IL265129A - - Google Patents

Info

Publication number
IL265129A
IL265129A IL26512919A IL26512919A IL265129A IL 265129 A IL265129 A IL 265129A IL 26512919 A IL26512919 A IL 26512919A IL 26512919 A IL26512919 A IL 26512919A IL 265129 A IL265129 A IL 265129A
Authority
IL
Israel
Application number
IL26512919A
Other languages
English (en)
Other versions
IL265129B2 (en
IL265129B1 (en
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2017/049689 external-priority patent/WO2018045208A1/en
Publication of IL265129A publication Critical patent/IL265129A/en
Publication of IL265129B1 publication Critical patent/IL265129B1/en
Publication of IL265129B2 publication Critical patent/IL265129B2/en

Links

Classifications

    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/04—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
    • H01J49/0431—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components for liquid samples
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Instruments for taking body samples for diagnostic purposes; Other methods or instruments for diagnosis, e.g. for vaccination diagnosis, sex determination or ovulation-period determination; Throat striking implements
    • A61B10/0045—Devices for taking samples of body liquids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/62—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating the ionisation of gases, e.g. aerosols; by investigating electric discharges, e.g. emission of cathode
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/02—Devices for withdrawing samples
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/62—Detectors specially adapted therefor
    • G01N30/72—Mass spectrometers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848—Methods of protein analysis involving mass spectrometry
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/0027—Methods for using particle spectrometers
    • H01J49/0031—Step by step routines describing the use of the apparatus
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/04—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/04—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
    • H01J49/0404—Capillaries used for transferring samples or ions
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/04—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
    • H01J49/0459—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components for solid samples
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0605—Metering of fluids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0633—Valves, specific forms thereof with moving parts
    • B01L2400/0655—Valves, specific forms thereof with moving parts pinch valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02—Burettes; Pipettes
    • B01L3/0289—Apparatus for withdrawing or distributing predetermined quantities of fluid
    • B01L3/0293—Apparatus for withdrawing or distributing predetermined quantities of fluid for liquids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/02—Devices for withdrawing samples
    • G01N2001/028—Sampling from a surface, swabbing, vaporising
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/40—Concentrating samples
    • G01N1/4055—Concentrating samples by solubility techniques
    • G01N2001/4061—Solvent extraction
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2560/00—Chemical aspects of mass spectrometric analysis of biological material

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Hematology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • Urology & Nephrology (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Biophysics (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • Clinical Laboratory Science (AREA)
  • Electrochemistry (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
IL265129A 2016-09-02 2017-08-31 Collection sensor and methods of using it IL265129B2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201662383234P 2016-09-02 2016-09-02
US201662411321P 2016-10-21 2016-10-21
US201762462524P 2017-02-23 2017-02-23
PCT/US2017/049689 WO2018045208A1 (en) 2016-09-02 2017-08-31 Collection probe and methods for the use thereof

Publications (3)

Publication Number Publication Date
IL265129A true IL265129A (cg-RX-API-DMAC7.html) 2019-04-30
IL265129B1 IL265129B1 (en) 2023-10-01
IL265129B2 IL265129B2 (en) 2024-02-01

Family

ID=62243007

Family Applications (1)

Application Number Title Priority Date Filing Date
IL265129A IL265129B2 (en) 2016-09-02 2017-08-31 Collection sensor and methods of using it

Country Status (11)

Country Link
US (6) US10643832B2 (cg-RX-API-DMAC7.html)
EP (2) EP4357784A3 (cg-RX-API-DMAC7.html)
JP (3) JP7195002B2 (cg-RX-API-DMAC7.html)
KR (1) KR102543773B1 (cg-RX-API-DMAC7.html)
CN (2) CN109789420B (cg-RX-API-DMAC7.html)
AU (1) AU2017318661B2 (cg-RX-API-DMAC7.html)
CA (1) CA3035743A1 (cg-RX-API-DMAC7.html)
ES (1) ES2971214T3 (cg-RX-API-DMAC7.html)
IL (1) IL265129B2 (cg-RX-API-DMAC7.html)
MX (1) MX2019002471A (cg-RX-API-DMAC7.html)
SG (1) SG11201901866TA (cg-RX-API-DMAC7.html)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109789420B (zh) 2016-09-02 2021-09-24 得克萨斯大学体系董事会 收集探针及其使用方法
WO2018069872A1 (en) * 2016-10-14 2018-04-19 Dh Technologies Development Pte. Ltd. Methods and systems for increasing sensitivity of direct sampling interfaces for mass spectrometric analysis
WO2018227079A1 (en) * 2017-06-08 2018-12-13 Board Of Regents, The University Of Texas System Systems and methods for microarray droplet ionization analysis
WO2019102350A1 (en) * 2017-11-21 2019-05-31 Dh Technologies Development Pte. Ltd. Methods and systems utilizing ultrasound-assisted sampling interfaces for mass spectrometric analysis
WO2019104328A1 (en) * 2017-11-27 2019-05-31 Board Of Regents, The University Of Texas System Minimally invasive collection probe and methods for the use thereof
US10147052B1 (en) * 2018-01-29 2018-12-04 C-SATS, Inc. Automated assessment of operator performance
EP3522201B1 (en) * 2018-02-02 2020-10-07 Tofwerk AG Autosampler
US12089932B2 (en) 2018-06-05 2024-09-17 Trace Matters Scientific Llc Apparatus, system, and method for transferring ions
US11219393B2 (en) 2018-07-12 2022-01-11 Trace Matters Scientific Llc Mass spectrometry system and method for analyzing biological samples
US11450519B2 (en) 2018-06-07 2022-09-20 Dh Technologies Development Pte. Ltd. Sampling interface for a mass spectrometer
GB201812561D0 (en) 2018-08-01 2018-09-12 Univ Manchester Biomarkers and uses thereof
EP3647763B1 (en) * 2018-10-29 2021-07-14 FEI Company A method of preparing a biological sample for study in an analysis device
EP3914891A4 (en) 2019-01-25 2022-09-28 Board of Regents, The University of Texas System DEVICE AND METHOD FOR CLEANING AND/OR REPLACING MEDICAL DEVICES
WO2020242911A1 (en) * 2019-05-31 2020-12-03 Purdue Research Foundation Integrated microfluidic probe (imfp) and methods of use thereof
WO2020247769A2 (en) 2019-06-06 2020-12-10 Board Of Regents, The University Of Texas System Using mass spectrometry to identify endometriosis tissue
CN114981919A (zh) * 2020-01-14 2022-08-30 Dh科技发展私人贸易有限公司 质量分析方法-控制opp操作溶剂的粘度
GB202001571D0 (en) * 2020-02-05 2020-03-18 Univ Manchester Identification of biomarkers and uses thereof
CN111351831A (zh) * 2020-02-26 2020-06-30 西安交通大学医学院第二附属医院 基于质谱分析组织术中检测、标记设备及其检测方法
WO2021222182A1 (en) * 2020-04-27 2021-11-04 Board Of Regents, The University Of Texas System Identifying and classifying microorganisms
WO2021222154A1 (en) * 2020-04-27 2021-11-04 Board Of Regents, The University Of Texas System Detecting chemical compounds for forensic analysis
WO2021252322A1 (en) * 2020-06-12 2021-12-16 Board Of Regents, The University Of Texas System Molecular markers and methods for sample analysis via mass spectrometry
US12399127B2 (en) * 2020-08-12 2025-08-26 14336186 Canada Corp. (Exclaro) Automated Raman signal collection device
WO2022047104A1 (en) * 2020-08-28 2022-03-03 Board Of Regents, The University Of Texas System Methods for fine needle sample analysis via mass spectrometry
CN112017942B (zh) * 2020-09-04 2021-03-02 中国地质科学院地质研究所 一种提高二次离子探针质谱仪质谱成像空间分辨率的方法
US20240234117A9 (en) * 2021-02-02 2024-07-11 Dh Technologies Development Pte. Ltd. Methods and Apparatus for Washing Sampling Probe for Use in Mass Spectrometry Systems
CN113764257B (zh) * 2021-08-25 2024-01-12 清华大学深圳国际研究生院 一种基于3d打印的解吸电喷雾离子化装置
US11848094B2 (en) 2022-04-08 2023-12-19 Ohio State Innovation Foundation Multidimensional optical tissue classification and display
EP4507825A1 (en) * 2022-04-14 2025-02-19 Board of Regents, The University of Texas System Collection probe and methods of use thereof
CN116169005B (zh) * 2023-02-28 2023-07-28 厦门金诺花科学仪器有限公司 一次性疏水纳升点样针头及点样测试方法
KR102702105B1 (ko) * 2023-10-04 2024-09-06 대한민국 휴대용 dna 검체 채취장치
WO2025085615A1 (en) * 2023-10-17 2025-04-24 Baylor College Of Medicine Methods to rapidly detect methylthioadenosine and related metabolites directly from patient samples to identify 9p21 loss cancers and treatment strategies for patients
CL2024001366A1 (es) * 2024-05-04 2024-12-13 Ignacio Alberto Moscoso Gutierrez Dispositivo analizador de gases de combustión de tejidos humanos

Family Cites Families (117)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0369012A4 (en) 1987-07-23 1990-12-27 Terumo Kabushiki Kaisha Catheter tube
US5711816A (en) 1990-07-06 1998-01-27 Advanced Technolgy Materials, Inc. Source reagent liquid delivery apparatus, and chemical vapor deposition system comprising same
US5119827A (en) 1990-09-05 1992-06-09 Board Of Regents, The University Of Texas System Mechanisms of antiestrogen resistance in breast cancer
US5100402A (en) * 1990-10-05 1992-03-31 Megadyne Medical Products, Inc. Electrosurgical laparoscopic cauterization electrode
US5241990A (en) 1992-07-10 1993-09-07 Inlet Medical, Inc. Irrigation/aspiration valve and probe for laparoscopy
US5470308A (en) 1992-08-12 1995-11-28 Vidamed, Inc. Medical probe with biopsy stylet
US5746720A (en) 1995-10-18 1998-05-05 Stouder, Jr.; Albert E. Method and apparatus for insertion of a cannula and trocar
US5742050A (en) * 1996-09-30 1998-04-21 Aviv Amirav Method and apparatus for sample introduction into a mass spectrometer for improving a sample analysis
US6297499B1 (en) 1997-07-17 2001-10-02 John B Fenn Method and apparatus for electrospray ionization
ATE386335T1 (de) 1999-10-29 2008-03-15 Mds Inc Through Its Mds Sciex Atmosphärendruckphotoionisation : ein neues ionisationsverfahren für flüssigchromatographie- massenspekrometrie
US6786884B1 (en) 1999-10-29 2004-09-07 Bard Access Systems, Inc. Bolus tip design for a multi-lumen catheter
JP2004522980A (ja) 2000-11-16 2004-07-29 シファーゲン バイオシステムズ， インコーポレイテッド 質量スペクトルを分析する方法
US6784439B2 (en) 2001-07-19 2004-08-31 Ut Battelle, Llc Thin-channel electrospray emitter
US6756586B2 (en) * 2001-10-15 2004-06-29 Vanderbilt University Methods and apparatus for analyzing biological samples by mass spectrometry
US20040014227A1 (en) 2002-01-04 2004-01-22 Frederick Erik D. Apparatus, method and computer program product for automated high-throughput sampling and data acquisition
US6803566B2 (en) * 2002-04-16 2004-10-12 Ut-Battelle, Llc Sampling probe for microarray read out using electrospray mass spectrometry
JP4095349B2 (ja) * 2002-06-03 2008-06-04 ペンタックス株式会社 蛍光測定装置
US6677593B1 (en) 2002-08-28 2004-01-13 Ut-Battelle, Llc Planar flow-by electrode capacitive electrospray ion source
CA2433205A1 (en) 2003-03-18 2004-09-18 James Alexander Keenan Drug delivery, bodily fluid drainage, and biopsy device with enhanced ultrasonic visibility
US7684934B2 (en) * 2003-06-06 2010-03-23 The United States Of America As Represented By The Department Of Health And Human Services Pattern recognition of whole cell mass spectra
US7335897B2 (en) 2004-03-30 2008-02-26 Purdue Research Foundation Method and system for desorption electrospray ionization
CA2563613A1 (en) * 2004-04-16 2005-12-08 Wei-Sing Chu Device for extracting biological molecules from tissue specimens
US7445603B2 (en) 2004-05-12 2008-11-04 Zkz Science Corp. Apparatus for removable distal internal cassette for in situ fixation and specimen processing with serial collection and storage of biopsy specimens
WO2006031842A2 (en) 2004-09-14 2006-03-23 Metara, Inc. In-process mass spectrometry with sample multiplexing
US20090286305A1 (en) * 2005-04-15 2009-11-19 Wei-Sing Chu Method for non-destructive macromolecule extraction from biological samples on slide
US7295026B2 (en) 2005-06-03 2007-11-13 Ut-Battelle, Llc Automated position control of a surface array relative to a liquid microjunction surface sampler
WO2006133325A2 (en) 2005-06-08 2006-12-14 Vanderbilt University Analysis of tissue samples surrounding malignancies
DE102005044307B4 (de) * 2005-09-16 2008-04-17 Bruker Daltonik Gmbh Ionisierung desorbierter Moleküle
US7714276B2 (en) * 2005-09-30 2010-05-11 New York University Methods for direct biomolecule identification by matrix-assisted laser desorption ionization (MALDI) mass spectrometry
CN101370534B (zh) 2005-12-14 2012-03-07 史赛克公司 医疗/手术废物收集和处理系统
US7544933B2 (en) 2006-01-17 2009-06-09 Purdue Research Foundation Method and system for desorption atmospheric pressure chemical ionization
EP2035121A4 (en) 2006-05-26 2010-04-28 Ionsense Inc DEVICE FOR HOLDING SOLIDS FOR USE WITH SURFACE TREATMENT TECHNOLOGY
HU226837B1 (hu) 2006-05-31 2009-12-28 Semmelweis Egyetem Folyadéksugárral mûködõ deszorpciós ionizációs eljárás és eszköz
US7800056B2 (en) * 2006-10-26 2010-09-21 Smiths Detection Montreal Inc. Document sampler and method of sampling a document
EP2087504A2 (en) * 2006-11-23 2009-08-12 Philips Intellectual Property & Standards GmbH Device for separation and maldi analysis of an analyte in a sample
US7847244B2 (en) * 2006-12-28 2010-12-07 Purdue Research Foundation Enclosed desorption electrospray ionization
WO2008097831A1 (en) * 2007-02-02 2008-08-14 Waters Investments Limited Device and method for analyzing a sample
US20080243141A1 (en) 2007-04-02 2008-10-02 Salvatore Privitera Surgical instrument with separate tool head and method of use
WO2008151153A1 (en) * 2007-06-02 2008-12-11 Cerno Bioscience Llc A self calibration approach for mass spectrometry
ES2407630T3 (es) 2008-01-03 2013-06-13 Board Of Regents, The University Of Texas System Detección no invasiva del cáncer de vejiga mediante hibridación fluorescente in situ de Aurora A
US20090324617A1 (en) * 2008-01-24 2009-12-31 Glykos Finland Ltd. Cancer specific glycans and use thereof
US9213030B2 (en) 2008-01-28 2015-12-15 National University Of Singapore Lipid tumour profile
JP5701615B2 (ja) 2008-03-03 2015-04-15 コーニンクレッカ フィリップス エヌ ヴェ 電磁トラッキング及び光針による生検誘導
EP2274444A4 (en) 2008-04-10 2011-10-05 Univ British Columbia METHOD FOR DIAGNOSING A CHRONIC EXHAUSTION OF ALLOGENIC HEART TRANSPLANTS
US8207494B2 (en) 2008-05-01 2012-06-26 Indiana University Research And Technology Corporation Laser ablation flowing atmospheric-pressure afterglow for ambient mass spectrometry
US8410452B2 (en) * 2008-05-29 2013-04-02 Universitaetsklinikum Muenster Ion source means for desorption/ionisation of analyte substances and method of desorbing/ionising of analyte substances
US8084735B2 (en) 2008-09-25 2011-12-27 Ut-Battelle, Llc Pulsed voltage electrospray ion source and method for preventing analyte electrolysis
WO2010039675A1 (en) 2008-09-30 2010-04-08 Prosolia, Inc. Method and apparatus for embedded heater for desorption and ionization of analytes
EP3998479A1 (en) 2008-12-19 2022-05-18 Medirista Biotechnologies AB Oxidized cardiolipin as a novel pro-inflammatory factor
US20100224013A1 (en) 2009-03-05 2010-09-09 Van Berkel Gary J Method and system for formation and withdrawal of a sample from a surface to be analyzed
EP2415067B1 (en) 2009-04-01 2017-12-20 Prosolia, Inc. Method and system for surface sampling
US9500572B2 (en) 2009-04-30 2016-11-22 Purdue Research Foundation Sample dispenser including an internal standard and methods of use thereof
US8704167B2 (en) 2009-04-30 2014-04-22 Purdue Research Foundation Mass spectrometry analysis of microorganisms in samples
CA2759987C (en) 2009-04-30 2018-10-02 Purdue Research Foundation Ion generation using wetted porous material
US9046448B2 (en) * 2009-05-27 2015-06-02 Micromass Uk Limited System and method for identification of biological tissues
CN102741965A (zh) 2009-06-03 2012-10-17 韦恩州立大学 使用激光喷雾电离的质谱法
WO2011022364A1 (en) 2009-08-17 2011-02-24 Temple University Of The Commonwealth System Of Higher Education Vaporization device and method for imaging mass spectrometry
US8546752B2 (en) 2009-12-07 2013-10-01 Advion Inc. Solid-phase extraction (SPE) tips and methods of use
EP2534488B1 (en) 2010-02-11 2014-10-01 Katholieke Universiteit Leuven Phospholipid profiling of cancer
WO2011127091A1 (en) 2010-04-05 2011-10-13 Indiana University Research And Technology Corporation Method for enhancement of mass resolution over a limited mass range for time-of-flight spectrometry
JP5596402B2 (ja) * 2010-04-19 2014-09-24 株式会社日立ハイテクノロジーズ 分析装置、イオン化装置及び分析方法
CA2798638C (en) * 2010-05-07 2016-01-05 Ut-Battelle, Llc System and method for extracting a sample from a surface
CN201811941U (zh) * 2010-05-26 2011-04-27 中国石油化工股份有限公司 液体样品解析电喷雾质谱desi-ms电离装置
WO2011163332A2 (en) 2010-06-23 2011-12-29 University Of Louisville Research Foundation, Inc. Methods for detecting cancer
EP2593790A4 (en) 2010-07-14 2015-04-01 Univ Colorado Regents METHOD AND SYSTEMS FOR IN VIVO MEASUREMENT OF CLINICAL DATA OF ANALYTES
US9153425B2 (en) * 2010-09-01 2015-10-06 Ut-Battelle, Llc Device for high spatial resolution chemical analysis of a sample and method of high spatial resolution chemical analysis
US9552973B2 (en) 2010-09-02 2017-01-24 University Of The Sciences In Philadelphia System and method for ionization of molecules for mass spectrometry and ion mobility spectrometry
US8486703B2 (en) * 2010-09-30 2013-07-16 Ut-Battelle, Llc Surface sampling concentration and reaction probe
HUE055674T2 (hu) 2010-10-29 2021-12-28 Thermo Fisher Scientific Oy Rendszerelrendezés automatizált mintaelõkészítõ és -elemzõ rendszerhez
CN103201627B (zh) * 2010-11-08 2016-10-12 丹麦达科有限公司 组织学样品中单个靶标分子的定量
CN102115741B (zh) * 2010-12-10 2013-07-17 许汉鹏 一种原位分类提取生物大分子的方法及其系统
CN102221614B (zh) * 2011-03-28 2013-07-17 山东大学 一种利用金纳米探针来鉴别小分子化合物作用靶点的分析方法
US9546979B2 (en) 2011-05-18 2017-01-17 Purdue Research Foundation Analyzing a metabolite level in a tissue sample using DESI
US9157921B2 (en) 2011-05-18 2015-10-13 Purdue Research Foundation Method for diagnosing abnormality in tissue samples by combination of mass spectral and optical imaging
US9024254B2 (en) * 2011-06-03 2015-05-05 Purdue Research Foundation Enclosed desorption electrospray ionization probes and method of use thereof
WO2013098645A2 (en) 2011-12-28 2013-07-04 Medimass, Ltd. System and method for rapid evaporative ionization of liquid phase samples
WO2013112680A1 (en) 2012-01-26 2013-08-01 University Of The Sciences In Philadelphia Ionization at intermediate pressure for atmospheric pressure ionization mass spectrometers
WO2013112836A2 (en) 2012-01-26 2013-08-01 The Cleveland Clinic Foundation Diagnostic and prognostic biomarkers for cancer
JP5955032B2 (ja) * 2012-03-01 2016-07-20 キヤノン株式会社 イオン化方法、質量分析方法、抽出方法及び精製方法
US9105458B2 (en) 2012-05-21 2015-08-11 Sarah Trimpin System and methods for ionizing compounds using matrix-assistance for mass spectrometry and ion mobility spectrometry
US20140179805A1 (en) 2012-06-15 2014-06-26 Harry Stylli Methods of detecting diseases or conditions
US20150226745A1 (en) 2012-09-20 2015-08-13 Tore Skotland Prostate cancer markers and uses thereof
CA2892822C (en) 2012-11-27 2023-08-08 Pontificia Universidad Catolica De Chile Compositions and methods for diagnosing thyroid tumors
WO2014106165A1 (en) 2012-12-30 2014-07-03 Brigham And Women's Hospital, Inc. System and method for analysis of bio-metabolites for-use in image-guided surgery
US10983126B2 (en) 2013-05-31 2021-04-20 The Brigham And Women's Hospital System and method for analyzing tissue for the presence of cancer using bio-marker profiles
CA2916977A1 (en) 2013-06-26 2014-12-31 Stealth Biotherapeutics Corp Methods and compositions for detecting and diagnosing diseases and conditions
FR3007634B1 (fr) 2013-06-28 2016-09-02 Commissariat Energie Atomique Dispositif de prelevement in vivo d'especes biologiques et procede automatise d'analyse d'especes biologiques capturees au moyen d'un tel dispositif
EP3022762B1 (en) 2013-07-19 2022-04-27 Smiths Detection Inc. Mass spectrometer inlet with reduced average flow
JP6323922B2 (ja) 2013-08-07 2018-05-16 ディーエイチ テクノロジーズ デベロップメント プライベート リミテッド 質量分析計供給源中への液体流れからの気泡除去
US9245722B2 (en) * 2013-09-16 2016-01-26 Georgia Tech Research Corporation SMS probe and SEM imaging system and methods of use
US20160341712A1 (en) 2013-10-23 2016-11-24 Brigham And Women's Hospital, Inc. System and method for analyzing tissue intra-operatively using mass spectrometry
WO2015100221A2 (en) * 2013-12-28 2015-07-02 Purdue Research Foundation Mass spectrometry probes and systems for ionizing a sample
US20150202005A1 (en) 2014-01-20 2015-07-23 Omniguide, Inc. System and Method To Control Surgical Energy Devices
JP2015171467A (ja) 2014-03-12 2015-10-01 セイコーエプソン株式会社 液体噴射装置および手術機器
US9297828B2 (en) 2014-03-27 2016-03-29 Ut-Battelle, Llc High heating rate thermal desorption for molecular surface sampling
US9595428B2 (en) 2014-06-17 2017-03-14 The Board Of Regents Of The University Oklahoma Cellular probe device, system and analysis method
US10000789B2 (en) 2014-06-17 2018-06-19 The Board Of Regents Of The University Of Oklahoma Cellular probe device, system and analysis method
US20160041138A1 (en) 2014-08-11 2016-02-11 Arizona Board Of Regents On Behalf Of Arizona State University Methods for Monitoring Airborne Contaminants and Agents using Atmospheric Condensate
EP3265797B1 (en) 2015-03-06 2022-10-05 Micromass UK Limited Inlet instrumentation for ion analyser coupled to rapid evaporative ionisation mass spectrometry ("reims") device
JP6845148B2 (ja) * 2015-03-06 2021-03-17 マイクロマス ユーケー リミテッド 電気外科的応用のための液体トラップ又は分離器
CN112557490B (zh) 2015-03-06 2025-05-23 英国质谱公司 拭子和活检样品的快速蒸发电离质谱和解吸电喷雾电离质谱分析
WO2016142689A1 (en) 2015-03-06 2016-09-15 Micromass Uk Limited Tissue analysis by mass spectrometry or ion mobility spectrometry
GB2556436B (en) * 2015-03-06 2022-01-26 Micromass Ltd Cell population analysis
GB2552430B (en) * 2015-03-06 2022-05-11 Micromass Ltd Collision surface for improved ionisation
US9632066B2 (en) 2015-04-09 2017-04-25 Ut-Battelle, Llc Open port sampling interface
US10060838B2 (en) 2015-04-09 2018-08-28 Ut-Battelle, Llc Capture probe
JP6726218B6 (ja) 2015-05-29 2020-08-19 パーデュー・リサーチ・ファウンデーションＰｕｒｄｕｅ Ｒｅｓｅａｒｃｈ Ｆｏｕｎｄａｔｉｏｎ 組織サンプルを分析するための方法
GB201509402D0 (en) 2015-06-01 2015-07-15 Micromass Ltd Lock mass library for internal correction
US11266383B2 (en) 2015-09-22 2022-03-08 University Health Network System and method for optimized mass spectrometry analysis
US20170097355A1 (en) 2015-10-06 2017-04-06 University Of Washington Biomarkers and methods to distinguish ovarian cancer from benign tumors
GB2548596A (en) 2016-03-22 2017-09-27 Micromass Ltd An interface probe
WO2018013678A2 (en) 2016-07-13 2018-01-18 Board Of Regents, The University Of Texas System Molecular markers and methods for sample analysis via mass spectrometry
CN109789420B (zh) 2016-09-02 2021-09-24 得克萨斯大学体系董事会 收集探针及其使用方法
WO2018045208A1 (en) 2016-09-02 2018-03-08 Board Of Regents, The University Of Texas System Collection probe and methods for the use thereof
US10492801B2 (en) 2016-09-20 2019-12-03 Osteomed Llc Power driven surgical tool
WO2019104328A1 (en) 2017-11-27 2019-05-31 Board Of Regents, The University Of Texas System Minimally invasive collection probe and methods for the use thereof
EP4585903A3 (en) 2018-02-23 2025-10-29 Board of Regents, The University of Texas System Tissue analysis by mass spectrometry

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