AU2018274100B2 - Substituted indoline derivatives as dengue viral replication inhibitors - Google Patents

Substituted indoline derivatives as dengue viral replication inhibitors Download PDF

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Publication number
AU2018274100B2
AU2018274100B2 AU2018274100A AU2018274100A AU2018274100B2 AU 2018274100 B2 AU2018274100 B2 AU 2018274100B2 AU 2018274100 A AU2018274100 A AU 2018274100A AU 2018274100 A AU2018274100 A AU 2018274100A AU 2018274100 B2 AU2018274100 B2 AU 2018274100B2
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compound
mmol
synthesis
mixture
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AU2018274100A1 (en
Inventor
Dorothée Alice Marie-Eve Bardiot
Jean-François BONFANTI
Erwin Coesemans
Jérôme Michel Claude FORTIN
Bart Rudolf Romanie Kesteleyn
Arnaud Didier M Marchand
Guillaume Jean Maurice Mercey
Pierre Jean-Marie Bernard Raboisson
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KU Leuven
Janssen Pharmaceuticals Inc
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KU Leuven
Janssen Pharmaceuticals Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
AU2018274100A 2017-05-22 2018-05-18 Substituted indoline derivatives as dengue viral replication inhibitors Active AU2018274100B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP17172237.4 2017-05-22
EP17172237 2017-05-22
PCT/EP2018/063028 WO2018215315A1 (en) 2017-05-22 2018-05-18 Substituted indoline derivatives as dengue viral replication inhibitors

Publications (2)

Publication Number Publication Date
AU2018274100A1 AU2018274100A1 (en) 2019-11-21
AU2018274100B2 true AU2018274100B2 (en) 2022-06-23

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AU2018274100A Active AU2018274100B2 (en) 2017-05-22 2018-05-18 Substituted indoline derivatives as dengue viral replication inhibitors

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US (2) US11407715B2 (enExample)
EP (1) EP3630723B1 (enExample)
JP (1) JP7203764B2 (enExample)
KR (1) KR102625988B1 (enExample)
CN (1) CN110691773B (enExample)
AR (1) AR111878A1 (enExample)
AU (1) AU2018274100B2 (enExample)
BR (1) BR112019024195A2 (enExample)
CA (1) CA3060583C (enExample)
CL (1) CL2019003294A1 (enExample)
CO (1) CO2019012035A2 (enExample)
CR (1) CR20190530A (enExample)
EA (1) EA201992782A1 (enExample)
EC (1) ECSP19083640A (enExample)
ES (1) ES2929667T3 (enExample)
IL (1) IL270726B2 (enExample)
MA (1) MA48943A (enExample)
MX (1) MX393586B (enExample)
NI (1) NI201900119A (enExample)
PE (1) PE20200604A1 (enExample)
PH (1) PH12019502559A1 (enExample)
TW (1) TWI758480B (enExample)
UA (1) UA125407C2 (enExample)
UY (1) UY37742A (enExample)
WO (1) WO2018215315A1 (enExample)

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Also Published As

Publication number Publication date
MA48943A (fr) 2021-04-28
US20200255376A1 (en) 2020-08-13
CA3060583C (en) 2024-06-04
EA201992782A1 (ru) 2020-03-24
CR20190530A (es) 2020-01-24
KR102625988B1 (ko) 2024-01-16
PH12019502559A1 (en) 2021-01-25
NI201900119A (es) 2020-03-23
MX393586B (es) 2025-03-24
UY37742A (es) 2018-11-30
PE20200604A1 (es) 2020-03-10
US20220340522A1 (en) 2022-10-27
CN110691773B (zh) 2023-06-23
TW201908291A (zh) 2019-03-01
UA125407C2 (uk) 2022-03-02
IL270726B1 (en) 2023-01-01
CA3060583A1 (en) 2018-11-29
JP2020520946A (ja) 2020-07-16
IL270726A (en) 2020-01-30
CN110691773A (zh) 2020-01-14
ES2929667T3 (es) 2022-11-30
KR20200009027A (ko) 2020-01-29
AU2018274100A1 (en) 2019-11-21
MX2019013893A (es) 2020-01-20
IL270726B2 (en) 2023-05-01
US11795149B2 (en) 2023-10-24
JP7203764B2 (ja) 2023-01-13
US11407715B2 (en) 2022-08-09
ECSP19083640A (es) 2019-11-30
EP3630723B1 (en) 2022-08-24
BR112019024195A2 (pt) 2020-06-23
CL2019003294A1 (es) 2020-03-20
AR111878A1 (es) 2019-08-28
EP3630723A1 (en) 2020-04-08
CO2019012035A2 (es) 2020-01-17
TWI758480B (zh) 2022-03-21
WO2018215315A1 (en) 2018-11-29

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