CN112601749B - 用于治疗认知损害的苯并二氮杂环庚三烯衍生物，组合物和方法 - Google Patents

用于治疗认知损害的苯并二氮杂环庚三烯衍生物，组合物和方法 Download PDF

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CN112601749B
CN112601749B CN201980053122.8A CN201980053122A CN112601749B CN 112601749 B CN112601749 B CN 112601749B CN 201980053122 A CN201980053122 A CN 201980053122A CN 112601749 B CN112601749 B CN 112601749B
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aryl
membered heteroaryl
isomer
aliphatic
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CN112601749A (zh
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B·梅科嫩
J·A·布特拉
黄建星
H·帕特尔
Q·江
R·J·赫尔
N·J·梅休
E·E·弗里曼
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Agenebio Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN201980053122.8A 2018-06-19 2019-06-19 用于治疗认知损害的苯并二氮杂环庚三烯衍生物，组合物和方法 Active CN112601749B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862687195P 2018-06-19 2018-06-19
US62/687,195 2018-06-19
PCT/US2019/038038 WO2019246300A1 (en) 2018-06-19 2019-06-19 Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment

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CN112601749A CN112601749A (zh) 2021-04-02
CN112601749B true CN112601749B (zh) 2024-03-26

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US (2) US11414425B2 (https=)
EP (1) EP3810611A4 (https=)
JP (1) JP7514534B2 (https=)
CN (1) CN112601749B (https=)
AU (1) AU2019288382B2 (https=)
BR (1) BR112020026062B1 (https=)
CA (1) CA3104478A1 (https=)
EA (1) EA202190076A1 (https=)
IL (1) IL279530B2 (https=)
MX (1) MX2020013927A (https=)
WO (1) WO2019246300A1 (https=)

Families Citing this family (11)

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Publication number Priority date Publication date Assignee Title
EP3083569B1 (en) 2013-12-20 2022-01-26 Agenebio, Inc. Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
JP6987384B2 (ja) 2015-06-19 2021-12-22 エージンバイオ， インコーポレイテッド ベンゾジアゼピン誘導体、組成物、および認知障害を処置するための方法
US20180170941A1 (en) 2016-12-19 2018-06-21 Agenebio, Inc. Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
US11505555B2 (en) * 2016-12-19 2022-11-22 Agenebio, Inc. Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
US11414425B2 (en) 2018-06-19 2022-08-16 Agenebio, Inc. Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
IL294031A (en) * 2019-12-19 2022-08-01 Agenebio Inc History of benzodiazepines, preparations and methods for the treatment of cognitive impairment
CA3189302A1 (en) * 2020-07-10 2022-01-13 Agenebio, Inc. Combinations of gabaa alpha 5 agonists and sv2a inhibitors and methods of using in the treatment of cognitive impairment
JP2023534190A (ja) * 2020-07-10 2023-08-08 エージンバイオ， インコーポレイテッド ＧＡＢＡＡα５アゴニストの多形および認知障害の処置において使用する方法
US20260033761A1 (en) 2022-07-29 2026-02-05 Hoffmann-La Roche Inc. Characterisation of neurological dysfunction
WO2024039886A1 (en) 2022-08-19 2024-02-22 Agenebio, Inc. Benzazepine derivatives, compositions, and methods for treating cognitive impairment
CN117756848A (zh) * 2023-11-30 2024-03-26 常州大学 一种th-302衍生物及其制备方法

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NZ772066A (en) 2025-05-30
EP3810611A1 (en) 2021-04-28
US12291535B2 (en) 2025-05-06
US20200048268A1 (en) 2020-02-13
CA3104478A1 (en) 2019-12-26
WO2019246300A1 (en) 2019-12-26
EA202190076A1 (ru) 2021-09-22
CN112601749A (zh) 2021-04-02
EP3810611A4 (en) 2022-03-30
US11414425B2 (en) 2022-08-16
AU2019288382A1 (en) 2021-02-11
JP7514534B2 (ja) 2024-07-11
JP2021528427A (ja) 2021-10-21
IL279530B2 (en) 2026-01-01
IL279530A (en) 2021-01-31
MX2020013927A (es) 2021-03-02
IL279530B1 (en) 2025-09-01
US20230107032A1 (en) 2023-04-06
BR112020026062A2 (pt) 2021-03-23
BR112020026062B1 (pt) 2023-04-04
AU2019288382B2 (en) 2024-07-25

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