IL258851B2 - Set up an electrowetting microfluidic device with a covalently bonded hydrophobic surface - Google Patents

Set up an electrowetting microfluidic device with a covalently bonded hydrophobic surface

Info

Publication number
IL258851B2
IL258851B2 IL258851A IL25885118A IL258851B2 IL 258851 B2 IL258851 B2 IL 258851B2 IL 258851 A IL258851 A IL 258851A IL 25885118 A IL25885118 A IL 25885118A IL 258851 B2 IL258851 B2 IL 258851B2
Authority
IL
Israel
Prior art keywords
droplet
microfluidic device
microfluidic
layer
substrate
Prior art date
Application number
IL258851A
Other languages
English (en)
Hebrew (he)
Other versions
IL258851A (en
IL258851B1 (en
Original Assignee
Berkeley Lights Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US15/135,707 external-priority patent/US10723988B2/en
Application filed by Berkeley Lights Inc filed Critical Berkeley Lights Inc
Publication of IL258851A publication Critical patent/IL258851A/en
Publication of IL258851B1 publication Critical patent/IL258851B1/en
Publication of IL258851B2 publication Critical patent/IL258851B2/en

Links

Classifications

    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/50273Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means or forces applied to move the fluids
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502707Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the manufacture of the container or its components
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502769Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements
    • B01L3/502784Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements specially adapted for droplet or plug flow, e.g. digital microfluidics
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502769Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements
    • B01L3/502784Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements specially adapted for droplet or plug flow, e.g. digital microfluidics
    • B01L3/502792Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements specially adapted for droplet or plug flow, e.g. digital microfluidics for moving individual droplets on a plate, e.g. by locally altering surface tension
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06Fluid handling related problems
    • B01L2200/0605Metering of fluids
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06Fluid handling related problems
    • B01L2200/0647Handling flowable solids, e.g. microscopic beads, cells, particles
    • B01L2200/0668Trapping microscopic beads
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06Fluid handling related problems
    • B01L2200/0673Handling of plugs of fluid surrounded by immiscible fluid
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/08Geometry, shape and general structure
    • B01L2300/0809Geometry, shape and general structure rectangular shaped
    • B01L2300/0816Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/08Geometry, shape and general structure
    • B01L2300/0861Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0864Configuration of multiple channels and/or chambers in a single devices comprising only one inlet and multiple receiving wells, e.g. for separation, splitting
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/16Surface properties and coatings
    • B01L2300/161Control and use of surface tension forces, e.g. hydrophobic, hydrophilic
    • B01L2300/165Specific details about hydrophobic, oleophobic surfaces
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00Moving or stopping fluids
    • B01L2400/04Moving fluids with specific forces or mechanical means
    • B01L2400/0403Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0415Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic
    • B01L2400/0424Dielectrophoretic forces
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00Moving or stopping fluids
    • B01L2400/04Moving fluids with specific forces or mechanical means
    • B01L2400/0403Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0415Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic
    • B01L2400/0427Electrowetting

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Clinical Laboratory Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Micromachines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
IL258851A 2015-10-27 2018-04-22 Set up an electrowetting microfluidic device with a covalently bonded hydrophobic surface IL258851B2 (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201562246605P 2015-10-27 2015-10-27
US201562247725P 2015-10-28 2015-10-28
US15/135,707 US10723988B2 (en) 2015-04-22 2016-04-22 Microfluidic cell culture
US201662342131P 2016-05-26 2016-05-26
US201662410238P 2016-10-19 2016-10-19
PCT/US2016/059234 WO2017075295A1 (en) 2015-10-27 2016-10-27 Microfluidic electrowetting device apparatus having a covalently bound hydrophobic surface

Publications (3)

Publication Number Publication Date
IL258851A IL258851A (en) 2018-06-28
IL258851B1 IL258851B1 (en) 2023-04-01
IL258851B2 true IL258851B2 (en) 2023-08-01

Family

ID=57281295

Family Applications (1)

Application Number Title Priority Date Filing Date
IL258851A IL258851B2 (en) 2015-10-27 2018-04-22 Set up an electrowetting microfluidic device with a covalently bonded hydrophobic surface

Country Status (10)

Country Link
EP (2) EP3862088A1 (ja)
JP (2) JP6891169B2 (ja)
KR (1) KR102426825B1 (ja)
CN (2) CN108472649B (ja)
AU (2) AU2016344171B2 (ja)
CA (1) CA3001616C (ja)
IL (1) IL258851B2 (ja)
SG (2) SG11201802968VA (ja)
TW (2) TWI714656B (ja)
WO (1) WO2017075295A1 (ja)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2019518223A (ja) 2016-03-24 2019-06-27 バイオロジカル ダイナミクス,インク. 使い捨て可能な流体カートリッジおよびコンポーネント
AU2017375631B2 (en) 2016-12-12 2023-06-15 xCella Biosciences, Inc. Methods and systems for screening using microcapillary arrays
CN110809495A (zh) * 2017-04-26 2020-02-18 伯克利之光生命科技公司 使用具有优化电润湿表面的微流体装置的生物处理系统和方法
CN110785236A (zh) * 2017-06-21 2020-02-11 贝斯4创新公司 研究诸如核酸之类的分子的方法
EP4450162A2 (en) * 2017-06-21 2024-10-23 Lightcast Discovery Ltd Microdroplet manipulation device
CN107803228B (zh) * 2017-11-06 2019-10-18 南京理工大学 一种自动分离水油混合液滴的装置及其分离方法
JP7036746B2 (ja) * 2017-11-29 2022-03-15 積水化学工業株式会社 マイクロ流体チップ
JP2021509265A (ja) 2017-12-19 2021-03-25 バイオロジカル ダイナミクス,インク. 生体サンプルからの複数の分析物の検出のための方法およびデバイス
US20190262829A1 (en) * 2018-02-28 2019-08-29 Volta Labs, Inc. Directing Motion of Droplets Using Differential Wetting
US11883833B2 (en) 2018-04-02 2024-01-30 Biological Dynamics, Inc. Dielectric materials
KR102040286B1 (ko) * 2018-07-09 2019-11-04 성균관대학교 산학협력단 종이기반 디지털 미세 유체역학기기의 제조 방법
WO2020021896A1 (ja) * 2018-07-25 2020-01-30 エイブル株式会社 細胞刺激装置、細胞刺激方法、培養生成物の製造方法、単離細胞の製造方法及び細胞増殖方法
CN112449682B (zh) * 2018-08-01 2024-03-08 澳门大学 用于芯片上微流体分配的设备和方法
US10913067B2 (en) * 2018-10-01 2021-02-09 Sharp Life Science (Eu) Limited Barrier droplet configurations against migration between droplets on AM-EWOD devices
WO2020081478A1 (en) * 2018-10-15 2020-04-23 E Ink Corporation Digital microfluidic delivery device
KR102585756B1 (ko) * 2018-11-12 2023-10-11 현대자동차주식회사 역전기습윤 에너지 수확장치
GB201909514D0 (en) * 2018-11-20 2019-08-14 Lightcast Discovery Ltd Device and method for microdroplet detection of cells
CN109487234A (zh) * 2018-12-18 2019-03-19 湖北大学 超疏油涂层及其制备方法和应用
WO2020147012A1 (zh) * 2019-01-15 2020-07-23 京东方科技集团股份有限公司 生物检测基板、微流控芯片及驱动方法、微流控检测组件
CN111450906B (zh) * 2019-01-22 2022-02-25 北京纳米能源与系统研究所 自驱动型电润湿阀门、纸基微流体芯片及免疫检测器件
CN109752856B (zh) * 2019-03-08 2022-08-12 京东方科技集团股份有限公司 数字微流器件、制作方法、裸眼三维显示装置和显示方法
EP3962651A4 (en) * 2019-04-30 2022-11-23 Nuclera Nucleics Ltd MICROFLUIDIC DEVICES AND METHODS OF MAKING THEIR
TWI745719B (zh) 2019-07-15 2021-11-11 長庚大學 奈米粒子控制量測系統及其運作方法
CA3155946A1 (en) * 2019-10-25 2021-04-29 Angel Navas ANGELES Systems for operating microfluidic devices
CN111056525B (zh) * 2019-11-12 2023-04-18 重庆大学 交流电浸润效应致微通道沸腾换热强化和流动不稳定性抑制方法
EP4061530A4 (en) 2019-11-20 2023-12-27 Nuclera Nucleics Ltd SPATIALLY VARIABLE HYDROPHOBIC LAYERS FOR DIGITAL MICROFLUIDICS
US11554374B2 (en) 2020-01-17 2023-01-17 Nuclera Nucleics Ltd. Spatially variable dielectric layers for digital microfluidics
WO2021154627A1 (en) 2020-01-27 2021-08-05 E Ink Corporation Method for degassing liquid droplets by electrowetting actuation at higher temperatures
JP2023513832A (ja) 2020-02-18 2023-04-03 ヌークレラ ヌクリークス, リミテッド Ewodアレイの高周波ac駆動のためのアダプティブゲート駆動
JP2023514278A (ja) 2020-02-19 2023-04-05 ヌークレラ ヌクリークス, リミテッド EWoDアレイの高周波数AC駆動のためのラッチ付きトランジスタ駆動
EP4142942A4 (en) 2020-04-27 2024-05-22 Nuclera Ltd SEGMENTED COVER PLATE FOR VARIABLE DRIVE AND SHORT CIRCUIT PROTECTION FOR DIGITAL MICROFLUIDICS
CN112175824B (zh) * 2020-09-17 2022-05-27 厦门德运芯准科技有限公司 一种基于数字微流控技术的全自动单细胞捕获芯片及其应用
CN114317220A (zh) * 2020-09-30 2022-04-12 富佳生技股份有限公司 核酸检测盒及核酸检测设备
JP2022058244A (ja) * 2020-09-30 2022-04-11 富佳生技股▲ふん▼有限公司 核酸検出箱及び核酸検出デバイス
US20220097052A1 (en) * 2020-09-30 2022-03-31 Icare Diagnostics International Co. Ltd. Detection chip, nucleic acid detection kit, and nucleic acid detection device
WO2022216283A1 (en) * 2021-04-07 2022-10-13 Hewlett-Packard Development Company, L.P. Dielectric layer for microfluidic receptacle
JP2023157546A (ja) * 2022-04-15 2023-10-26 Toppanホールディングス株式会社 マイクロ流路チップおよびマイクロ流路チップの製造方法
TWI837762B (zh) * 2022-08-10 2024-04-01 醫華生技股份有限公司 非接觸式分選裝置與其光感應結構、及生物微粒分選設備
WO2024081151A1 (en) * 2022-10-11 2024-04-18 Ohio State Innovation Foundation Detection of an amphiphile using visual inspection of a ligand-modified substrate
CN116060148B (zh) * 2023-02-17 2024-06-07 西南石油大学 一种纳米通道原位可控疏水改性方法
CN117920372B (zh) * 2024-03-18 2024-07-05 微纳动力(北京)科技有限责任公司 一种光电镊芯片及其制造方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080225378A1 (en) * 2007-03-13 2008-09-18 Varioptic Dielectric coatings for electrowetting applications
US20090170186A1 (en) * 2004-04-12 2009-07-02 Ming Chiang Wu Optoelectronic tweezers for microparticle and cell manipulation

Family Cites Families (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6379929B1 (en) * 1996-11-20 2002-04-30 The Regents Of The University Of Michigan Chip-based isothermal amplification devices and methods
US6294063B1 (en) 1999-02-12 2001-09-25 Board Of Regents, The University Of Texas System Method and apparatus for programmable fluidic processing
CN1181337C (zh) * 2000-08-08 2004-12-22 清华大学 微流体系统中实体分子的操纵方法及相关试剂盒
US6942776B2 (en) 1999-05-18 2005-09-13 Silicon Biosystems S.R.L. Method and apparatus for the manipulation of particles by means of dielectrophoresis
US6958132B2 (en) * 2002-05-31 2005-10-25 The Regents Of The University Of California Systems and methods for optical actuation of microfluidics based on opto-electrowetting
JP2006507921A (ja) 2002-06-28 2006-03-09 プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ 流体分散のための方法および装置
US6911132B2 (en) * 2002-09-24 2005-06-28 Duke University Apparatus for manipulating droplets by electrowetting-based techniques
US7041481B2 (en) 2003-03-14 2006-05-09 The Regents Of The University Of California Chemical amplification based on fluid partitioning
US20050164402A1 (en) * 2003-07-14 2005-07-28 Belisle Christopher M. Sample presentation device
JP4773360B2 (ja) * 2003-11-17 2011-09-14 コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ 流体を操作するためのシステム
TWI258456B (en) * 2005-05-31 2006-07-21 Academia Sinica Fluid driving device
JP2009536313A (ja) 2006-01-11 2009-10-08 レインダンス テクノロジーズ, インコーポレイテッド ナノリアクターの形成および制御において使用するマイクロ流体デバイスおよび方法
US20150107995A1 (en) * 2006-04-18 2015-04-23 Advanced Liquid Logic, Inc. Droplet Actuator Devices and Methods for Manipulating Beads
US20080014589A1 (en) 2006-05-11 2008-01-17 Link Darren R Microfluidic devices and methods of use thereof
JP2008089752A (ja) * 2006-09-29 2008-04-17 Sony Corp エレクトロウエッティング装置とこれを用いた可変焦点レンズ、光ピックアップ装置、光記録再生装置、液滴操作装置、光学素子、ズームレンズ、撮像装置、光変調装置及び表示装置
US20080153134A1 (en) * 2006-12-22 2008-06-26 Willy Wiyatno Methods and apparatus for generating hydrophilic patterning of high density microplates using an amphiphilic polymer
US8685344B2 (en) 2007-01-22 2014-04-01 Advanced Liquid Logic, Inc. Surface assisted fluid loading and droplet dispensing
WO2008119066A1 (en) 2007-03-28 2008-10-02 The Regents Of The University Of California Single-sided lateral-field and phototransistor-based optoelectronic tweezers
TWI479195B (zh) * 2007-09-12 2015-04-01 Univ Cincinnati 電流體裝置、視覺顯示器及製造與操作該等電流體裝置之方法
US9279435B2 (en) * 2008-02-25 2016-03-08 University of Washington through its Center for Communication Vibration-driven droplet transport devices
WO2009111723A1 (en) * 2008-03-07 2009-09-11 Drexel University Electrowetting microarray printing system and methods for bioactive tissue construct manufacturing
JP2010107908A (ja) * 2008-10-31 2010-05-13 Sony Corp エレクトロウェッティング装置、可変焦点レンズ、光ピックアップ装置、光記録再生装置、液滴操作装置、光学素子、ズームレンズ、撮像装置、光変調装置、表示装置、ストロボ装置及びエレクトロウェッティング装置の駆動方法
CN101592627B (zh) * 2009-03-19 2012-12-05 中国科学院苏州纳米技术与纳米仿生研究所 多通道高灵敏生物传感器的制作集成方法
FR2946658B1 (fr) * 2009-06-11 2011-08-05 Commissariat Energie Atomique Dispositif microfluidique comportant deux couches hydrophobes assemblees l'une a l'autre et procede d'assemblage
US8685325B2 (en) * 2010-03-09 2014-04-01 Sparkle Power Inc. Field-programmable lab-on-a-chip based on microelectrode array architecture
KR20120066100A (ko) * 2010-12-14 2012-06-22 한국전자통신연구원 혈액 분석용 소자 및 이를 이용한 혈액 분석 방법
CN102671724B (zh) * 2011-02-17 2015-03-11 王崇智 微电极阵列结构
US9227200B2 (en) 2011-06-03 2016-01-05 The Regents Of The University Of California Microfluidic devices with flexible optically transparent electrodes
US8883014B2 (en) * 2011-06-03 2014-11-11 The Regents Of The University Of California Monolithically formed EWOD device and method of making the same
US20130062205A1 (en) * 2011-09-14 2013-03-14 Sharp Kabushiki Kaisha Active matrix device for fluid control by electro-wetting and dielectrophoresis and method of driving
CN102500436A (zh) * 2011-09-28 2012-06-20 复旦大学 基于电润湿的单面二维驱动数字微流控芯片
US8821705B2 (en) * 2011-11-25 2014-09-02 Tecan Trading Ag Digital microfluidics system with disposable cartridges
JP6388541B2 (ja) * 2012-01-10 2018-09-12 プレジデント アンド フェローズ オブ ハーバード カレッジ 流体および固体反発性のための表面の改質
WO2013110146A2 (en) * 2012-01-24 2013-08-01 Katholieke Universiteit Leuven Patterning device
CN102866193B (zh) * 2012-09-04 2015-04-01 吴传勇 基于介电泳来操控液体中的粒子的器件及方法
US9857333B2 (en) * 2012-10-31 2018-01-02 Berkeley Lights, Inc. Pens for biological micro-objects
US9403172B2 (en) 2012-11-08 2016-08-02 Berkeley Lights, Inc. Circuit based optoelectronic tweezers
US9239328B2 (en) * 2012-12-17 2016-01-19 Taiwan Semiconductor Manufacturing Company, Ltd. Systems and methods for an integrated bio-entity manipulation and processing semiconductor device
US9366647B2 (en) * 2013-03-14 2016-06-14 Taiwan Semiconductor Manufacturing Company, Ltd. Optical detection for bio-entities
CN104661754B (zh) * 2013-01-09 2018-03-27 泰肯贸易股份公司 用于微流体系统的可置换盒体
US9453838B2 (en) * 2013-03-12 2016-09-27 Asociación Centro de Investigación Cooperative en Biomateriales Methods for making microarrays and their uses
WO2014167858A1 (ja) * 2013-04-12 2014-10-16 パナソニック株式会社 溶媒制御方法およびエレクトロウェッティング用溶媒
CN103470852A (zh) * 2013-09-12 2013-12-25 东南大学 一种基于电润湿技术的微流体阀装置
WO2015092064A1 (en) * 2013-12-20 2015-06-25 Universiteit Gent Adiabatic coupler
CN106461696B (zh) * 2014-04-25 2019-06-07 伯克利之光生命科技公司 在同一微流体装置中提供dep操控设备和可控电润湿设备
US20150377831A1 (en) * 2014-06-27 2015-12-31 The Governing Council Of The University Of Toronto Digital microfluidic devices and methods employing integrated nanostructured electrodeposited electrodes
CN107257711B (zh) * 2014-12-05 2019-11-22 加利福尼亚大学董事会 具有集成网状地线的单面光致动微流体器件

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090170186A1 (en) * 2004-04-12 2009-07-02 Ming Chiang Wu Optoelectronic tweezers for microparticle and cell manipulation
US20080225378A1 (en) * 2007-03-13 2008-09-18 Varioptic Dielectric coatings for electrowetting applications

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
FURUTA, TSUTOMU, ET AL. , TSUTOMU, ET AL., FURUTA, 31 December 2012 (2012-12-31) *

Also Published As

Publication number Publication date
TW202126571A (zh) 2021-07-16
JP2018535088A (ja) 2018-11-29
TW201726540A (zh) 2017-08-01
AU2016344171B2 (en) 2021-09-23
JP2021126656A (ja) 2021-09-02
SG11201802968VA (en) 2018-05-30
CN114289087A (zh) 2022-04-08
EP3370868B1 (en) 2020-12-09
IL258851A (en) 2018-06-28
EP3370868A1 (en) 2018-09-12
CA3001616A1 (en) 2017-05-04
CN108472649B (zh) 2022-01-14
AU2021286430A1 (en) 2022-01-20
AU2016344171A1 (en) 2018-05-10
IL258851B1 (en) 2023-04-01
WO2017075295A8 (en) 2018-05-31
EP3862088A1 (en) 2021-08-11
CN114289087B (zh) 2024-03-26
WO2017075295A1 (en) 2017-05-04
JP6891169B2 (ja) 2021-06-18
KR102426825B1 (ko) 2022-07-28
CA3001616C (en) 2023-09-05
CN108472649A (zh) 2018-08-31
TWI781484B (zh) 2022-10-21
KR20180072812A (ko) 2018-06-29
TWI714656B (zh) 2021-01-01
SG10202107069UA (en) 2021-07-29

Similar Documents

Publication Publication Date Title
US11964275B2 (en) Microfluidic apparatus having an optimized electrowetting surface and related systems and methods
EP3370868B1 (en) Microfluidic electrowetting device apparatus having a covalently bound hydrophobic surface
US10569271B2 (en) Single-sided light-actuated microfluidic device with integrated mesh ground
US11192108B2 (en) Actuated microfluidic structures for directed flow in a microfluidic device and methods of use thereof
US20200171501A1 (en) Biological Process Systems and Methods Using Microfluidic Apparatus Having an Optimized Electrowetting Surface
US10766033B2 (en) Droplet generation in a microfluidic device having an optoelectrowetting configuration
US20160199837A1 (en) Movement and selection of micro-objects in a microfluidic apparatus