DK3294756T3 - Retroviral partikel, omfattende mindst to forskellige indkapslede, ikke-virale RNA'er - Google Patents
Retroviral partikel, omfattende mindst to forskellige indkapslede, ikke-virale RNA'er Download PDFInfo
- Publication number
- DK3294756T3 DK3294756T3 DK16729025.3T DK16729025T DK3294756T3 DK 3294756 T3 DK3294756 T3 DK 3294756T3 DK 16729025 T DK16729025 T DK 16729025T DK 3294756 T3 DK3294756 T3 DK 3294756T3
- Authority
- DK
- Denmark
- Prior art keywords
- retroviral particle
- viral rnas
- different encapsulated
- encapsulated
- different
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
- C12N7/02—Recovery or purification
- C12N7/025—Packaging cell lines, e.g. transcomplementing cell lines, for production of virus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/0008—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
- C12N7/04—Inactivation or attenuation; Producing viral sub-units
- C12N7/045—Pseudoviral particles; Non infectious pseudovirions, e.g. genetically engineered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/85—Fusion polypeptide containing an RNA binding domain
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/15011—Lentivirus, not HIV, e.g. FIV, SIV
- C12N2740/15021—Viruses as such, e.g. new isolates, mutants or their genomic sequences
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16041—Use of virus, viral particle or viral elements as a vector
- C12N2740/16042—Use of virus, viral particle or viral elements as a vector virus or viral particle as vehicle, e.g. encapsulating small organic molecule
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16051—Methods of production or purification of viral material
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16051—Methods of production or purification of viral material
- C12N2740/16052—Methods of production or purification of viral material relating to complementing cells and packaging systems for producing virus or viral particles
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16071—Demonstrated in vivo effect
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16211—Human Immunodeficiency Virus, HIV concerning HIV gagpol
- C12N2740/16222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2795/00—Bacteriophages
- C12N2795/00011—Details
- C12N2795/18011—Details ssRNA Bacteriophages positive-sense
- C12N2795/18111—Leviviridae
- C12N2795/18151—Methods of production or purification of viral material
- C12N2795/18152—Methods of production or purification of viral material relating to complementing cells and packaging systems for producing virus or viral particles
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR1554381A FR3036118B1 (fr) | 2015-05-15 | 2015-05-15 | Particule retrovirale comportant au moins deux arn non viraux encapsides. |
FR1653280 | 2016-04-13 | ||
PCT/FR2016/051152 WO2016185125A1 (fr) | 2015-05-15 | 2016-05-13 | Particule rétrovirale comportant au moins deux arn non viraux encapsidés |
Publications (1)
Publication Number | Publication Date |
---|---|
DK3294756T3 true DK3294756T3 (da) | 2021-02-22 |
Family
ID=56121117
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK16729025.3T DK3294756T3 (da) | 2015-05-15 | 2016-05-13 | Retroviral partikel, omfattende mindst to forskellige indkapslede, ikke-virale RNA'er |
Country Status (12)
Country | Link |
---|---|
US (2) | US11124775B2 (da) |
EP (1) | EP3294756B1 (da) |
JP (1) | JP6895391B2 (da) |
CN (1) | CN107624131B (da) |
CA (1) | CA2986051C (da) |
DK (1) | DK3294756T3 (da) |
ES (1) | ES2856901T3 (da) |
HK (1) | HK1244818A1 (da) |
IL (1) | IL255566B (da) |
PT (1) | PT3294756T (da) |
SG (1) | SG11201709336SA (da) |
WO (1) | WO2016185125A1 (da) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PT3294756T (pt) * | 2015-05-15 | 2021-03-04 | Flash Therapeutics | Partícula retroviral que contém pelo menos dois arns não virais encapsidados diferentes |
FR3064276B1 (fr) * | 2017-03-21 | 2021-03-19 | Centre Nat Rech Scient | Production d'arn par des levures a particules peseudo-virales recombinantes |
CN108504689B (zh) * | 2018-05-29 | 2021-01-29 | 上海本导基因技术有限公司 | 慢病毒载体及其递送外源rna的方法 |
AU2019343045A1 (en) * | 2018-09-18 | 2021-05-13 | Vnv Newco Inc. | ARC-based capsids and uses thereof |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2375880A1 (en) * | 1999-06-22 | 2000-12-28 | Dnavec Research Inc. | A vector for the expression of two foreign genes |
WO2007038757A2 (en) | 2005-09-28 | 2007-04-05 | Attagene Inc. | Methods and compositions for non-invasive assessment of gene expression |
GB0526210D0 (en) * | 2005-12-22 | 2006-02-01 | Oxford Biomedica Ltd | Vectors |
JP6212039B2 (ja) * | 2011-07-27 | 2017-10-11 | ブクタリ | 真核細胞の形質導入に有用なウイルスベースのベクター組成物 |
EP2831225A1 (en) * | 2012-03-26 | 2015-02-04 | The United States of America, As Represented by the Secretary, Dept. of Health & Human Services Office of Technology Transfer | Delivery of packaged rna to mammalian cells |
PT3294756T (pt) * | 2015-05-15 | 2021-03-04 | Flash Therapeutics | Partícula retroviral que contém pelo menos dois arns não virais encapsidados diferentes |
BR112018010639A2 (pt) * | 2015-11-24 | 2019-01-22 | Glaxosmithkline Ip Dev Ltd | método de transfecção transitória para produção retroviral. |
DK3455239T3 (da) * | 2016-05-13 | 2021-07-05 | Flash Therapeutics | Partikel til indkapsling af et genomteknisk system |
AU2017263138B2 (en) * | 2016-05-13 | 2022-08-25 | Flash Therapeutics | Viral particle for RNA transfer, especially into cells involved in immune response |
-
2016
- 2016-05-13 PT PT167290253T patent/PT3294756T/pt unknown
- 2016-05-13 CA CA2986051A patent/CA2986051C/fr active Active
- 2016-05-13 JP JP2017559389A patent/JP6895391B2/ja active Active
- 2016-05-13 CN CN201680027973.1A patent/CN107624131B/zh active Active
- 2016-05-13 DK DK16729025.3T patent/DK3294756T3/da active
- 2016-05-13 SG SG11201709336SA patent/SG11201709336SA/en unknown
- 2016-05-13 EP EP16729025.3A patent/EP3294756B1/fr active Active
- 2016-05-13 WO PCT/FR2016/051152 patent/WO2016185125A1/fr active Application Filing
- 2016-05-13 ES ES16729025T patent/ES2856901T3/es active Active
- 2016-05-13 US US15/574,337 patent/US11124775B2/en active Active
-
2017
- 2017-11-09 IL IL255566A patent/IL255566B/en unknown
-
2018
- 2018-03-22 HK HK18104001.9A patent/HK1244818A1/zh unknown
-
2021
- 2021-05-11 US US17/317,025 patent/US20210301265A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
CA2986051C (fr) | 2023-09-26 |
EP3294756B1 (fr) | 2020-12-02 |
WO2016185125A1 (fr) | 2016-11-24 |
IL255566A (en) | 2018-01-31 |
CN107624131B (zh) | 2022-05-17 |
CN107624131A (zh) | 2018-01-23 |
US20180135025A1 (en) | 2018-05-17 |
ES2856901T3 (es) | 2021-09-28 |
IL255566B (en) | 2022-04-01 |
EP3294756A1 (fr) | 2018-03-21 |
US20210301265A1 (en) | 2021-09-30 |
CA2986051A1 (fr) | 2016-11-24 |
SG11201709336SA (en) | 2017-12-28 |
JP6895391B2 (ja) | 2021-06-30 |
PT3294756T (pt) | 2021-03-04 |
JP2018516558A (ja) | 2018-06-28 |
HK1244818A1 (zh) | 2018-08-17 |
US11124775B2 (en) | 2021-09-21 |
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