IL296476B2 - TRANSTHYRETIN (TTR) iRNA COMPOSITIONS AND METHODS OF USE THEREOF FOR TREATING OR PREVENTING TTR-ASSOCIATED DISEASES - Google Patents

TRANSTHYRETIN (TTR) iRNA COMPOSITIONS AND METHODS OF USE THEREOF FOR TREATING OR PREVENTING TTR-ASSOCIATED DISEASES

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Publication number
IL296476B2
IL296476B2 IL296476A IL29647622A IL296476B2 IL 296476 B2 IL296476 B2 IL 296476B2 IL 296476 A IL296476 A IL 296476A IL 29647622 A IL29647622 A IL 29647622A IL 296476 B2 IL296476 B2 IL 296476B2
Authority
IL
Israel
Prior art keywords
double stranded
rnai agent
ttr
nucleotides
stranded rnai
Prior art date
Application number
IL296476A
Other languages
English (en)
Hebrew (he)
Other versions
IL296476A (en
IL296476B1 (en
Original Assignee
Alnylam Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alnylam Pharmaceuticals Inc filed Critical Alnylam Pharmaceuticals Inc
Publication of IL296476A publication Critical patent/IL296476A/en
Publication of IL296476B1 publication Critical patent/IL296476B1/en
Publication of IL296476B2 publication Critical patent/IL296476B2/en

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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • A61K31/00—Medicinal preparations containing organic active ingredients
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    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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IL296476A 2015-07-31 2016-07-28 TRANSTHYRETIN (TTR) iRNA COMPOSITIONS AND METHODS OF USE THEREOF FOR TREATING OR PREVENTING TTR-ASSOCIATED DISEASES IL296476B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562199563P 2015-07-31 2015-07-31
US201662287518P 2016-01-27 2016-01-27
PCT/US2016/044359 WO2017023660A1 (en) 2015-07-31 2016-07-28 TRANSTHYRETIN (TTR) iRNA COMPOSITIONS AND METHODS OF USE THEREOF FOR TREATING OR PREVENTING TTR-ASSOCIATED DISEASES

Publications (3)

Publication Number Publication Date
IL296476A IL296476A (en) 2022-11-01
IL296476B1 IL296476B1 (en) 2024-06-01
IL296476B2 true IL296476B2 (en) 2024-10-01

Family

ID=56682264

Family Applications (3)

Application Number Title Priority Date Filing Date
IL296476A IL296476B2 (en) 2015-07-31 2016-07-28 TRANSTHYRETIN (TTR) iRNA COMPOSITIONS AND METHODS OF USE THEREOF FOR TREATING OR PREVENTING TTR-ASSOCIATED DISEASES
IL313082A IL313082A (en) 2015-07-31 2016-07-28 TRANSTHYRETIN (TTR) iRNA COMPOSITIONS AND METHODS OF USE THEREOF FOR TREATING OR PREVENTING TTR-ASSOCIATED DISEASES
IL256614A IL256614B2 (en) 2015-07-31 2017-12-27 Transthyretin (ttr) irna compositions and methods of use thereof for treating or preventing ttr-associated diseases

Family Applications After (2)

Application Number Title Priority Date Filing Date
IL313082A IL313082A (en) 2015-07-31 2016-07-28 TRANSTHYRETIN (TTR) iRNA COMPOSITIONS AND METHODS OF USE THEREOF FOR TREATING OR PREVENTING TTR-ASSOCIATED DISEASES
IL256614A IL256614B2 (en) 2015-07-31 2017-12-27 Transthyretin (ttr) irna compositions and methods of use thereof for treating or preventing ttr-associated diseases

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Country Link
US (5) US10208307B2 (enExample)
EP (1) EP3329002B1 (enExample)
JP (4) JP6896703B2 (enExample)
KR (2) KR102667020B1 (enExample)
CN (2) CN108138182B (enExample)
BR (1) BR112018000542B1 (enExample)
CA (1) CA2994285A1 (enExample)
CL (1) CL2018000198A1 (enExample)
CY (1) CY1124545T1 (enExample)
DK (1) DK3329002T3 (enExample)
EA (1) EA201890394A1 (enExample)
ES (1) ES2842300T3 (enExample)
FI (1) FIC20230006I1 (enExample)
FR (1) FR23C1008I2 (enExample)
HK (1) HK1256683A1 (enExample)
HR (1) HRP20202082T1 (enExample)
HU (2) HUE051998T2 (enExample)
IL (3) IL296476B2 (enExample)
LT (2) LT3329002T (enExample)
LU (1) LUC00297I2 (enExample)
MA (1) MA43335B1 (enExample)
MX (2) MX2018000981A (enExample)
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NL (1) NL301216I2 (enExample)
NO (1) NO2023007I1 (enExample)
PL (1) PL3329002T3 (enExample)
PT (1) PT3329002T (enExample)
RS (1) RS61297B1 (enExample)
SG (1) SG10201912341SA (enExample)
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TW (4) TW202532647A (enExample)
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ZA (2) ZA201800571B (enExample)

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WO2010048228A2 (en) 2008-10-20 2010-04-29 Alnylam Pharmaceuticals, Inc. Compositions and methods for inhibiting expression of transthyretin
KR101881596B1 (ko) 2008-12-02 2018-07-24 웨이브 라이프 사이언시스 재팬 인코포레이티드 인 원자 변형된 핵산의 합성 방법
RU2612521C2 (ru) 2009-07-06 2017-03-09 Онтории, Инк. Новые пролекарства нуклеиновых кислот и способы их применения
JP5896175B2 (ja) 2010-04-29 2016-03-30 アイオーニス ファーマシューティカルズ， インコーポレーテッドＩｏｎｉｓ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ，Ｉｎｃ． トランスサイレチン発現の調節
JP5868324B2 (ja) 2010-09-24 2016-02-24 株式会社Wave Life Sciences Japan 不斉補助基
BR112014001244A2 (pt) 2011-07-19 2017-02-21 Wave Life Sciences Pte Ltd métodos para a síntese de ácidos nucléicos funcionalizados
AU2012340159B2 (en) 2011-11-18 2017-09-07 Alnylam Pharmaceuticals, Inc. RNAi agents, compositions and methods of use thereof for treating transthyretin (TTR) associated diseases
FI3366775T4 (fi) 2011-11-18 2025-11-14 Alnylam Pharmaceuticals Inc Modifioituja rnai-agensseja
CN112007045A (zh) 2012-07-13 2020-12-01 波涛生命科学有限公司 手性控制
ES2862073T3 (es) 2012-07-13 2021-10-06 Wave Life Sciences Ltd Grupo auxiliar asimétrico
US10144933B2 (en) 2014-01-15 2018-12-04 Shin Nippon Biomedical Laboratories, Ltd. Chiral nucleic acid adjuvant having immunity induction activity, and immunity induction activator
EP3095459A4 (en) 2014-01-15 2017-08-23 Shin Nippon Biomedical Laboratories, Ltd. Chiral nucleic acid adjuvant having antitumor effect and antitumor agent
CN113278617A (zh) 2014-01-16 2021-08-20 波涛生命科学有限公司 手性设计
DK3329002T3 (da) 2015-07-31 2021-01-11 Alnylam Pharmaceuticals Inc Transthyretin (ttr)-irna-sammensætninger og fremgangsmåder til anvendelse deraf til behandling eller forebyggelse af ttr-forbundne sygdomme
JOP20210043A1 (ar) * 2015-10-01 2017-06-16 Arrowhead Pharmaceuticals Inc تراكيب وأساليب لتثبيط تعبير جيني للـ lpa
TWI790217B (zh) * 2016-12-16 2023-01-21 美商阿尼拉製藥公司 使用甲狀腺素運載蛋白（ＴＴＲ）ｉＲＮＡ組成物於治療或預防ＴＴＲ相關疾病之方法
KR20250046363A (ko) 2017-09-19 2025-04-02 알닐람 파마슈티칼스 인코포레이티드 트랜스타이레틴(ttr) 매개 아밀로이드증을 치료하기 위한 조성물 및 방법
EP3719128B1 (en) * 2017-12-01 2025-01-15 Suzhou Ribo Life Science Co., Ltd. Double-stranded oligonucleotide, composition and conjugate comprising double-stranded oligonucleotide, preparation method therefor and use thereof
TW202028465A (zh) * 2018-09-28 2020-08-01 美商阿尼拉製藥公司 甲狀腺素運載蛋白（ＴＴＲ）ｉＲＮＡ組成物及其治療或預防ＴＴＲ相關眼部疾病之使用方法
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