方法
KR20200118824A (ko) 2018-02-08 2020-10-16 드래곤플라이 쎄라퓨틱스, 인크. 자연 살해 세포를 활성화시키는 다중-특이성 결합 단백질을 수반하는 암의 병용 요법
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CA3106108A1 (en) * 2018-07-11 2020-01-16 Momenta Pharmaceuticals, Inc. Compositions and methods related to engineered fc-antigen binding domain constructs targeted to pd-l1
AU2019318083A1 (en) * 2018-08-08 2021-02-25 Dragonfly Therapeutics, Inc. Multi-specific binding proteins that bind BCMA, NKG2D and CD16, and methods of use
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EA202091888A1 (ru) 2018-08-08 2020-10-23 Драгонфлай Терапьютикс, Инк. Вариабельные домены антител, нацеленные на рецептор nkg2d
CA3108646A1 (en) * 2018-08-08 2020-02-13 Dragonfly Therapeutics, Inc. Proteins binding nkg2d, cd16 and a tumor-associated antigen
WO2020086741A1 (en) * 2018-10-24 2020-04-30 Shire-Nps Pharmaceuticals, Inc. Glp-2 fusion polypeptides and uses for treating and preventing gastrointestinal conditions
MX2022001049A (es) * 2019-07-26 2022-05-03 Janssen Biotech Inc Proteínas que comprenden dominios de unión al antígeno de la peptidasa 2 relacionada con la calicreína y sus usos.
MX2022013944A (es) 2020-05-06 2022-11-30 Dragonfly Therapeutics Inc Proteinas que se unen al receptor activador de celulas asesinas naturales grupo 2 miembro d (nkg2d), cumulo de diferenciacion (cd16) y miembro a de la familia de dominios de lectina tipo c 12 (clec12a).
WO2022094255A2 (en) * 2020-10-29 2022-05-05 Regenxbio Inc. Vectorized factor xii antibodies and administration thereof
CN114790245A (zh) * 2021-01-25 2022-07-26 成都康弘生物科技有限公司 一种抗体及其用途
CN114790246A (zh) * 2021-01-25 2022-07-26 成都康弘生物科技有限公司 一种抗体及其用途
JP2024508894A (ja) 2021-03-03 2024-02-28 ドラゴンフライ セラピューティクス， インコーポレイテッド Ｎｋｇ２ｄ、ｃｄ１６、及び腫瘍関連抗原に結合する多特異性結合タンパク質を使用して癌を治療する方法
CN115925967A (zh) * 2021-04-22 2023-04-07 广东菲鹏制药股份有限公司 双特异性多功能融合多肽
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Also Published As

Publication number Publication date
CO2017007123A2 (es) 2017-12-15
US20230117565A1 (en) 2023-04-20
JP2022023038A (ja) 2022-02-07
EA201791527A1 (ru) 2017-12-29
NZ733580A (en) 2024-02-23
US20180118851A1 (en) 2018-05-03
CN114316061A (zh) 2022-04-12
KR20170118058A (ko) 2017-10-24
CN114316061B (zh) 2024-11-01
IL253180B2 (en) 2023-04-01
EP3240570C0 (en) 2025-09-24
NZ771568A (en) 2024-11-29
CN107405399A (zh) 2017-11-28
BR112017014308A2 (pt) 2018-03-06
IL253180A0 (en) 2017-08-31
AU2015373910A1 (en) 2017-07-27
JP2023065659A (ja) 2023-05-12
MX2024000317A (es) 2024-01-25
US12240918B2 (en) 2025-03-04
EP3240570A1 (en) 2017-11-08
JP2018502572A (ja) 2018-02-01
IL253180B (en) 2022-12-01
JP6744313B2 (ja) 2020-08-26
AU2022201076A1 (en) 2022-03-10
JP7635285B2 (ja) 2025-02-25
EP4670785A2 (en) 2025-12-31
JP7003347B2 (ja) 2022-02-04
US11390687B2 (en) 2022-07-19
CN107405399B (zh) 2022-02-08
KR20240091031A (ko) 2024-06-21
CA2972800A1 (en) 2016-07-07
AU2015373910B2 (en) 2021-11-18
WO2016109774A1 (en) 2016-07-07
EP3240570A4 (en) 2018-08-08
JP7241827B2 (ja) 2023-03-17
EP3240570B1 (en) 2025-09-24
JP2020186248A (ja) 2020-11-19
AU2022201076B2 (en) 2025-05-15
MX2017008541A (es) 2017-12-04
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IL298086A (en) 2023-01-01
KR102670705B1 (ko) 2024-05-31

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