IL279530B2 - Benzodiazepine history, preparations, and methods for treating cognitive disorder - Google Patents

Benzodiazepine history, preparations, and methods for treating cognitive disorder

Info

Publication number
IL279530B2
IL279530B2 IL279530A IL27953020A IL279530B2 IL 279530 B2 IL279530 B2 IL 279530B2 IL 279530 A IL279530 A IL 279530A IL 27953020 A IL27953020 A IL 27953020A IL 279530 B2 IL279530 B2 IL 279530B2
Authority
IL
Israel
Prior art keywords
alkyl
aryl
membered heteroaryl
aliphatic
isomer
Prior art date
Application number
IL279530A
Other languages
English (en)
Hebrew (he)
Other versions
IL279530A (en
IL279530B1 (en
Original Assignee
Agenebio Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Agenebio Inc filed Critical Agenebio Inc
Publication of IL279530A publication Critical patent/IL279530A/en
Publication of IL279530B1 publication Critical patent/IL279530B1/en
Publication of IL279530B2 publication Critical patent/IL279530B2/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
IL279530A 2018-06-19 2019-06-19 Benzodiazepine history, preparations, and methods for treating cognitive disorder IL279530B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862687195P 2018-06-19 2018-06-19
PCT/US2019/038038 WO2019246300A1 (en) 2018-06-19 2019-06-19 Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment

Publications (3)

Publication Number Publication Date
IL279530A IL279530A (en) 2021-01-31
IL279530B1 IL279530B1 (en) 2025-09-01
IL279530B2 true IL279530B2 (en) 2026-01-01

Family

ID=68984202

Family Applications (1)

Application Number Title Priority Date Filing Date
IL279530A IL279530B2 (en) 2018-06-19 2019-06-19 Benzodiazepine history, preparations, and methods for treating cognitive disorder

Country Status (11)

Country Link
US (2) US11414425B2 (https=)
EP (1) EP3810611A4 (https=)
JP (1) JP7514534B2 (https=)
CN (1) CN112601749B (https=)
AU (1) AU2019288382B2 (https=)
BR (1) BR112020026062B1 (https=)
CA (1) CA3104478A1 (https=)
EA (1) EA202190076A1 (https=)
IL (1) IL279530B2 (https=)
MX (1) MX2020013927A (https=)
WO (1) WO2019246300A1 (https=)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3083569B1 (en) 2013-12-20 2022-01-26 Agenebio, Inc. Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
JP6987384B2 (ja) 2015-06-19 2021-12-22 エージンバイオ， インコーポレイテッド ベンゾジアゼピン誘導体、組成物、および認知障害を処置するための方法
US20180170941A1 (en) 2016-12-19 2018-06-21 Agenebio, Inc. Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
US11505555B2 (en) * 2016-12-19 2022-11-22 Agenebio, Inc. Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
US11414425B2 (en) 2018-06-19 2022-08-16 Agenebio, Inc. Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
IL294031A (en) * 2019-12-19 2022-08-01 Agenebio Inc History of benzodiazepines, preparations and methods for the treatment of cognitive impairment
CA3189302A1 (en) * 2020-07-10 2022-01-13 Agenebio, Inc. Combinations of gabaa alpha 5 agonists and sv2a inhibitors and methods of using in the treatment of cognitive impairment
JP2023534190A (ja) * 2020-07-10 2023-08-08 エージンバイオ， インコーポレイテッド ＧＡＢＡＡα５アゴニストの多形および認知障害の処置において使用する方法
US20260033761A1 (en) 2022-07-29 2026-02-05 Hoffmann-La Roche Inc. Characterisation of neurological dysfunction
WO2024039886A1 (en) 2022-08-19 2024-02-22 Agenebio, Inc. Benzazepine derivatives, compositions, and methods for treating cognitive impairment
CN117756848A (zh) * 2023-11-30 2024-03-26 常州大学 一种th-302衍生物及其制备方法

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WO2016205739A1 (en) * 2015-06-19 2016-12-22 Belew Mekonnen Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
WO2018130868A1 (en) * 2016-12-19 2018-07-19 Agenebio, Inc. Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment

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Also Published As

Publication number Publication date
NZ772066A (en) 2025-05-30
EP3810611A1 (en) 2021-04-28
US12291535B2 (en) 2025-05-06
US20200048268A1 (en) 2020-02-13
CA3104478A1 (en) 2019-12-26
WO2019246300A1 (en) 2019-12-26
EA202190076A1 (ru) 2021-09-22
CN112601749A (zh) 2021-04-02
CN112601749B (zh) 2024-03-26
EP3810611A4 (en) 2022-03-30
US11414425B2 (en) 2022-08-16
AU2019288382A1 (en) 2021-02-11
JP7514534B2 (ja) 2024-07-11
JP2021528427A (ja) 2021-10-21
IL279530A (en) 2021-01-31
MX2020013927A (es) 2021-03-02
IL279530B1 (en) 2025-09-01
US20230107032A1 (en) 2023-04-06
BR112020026062A2 (pt) 2021-03-23
BR112020026062B1 (pt) 2023-04-04
AU2019288382B2 (en) 2024-07-25

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