IL268125B2 - Pridopidine for the treatment of fragile x syndrome - Google Patents
Pridopidine for the treatment of fragile x syndromeInfo
- Publication number
- IL268125B2 IL268125B2 IL268125A IL26812519A IL268125B2 IL 268125 B2 IL268125 B2 IL 268125B2 IL 268125 A IL268125 A IL 268125A IL 26812519 A IL26812519 A IL 26812519A IL 268125 B2 IL268125 B2 IL 268125B2
- Authority
- IL
- Israel
- Prior art keywords
- pridopidine
- pharmaceutical composition
- fxs
- subject
- amount
- Prior art date
Links
- 208000001914 Fragile X syndrome Diseases 0.000 title claims description 111
- YGKUEOZJFIXDGI-UHFFFAOYSA-N pridopidine Chemical compound C1CN(CCC)CCC1C1=CC=CC(S(C)(=O)=O)=C1 YGKUEOZJFIXDGI-UHFFFAOYSA-N 0.000 title claims description 108
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- 238000011282 treatment Methods 0.000 title claims description 18
- 239000008194 pharmaceutical composition Substances 0.000 claims description 47
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- MSRILKIQRXUYCT-UHFFFAOYSA-M valproate semisodium Chemical compound [Na+].CCCC(C(O)=O)CCC.CCCC(C([O-])=O)CCC MSRILKIQRXUYCT-UHFFFAOYSA-M 0.000 claims description 24
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- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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- A61K31/451—Non condensed piperidines, e.g. piperocaine having a carbocyclic group directly attached to the heterocyclic ring, e.g. glutethimide, meperidine, loperamide, phencyclidine, piminodine
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- A—HUMAN NECESSITIES
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- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
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- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
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| JP2013536825A (ja) | 2010-09-03 | 2013-09-26 | イバックス・インターナショナル・ゲーエムベーハー | ドパミン作動性安定化剤として有用なプリドピジンの重水素化類似体 |
| US11090297B2 (en) | 2013-06-21 | 2021-08-17 | Prilenia Neurotherapeutics Ltd. | Pridopidine for treating huntington's disease |
| EP3503890B1 (en) | 2016-08-24 | 2024-12-18 | Prilenia Neurotherapeutics Ltd. | Use of pridopidine for treating dystonias |
| MX390627B (es) | 2016-08-24 | 2025-03-21 | Prilenia Neurotherapeutics Ltd | Uso de pridopidina para el tratamiento de la disminucion funcional. |
| US12102627B2 (en) | 2016-09-16 | 2024-10-01 | Prilenia Neurotherapeutics Ltd. | Use of pridopidine for treating rett syndrome |
| US12036213B2 (en) | 2017-09-08 | 2024-07-16 | Prilenia Neurotherapeutics Ltd. | Pridopidine for treating drug induced dyskinesias |
| CN111343982A (zh) | 2017-09-08 | 2020-06-26 | 普瑞尼亚神经治疗有限公司 | 用于治疗药物诱发的异动症的普利多匹定 |
| BR112021015346A2 (pt) | 2019-02-04 | 2021-10-05 | Prilenia Neurotherapeutics Ltd. | Uso de pridopidina de baixa dose para a doença de parkinson e outras doenças associadas ao parkinsonismo |
| JP7490064B2 (ja) * | 2020-01-08 | 2024-05-24 | ニューロヴェンティ カンパニー リミテッド | リスリード化合物を有効成分として含む脆弱ｘ症候群または関連発達障害治療用組成物 |
| CN116472043A (zh) * | 2020-10-20 | 2023-07-21 | 普瑞尼亚神经治疗有限公司 | 普利多匹定和类似物用于治疗焦虑和抑郁的用途 |
Citations (2)
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| WO2001046145A1 (en) * | 1999-12-22 | 2001-06-28 | A. Carlsson Research Ab | New modulators of dopamine neurotransmission |
| WO2016138130A1 (en) * | 2015-02-25 | 2016-09-01 | Teva Pharmaceuticals International Gmbh | Use of pridopidine to improve cognitive function and for treating alzheimer's disease |
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| USRE46117E1 (en) | 1999-12-22 | 2016-08-23 | Teva Pharmaceuticals International Gmbh | Modulators of dopamine neurotransmission |
| CA2584831C (en) | 2004-10-13 | 2013-09-17 | Neurosearch Sweden Ab | Process for the synthesis of 4-(3-methanesulfonylphenyl)-1-n-propyl-piperidine |
| WO2008127188A1 (en) | 2007-04-12 | 2008-10-23 | Allbay Ab | N-oxide and/or di-n-oxide derivatives of dopamine receptor stabilizers/modulators displaying improved cardiovascular side-effects profiles |
| TW200848063A (en) * | 2007-04-23 | 2008-12-16 | Combinatorx Inc | Methods and compositions for the treatment of neurodegenerative disorders |
| JP2013532233A (ja) | 2010-07-02 | 2013-08-15 | アクティエボラゲット・エスコーエッフ | 機械構成要素、および表面硬化方法 |
| JP2013536825A (ja) | 2010-09-03 | 2013-09-26 | イバックス・インターナショナル・ゲーエムベーハー | ドパミン作動性安定化剤として有用なプリドピジンの重水素化類似体 |
| PL2667715T3 (pl) * | 2011-01-27 | 2018-02-28 | Neuren Pharmaceuticals Limited | Leczenie zaburzeń spektrum autystycznego z wykorzystaniem kwasu glicylo-l- 2-metyloprolilo-l-glutaminowego |
| EP2753603B1 (en) | 2011-09-07 | 2017-06-21 | Teva Pharmaceuticals International GmbH | Polymorphic form of pridopidine hydrochloride |
| WO2013086425A1 (en) | 2011-12-08 | 2013-06-13 | IVAX International GmbH | The hydrobromide salt of pridopidine |
| US20130267552A1 (en) | 2012-04-04 | 2013-10-10 | IVAX International GmbH | Pharmaceutical compositions for combination therapy |
| CN104768545A (zh) * | 2012-09-27 | 2015-07-08 | 泰华制药工业有限公司 | 雷沙吉兰和普多比啶组合以治疗神经退化性病症,尤其亨廷顿氏病 |
| UA122999C2 (uk) | 2013-06-21 | 2021-02-03 | Прайлінія Н'Юротерапьютікс Лтд. | Застосування придопідину для лікування хвороби гантінгтона |
| JP6949487B2 (ja) | 2014-01-22 | 2021-10-13 | プリレニア・ニューロセラピューティクス・エルティーディーＰｒｉｌｅｎｉａ Ｎｅｕｒｏｔｈｅｒａｐｅｕｔｉｃｓ Ｌｔｄ | プリドピジンの調節放出製剤 |
| TW201613859A (en) | 2014-06-30 | 2016-04-16 | Teva Pharma | Analogs of PRIDOPIDINE, their preparation and use |
| CA2970799A1 (en) | 2014-12-22 | 2016-06-30 | Teva Pharmaceuticals International Gmbh | L-tartrate salt of pridopidine |
| WO2016138135A1 (en) | 2015-02-25 | 2016-09-01 | Teva Pharmaceuticals International Gmbh | Sigma-1 receptor modulators for treating huntington's disease |
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2018
- 2018-01-18 HU HUE18741607A patent/HUE068300T2/hu unknown
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- 2018-01-18 IL IL268125A patent/IL268125B2/en unknown
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001046145A1 (en) * | 1999-12-22 | 2001-06-28 | A. Carlsson Research Ab | New modulators of dopamine neurotransmission |
| WO2016138130A1 (en) * | 2015-02-25 | 2016-09-01 | Teva Pharmaceuticals International Gmbh | Use of pridopidine to improve cognitive function and for treating alzheimer's disease |
Non-Patent Citations (1)
| Title |
|---|
| HAMPSON D. R.ET AL.:, THE NEUROCHEMICAL BASIS FOR THE TREATMENT OF AUTISM SPECTRUM DISORDERS AND FRAGILE X SYNDROME, 17 February 2011 (2011-02-17) * |
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| JP7114604B2 (ja) | 2022-08-08 |
| CN110505902B (zh) | 2022-11-11 |
| EP3570940A4 (en) | 2020-10-28 |
| PL3570940T3 (pl) | 2024-06-17 |
| EP3570940B1 (en) | 2023-12-13 |
| IL268125B (en) | 2022-12-01 |
| HUE068300T2 (hu) | 2024-12-28 |
| DK3570940T3 (da) | 2024-02-19 |
| US20220202798A1 (en) | 2022-06-30 |
| WO2018136600A1 (en) | 2018-07-26 |
| US20190336488A1 (en) | 2019-11-07 |
| BR112019015000A2 (pt) | 2020-04-07 |
| CA3050700A1 (en) | 2018-07-26 |
| EP3570940A1 (en) | 2019-11-27 |
| AU2018210145B2 (en) | 2023-06-29 |
| AU2018210145A1 (en) | 2019-08-29 |
| JP2020514313A (ja) | 2020-05-21 |
| IL268125A (en) | 2019-09-26 |
| CN110505902A (zh) | 2019-11-26 |
| CA3050700C (en) | 2023-10-03 |
| US11234973B2 (en) | 2022-02-01 |
| ES2972205T3 (es) | 2024-06-11 |
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