IL278069A - Imidazopyridines are useful as mitochondrial unpairers - Google Patents
Imidazopyridines are useful as mitochondrial unpairersInfo
- Publication number
- IL278069A IL278069A IL278069A IL27806920A IL278069A IL 278069 A IL278069 A IL 278069A IL 278069 A IL278069 A IL 278069A IL 27806920 A IL27806920 A IL 27806920A IL 278069 A IL278069 A IL 278069A
- Authority
- IL
- Israel
- Prior art keywords
- mitochondrial uncouplers
- imidazopyridines
- useful
- imidazopyridines useful
- uncouplers
- Prior art date
Links
- 150000005232 imidazopyridines Chemical class 0.000 title 1
- 230000002438 mitochondrial effect Effects 0.000 title 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/18—Oxygen or sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/73—Unsubstituted amino or imino radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/16—Halogen atoms; Nitro radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/20—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- C07F5/025—Boronic and borinic acid compounds
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Epidemiology (AREA)
- Child & Adolescent Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Immunology (AREA)
- Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Gastroenterology & Hepatology (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201862660880P | 2018-04-20 | 2018-04-20 | |
PCT/US2019/028555 WO2019204816A1 (en) | 2018-04-20 | 2019-04-22 | Imidazopyridines useful as mitochondrial uncouplers |
Publications (1)
Publication Number | Publication Date |
---|---|
IL278069A true IL278069A (en) | 2020-11-30 |
Family
ID=67139787
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL278069A IL278069A (en) | 2018-04-20 | 2020-10-15 | Imidazopyridines are useful as mitochondrial unpairers |
IL278070A IL278070A (en) | 2018-04-20 | 2020-10-15 | Oxadiazolopyrazines and oxadiazolopyridines are useful as mitochondrial unpairs |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL278070A IL278070A (en) | 2018-04-20 | 2020-10-15 | Oxadiazolopyrazines and oxadiazolopyridines are useful as mitochondrial unpairs |
Country Status (12)
Country | Link |
---|---|
US (3) | US20210253594A1 (de) |
EP (3) | EP3781165A4 (de) |
JP (3) | JP2021523933A (de) |
KR (3) | KR20210009321A (de) |
CN (3) | CN112262141A (de) |
AU (2) | AU2019256722A1 (de) |
BR (2) | BR112020021469A2 (de) |
CA (2) | CA3097752A1 (de) |
IL (2) | IL278069A (de) |
MX (2) | MX2020011050A (de) |
WO (3) | WO2019204816A1 (de) |
ZA (2) | ZA202006296B (de) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA3097752A1 (en) * | 2018-04-20 | 2019-10-24 | Virginia Tech Intellectual Properties, Inc. | Imidazopyridines useful as mitochondrial uncouplers |
WO2020191503A1 (en) * | 2019-03-27 | 2020-10-01 | Algernon Pharmaceuticals Inc. | Methods and uses of bromantane and derivatives thereof for treating lung disease, fatty liver disease, and kidney disorders |
US11351149B2 (en) | 2020-09-03 | 2022-06-07 | Pfizer Inc. | Nitrile-containing antiviral compounds |
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FR2501680A1 (fr) | 1981-03-12 | 1982-09-17 | Elf Aquitaine | Synthese de tetra mercaptides stanniques |
US4472840A (en) | 1981-09-21 | 1984-09-25 | Jefferies Steven R | Method of inducing osseous formation by implanting bone graft material |
US4559157A (en) | 1983-04-21 | 1985-12-17 | Creative Products Resource Associates, Ltd. | Cosmetic applicator useful for skin moisturizing |
LU84979A1 (fr) | 1983-08-30 | 1985-04-24 | Oreal | Composition cosmetique ou pharmaceutique sous forme aqueuse ou anhydre dont la phase grasse contient un polyether oligomere et polyethers oligomeres nouveaux |
US4820508A (en) | 1987-06-23 | 1989-04-11 | Neutrogena Corporation | Skin protective composition |
US5606019A (en) | 1987-10-29 | 1997-02-25 | Protien Polymer Technologies, Inc. | Synthetic protein as implantables |
JP2668259B2 (ja) * | 1988-02-18 | 1997-10-27 | 塩野義製薬株式会社 | 複素環化合物および抗潰瘍剤 |
GB2215209B (en) | 1988-03-14 | 1992-08-26 | Osmed Inc | Method and apparatus for biodegradable, osteogenic, bone graft substitute device |
US4992478A (en) | 1988-04-04 | 1991-02-12 | Warner-Lambert Company | Antiinflammatory skin moisturizing composition and method of preparing same |
US4938949A (en) | 1988-09-12 | 1990-07-03 | University Of New York | Treatment of damaged bone marrow and dosage units therefor |
JPH0327172A (ja) | 1989-06-19 | 1991-02-05 | Nissan Chem Ind Ltd | 布の漂白方法 |
US5645591A (en) | 1990-05-29 | 1997-07-08 | Stryker Corporation | Synthetic bone matrix |
JPH0741461A (ja) * | 1993-05-27 | 1995-02-10 | Eisai Co Ltd | スルホン酸エステル誘導体 |
WO2000052001A1 (en) * | 1999-03-03 | 2000-09-08 | Samjin Pharmaceutical Co., Ltd. | Piperazine derivatives and process for the preparation thereof |
BR0108363A (pt) * | 2000-02-16 | 2004-02-10 | Neurogen Corp | Composto, métodos para modular função de receptor de crf e acoplado a proteìna g, para tratar um distúrbio ou doença do snc, para localizar receptores de crf em amostras de seção de tecidos, para inibir a ligação de crf a um receptor de crf¹ e para alterar a atividade de transdução de sinal de um receptor de crf¹ e composição farmacêutica |
US6777446B2 (en) * | 2000-09-05 | 2004-08-17 | Tularik, Inc. | FXR modulators |
US20060004010A1 (en) * | 2002-07-10 | 2006-01-05 | Hiromu Habashita | Ccr4 antagonist and medical use thereof |
EP1529531A1 (de) * | 2003-11-04 | 2005-05-11 | 4Sc Ag | Oxadiazolopyrazin-Derivate als pharmazeutisch aktive Wirkstoffe |
WO2005044270A1 (en) | 2003-11-04 | 2005-05-19 | 4Sc Ag | Oxadiazolopyrazine derivatives as pharmaceutically active compounds |
WO2006044402A1 (en) * | 2004-10-14 | 2006-04-27 | Compass Pharmaceuticals Llc | Furazano `3, 4-b ! pyrazynes and their use as anti-tumor agents |
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ES2270715B1 (es) * | 2005-07-29 | 2008-04-01 | Laboratorios Almirall S.A. | Nuevos derivados de pirazina. |
EP1966164B1 (de) * | 2005-12-21 | 2013-03-06 | Janssen Pharmaceutica N.V. | Neue substituierte pyrazinonderivate zur verwendung bei durch mch-1 vermittelten krankheiten |
EP2017277A1 (de) * | 2007-06-29 | 2009-01-21 | 4Sc Ag | Thiophen-Imidazopyridine |
CA2709784A1 (en) | 2007-12-21 | 2009-07-09 | University Of Rochester | Method for altering the lifespan of eukaryotic organisms |
WO2010127197A2 (en) * | 2009-04-30 | 2010-11-04 | Midwestern University | Method and composition for treating diabetic ketoacidosis |
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KR101428622B1 (ko) * | 2014-01-07 | 2014-08-13 | 국방과학연구소 | 옥사디아졸로 피라진기를 포함하는 화합물 또는 염을 포함하는 리튬 이차 전지용 전극 및 이를 포함하는 리튬 이차 전지 |
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JP2020520949A (ja) * | 2017-05-22 | 2020-07-16 | ユニバーシティ オブ ヴァージニア パテント ファウンデーションUniversity Of Verginia Patent Foundation | 組成物、並びにミトコンドリア脱共役剤を調製及び使用する方法 |
CA3097752A1 (en) * | 2018-04-20 | 2019-10-24 | Virginia Tech Intellectual Properties, Inc. | Imidazopyridines useful as mitochondrial uncouplers |
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2019
- 2019-04-22 CA CA3097752A patent/CA3097752A1/en active Pending
- 2019-04-22 CN CN201980038722.7A patent/CN112262141A/zh active Pending
- 2019-04-22 KR KR1020207033356A patent/KR20210009321A/ko unknown
- 2019-04-22 EP EP19789309.2A patent/EP3781165A4/de not_active Withdrawn
- 2019-04-22 JP JP2021506390A patent/JP2021523933A/ja active Pending
- 2019-04-22 BR BR112020021469-8A patent/BR112020021469A2/pt not_active Application Discontinuation
- 2019-04-22 JP JP2021506388A patent/JP2021522327A/ja active Pending
- 2019-04-22 KR KR1020207033297A patent/KR20210003831A/ko not_active Application Discontinuation
- 2019-04-22 US US17/048,897 patent/US20210253594A1/en active Pending
- 2019-04-22 CN CN201980038852.0A patent/CN112261941A/zh active Pending
- 2019-04-22 JP JP2021506391A patent/JP2021523934A/ja active Pending
- 2019-04-22 US US17/049,232 patent/US11708376B2/en active Active
- 2019-04-22 CA CA3097751A patent/CA3097751A1/en active Pending
- 2019-04-22 AU AU2019256722A patent/AU2019256722A1/en active Pending
- 2019-04-22 MX MX2020011050A patent/MX2020011050A/es unknown
- 2019-04-22 CN CN201980038732.0A patent/CN112262146A/zh active Pending
- 2019-04-22 EP EP19735420.2A patent/EP3781572A1/de active Pending
- 2019-04-22 US US17/049,145 patent/US20210253538A1/en not_active Abandoned
- 2019-04-22 AU AU2019256719A patent/AU2019256719A1/en active Pending
- 2019-04-22 KR KR1020207033337A patent/KR20210011928A/ko not_active Application Discontinuation
- 2019-04-22 EP EP19735421.0A patent/EP3781567B1/de active Active
- 2019-04-22 BR BR112020021466-3A patent/BR112020021466A2/pt unknown
- 2019-04-22 WO PCT/US2019/028555 patent/WO2019204816A1/en unknown
- 2019-04-22 WO PCT/US2019/028544 patent/WO2019204813A1/en unknown
- 2019-04-22 WO PCT/US2019/028560 patent/WO2019204819A1/en unknown
- 2019-04-22 MX MX2020011049A patent/MX2020011049A/es unknown
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2020
- 2020-10-09 ZA ZA2020/06296A patent/ZA202006296B/en unknown
- 2020-10-09 ZA ZA2020/06295A patent/ZA202006295B/en unknown
- 2020-10-15 IL IL278069A patent/IL278069A/en unknown
- 2020-10-15 IL IL278070A patent/IL278070A/en unknown
Also Published As
Publication number | Publication date |
---|---|
EP3781567B1 (de) | 2022-08-24 |
JP2021523934A (ja) | 2021-09-09 |
MX2020011050A (es) | 2021-03-09 |
KR20210003831A (ko) | 2021-01-12 |
CN112261941A (zh) | 2021-01-22 |
CA3097752A1 (en) | 2019-10-24 |
WO2019204816A1 (en) | 2019-10-24 |
CA3097751A1 (en) | 2019-10-24 |
US20210253538A1 (en) | 2021-08-19 |
MX2020011049A (es) | 2021-01-08 |
EP3781165A4 (de) | 2022-02-23 |
WO2019204813A1 (en) | 2019-10-24 |
CN112262141A (zh) | 2021-01-22 |
EP3781567A1 (de) | 2021-02-24 |
ZA202006296B (en) | 2023-03-29 |
JP2021523933A (ja) | 2021-09-09 |
IL278070A (en) | 2020-11-30 |
US20210253594A1 (en) | 2021-08-19 |
WO2019204819A1 (en) | 2019-10-24 |
KR20210009321A (ko) | 2021-01-26 |
AU2019256719A1 (en) | 2020-11-05 |
US11708376B2 (en) | 2023-07-25 |
JP2021522327A (ja) | 2021-08-30 |
EP3781165A1 (de) | 2021-02-24 |
CN112262146A (zh) | 2021-01-22 |
BR112020021466A2 (pt) | 2021-01-19 |
ZA202006295B (en) | 2023-03-29 |
US20210238181A1 (en) | 2021-08-05 |
EP3781572A1 (de) | 2021-02-24 |
BR112020021469A2 (pt) | 2021-01-19 |
AU2019256722A1 (en) | 2020-11-05 |
KR20210011928A (ko) | 2021-02-02 |
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