IL23561A - Delta16-androsten-11-ones and process for their preparation - Google Patents
Delta16-androsten-11-ones and process for their preparationInfo
- Publication number
- IL23561A IL23561A IL23561A IL2356165A IL23561A IL 23561 A IL23561 A IL 23561A IL 23561 A IL23561 A IL 23561A IL 2356165 A IL2356165 A IL 2356165A IL 23561 A IL23561 A IL 23561A
- Authority
- IL
- Israel
- Prior art keywords
- group
- formula
- compound
- radical
- reducing
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims description 7
- 238000002360 preparation method Methods 0.000 title description 2
- 150000001875 compounds Chemical class 0.000 claims description 5
- 229910052751 metal Inorganic materials 0.000 claims description 5
- 239000002184 metal Substances 0.000 claims description 5
- 239000002253 acid Substances 0.000 claims description 3
- 150000002576 ketones Chemical class 0.000 claims description 3
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 2
- 239000003960 organic solvent Substances 0.000 claims description 2
- 238000010992 reflux Methods 0.000 claims description 2
- 229910052708 sodium Inorganic materials 0.000 claims description 2
- 239000011734 sodium Substances 0.000 claims description 2
- DNIAPMSPPWPWGF-GSVOUGTGSA-N (R)-(-)-Propylene glycol Chemical compound C[C@@H](O)CO DNIAPMSPPWPWGF-GSVOUGTGSA-N 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 230000001225 therapeutic effect Effects 0.000 claims 2
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 claims 1
- 229910052783 alkali metal Inorganic materials 0.000 claims 1
- 150000001340 alkali metals Chemical class 0.000 claims 1
- NXQOQNROJJFYCJ-FZFXZXLVSA-N androst-16-ene Chemical compound C1CCC[C@]2(C)[C@H]3CC[C@](C)(C=CC4)[C@@H]4[C@@H]3CCC21 NXQOQNROJJFYCJ-FZFXZXLVSA-N 0.000 claims 1
- 125000004432 carbon atom Chemical group C* 0.000 claims 1
- 150000001732 carboxylic acid derivatives Chemical class 0.000 claims 1
- 150000007522 mineralic acids Chemical class 0.000 claims 1
- 150000007524 organic acids Chemical class 0.000 claims 1
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- 239000003638 chemical reducing agent Substances 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- QZLYKIGBANMMBK-UGCZWRCOSA-N 5α-Androstane Chemical class C([C@@H]1CC2)CCC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CCC[C@@]2(C)CC1 QZLYKIGBANMMBK-UGCZWRCOSA-N 0.000 description 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 1
- 125000001931 aliphatic group Chemical group 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 230000001766 physiological effect Effects 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 239000011541 reaction mixture Substances 0.000 description 1
- 125000001424 substituent group Chemical group 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0003—Androstane derivatives
- C07J1/0011—Androstane derivatives substituted in position 17 by a keto group
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0003—Androstane derivatives
- C07J1/0014—Androstane derivatives substituted in position 17 alfa, not substituted in position 17 beta
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0003—Androstane derivatives
- C07J1/0018—Androstane derivatives substituted in position 17 beta, not substituted in position 17 alfa
- C07J1/0022—Androstane derivatives substituted in position 17 beta, not substituted in position 17 alfa the substituent being an OH group free esterified or etherified
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J13/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17
- C07J13/005—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17 with double bond in position 16 (17)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
- C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR975520A FR1514076A (fr) | 1964-05-22 | 1964-05-22 | Nouvelles cétones insaturées de la série de l'androstane et procédé de préparation |
| FR985626A FR3808M (fr) | 1964-05-22 | 1964-08-19 | Nouveau médicament neurosédatif, hypnogene et relaxant musculaire. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL23561A true IL23561A (en) | 1968-12-26 |
Family
ID=26207820
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL23561A IL23561A (en) | 1964-05-22 | 1965-05-18 | Delta16-androsten-11-ones and process for their preparation |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US3324001A (fr) |
| BE (1) | BE663949A (fr) |
| BR (1) | BR6569824D0 (fr) |
| CH (1) | CH436281A (fr) |
| DE (1) | DE1468911B1 (fr) |
| DK (1) | DK121225B (fr) |
| FR (2) | FR1514076A (fr) |
| GB (2) | GB1057336A (fr) |
| IL (1) | IL23561A (fr) |
| NL (2) | NL6506520A (fr) |
| SE (1) | SE323366B (fr) |
-
0
- NL NL125070D patent/NL125070C/xx active
-
1964
- 1964-05-22 FR FR975520A patent/FR1514076A/fr not_active Expired
- 1964-08-19 FR FR985626A patent/FR3808M/fr active Active
-
1965
- 1965-05-05 DE DE19651468911 patent/DE1468911B1/de not_active Withdrawn
- 1965-05-06 SE SE5968/65A patent/SE323366B/xx unknown
- 1965-05-07 DK DK230965AA patent/DK121225B/da unknown
- 1965-05-12 CH CH657965A patent/CH436281A/fr unknown
- 1965-05-13 US US455603A patent/US3324001A/en not_active Expired - Lifetime
- 1965-05-14 BE BE663949D patent/BE663949A/xx unknown
- 1965-05-18 IL IL23561A patent/IL23561A/en unknown
- 1965-05-20 GB GB21415/65A patent/GB1057336A/en not_active Expired
- 1965-05-20 GB GB31461/66A patent/GB1057337A/en not_active Expired
- 1965-05-21 NL NL6506520A patent/NL6506520A/xx unknown
- 1965-05-21 BR BR169824/65A patent/BR6569824D0/pt unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NL125070C (fr) | |
| SE323366B (fr) | 1970-05-04 |
| DE1468911B1 (de) | 1971-05-27 |
| GB1057336A (en) | 1967-02-01 |
| BE663949A (fr) | 1965-11-16 |
| FR1514076A (fr) | 1968-02-23 |
| DK121225B (da) | 1971-09-27 |
| NL6506520A (fr) | 1965-11-23 |
| FR3808M (fr) | 1966-01-03 |
| US3324001A (en) | 1967-06-06 |
| BR6569824D0 (pt) | 1973-08-16 |
| GB1057337A (en) | 1967-02-01 |
| CH436281A (fr) | 1967-05-31 |
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