IL259223B - A transient transfection method for the production of retroviruses - Google Patents
A transient transfection method for the production of retrovirusesInfo
- Publication number
- IL259223B IL259223B IL259223A IL25922318A IL259223B IL 259223 B IL259223 B IL 259223B IL 259223 A IL259223 A IL 259223A IL 25922318 A IL25922318 A IL 25922318A IL 259223 B IL259223 B IL 259223B
- Authority
- IL
- Israel
- Prior art keywords
- transient transfection
- transfection method
- retroviral production
- retroviral
- production
- Prior art date
Links
- 238000000034 method Methods 0.000 title 1
- 230000001177 retroviral effect Effects 0.000 title 1
- 238000003146 transient transfection Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/64—General methods for preparing the vector, for introducing it into the cell or for selecting the vector-containing host
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/67—General methods for enhancing the expression
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/88—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using amphiphile liposome vesicle
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/89—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microinjection
- C12N15/895—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microinjection using biolistic methods
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16041—Use of virus, viral particle or viral elements as a vector
- C12N2740/16043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16051—Methods of production or purification of viral material
- C12N2740/16052—Methods of production or purification of viral material relating to complementing cells and packaging systems for producing virus or viral particles
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2800/00—Nucleic acids vectors
- C12N2800/20—Pseudochromosomes, minichrosomosomes
- C12N2800/204—Pseudochromosomes, minichrosomosomes of bacterial origin, e.g. BAC
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2800/00—Nucleic acids vectors
- C12N2800/22—Vectors comprising a coding region that has been codon optimised for expression in a respective host
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2800/00—Nucleic acids vectors
- C12N2800/50—Vectors for producing vectors
Landscapes
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Molecular Biology (AREA)
- Virology (AREA)
- Cell Biology (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1520764.0A GB201520764D0 (en) | 2015-11-24 | 2015-11-24 | Transient transfection method for retroviral production |
| GBGB1609354.4A GB201609354D0 (en) | 2016-05-26 | 2016-05-26 | Transient transfection method for retroviral production |
| PCT/EP2016/078334 WO2017089307A1 (en) | 2015-11-24 | 2016-11-21 | Transient transfection method for retroviral production |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL259223A IL259223A (en) | 2018-07-31 |
| IL259223B true IL259223B (en) | 2022-05-01 |
Family
ID=57348703
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL259223A IL259223B (en) | 2015-11-24 | 2018-05-08 | A transient transfection method for the production of retroviruses |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US10450574B2 (OSRAM) |
| EP (1) | EP3380605A1 (OSRAM) |
| JP (1) | JP7110096B2 (OSRAM) |
| KR (1) | KR102067352B1 (OSRAM) |
| CN (1) | CN108291211A (OSRAM) |
| AU (1) | AU2016359838B2 (OSRAM) |
| BR (1) | BR112018010639A2 (OSRAM) |
| CA (1) | CA3006285A1 (OSRAM) |
| DE (1) | DE102016122317A1 (OSRAM) |
| FR (1) | FR3044017B1 (OSRAM) |
| IL (1) | IL259223B (OSRAM) |
| IT (1) | IT201600117287A1 (OSRAM) |
| RU (1) | RU2749717C2 (OSRAM) |
| SA (1) | SA518391585B1 (OSRAM) |
| WO (1) | WO2017089307A1 (OSRAM) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK3294756T3 (da) * | 2015-05-15 | 2021-02-22 | Flash Therapeutics | Retroviral partikel, omfattende mindst to forskellige indkapslede, ikke-virale RNA'er |
| BR112018010635A2 (pt) * | 2015-11-24 | 2018-11-27 | Glaxosmithkline Ip Dev Ltd | linhagens celulares estáveis para a produção retroviral |
| GB201706121D0 (en) * | 2017-04-18 | 2017-05-31 | Glaxosmithkline Ip Dev Ltd | Stable cell lines for retroviral production |
| GB201715052D0 (en) | 2017-09-19 | 2017-11-01 | Oxford Genetics Ltd | Vectors |
| FI3633040T3 (fi) | 2017-12-22 | 2023-08-03 | Oxford Biomedica Ltd | Retrovirusvektori |
| GB201816919D0 (en) * | 2018-10-17 | 2018-11-28 | Glaxosmithkline Ip Dev Ltd | Adeno-associated viral vector producer cell lines |
| CN110684804B (zh) * | 2019-10-15 | 2023-04-18 | 上海本导基因技术有限公司 | 递送外源rnp的慢病毒载体及其制备方法 |
| GB202004371D0 (en) | 2020-03-26 | 2020-05-13 | Glaxosmithkline Ip Dev Ltd | CAR constructs |
| GB202005096D0 (en) | 2020-04-07 | 2020-05-20 | Glaxosmithkline | Modified vectors for production of retrovirus |
| KR20220166825A (ko) * | 2020-04-10 | 2022-12-19 | 사우스웨스트 리서치 인스티튜트 | 바이러스 벡터 생산을 위한 3차원 생물 반응기 |
| EP4308605A1 (en) | 2021-03-19 | 2024-01-24 | GlaxoSmithKline Intellectual Property Development Limited | Chimeric antigen receptors targeting claudin-3 and methods for treating cancer |
| CN113373266B (zh) * | 2021-06-22 | 2022-07-01 | 内蒙古农业大学 | 一种用于检测绵羊肺腺瘤病毒的荧光rpa引物、试剂盒和检测方法 |
| WO2024218341A1 (en) | 2023-04-19 | 2024-10-24 | Glaxosmithkline Intellectual Property Development Limited | Cytotoxicity targeting chimeras for car-t and car-nk cells |
| WO2024218345A1 (en) | 2023-04-21 | 2024-10-24 | Glaxosmithkline Intellectual Property Development Limited | Cytotoxicity targeting chimeras for antibody-drug conjugates and bispecific antibodies |
Family Cites Families (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5593972A (en) * | 1993-01-26 | 1997-01-14 | The Wistar Institute | Genetic immunization |
| WO1995003400A1 (en) | 1993-07-23 | 1995-02-02 | Johns Hopkins University School Of Medicine | Recombinationally targeted cloning in yeast artificial chromosomes |
| ES2253754T3 (es) * | 1995-06-27 | 2006-06-01 | Bavarian Nordic A/S | Celulas encapsuladas que producen particulas viricas. |
| WO1997030169A1 (en) | 1996-02-13 | 1997-08-21 | Fred Hutchinson Cancer Research Center | 10a1 retroviral packaging cells and uses thereof |
| FR2751223B1 (fr) * | 1996-07-19 | 1998-12-04 | Rhone Merieux | Formule de vaccin polynucleotidique felin |
| US6277621B1 (en) | 1998-02-26 | 2001-08-21 | Medigene, Inc. | Artificial chromosome constructs containing foreign nucleic acid sequences |
| ATE384795T1 (de) | 1998-12-31 | 2008-02-15 | Novartis Vaccines & Diagnostic | Modifizierte hiv env polypeptide |
| AU4364700A (en) | 1999-04-22 | 2000-11-10 | General Hospital Corporation, The | Triple hybrid amplicon vector systems to generate retroviral packaging lines |
| US6677155B1 (en) | 1999-04-22 | 2004-01-13 | The General Hospital Corporation | Triple hybrid amplicon vector systems to generate retroviral packaging lines |
| WO2000066758A1 (en) | 1999-04-29 | 2000-11-09 | Aarhus University | Expression of heterologous genes from an ires translational cassette in retroviral vectors |
| AU5597200A (en) | 1999-06-07 | 2000-12-28 | Cell Genesys, Inc. | Hybrid yeast-bacteria cloning system and uses thereof |
| WO2001027304A2 (en) | 1999-10-12 | 2001-04-19 | Institut Pasteur | Lentiviral triplex dna, and vectors and recombinant cells containing lentiviral triplex dna |
| US20060057553A1 (en) * | 2000-05-30 | 2006-03-16 | Estuardo Aguilar-Cordova | Chimeric viral vectors for gene therapy |
| AU2001292711A1 (en) | 2000-09-18 | 2002-03-26 | Genetic Therapy, Inc. | Stress resistant retroviruses |
| US6586251B2 (en) * | 2000-10-31 | 2003-07-01 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
| US7214515B2 (en) | 2001-01-05 | 2007-05-08 | The General Hospital Corporation | Viral delivery system for infectious transfer of large genomic DNA inserts |
| DE10111433A1 (de) | 2001-03-09 | 2002-09-19 | Bundesrepublik Deutschland Let | Replikationskompetente molekulare Klone von porcinem endogenem Retrovirus der Klasse A und Klasse B,abgeleitet von Schweine- und humanen Zellen |
| WO2002097059A2 (en) | 2001-05-30 | 2002-12-05 | Chromos Molecular Systems, Inc. | Chromosome-based platforms |
| US6835568B2 (en) * | 2001-10-30 | 2004-12-28 | Virxsys Corporation | Regulated nucleic acid expression system |
| EP2348119B1 (en) | 2002-02-01 | 2017-04-26 | Oxford BioMedica (UK) Limited | Multicistronic lentiviral vector |
| ATE471382T1 (de) | 2002-04-10 | 2010-07-15 | Us Gov Health & Human Serv | Vac-bac-shuttlevektor-system |
| US7300658B2 (en) * | 2002-11-25 | 2007-11-27 | Bavarian Nordic A/S | Recombinant poxvirus comprising at least two compox ATI promoters |
| WO2005106002A2 (en) * | 2004-04-28 | 2005-11-10 | The Trustees Of The University Of Pennsylvania | Polyvalent viral vectors and a system for production thereof |
| US20080226677A1 (en) | 2004-05-06 | 2008-09-18 | Yasuko Mori | Recombinant virus vector for gene transfer into lymphoid cells |
| EP1652932A1 (en) | 2004-11-02 | 2006-05-03 | GBF Gesellschaft für Biotechnologische Forschung mbH | Method for the generation of virus producing cell lines and cell lines |
| EP1817422A2 (en) | 2004-11-24 | 2007-08-15 | Nanovector Limited | Viral vectors |
| EP1829963A4 (en) * | 2004-11-24 | 2009-01-28 | Anaeropharma Science Inc | NEW SHUTTLE VECTOR |
| EP2062246A4 (en) | 2006-08-18 | 2010-09-29 | Univ North Carolina | VACCINES AGAINST CHIMARICAL VIRUSES |
| GB0702695D0 (en) * | 2007-02-12 | 2007-03-21 | Ark Therapeutics Ltd | Production of vectors |
| CN101743306A (zh) * | 2007-03-23 | 2010-06-16 | 威斯康星校友研究基金会 | 体细胞重编程 |
| WO2009146150A2 (en) | 2008-04-04 | 2009-12-03 | University Of Miami | Viral recombineering and uses thereof |
| BR112013005120A2 (pt) | 2010-09-02 | 2021-04-20 | Molmed S.P.A | produção semiestável de vetores lentivirais |
| US9273324B2 (en) | 2010-12-05 | 2016-03-01 | Andrew S. Belmont | Recombinant gene expression |
| WO2012170431A2 (en) | 2011-06-06 | 2012-12-13 | Bluebird Bio, Inc. | Improved geneswitch systems |
| GB201202516D0 (en) | 2012-02-13 | 2012-03-28 | Ucl Business Plc | Materials and methods relating to packaging cell lines |
| WO2014043131A1 (en) * | 2012-09-14 | 2014-03-20 | The Regents Of The University Of California | Lentiviral vector for stem cell gene therapy of sickle cell disease |
| US10590433B2 (en) * | 2014-03-14 | 2020-03-17 | University Of Washington | Genomic insulator elements and uses thereof |
| GB2538321A (en) | 2015-05-15 | 2016-11-16 | Glaxosmithkline Ip Dev Ltd | Artificial chromosome for retroviral production |
| GB2538324A (en) | 2015-05-15 | 2016-11-16 | Glaxosmithkline Ip Dev Ltd | Packaging cell line for retroviral production |
| KR102058113B1 (ko) * | 2015-11-23 | 2019-12-23 | 주식회사 엘지화학 | 접착력이 개선된 리튬 이차전지용 전극 및 이의 제조방법 |
| BR112018010635A2 (pt) | 2015-11-24 | 2018-11-27 | Glaxosmithkline Ip Dev Ltd | linhagens celulares estáveis para a produção retroviral |
-
2016
- 2016-11-21 WO PCT/EP2016/078334 patent/WO2017089307A1/en not_active Ceased
- 2016-11-21 CN CN201680068697.3A patent/CN108291211A/zh active Pending
- 2016-11-21 US US15/356,813 patent/US10450574B2/en active Active
- 2016-11-21 IT IT102016000117287A patent/IT201600117287A1/it unknown
- 2016-11-21 JP JP2018526787A patent/JP7110096B2/ja active Active
- 2016-11-21 EP EP16798223.0A patent/EP3380605A1/en not_active Withdrawn
- 2016-11-21 KR KR1020187014239A patent/KR102067352B1/ko not_active Expired - Fee Related
- 2016-11-21 FR FR1661254A patent/FR3044017B1/fr not_active Expired - Fee Related
- 2016-11-21 RU RU2018118964A patent/RU2749717C2/ru active
- 2016-11-21 DE DE102016122317.4A patent/DE102016122317A1/de not_active Withdrawn
- 2016-11-21 AU AU2016359838A patent/AU2016359838B2/en not_active Ceased
- 2016-11-21 CA CA3006285A patent/CA3006285A1/en active Pending
- 2016-11-21 BR BR112018010639A patent/BR112018010639A2/pt not_active Application Discontinuation
-
2018
- 2018-05-08 IL IL259223A patent/IL259223B/en unknown
- 2018-05-15 SA SA518391585A patent/SA518391585B1/ar unknown
-
2019
- 2019-10-21 US US16/658,293 patent/US20200063144A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| RU2018118964A3 (OSRAM) | 2020-04-02 |
| BR112018010639A2 (pt) | 2019-01-22 |
| IT201600117287A1 (it) | 2018-05-21 |
| RU2018118964A (ru) | 2019-12-26 |
| CN108291211A (zh) | 2018-07-17 |
| FR3044017A1 (fr) | 2017-05-26 |
| US20200063144A1 (en) | 2020-02-27 |
| IL259223A (en) | 2018-07-31 |
| AU2016359838A1 (en) | 2018-05-24 |
| JP2019500030A (ja) | 2019-01-10 |
| EP3380605A1 (en) | 2018-10-03 |
| AU2016359838B2 (en) | 2020-08-06 |
| US20170145427A1 (en) | 2017-05-25 |
| JP7110096B2 (ja) | 2022-08-01 |
| DE102016122317A1 (de) | 2017-05-24 |
| KR20180073624A (ko) | 2018-07-02 |
| SA518391585B1 (ar) | 2020-10-26 |
| CA3006285A1 (en) | 2017-06-01 |
| WO2017089307A1 (en) | 2017-06-01 |
| RU2749717C2 (ru) | 2021-06-16 |
| KR102067352B1 (ko) | 2020-01-16 |
| US10450574B2 (en) | 2019-10-22 |
| FR3044017B1 (fr) | 2019-05-03 |
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