IL284969B - Diagnosis and treatment of autoimmune diseases - Google Patents

Diagnosis and treatment of autoimmune diseases

Info

Publication number
IL284969B
IL284969B IL284969A IL28496921A IL284969B IL 284969 B IL284969 B IL 284969B IL 284969 A IL284969 A IL 284969A IL 28496921 A IL28496921 A IL 28496921A IL 284969 B IL284969 B IL 284969B
Authority
IL
Israel
Prior art keywords
protein
antibody
human
hmwk
kallikrein
Prior art date
Application number
IL284969A
Other languages
English (en)
Hebrew (he)
Other versions
IL284969A (en
Original Assignee
Dyax Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dyax Corp filed Critical Dyax Corp
Publication of IL284969A publication Critical patent/IL284969A/en
Publication of IL284969B publication Critical patent/IL284969B/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/564Immunoassay; Biospecific binding assay; Materials therefor for pre-existing immune complex or autoimmune disease, i.e. systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, rheumatoid factors or complement components C1-C9
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/86Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood coagulating time or factors, or their receptors
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/745Assays involving non-enzymic blood coagulation factors
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/81Protease inhibitors
    • G01N2333/8107Endopeptidase (E.C. 3.4.21-99) inhibitors
    • G01N2333/8139Cysteine protease (E.C. 3.4.22) inhibitors, e.g. cystatin
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/06Gastro-intestinal diseases
    • G01N2800/065Bowel diseases, e.g. Crohn, ulcerative colitis, IBS
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/10Musculoskeletal or connective tissue disorders
    • G01N2800/101Diffuse connective tissue disease, e.g. Sjögren, Wegener's granulomatosis
    • G01N2800/102Arthritis; Rheumatoid arthritis, i.e. inflammation of peripheral joints
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/52Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/56Staging of a disease; Further complications associated with the disease

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Rheumatology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Rehabilitation Therapy (AREA)
  • Pain & Pain Management (AREA)
  • Transplantation (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
IL284969A 2013-10-21 2014-10-17 Diagnosis and treatment of autoimmune diseases IL284969B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361893542P 2013-10-21 2013-10-21
PCT/US2014/061242 WO2015061182A1 (en) 2013-10-21 2014-10-17 Diagnosis and treatment of autoimmune diseases

Publications (2)

Publication Number Publication Date
IL284969A IL284969A (en) 2021-08-31
IL284969B true IL284969B (en) 2022-07-01

Family

ID=52993412

Family Applications (4)

Application Number Title Priority Date Filing Date
IL293948A IL293948A (en) 2013-10-21 2014-10-17 Diagnosis and treatment of autoimmune diseases
IL284969A IL284969B (en) 2013-10-21 2014-10-17 Diagnosis and treatment of autoimmune diseases
IL245206A IL245206B (en) 2013-10-21 2016-04-19 Diagnosis and treatment of autoimmune diseases
IL275368A IL275368B (en) 2013-10-21 2020-06-14 Diagnosis and treatment of autoimmune diseases

Family Applications Before (1)

Application Number Title Priority Date Filing Date
IL293948A IL293948A (en) 2013-10-21 2014-10-17 Diagnosis and treatment of autoimmune diseases

Family Applications After (2)

Application Number Title Priority Date Filing Date
IL245206A IL245206B (en) 2013-10-21 2016-04-19 Diagnosis and treatment of autoimmune diseases
IL275368A IL275368B (en) 2013-10-21 2020-06-14 Diagnosis and treatment of autoimmune diseases

Country Status (14)

Country Link
US (3) US10101344B2 (enExample)
EP (2) EP3913364A1 (enExample)
JP (3) JP6657098B2 (enExample)
KR (3) KR102665705B1 (enExample)
CN (2) CN105874332B (enExample)
AU (4) AU2014340449B2 (enExample)
BR (1) BR112016008975B1 (enExample)
CA (1) CA2927695C (enExample)
DK (1) DK3060908T3 (enExample)
ES (1) ES2873204T3 (enExample)
IL (4) IL293948A (enExample)
PL (1) PL3060908T3 (enExample)
PT (1) PT3060908T (enExample)
WO (1) WO2015061182A1 (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111044725B (zh) 2013-01-20 2024-03-29 武田药品工业株式会社 缓激肽介导的病症的评估和治疗
PT3060908T (pt) 2013-10-21 2021-05-27 Dyax Corp Diagnóstico e tratamento de doenças autoimunes
KR20250066486A (ko) 2013-10-21 2025-05-13 다케다 파머수티컬 컴패니 리미티드 혈장 칼리크레인 시스템 바이오마커를 결정하기 위한 검정법
JP6903648B2 (ja) 2015-10-19 2021-07-14 ダイアックス コーポレーション 切断高分子量キニノーゲンを検出するイムノアッセイ
EP3513196A1 (en) * 2016-09-16 2019-07-24 Dyax Corp. Protein biomarkers for diseases associated with the contact activation system
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EP4548103A2 (en) * 2022-06-30 2025-05-07 Takeda Pharmaceutical Company Limited Protein biomarkers for lanadelumab treatment

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PT3060908T (pt) 2013-10-21 2021-05-27 Dyax Corp Diagnóstico e tratamento de doenças autoimunes
KR102424183B1 (ko) 2014-01-21 2022-07-26 다케다 파머수티컬 컴패니 리미티드 혈장 칼리크레인 결합 단백질 및 유전성 혈관부종을 치료하는 데 있어서의 이의 용도
JP6903648B2 (ja) 2015-10-19 2021-07-14 ダイアックス コーポレーション 切断高分子量キニノーゲンを検出するイムノアッセイ
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Also Published As

Publication number Publication date
CA2927695A1 (en) 2015-04-30
ES2873204T3 (es) 2021-11-03
KR102295623B1 (ko) 2021-08-31
KR102665705B1 (ko) 2024-05-14
IL245206A0 (en) 2016-06-30
US20200371120A1 (en) 2020-11-26
BR112016008975B1 (pt) 2023-02-28
CN105874332A (zh) 2016-08-17
JP2022191343A (ja) 2022-12-27
IL245206B (en) 2020-06-30
JP2020091296A (ja) 2020-06-11
CN110658337B (zh) 2023-06-16
IL284969A (en) 2021-08-31
AU2020200423A1 (en) 2020-02-13
PT3060908T (pt) 2021-05-27
WO2015061182A1 (en) 2015-04-30
KR102485948B1 (ko) 2023-01-06
JP7541560B2 (ja) 2024-08-28
IL275368A (en) 2020-07-30
IL293948A (en) 2022-08-01
EP3060908B1 (en) 2021-02-24
PL3060908T3 (pl) 2021-10-25
AU2022204649B2 (en) 2024-08-22
KR20160089368A (ko) 2016-07-27
US10101344B2 (en) 2018-10-16
KR20230010003A (ko) 2023-01-17
JP2017500584A (ja) 2017-01-05
US20190120862A1 (en) 2019-04-25
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