IL259141A - Modified friedreich ataxia genes and vectors for gene therapy - Google Patents
Modified friedreich ataxia genes and vectors for gene therapyInfo
- Publication number
- IL259141A IL259141A IL259141A IL25914118A IL259141A IL 259141 A IL259141 A IL 259141A IL 259141 A IL259141 A IL 259141A IL 25914118 A IL25914118 A IL 25914118A IL 259141 A IL259141 A IL 259141A
- Authority
- IL
- Israel
- Prior art keywords
- vectors
- gene therapy
- friedreich ataxia
- modified
- ataxia genes
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/76—Viruses; Subviral particles; Bacteriophages
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/0075—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the delivery route, e.g. oral, subcutaneous
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14141—Use of virus, viral particle or viral elements as a vector
- C12N2750/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2800/00—Nucleic acids vectors
- C12N2800/22—Vectors comprising a coding region that has been codon optimised for expression in a respective host
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Neurology (AREA)
- Wood Science & Technology (AREA)
- Microbiology (AREA)
- Virology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biochemistry (AREA)
- Neurosurgery (AREA)
- General Engineering & Computer Science (AREA)
- Marine Sciences & Fisheries (AREA)
- Biophysics (AREA)
- Mycology (AREA)
- Toxicology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Plant Pathology (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562251288P | 2015-11-05 | 2015-11-05 | |
US201662411980P | 2016-10-24 | 2016-10-24 | |
PCT/IB2016/056572 WO2017077451A1 (en) | 2015-11-05 | 2016-11-01 | Modified friedreich ataxia genes and vectors for gene therapy |
Publications (1)
Publication Number | Publication Date |
---|---|
IL259141A true IL259141A (en) | 2018-06-28 |
Family
ID=57288476
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL259141A IL259141A (en) | 2015-11-05 | 2018-05-03 | Modified friedreich ataxia genes and vectors for gene therapy |
Country Status (18)
Country | Link |
---|---|
US (2) | US10548947B2 (pt) |
EP (1) | EP3370778A1 (pt) |
JP (2) | JP6767483B2 (pt) |
KR (2) | KR102200642B1 (pt) |
CN (1) | CN108348621A (pt) |
AU (2) | AU2016347887B2 (pt) |
BR (1) | BR112018007453A2 (pt) |
CA (1) | CA2947584A1 (pt) |
CO (1) | CO2018004564A2 (pt) |
HK (1) | HK1250924A1 (pt) |
IL (1) | IL259141A (pt) |
MX (1) | MX2018005084A (pt) |
PE (1) | PE20181156A1 (pt) |
PH (1) | PH12018500964A1 (pt) |
RU (2) | RU2021102893A (pt) |
SG (2) | SG11201802408RA (pt) |
TW (2) | TWI654301B (pt) |
WO (1) | WO2017077451A1 (pt) |
Families Citing this family (42)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2016172659A1 (en) * | 2015-04-24 | 2016-10-27 | University Of Florida Research Foundation, Inc. | Aav vector for treatment of friedreich's ataxia |
GB201508026D0 (en) | 2015-05-11 | 2015-06-24 | Ucl Business Plc | Capsid |
ES2799515T3 (es) | 2015-05-22 | 2020-12-18 | Dmitry Dmitrievich Genkin | ADN extracelular como una diana terapéutica en la neurodegeneración |
EP3370778A1 (en) * | 2015-11-05 | 2018-09-12 | Bamboo Therapeutics, Inc. | Modified friedreich ataxia genes and vectors for gene therapy |
US12011488B2 (en) | 2016-03-23 | 2024-06-18 | The Regents Of The University Of California | Methods of treating mitochondrial disorders |
WO2017165167A1 (en) | 2016-03-23 | 2017-09-28 | The Regents Of The University Of California | Methods of treating mitochondrial disorders |
US10935747B2 (en) | 2016-09-21 | 2021-03-02 | Commscope Technologies Llc | Adapter block assembly |
BR112019009446A2 (pt) | 2016-11-09 | 2019-07-30 | Intrexon Corp | construtos de expressão da frataxina |
KR20200074132A (ko) | 2017-10-03 | 2020-06-24 | 프리베일 테라퓨틱스, 인크. | 리소좀 장애를 위한 유전자 요법 |
WO2019070893A1 (en) | 2017-10-03 | 2019-04-11 | Prevail Therapeutics, Inc. | GENE THERAPIES FOR LYSOSOMAL DISORDERS |
MX2020004005A (es) | 2017-10-03 | 2020-10-05 | Prevail Therapeutics Inc | Terapias genicas para los trastornos lisosomales. |
EP3697914B9 (en) * | 2017-10-17 | 2023-10-04 | Fundació Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol | Vectors for the treatment of friedreich's ataxia |
KR20200122320A (ko) | 2018-01-16 | 2020-10-27 | 씨엘에스 테라퓨틱스 리미티드 | 데옥시리보뉴클레아제 (dnase) 활성을 갖는 효소의 간 발현에 의한 질환의 치료 |
CN112272672A (zh) | 2018-04-03 | 2021-01-26 | 斯特里迪比奥公司 | 抗体逃避性病毒载体 |
CA3108386A1 (en) * | 2018-08-02 | 2020-02-06 | Dyne Therapeutics, Inc. | Muscle targeting complexes and uses thereof for treating friedreich's ataxia |
JP2021533200A (ja) | 2018-08-02 | 2021-12-02 | ダイン セラピューティクス, インコーポレーテッドDyne Therapeutics, Inc. | 顔面・肩甲・上腕筋ジストロフィーを処置するための筋標的化複合体およびそれらの使用 |
AU2018436152A1 (en) * | 2018-08-10 | 2021-02-04 | Logicbio Therapeutics, Inc. | Non-disruptive gene therapy for the treatment of MMA |
AU2019346655A1 (en) * | 2018-09-28 | 2021-05-06 | Voyager Therapeutics, Inc. | Frataxin expression constructs having engineered promoters and methods of use thereof |
US20220054656A1 (en) * | 2018-11-16 | 2022-02-24 | Asklepios Biopharmaceutical, Inc. | Therapeutic adeno-associated virus for treating pompe disease |
CA3120289A1 (en) * | 2018-11-21 | 2020-05-28 | Stridebio, Inc. | Recombinant viral vectors and nucleic acids for producing the same |
AR118465A1 (es) | 2019-03-21 | 2021-10-06 | Stridebio Inc | Vectores de virus adenoasociados recombinantes |
CA3133357A1 (en) * | 2019-03-27 | 2020-10-01 | Sigilon Therapeutics, Inc. | Compositions, devices and methods for factor vii therapy |
WO2020210713A1 (en) | 2019-04-10 | 2020-10-15 | Prevail Therapeutics, Inc. | Gene therapies for lysosomal disorders |
EP3989994A4 (en) * | 2019-06-30 | 2023-08-09 | John Fraser Wright | RECOMBINANT AAV VECTORS WITH ALTERED IMMUNOGENICITY AND METHODS FOR THEIR PRODUCTION |
EP3999120A4 (en) * | 2019-07-04 | 2024-02-21 | Children's Medical Research Institute | METHODS AND ADENO-ASSOCIATED VIRUS VECTORS FOR IN VIVO TRANSDUCTION |
CA3147034A1 (en) * | 2019-07-12 | 2021-01-21 | Cls Therapeutics Limited | Treatment of diseases associated with protein misfolding by nervous system expression of an enzyme which has a deoxyribonuclease (dnase) activity |
AU2020346914A1 (en) * | 2019-09-13 | 2022-04-21 | Prevail Therapeutics, Inc. | Compositions and methods for treatment of Friedreich's Ataxia |
IL292297A (en) | 2019-10-17 | 2022-06-01 | Stridebio Inc | Adeno-associated viral vectors for the treatment of Niemann-Pick type c disease |
US20230211012A1 (en) * | 2019-12-19 | 2023-07-06 | The Trustees Of The University Of Pennsylvania | Compositions for treating friedreich’s ataxia |
CN113755524B (zh) * | 2020-06-02 | 2023-11-03 | 舒泰神(北京)生物制药股份有限公司 | 用于治疗脊髓性肌萎缩的腺相关病毒载体及其用途 |
WO2022026516A1 (en) * | 2020-07-29 | 2022-02-03 | The Board Of Regents Of The University Of Texas System | Transgene cassettes, aav vectors, and aav viral vectors for expression of human codon-optimized cstb |
WO2022097008A1 (en) | 2020-11-03 | 2022-05-12 | Pfizer Inc. | Methods for purification of aav vectors by anion exchange chromatography |
MX2023007612A (es) | 2020-12-23 | 2023-07-12 | Pfizer | Metodos para purificacion de vectores aav por cromatografia de afinidad. |
AU2022205088A1 (en) * | 2021-01-04 | 2023-07-20 | Aavantibio, Inc. | Methods and compositions for treatment of friedreich's ataxia |
US20240050521A1 (en) * | 2021-01-11 | 2024-02-15 | The Trustees Of The University Of Pennsylvania | Compositions for treating friedreich's ataxia |
US11638761B2 (en) | 2021-07-09 | 2023-05-02 | Dyne Therapeutics, Inc. | Muscle targeting complexes and uses thereof for treating Facioscapulohumeral muscular dystrophy |
WO2023114816A1 (en) | 2021-12-14 | 2023-06-22 | Neurogene, Inc. | Recombinant optimized galc constructs and methods for treating galc-associated disorders |
GB202201242D0 (en) | 2022-01-31 | 2022-03-16 | Univ Edinburgh | Recombinant optimized mecp2 cassettes and methods for treating rett syndrome and related disorders |
GB202206336D0 (en) | 2022-04-29 | 2022-06-15 | Univ Edinburgh | Recombinant therapeutic FMR1 constructs and methods of treating fragile X syndrome and related disorders |
WO2024003687A1 (en) | 2022-06-28 | 2024-01-04 | Pfizer Inc. | Nucleic acids encoding acid alpha-glucosidase (gaa) and vectors for gene therapy |
WO2024011109A2 (en) * | 2022-07-06 | 2024-01-11 | Adverum Biotechnologies, Inc. | Compositions and methods for treatment of achromotopsia |
CN117089514A (zh) * | 2023-10-13 | 2023-11-21 | 思鹏生物科技(苏州)有限公司 | 提升hek293细胞系aav生产效率的细胞筛选驯化方法 |
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EP0871483B1 (en) | 1995-06-07 | 2003-04-16 | The University Of North Carolina At Chapel Hill | Helper virus-free aav production |
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JP4860886B2 (ja) | 2000-06-01 | 2012-01-25 | ユニヴァーシティ・オヴ・ノース・キャロライナ・アト・チャペル・ヒル | 二本鎖パルボウイルスベクター |
WO2002046359A2 (en) | 2000-12-07 | 2002-06-13 | Universite De Nantes | Inducible highly productive raav packaging cell-lines |
SI2292780T1 (sl) | 2003-09-30 | 2017-12-29 | The Trustees Of The University Of Pennsylvania | Genotipske skupine, zaporedja, vektorji, ki vsebujejo le-te z adenovirusi povezanega virusa (aav) in njihova uporaba |
WO2006066066A2 (en) | 2004-12-15 | 2006-06-22 | University Of North Carolina At Chapel Hill | Chimeric vectors |
DK3216802T3 (da) | 2007-08-20 | 2021-01-04 | Glaxo Group Ltd | Produktionsfremgangsmåde |
WO2010093784A2 (en) | 2009-02-11 | 2010-08-19 | The University Of North Carolina At Chapel Hill | Modified virus vectors and methods of making and using the same |
EP2516664B1 (en) | 2009-12-21 | 2015-07-22 | Pharmathene Inc. | Recombinant butyrylcholinesterases and truncates thereof |
KR101784177B1 (ko) * | 2010-02-08 | 2017-10-11 | 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 | Rantes를 암호화하는 핵산 분자, 그리고 이를 포함하는 조성물 및 이의 사용 방법 |
EP2394667A1 (en) * | 2010-06-10 | 2011-12-14 | Laboratorios Del Dr. Esteve, S.A. | Vectors and sequences for the treatment of diseases |
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US9066966B2 (en) * | 2013-02-01 | 2015-06-30 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Methods and pharmaceutical compositions for the treatment of cardiomyopathy due to friedreich ataxia |
KR102527259B1 (ko) | 2013-03-15 | 2023-04-27 | 더 칠드런스 호스피탈 오브 필라델피아 | 스터퍼/필러 폴리누클레오티드 서열을 포함하는 벡터 및 사용 방법 |
DK2968605T3 (da) | 2013-03-15 | 2022-09-26 | Univ North Carolina Chapel Hill | Fremgangsmåder og sammensætninger til dobbelte glycanbindende aav-vektorer |
US11136557B2 (en) | 2013-05-31 | 2021-10-05 | The Regents Of The University Of California | Adeno-associated virus variants and methods of use thereof |
AU2014287005C1 (en) | 2013-07-12 | 2021-06-03 | The Children's Hospital Of Philadelphia | AAV vector and assay for anti-AAV (adeno-associated virus) neutralizing antibodies |
ES2774966T3 (es) | 2013-07-22 | 2020-07-23 | Childrens Hospital Philadelphia | Variantes de aav y composiciones, métodos y usos para la transferencia de genes a células, órganos y tejidos |
PT3459965T (pt) | 2013-10-11 | 2021-02-25 | Massachusetts Eye & Ear Infirmary | Métodos de previsão de sequências de vírus ancestrais e suas utilizações |
GB201403684D0 (en) | 2014-03-03 | 2014-04-16 | King S College London | Vector |
EP3370778A1 (en) * | 2015-11-05 | 2018-09-12 | Bamboo Therapeutics, Inc. | Modified friedreich ataxia genes and vectors for gene therapy |
-
2016
- 2016-11-01 EP EP16795164.9A patent/EP3370778A1/en not_active Withdrawn
- 2016-11-01 SG SG11201802408RA patent/SG11201802408RA/en unknown
- 2016-11-01 AU AU2016347887A patent/AU2016347887B2/en active Active
- 2016-11-01 RU RU2021102893A patent/RU2021102893A/ru unknown
- 2016-11-01 CN CN201680064440.0A patent/CN108348621A/zh active Pending
- 2016-11-01 KR KR1020187015819A patent/KR102200642B1/ko active IP Right Grant
- 2016-11-01 WO PCT/IB2016/056572 patent/WO2017077451A1/en active Application Filing
- 2016-11-01 JP JP2018521395A patent/JP6767483B2/ja active Active
- 2016-11-01 PE PE2018000726A patent/PE20181156A1/es unknown
- 2016-11-01 US US15/340,721 patent/US10548947B2/en active Active
- 2016-11-01 KR KR1020217000034A patent/KR20210005994A/ko active Application Filing
- 2016-11-01 BR BR112018007453A patent/BR112018007453A2/pt not_active IP Right Cessation
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- 2016-11-04 TW TW105135911A patent/TWI654301B/zh active
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2018
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2019
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2020
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