IL270726B2 - Transduced indulin derivatives as inhibitors of dengue virus replication - Google Patents

Transduced indulin derivatives as inhibitors of dengue virus replication

Info

Publication number
IL270726B2
IL270726B2 IL270726A IL27072619A IL270726B2 IL 270726 B2 IL270726 B2 IL 270726B2 IL 270726 A IL270726 A IL 270726A IL 27072619 A IL27072619 A IL 27072619A IL 270726 B2 IL270726 B2 IL 270726B2
Authority
IL
Israel
Prior art keywords
ome
compound
mmol
fffnh
noo
Prior art date
Application number
IL270726A
Other languages
English (en)
Hebrew (he)
Other versions
IL270726B1 (en
IL270726A (en
Original Assignee
Janssen Pharmaceuticals Inc
Univ Leuven Kath
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceuticals Inc, Univ Leuven Kath filed Critical Janssen Pharmaceuticals Inc
Publication of IL270726A publication Critical patent/IL270726A/en
Publication of IL270726B1 publication Critical patent/IL270726B1/en
Publication of IL270726B2 publication Critical patent/IL270726B2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
IL270726A 2017-05-22 2019-11-18 Transduced indulin derivatives as inhibitors of dengue virus replication IL270726B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP17172237 2017-05-22
PCT/EP2018/063028 WO2018215315A1 (en) 2017-05-22 2018-05-18 Substituted indoline derivatives as dengue viral replication inhibitors

Publications (3)

Publication Number Publication Date
IL270726A IL270726A (en) 2020-01-30
IL270726B1 IL270726B1 (en) 2023-01-01
IL270726B2 true IL270726B2 (en) 2023-05-01

Family

ID=58745157

Family Applications (1)

Application Number Title Priority Date Filing Date
IL270726A IL270726B2 (en) 2017-05-22 2019-11-18 Transduced indulin derivatives as inhibitors of dengue virus replication

Country Status (25)

Country Link
US (2) US11407715B2 (enExample)
EP (1) EP3630723B1 (enExample)
JP (1) JP7203764B2 (enExample)
KR (1) KR102625988B1 (enExample)
CN (1) CN110691773B (enExample)
AR (1) AR111878A1 (enExample)
AU (1) AU2018274100B2 (enExample)
BR (1) BR112019024195A2 (enExample)
CA (1) CA3060583C (enExample)
CL (1) CL2019003294A1 (enExample)
CO (1) CO2019012035A2 (enExample)
CR (1) CR20190530A (enExample)
EA (1) EA201992782A1 (enExample)
EC (1) ECSP19083640A (enExample)
ES (1) ES2929667T3 (enExample)
IL (1) IL270726B2 (enExample)
MA (1) MA48943A (enExample)
MX (1) MX393586B (enExample)
NI (1) NI201900119A (enExample)
PE (1) PE20200604A1 (enExample)
PH (1) PH12019502559A1 (enExample)
TW (1) TWI758480B (enExample)
UA (1) UA125407C2 (enExample)
UY (1) UY37742A (enExample)
WO (1) WO2018215315A1 (enExample)

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GB201116559D0 (en) 2011-09-26 2011-11-09 Univ Leuven Kath Novel viral replication inhibitors
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JOP20160198B1 (ar) 2015-09-16 2022-03-14 Janssen Pharmaceuticals Inc مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك
JO3633B1 (ar) 2015-09-16 2020-08-27 Katholieke Univ Leuven Ku Leuven Research & Development مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك
HUE054936T2 (hu) 2016-03-31 2021-10-28 Janssen Pharmaceuticals Inc Helyettesített indol-származékok mint a dengue-vírus replikációjának inhibitorai
CA3013407A1 (en) 2016-03-31 2017-10-05 Janssen Pharmaceuticals, Inc. Substituted indoline derivatives as dengue viral replication inhibitors
JOP20170069B1 (ar) 2016-04-01 2021-08-17 1 Janssen Pharmaceuticals Inc مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك
EP3436004B1 (en) 2016-04-01 2024-12-11 Janssen Pharmaceuticals, Inc. Substituted indole compound derivatives as dengue viral replication inhibitors
JOP20180025B1 (ar) 2017-03-31 2021-08-17 Janssen Pharmaceuticals Inc مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك
JOP20180026A1 (ar) 2017-03-31 2019-01-30 Univ Leuven Kath مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك
EA039702B1 (ru) 2017-05-22 2022-03-01 Янссен Фармасьютикалз, Инк. Замещенные производные индолина в качестве ингибиторов репликации вирусов денге
WO2024252254A1 (en) * 2023-06-05 2024-12-12 Zydus Lifesciences Limited Novel compounds to treat viral infections

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Also Published As

Publication number Publication date
JP7203764B2 (ja) 2023-01-13
MA48943A (fr) 2021-04-28
PE20200604A1 (es) 2020-03-10
ECSP19083640A (es) 2019-11-30
BR112019024195A2 (pt) 2020-06-23
MX393586B (es) 2025-03-24
PH12019502559A1 (en) 2021-01-25
JP2020520946A (ja) 2020-07-16
UY37742A (es) 2018-11-30
US11407715B2 (en) 2022-08-09
CN110691773A (zh) 2020-01-14
KR102625988B1 (ko) 2024-01-16
US20200255376A1 (en) 2020-08-13
MX2019013893A (es) 2020-01-20
EP3630723B1 (en) 2022-08-24
CA3060583C (en) 2024-06-04
US11795149B2 (en) 2023-10-24
AU2018274100B2 (en) 2022-06-23
AU2018274100A1 (en) 2019-11-21
TW201908291A (zh) 2019-03-01
WO2018215315A1 (en) 2018-11-29
IL270726B1 (en) 2023-01-01
UA125407C2 (uk) 2022-03-02
US20220340522A1 (en) 2022-10-27
ES2929667T3 (es) 2022-11-30
CA3060583A1 (en) 2018-11-29
CL2019003294A1 (es) 2020-03-20
CN110691773B (zh) 2023-06-23
CO2019012035A2 (es) 2020-01-17
CR20190530A (es) 2020-01-24
KR20200009027A (ko) 2020-01-29
EP3630723A1 (en) 2020-04-08
AR111878A1 (es) 2019-08-28
TWI758480B (zh) 2022-03-21
IL270726A (en) 2020-01-30
NI201900119A (es) 2020-03-23
EA201992782A1 (ru) 2020-03-24

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