IL228630A - Compounds for the treatment of metabolic syndrome and intermediates for the synthesis of these compounds - Google Patents
Compounds for the treatment of metabolic syndrome and intermediates for the synthesis of these compoundsInfo
- Publication number
- IL228630A IL228630A IL228630A IL22863013A IL228630A IL 228630 A IL228630 A IL 228630A IL 228630 A IL228630 A IL 228630A IL 22863013 A IL22863013 A IL 22863013A IL 228630 A IL228630 A IL 228630A
- Authority
- IL
- Israel
- Prior art keywords
- straight
- hydrocarbon radical
- compound
- alkyl
- alkoxy
- Prior art date
Links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/04—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
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- A—HUMAN NECESSITIES
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- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2200/00—Function of food ingredients
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- A23V2200/326—Foods, ingredients or supplements having a functional effect on health having effect on cardiovascular health
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2200/00—Function of food ingredients
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- A23V2200/328—Foods, ingredients or supplements having a functional effect on health having effect on glycaemic control and diabetes
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
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- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
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- Chemical & Material Sciences (AREA)
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- Inorganic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Cosmetics (AREA)
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| US201161468163P | 2011-03-28 | 2011-03-28 | |
| PCT/EP2012/055570 WO2012130912A1 (en) | 2011-03-28 | 2012-03-28 | Compounds for treatment of metabolic syndrome |
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| IL228630A0 IL228630A0 (en) | 2013-12-31 |
| IL228630A true IL228630A (en) | 2017-03-30 |
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| IL228630A IL228630A (en) | 2011-03-28 | 2013-09-29 | Compounds for the treatment of metabolic syndrome and intermediates for the synthesis of these compounds |
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| CN106317180B (zh) * | 2015-06-24 | 2019-09-13 | 首都医科大学 | β-咔啉-3-甲酰-Orn-AA-NHCH2C6H5其合成，活性和应用 |
| WO2018142379A1 (en) | 2017-02-06 | 2018-08-09 | Joslin Diabetes Center, Inc. | Methods and compositions for treating metabolic disorders |
| US10857136B2 (en) | 2017-03-14 | 2020-12-08 | Sjt Molecular Research, Sl | Compounds for use in the prevention and/or treatment of non-alcoholic fat liver disease and non-alcoholic steatohepatitis |
| CN109134460B (zh) * | 2018-08-02 | 2021-04-06 | 南开大学 | 一种β-咔啉类化合物的合成方法 |
| CN109628358B (zh) | 2019-02-20 | 2021-03-19 | 无限极（中国）有限公司 | 一种复合益生菌及其应用 |
| CN109666615B (zh) | 2019-02-20 | 2021-03-19 | 无限极（中国）有限公司 | 一种益生菌组合物及其应用 |
| CN110585202A (zh) * | 2019-10-27 | 2019-12-20 | 淮安市厚沐医疗技术咨询中心 | 一种β-咔啉生物碱及其葡萄糖苷用于抑制肝脏糖异生的用途 |
| WO2021195603A1 (en) * | 2020-03-27 | 2021-09-30 | Virginia Polytechnic Institute And State University | Anti-malarial compounds and uses thereof |
| CN111892596B (zh) * | 2020-08-28 | 2022-07-15 | 南通大学 | 含多氟吡唑结构的β-咔啉类化合物的制备和应用 |
| CN112047940B (zh) * | 2020-08-28 | 2021-06-29 | 南通大学 | 含1-(3,4-二甲氧基苯基)-β-咔啉单元的吡唑化合物的制备与用途 |
| CN116675689A (zh) * | 2023-05-05 | 2023-09-01 | 五邑大学 | 一种β-咔啉类衍生物及其制备方法和应用 |
| CN117700409A (zh) * | 2023-05-16 | 2024-03-15 | 赣南医学院 | 一种用于降血脂的药物及其制备方法和应用 |
| CN119613401B (zh) * | 2024-11-04 | 2025-09-09 | 兰州大学第二医院 | 一种苯基哌嗪基β-咔啉类衍生物及其制备方法和应用 |
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| EP1086101B1 (en) * | 1998-06-12 | 2002-12-18 | Societe De Conseils De Recherches Et D'applications Scientifiques S.A.S. | Beta-carboline compounds |
| RU2271350C2 (ru) * | 2000-06-09 | 2006-03-10 | Санофи-Авентис Дойчланд Гмбх | Производные ацилфенилмочевины, фармацевтическая композиция и способ ее получения |
| KR20060006031A (ko) * | 2003-04-09 | 2006-01-18 | 밀레니엄 파머슈티컬스 인코퍼레이티드 | 염증 질환 치료에 유용한 베타-카르볼린 |
| WO2008103470A2 (en) * | 2007-02-21 | 2008-08-28 | Trustees Of Columbia University In The City Of New York | Oncogenic-ras-signal dependent lethal compounds |
| EP2033962A1 (en) * | 2007-08-22 | 2009-03-11 | 4Sc Ag | Tetracyclic indolopyridines as EG5 inhibitors |
| US8143269B2 (en) | 2008-10-03 | 2012-03-27 | Calcimedica, Inc. | Inhibitors of store operated calcium release |
| US20100173931A1 (en) | 2009-01-06 | 2010-07-08 | Osteogenex Inc. | Harmine derivatives for reducing body weight |
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| JP6049216B2 (ja) | 2016-12-21 |
| CN107652283A (zh) | 2018-02-02 |
| BR112013024602A2 (pt) | 2020-10-13 |
| US9440966B2 (en) | 2016-09-13 |
| MX349254B (es) | 2017-07-19 |
| EP2691394A1 (en) | 2014-02-05 |
| CN103596949A (zh) | 2014-02-19 |
| AU2012234230B2 (en) | 2016-12-01 |
| EP2691394B1 (en) | 2017-05-10 |
| WO2012130912A1 (en) | 2012-10-04 |
| RU2615136C2 (ru) | 2017-04-04 |
| JP2014510741A (ja) | 2014-05-01 |
| CN107652283B (zh) | 2021-07-06 |
| IL228630A0 (en) | 2013-12-31 |
| MX2013011124A (es) | 2014-03-31 |
| DK2691394T3 (en) | 2017-08-28 |
| AU2012234230A1 (en) | 2013-10-17 |
| KR20140025401A (ko) | 2014-03-04 |
| ES2635415T3 (es) | 2017-10-03 |
| CA2831716A1 (en) | 2012-10-04 |
| US20150051204A1 (en) | 2015-02-19 |
| RU2013147629A (ru) | 2015-05-10 |
| KR101784284B1 (ko) | 2017-10-11 |
| US20160340355A1 (en) | 2016-11-24 |
| PT2691394T (pt) | 2017-08-14 |
| PL2691394T3 (pl) | 2017-10-31 |
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