JP7195002B2 - 回収プローブ及びその使用のための方法 - Google Patents

回収プローブ及びその使用のための方法 Download PDF

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JP7195002B2
JP7195002B2 JP2019512672A JP2019512672A JP7195002B2 JP 7195002 B2 JP7195002 B2 JP 7195002B2 JP 2019512672 A JP2019512672 A JP 2019512672A JP 2019512672 A JP2019512672 A JP 2019512672A JP 7195002 B2 JP7195002 B2 JP 7195002B2
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tissue
conduit
solvent
reservoir
ionization
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JP2019534724A5 (cg-RX-API-DMAC7.html
JP2019534724A (ja
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リヴィア シャヴィナート エバーリン
トーマス ミルナー
チヤリン チャン
ジョン リン
ジョン レクター
ニテシュ カッター
アイドゥン ザヘディヴァシュ
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ボード オブ リージェンツ ザ ユニヴァーシティ オブ テキサス システム
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Priority claimed from PCT/US2017/049689 external-priority patent/WO2018045208A1/en
Publication of JP2019534724A publication Critical patent/JP2019534724A/ja
Publication of JP2019534724A5 publication Critical patent/JP2019534724A5/ja
Priority to JP2022123679A priority Critical patent/JP7653952B2/ja
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    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/04—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
    • H01J49/0431—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components for liquid samples
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/62—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating the ionisation of gases, e.g. aerosols; by investigating electric discharges, e.g. emission of cathode
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Instruments for taking body samples for diagnostic purposes; Other methods or instruments for diagnosis, e.g. for vaccination diagnosis, sex determination or ovulation-period determination; Throat striking implements
    • A61B10/0045—Devices for taking samples of body liquids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/02—Devices for withdrawing samples
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/62—Detectors specially adapted therefor
    • G01N30/72—Mass spectrometers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848—Methods of protein analysis involving mass spectrometry
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/0027—Methods for using particle spectrometers
    • H01J49/0031—Step by step routines describing the use of the apparatus
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/04—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/04—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
    • H01J49/0404—Capillaries used for transferring samples or ions
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/04—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
    • H01J49/0459—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components for solid samples
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0605—Metering of fluids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0633—Valves, specific forms thereof with moving parts
    • B01L2400/0655—Valves, specific forms thereof with moving parts pinch valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02—Burettes; Pipettes
    • B01L3/0289—Apparatus for withdrawing or distributing predetermined quantities of fluid
    • B01L3/0293—Apparatus for withdrawing or distributing predetermined quantities of fluid for liquids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/02—Devices for withdrawing samples
    • G01N2001/028—Sampling from a surface, swabbing, vaporising
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/40—Concentrating samples
    • G01N1/4055—Concentrating samples by solubility techniques
    • G01N2001/4061—Solvent extraction
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2560/00—Chemical aspects of mass spectrometric analysis of biological material

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Hematology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • Urology & Nephrology (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Biophysics (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • Clinical Laboratory Science (AREA)
  • Electrochemistry (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
JP2019512672A 2016-09-02 2017-08-31 回収プローブ及びその使用のための方法 Active JP7195002B2 (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2022123679A JP7653952B2 (ja) 2016-09-02 2022-08-03 回収プローブ及びその使用のための方法
JP2024107850A JP7699274B2 (ja) 2016-09-02 2024-07-04 回収プローブ及びその使用のための方法

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201662383234P 2016-09-02 2016-09-02
US62/383,234 2016-09-02
US201662411321P 2016-10-21 2016-10-21
US62/411,321 2016-10-21
US201762462524P 2017-02-23 2017-02-23
US62/462,524 2017-02-23
PCT/US2017/049689 WO2018045208A1 (en) 2016-09-02 2017-08-31 Collection probe and methods for the use thereof

Related Child Applications (1)

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JP2022123679A Division JP7653952B2 (ja) 2016-09-02 2022-08-03 回収プローブ及びその使用のための方法

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JP2019534724A JP2019534724A (ja) 2019-12-05
JP2019534724A5 JP2019534724A5 (cg-RX-API-DMAC7.html) 2020-10-08
JP7195002B2 true JP7195002B2 (ja) 2022-12-23

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JP2022123679A Active JP7653952B2 (ja) 2016-09-02 2022-08-03 回収プローブ及びその使用のための方法
JP2024107850A Active JP7699274B2 (ja) 2016-09-02 2024-07-04 回収プローブ及びその使用のための方法

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JP2024107850A Active JP7699274B2 (ja) 2016-09-02 2024-07-04 回収プローブ及びその使用のための方法

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US (6) US10643832B2 (cg-RX-API-DMAC7.html)
EP (2) EP4357784A3 (cg-RX-API-DMAC7.html)
JP (3) JP7195002B2 (cg-RX-API-DMAC7.html)
KR (1) KR102543773B1 (cg-RX-API-DMAC7.html)
CN (2) CN109789420B (cg-RX-API-DMAC7.html)
AU (1) AU2017318661B2 (cg-RX-API-DMAC7.html)
CA (1) CA3035743A1 (cg-RX-API-DMAC7.html)
ES (1) ES2971214T3 (cg-RX-API-DMAC7.html)
IL (1) IL265129B2 (cg-RX-API-DMAC7.html)
MX (1) MX2019002471A (cg-RX-API-DMAC7.html)
SG (1) SG11201901866TA (cg-RX-API-DMAC7.html)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109789420B (zh) 2016-09-02 2021-09-24 得克萨斯大学体系董事会 收集探针及其使用方法
WO2018069872A1 (en) * 2016-10-14 2018-04-19 Dh Technologies Development Pte. Ltd. Methods and systems for increasing sensitivity of direct sampling interfaces for mass spectrometric analysis
WO2018227079A1 (en) * 2017-06-08 2018-12-13 Board Of Regents, The University Of Texas System Systems and methods for microarray droplet ionization analysis
WO2019102350A1 (en) * 2017-11-21 2019-05-31 Dh Technologies Development Pte. Ltd. Methods and systems utilizing ultrasound-assisted sampling interfaces for mass spectrometric analysis
WO2019104328A1 (en) * 2017-11-27 2019-05-31 Board Of Regents, The University Of Texas System Minimally invasive collection probe and methods for the use thereof
US10147052B1 (en) * 2018-01-29 2018-12-04 C-SATS, Inc. Automated assessment of operator performance
EP3522201B1 (en) * 2018-02-02 2020-10-07 Tofwerk AG Autosampler
US12089932B2 (en) 2018-06-05 2024-09-17 Trace Matters Scientific Llc Apparatus, system, and method for transferring ions
US11219393B2 (en) 2018-07-12 2022-01-11 Trace Matters Scientific Llc Mass spectrometry system and method for analyzing biological samples
US11450519B2 (en) 2018-06-07 2022-09-20 Dh Technologies Development Pte. Ltd. Sampling interface for a mass spectrometer
GB201812561D0 (en) 2018-08-01 2018-09-12 Univ Manchester Biomarkers and uses thereof
EP3647763B1 (en) * 2018-10-29 2021-07-14 FEI Company A method of preparing a biological sample for study in an analysis device
EP3914891A4 (en) 2019-01-25 2022-09-28 Board of Regents, The University of Texas System DEVICE AND METHOD FOR CLEANING AND/OR REPLACING MEDICAL DEVICES
WO2020242911A1 (en) * 2019-05-31 2020-12-03 Purdue Research Foundation Integrated microfluidic probe (imfp) and methods of use thereof
WO2020247769A2 (en) 2019-06-06 2020-12-10 Board Of Regents, The University Of Texas System Using mass spectrometry to identify endometriosis tissue
CN114981919A (zh) * 2020-01-14 2022-08-30 Dh科技发展私人贸易有限公司 质量分析方法-控制opp操作溶剂的粘度
GB202001571D0 (en) * 2020-02-05 2020-03-18 Univ Manchester Identification of biomarkers and uses thereof
CN111351831A (zh) * 2020-02-26 2020-06-30 西安交通大学医学院第二附属医院 基于质谱分析组织术中检测、标记设备及其检测方法
WO2021222182A1 (en) * 2020-04-27 2021-11-04 Board Of Regents, The University Of Texas System Identifying and classifying microorganisms
WO2021222154A1 (en) * 2020-04-27 2021-11-04 Board Of Regents, The University Of Texas System Detecting chemical compounds for forensic analysis
WO2021252322A1 (en) * 2020-06-12 2021-12-16 Board Of Regents, The University Of Texas System Molecular markers and methods for sample analysis via mass spectrometry
US12399127B2 (en) * 2020-08-12 2025-08-26 14336186 Canada Corp. (Exclaro) Automated Raman signal collection device
WO2022047104A1 (en) * 2020-08-28 2022-03-03 Board Of Regents, The University Of Texas System Methods for fine needle sample analysis via mass spectrometry
CN112017942B (zh) * 2020-09-04 2021-03-02 中国地质科学院地质研究所 一种提高二次离子探针质谱仪质谱成像空间分辨率的方法
US20240234117A9 (en) * 2021-02-02 2024-07-11 Dh Technologies Development Pte. Ltd. Methods and Apparatus for Washing Sampling Probe for Use in Mass Spectrometry Systems
CN113764257B (zh) * 2021-08-25 2024-01-12 清华大学深圳国际研究生院 一种基于3d打印的解吸电喷雾离子化装置
US11848094B2 (en) 2022-04-08 2023-12-19 Ohio State Innovation Foundation Multidimensional optical tissue classification and display
EP4507825A1 (en) * 2022-04-14 2025-02-19 Board of Regents, The University of Texas System Collection probe and methods of use thereof
CN116169005B (zh) * 2023-02-28 2023-07-28 厦门金诺花科学仪器有限公司 一次性疏水纳升点样针头及点样测试方法
KR102702105B1 (ko) * 2023-10-04 2024-09-06 대한민국 휴대용 dna 검체 채취장치
WO2025085615A1 (en) * 2023-10-17 2025-04-24 Baylor College Of Medicine Methods to rapidly detect methylthioadenosine and related metabolites directly from patient samples to identify 9p21 loss cancers and treatment strategies for patients
CL2024001366A1 (es) * 2024-05-04 2024-12-13 Ignacio Alberto Moscoso Gutierrez Dispositivo analizador de gases de combustión de tejidos humanos

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004000377A (ja) 2002-06-03 2004-01-08 Pentax Corp 蛍光測定装置
US20120053065A1 (en) 2010-09-01 2012-03-01 Van Berkel Gary J Device for high spatial resolution chemical analysis of a sample and method of high spatial resolution chemical analysis
US20120080592A1 (en) 2009-04-01 2012-04-05 The Brigham And Women's Hospital, Inc. Method and system for surface sampling
JP2012519847A (ja) 2009-03-05 2012-08-30 ユーティバトル・エルエルシイ 試料を形成して被分析面から吸引する方法及びそのためのシステム
JP2012528320A (ja) 2009-05-27 2012-11-12 メディマス・ケーエフティー 生体組織の識別用のシステム及び方法

Family Cites Families (112)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0369012A4 (en) 1987-07-23 1990-12-27 Terumo Kabushiki Kaisha Catheter tube
US5711816A (en) 1990-07-06 1998-01-27 Advanced Technolgy Materials, Inc. Source reagent liquid delivery apparatus, and chemical vapor deposition system comprising same
US5119827A (en) 1990-09-05 1992-06-09 Board Of Regents, The University Of Texas System Mechanisms of antiestrogen resistance in breast cancer
US5100402A (en) * 1990-10-05 1992-03-31 Megadyne Medical Products, Inc. Electrosurgical laparoscopic cauterization electrode
US5241990A (en) 1992-07-10 1993-09-07 Inlet Medical, Inc. Irrigation/aspiration valve and probe for laparoscopy
US5470308A (en) 1992-08-12 1995-11-28 Vidamed, Inc. Medical probe with biopsy stylet
US5746720A (en) 1995-10-18 1998-05-05 Stouder, Jr.; Albert E. Method and apparatus for insertion of a cannula and trocar
US5742050A (en) * 1996-09-30 1998-04-21 Aviv Amirav Method and apparatus for sample introduction into a mass spectrometer for improving a sample analysis
US6297499B1 (en) 1997-07-17 2001-10-02 John B Fenn Method and apparatus for electrospray ionization
ATE386335T1 (de) 1999-10-29 2008-03-15 Mds Inc Through Its Mds Sciex Atmosphärendruckphotoionisation : ein neues ionisationsverfahren für flüssigchromatographie- massenspekrometrie
US6786884B1 (en) 1999-10-29 2004-09-07 Bard Access Systems, Inc. Bolus tip design for a multi-lumen catheter
JP2004522980A (ja) 2000-11-16 2004-07-29 シファーゲン バイオシステムズ， インコーポレイテッド 質量スペクトルを分析する方法
US6784439B2 (en) 2001-07-19 2004-08-31 Ut Battelle, Llc Thin-channel electrospray emitter
US6756586B2 (en) * 2001-10-15 2004-06-29 Vanderbilt University Methods and apparatus for analyzing biological samples by mass spectrometry
US20040014227A1 (en) 2002-01-04 2004-01-22 Frederick Erik D. Apparatus, method and computer program product for automated high-throughput sampling and data acquisition
US6803566B2 (en) * 2002-04-16 2004-10-12 Ut-Battelle, Llc Sampling probe for microarray read out using electrospray mass spectrometry
US6677593B1 (en) 2002-08-28 2004-01-13 Ut-Battelle, Llc Planar flow-by electrode capacitive electrospray ion source
CA2433205A1 (en) 2003-03-18 2004-09-18 James Alexander Keenan Drug delivery, bodily fluid drainage, and biopsy device with enhanced ultrasonic visibility
US7684934B2 (en) * 2003-06-06 2010-03-23 The United States Of America As Represented By The Department Of Health And Human Services Pattern recognition of whole cell mass spectra
US7335897B2 (en) 2004-03-30 2008-02-26 Purdue Research Foundation Method and system for desorption electrospray ionization
CA2563613A1 (en) * 2004-04-16 2005-12-08 Wei-Sing Chu Device for extracting biological molecules from tissue specimens
US7445603B2 (en) 2004-05-12 2008-11-04 Zkz Science Corp. Apparatus for removable distal internal cassette for in situ fixation and specimen processing with serial collection and storage of biopsy specimens
WO2006031842A2 (en) 2004-09-14 2006-03-23 Metara, Inc. In-process mass spectrometry with sample multiplexing
US20090286305A1 (en) * 2005-04-15 2009-11-19 Wei-Sing Chu Method for non-destructive macromolecule extraction from biological samples on slide
US7295026B2 (en) 2005-06-03 2007-11-13 Ut-Battelle, Llc Automated position control of a surface array relative to a liquid microjunction surface sampler
WO2006133325A2 (en) 2005-06-08 2006-12-14 Vanderbilt University Analysis of tissue samples surrounding malignancies
DE102005044307B4 (de) * 2005-09-16 2008-04-17 Bruker Daltonik Gmbh Ionisierung desorbierter Moleküle
US7714276B2 (en) * 2005-09-30 2010-05-11 New York University Methods for direct biomolecule identification by matrix-assisted laser desorption ionization (MALDI) mass spectrometry
CN101370534B (zh) 2005-12-14 2012-03-07 史赛克公司 医疗/手术废物收集和处理系统
US7544933B2 (en) 2006-01-17 2009-06-09 Purdue Research Foundation Method and system for desorption atmospheric pressure chemical ionization
EP2035121A4 (en) 2006-05-26 2010-04-28 Ionsense Inc DEVICE FOR HOLDING SOLIDS FOR USE WITH SURFACE TREATMENT TECHNOLOGY
HU226837B1 (hu) 2006-05-31 2009-12-28 Semmelweis Egyetem Folyadéksugárral mûködõ deszorpciós ionizációs eljárás és eszköz
US7800056B2 (en) * 2006-10-26 2010-09-21 Smiths Detection Montreal Inc. Document sampler and method of sampling a document
EP2087504A2 (en) * 2006-11-23 2009-08-12 Philips Intellectual Property & Standards GmbH Device for separation and maldi analysis of an analyte in a sample
US7847244B2 (en) * 2006-12-28 2010-12-07 Purdue Research Foundation Enclosed desorption electrospray ionization
WO2008097831A1 (en) * 2007-02-02 2008-08-14 Waters Investments Limited Device and method for analyzing a sample
US20080243141A1 (en) 2007-04-02 2008-10-02 Salvatore Privitera Surgical instrument with separate tool head and method of use
WO2008151153A1 (en) * 2007-06-02 2008-12-11 Cerno Bioscience Llc A self calibration approach for mass spectrometry
ES2407630T3 (es) 2008-01-03 2013-06-13 Board Of Regents, The University Of Texas System Detección no invasiva del cáncer de vejiga mediante hibridación fluorescente in situ de Aurora A
US20090324617A1 (en) * 2008-01-24 2009-12-31 Glykos Finland Ltd. Cancer specific glycans and use thereof
US9213030B2 (en) 2008-01-28 2015-12-15 National University Of Singapore Lipid tumour profile
JP5701615B2 (ja) 2008-03-03 2015-04-15 コーニンクレッカ フィリップス エヌ ヴェ 電磁トラッキング及び光針による生検誘導
EP2274444A4 (en) 2008-04-10 2011-10-05 Univ British Columbia METHOD FOR DIAGNOSING A CHRONIC EXHAUSTION OF ALLOGENIC HEART TRANSPLANTS
US8207494B2 (en) 2008-05-01 2012-06-26 Indiana University Research And Technology Corporation Laser ablation flowing atmospheric-pressure afterglow for ambient mass spectrometry
US8410452B2 (en) * 2008-05-29 2013-04-02 Universitaetsklinikum Muenster Ion source means for desorption/ionisation of analyte substances and method of desorbing/ionising of analyte substances
US8084735B2 (en) 2008-09-25 2011-12-27 Ut-Battelle, Llc Pulsed voltage electrospray ion source and method for preventing analyte electrolysis
WO2010039675A1 (en) 2008-09-30 2010-04-08 Prosolia, Inc. Method and apparatus for embedded heater for desorption and ionization of analytes
EP3998479A1 (en) 2008-12-19 2022-05-18 Medirista Biotechnologies AB Oxidized cardiolipin as a novel pro-inflammatory factor
US9500572B2 (en) 2009-04-30 2016-11-22 Purdue Research Foundation Sample dispenser including an internal standard and methods of use thereof
US8704167B2 (en) 2009-04-30 2014-04-22 Purdue Research Foundation Mass spectrometry analysis of microorganisms in samples
CA2759987C (en) 2009-04-30 2018-10-02 Purdue Research Foundation Ion generation using wetted porous material
CN102741965A (zh) 2009-06-03 2012-10-17 韦恩州立大学 使用激光喷雾电离的质谱法
WO2011022364A1 (en) 2009-08-17 2011-02-24 Temple University Of The Commonwealth System Of Higher Education Vaporization device and method for imaging mass spectrometry
US8546752B2 (en) 2009-12-07 2013-10-01 Advion Inc. Solid-phase extraction (SPE) tips and methods of use
EP2534488B1 (en) 2010-02-11 2014-10-01 Katholieke Universiteit Leuven Phospholipid profiling of cancer
WO2011127091A1 (en) 2010-04-05 2011-10-13 Indiana University Research And Technology Corporation Method for enhancement of mass resolution over a limited mass range for time-of-flight spectrometry
JP5596402B2 (ja) * 2010-04-19 2014-09-24 株式会社日立ハイテクノロジーズ 分析装置、イオン化装置及び分析方法
CA2798638C (en) * 2010-05-07 2016-01-05 Ut-Battelle, Llc System and method for extracting a sample from a surface
CN201811941U (zh) * 2010-05-26 2011-04-27 中国石油化工股份有限公司 液体样品解析电喷雾质谱desi-ms电离装置
WO2011163332A2 (en) 2010-06-23 2011-12-29 University Of Louisville Research Foundation, Inc. Methods for detecting cancer
EP2593790A4 (en) 2010-07-14 2015-04-01 Univ Colorado Regents METHOD AND SYSTEMS FOR IN VIVO MEASUREMENT OF CLINICAL DATA OF ANALYTES
US9552973B2 (en) 2010-09-02 2017-01-24 University Of The Sciences In Philadelphia System and method for ionization of molecules for mass spectrometry and ion mobility spectrometry
US8486703B2 (en) * 2010-09-30 2013-07-16 Ut-Battelle, Llc Surface sampling concentration and reaction probe
HUE055674T2 (hu) 2010-10-29 2021-12-28 Thermo Fisher Scientific Oy Rendszerelrendezés automatizált mintaelõkészítõ és -elemzõ rendszerhez
CN103201627B (zh) * 2010-11-08 2016-10-12 丹麦达科有限公司 组织学样品中单个靶标分子的定量
CN102115741B (zh) * 2010-12-10 2013-07-17 许汉鹏 一种原位分类提取生物大分子的方法及其系统
CN102221614B (zh) * 2011-03-28 2013-07-17 山东大学 一种利用金纳米探针来鉴别小分子化合物作用靶点的分析方法
US9546979B2 (en) 2011-05-18 2017-01-17 Purdue Research Foundation Analyzing a metabolite level in a tissue sample using DESI
US9157921B2 (en) 2011-05-18 2015-10-13 Purdue Research Foundation Method for diagnosing abnormality in tissue samples by combination of mass spectral and optical imaging
US9024254B2 (en) * 2011-06-03 2015-05-05 Purdue Research Foundation Enclosed desorption electrospray ionization probes and method of use thereof
WO2013098645A2 (en) 2011-12-28 2013-07-04 Medimass, Ltd. System and method for rapid evaporative ionization of liquid phase samples
WO2013112680A1 (en) 2012-01-26 2013-08-01 University Of The Sciences In Philadelphia Ionization at intermediate pressure for atmospheric pressure ionization mass spectrometers
WO2013112836A2 (en) 2012-01-26 2013-08-01 The Cleveland Clinic Foundation Diagnostic and prognostic biomarkers for cancer
JP5955032B2 (ja) * 2012-03-01 2016-07-20 キヤノン株式会社 イオン化方法、質量分析方法、抽出方法及び精製方法
US9105458B2 (en) 2012-05-21 2015-08-11 Sarah Trimpin System and methods for ionizing compounds using matrix-assistance for mass spectrometry and ion mobility spectrometry
US20140179805A1 (en) 2012-06-15 2014-06-26 Harry Stylli Methods of detecting diseases or conditions
US20150226745A1 (en) 2012-09-20 2015-08-13 Tore Skotland Prostate cancer markers and uses thereof
CA2892822C (en) 2012-11-27 2023-08-08 Pontificia Universidad Catolica De Chile Compositions and methods for diagnosing thyroid tumors
WO2014106165A1 (en) 2012-12-30 2014-07-03 Brigham And Women's Hospital, Inc. System and method for analysis of bio-metabolites for-use in image-guided surgery
US10983126B2 (en) 2013-05-31 2021-04-20 The Brigham And Women's Hospital System and method for analyzing tissue for the presence of cancer using bio-marker profiles
CA2916977A1 (en) 2013-06-26 2014-12-31 Stealth Biotherapeutics Corp Methods and compositions for detecting and diagnosing diseases and conditions
FR3007634B1 (fr) 2013-06-28 2016-09-02 Commissariat Energie Atomique Dispositif de prelevement in vivo d'especes biologiques et procede automatise d'analyse d'especes biologiques capturees au moyen d'un tel dispositif
EP3022762B1 (en) 2013-07-19 2022-04-27 Smiths Detection Inc. Mass spectrometer inlet with reduced average flow
JP6323922B2 (ja) 2013-08-07 2018-05-16 ディーエイチ テクノロジーズ デベロップメント プライベート リミテッド 質量分析計供給源中への液体流れからの気泡除去
US9245722B2 (en) * 2013-09-16 2016-01-26 Georgia Tech Research Corporation SMS probe and SEM imaging system and methods of use
US20160341712A1 (en) 2013-10-23 2016-11-24 Brigham And Women's Hospital, Inc. System and method for analyzing tissue intra-operatively using mass spectrometry
WO2015100221A2 (en) * 2013-12-28 2015-07-02 Purdue Research Foundation Mass spectrometry probes and systems for ionizing a sample
US20150202005A1 (en) 2014-01-20 2015-07-23 Omniguide, Inc. System and Method To Control Surgical Energy Devices
JP2015171467A (ja) 2014-03-12 2015-10-01 セイコーエプソン株式会社 液体噴射装置および手術機器
US9297828B2 (en) 2014-03-27 2016-03-29 Ut-Battelle, Llc High heating rate thermal desorption for molecular surface sampling
US9595428B2 (en) 2014-06-17 2017-03-14 The Board Of Regents Of The University Oklahoma Cellular probe device, system and analysis method
US10000789B2 (en) 2014-06-17 2018-06-19 The Board Of Regents Of The University Of Oklahoma Cellular probe device, system and analysis method
US20160041138A1 (en) 2014-08-11 2016-02-11 Arizona Board Of Regents On Behalf Of Arizona State University Methods for Monitoring Airborne Contaminants and Agents using Atmospheric Condensate
EP3265797B1 (en) 2015-03-06 2022-10-05 Micromass UK Limited Inlet instrumentation for ion analyser coupled to rapid evaporative ionisation mass spectrometry ("reims") device
JP6845148B2 (ja) * 2015-03-06 2021-03-17 マイクロマス ユーケー リミテッド 電気外科的応用のための液体トラップ又は分離器
CN112557490B (zh) 2015-03-06 2025-05-23 英国质谱公司 拭子和活检样品的快速蒸发电离质谱和解吸电喷雾电离质谱分析
WO2016142689A1 (en) 2015-03-06 2016-09-15 Micromass Uk Limited Tissue analysis by mass spectrometry or ion mobility spectrometry
GB2556436B (en) * 2015-03-06 2022-01-26 Micromass Ltd Cell population analysis
GB2552430B (en) * 2015-03-06 2022-05-11 Micromass Ltd Collision surface for improved ionisation
US9632066B2 (en) 2015-04-09 2017-04-25 Ut-Battelle, Llc Open port sampling interface
US10060838B2 (en) 2015-04-09 2018-08-28 Ut-Battelle, Llc Capture probe
JP6726218B6 (ja) 2015-05-29 2020-08-19 パーデュー・リサーチ・ファウンデーションＰｕｒｄｕｅ Ｒｅｓｅａｒｃｈ Ｆｏｕｎｄａｔｉｏｎ 組織サンプルを分析するための方法
GB201509402D0 (en) 2015-06-01 2015-07-15 Micromass Ltd Lock mass library for internal correction
US11266383B2 (en) 2015-09-22 2022-03-08 University Health Network System and method for optimized mass spectrometry analysis
US20170097355A1 (en) 2015-10-06 2017-04-06 University Of Washington Biomarkers and methods to distinguish ovarian cancer from benign tumors
GB2548596A (en) 2016-03-22 2017-09-27 Micromass Ltd An interface probe
WO2018013678A2 (en) 2016-07-13 2018-01-18 Board Of Regents, The University Of Texas System Molecular markers and methods for sample analysis via mass spectrometry
CN109789420B (zh) 2016-09-02 2021-09-24 得克萨斯大学体系董事会 收集探针及其使用方法
WO2018045208A1 (en) 2016-09-02 2018-03-08 Board Of Regents, The University Of Texas System Collection probe and methods for the use thereof
US10492801B2 (en) 2016-09-20 2019-12-03 Osteomed Llc Power driven surgical tool
WO2019104328A1 (en) 2017-11-27 2019-05-31 Board Of Regents, The University Of Texas System Minimally invasive collection probe and methods for the use thereof
EP4585903A3 (en) 2018-02-23 2025-10-29 Board of Regents, The University of Texas System Tissue analysis by mass spectrometry

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004000377A (ja) 2002-06-03 2004-01-08 Pentax Corp 蛍光測定装置
JP2012519847A (ja) 2009-03-05 2012-08-30 ユーティバトル・エルエルシイ 試料を形成して被分析面から吸引する方法及びそのためのシステム
US20120080592A1 (en) 2009-04-01 2012-04-05 The Brigham And Women's Hospital, Inc. Method and system for surface sampling
JP2012528320A (ja) 2009-05-27 2012-11-12 メディマス・ケーエフティー 生体組織の識別用のシステム及び方法
US20120053065A1 (en) 2010-09-01 2012-03-01 Van Berkel Gary J Device for high spatial resolution chemical analysis of a sample and method of high spatial resolution chemical analysis

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