IE37657B1 - Derivatives of 6alpha-methyl-prednisolone processes for their preparation and compositions incorporating them - Google Patents

Derivatives of 6alpha-methyl-prednisolone processes for their preparation and compositions incorporating them

Info

Publication number
IE37657B1
IE37657B1 IE811/73A IE81173A IE37657B1 IE 37657 B1 IE37657 B1 IE 37657B1 IE 811/73 A IE811/73 A IE 811/73A IE 81173 A IE81173 A IE 81173A IE 37657 B1 IE37657 B1 IE 37657B1
Authority
IE
Ireland
Prior art keywords
sulphobenzoate
6alpha
prednisolone
derivatives
methyl
Prior art date
Application number
IE811/73A
Other versions
IE37657L (en
Original Assignee
Roussel Uclaf
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roussel Uclaf filed Critical Roussel Uclaf
Publication of IE37657L publication Critical patent/IE37657L/en
Publication of IE37657B1 publication Critical patent/IE37657B1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2009—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring

Abstract

1375357 Corticoid 21-sulphobenzoate ROUSSEL UCLAF 21 May 1973 [19 May 1972] 24013/73 Heading C2U The invention comprises 6α-methylprednisolone 21-(m-sulphobenzoate) and its alkali metal salts. The salts are prepared from the corresponding 21-methanesulphonate by reaction with a di-(alkali metal) m-sulphobenzoate in the presence of an N-alkyl-amide (e.g. DMF), and may be converted to the free acid by passing over an acidic ion-exchange resin. The free acid may thereafter be resalified. 6α-Methylprednisolone 21-methanesulphonate is prepared from the free 21-ol by reaction with mesyl chloride. Antiinflammatory compositions for oral, parenteral, topical and rectal administration comprise a compound of the invention and a carrier. [GB1375357A]
IE811/73A 1972-05-19 1973-05-21 Derivatives of 6alpha-methyl-prednisolone processes for their preparation and compositions incorporating them IE37657B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7218035A FR2193576B1 (en) 1972-05-19 1972-05-19

Publications (2)

Publication Number Publication Date
IE37657L IE37657L (en) 1973-11-19
IE37657B1 true IE37657B1 (en) 1977-09-14

Family

ID=9098837

Family Applications (1)

Application Number Title Priority Date Filing Date
IE811/73A IE37657B1 (en) 1972-05-19 1973-05-21 Derivatives of 6alpha-methyl-prednisolone processes for their preparation and compositions incorporating them

Country Status (25)

Country Link
JP (1) JPS5212777B2 (en)
AT (1) AT325221B (en)
AU (1) AU473292B2 (en)
BE (1) BE799615A (en)
CA (1) CA977746A (en)
CH (1) CH572068A5 (en)
CS (1) CS165956B2 (en)
DD (1) DD104787A5 (en)
DK (1) DK133683B (en)
EG (1) EG11080A (en)
ES (1) ES414870A1 (en)
FI (1) FI52588C (en)
FR (1) FR2193576B1 (en)
GB (1) GB1375357A (en)
HU (1) HU165993B (en)
IE (1) IE37657B1 (en)
IL (1) IL42250A (en)
NL (1) NL7306962A (en)
NO (1) NO138148C (en)
PH (1) PH12351A (en)
PL (1) PL85506B1 (en)
SE (1) SE399711B (en)
SU (1) SU493961A3 (en)
YU (1) YU35037B (en)
ZA (1) ZA733340B (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5112816A (en) * 1975-04-03 1976-01-31 Wakao Kanao TAIRUBARIPUREKYASUTOKONKURIITONO SEIZOHOHO
JPS51122118A (en) * 1975-04-15 1976-10-26 Wakao Kanao Production of tiled precast concrete
US4588718A (en) * 1984-03-28 1986-05-13 The Upjohn Company Carboxy containing ester prodrugs of corticosteroids
US4948533A (en) * 1984-03-28 1990-08-14 The Upjohn Company 11a-hydroxy steroid diester

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3089881A (en) * 1957-10-29 1963-05-14 Schering Corp Sulfocarboxylic acid esters of hydroxylated steroids

Also Published As

Publication number Publication date
PH12351A (en) 1979-01-29
FI52588B (en) 1977-06-30
ZA733340B (en) 1974-11-27
CH572068A5 (en) 1976-01-30
FR2193576A1 (en) 1974-02-22
EG11080A (en) 1977-04-30
DK133683B (en) 1976-06-28
ES414870A1 (en) 1976-05-01
SE399711B (en) 1978-02-27
SU493961A3 (en) 1975-11-28
PL85506B1 (en) 1976-04-30
HU165993B (en) 1974-12-28
CA977746A (en) 1975-11-11
AU473292B2 (en) 1976-06-17
YU127873A (en) 1979-12-31
JPS5212777B2 (en) 1977-04-09
GB1375357A (en) 1974-11-27
DE2325358B2 (en) 1976-01-29
CS165956B2 (en) 1975-12-22
BE799615A (en) 1973-11-16
AT325221B (en) 1975-10-10
DE2325358A1 (en) 1973-11-29
NO138148B (en) 1978-04-03
IL42250A0 (en) 1973-07-30
NL7306962A (en) 1973-11-21
DK133683C (en) 1976-11-15
DD104787A5 (en) 1974-03-20
IL42250A (en) 1977-06-30
NO138148C (en) 1978-07-12
AU5590073A (en) 1974-11-21
JPS4948653A (en) 1974-05-11
FI52588C (en) 1977-10-10
IE37657L (en) 1973-11-19
FR2193576B1 (en) 1975-08-08
YU35037B (en) 1980-06-30

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