RU2615136C2 - Соединения для лечения метаболического синдрома - Google Patents

Соединения для лечения метаболического синдрома Download PDF

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RU2615136C2
RU2615136C2 RU2013147629A RU2013147629A RU2615136C2 RU 2615136 C2 RU2615136 C2 RU 2615136C2 RU 2013147629 A RU2013147629 A RU 2013147629A RU 2013147629 A RU2013147629 A RU 2013147629A RU 2615136 C2 RU2615136 C2 RU 2615136C2
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carbon atoms
compound
denotes
linear alkyl
hydrocarbon radical
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RU2013147629A
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RU2013147629A (ru
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НАВАХАС Хуан Карлос АГРЕДА
КАССУЙА Роберто МИКИО
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ЭсДжейТи МОЛЕКЬЮЛАР РИСЁРЧ, С.Л.
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
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    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
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    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/16—Inorganic salts, minerals or trace elements
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    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/30—Dietetic or nutritional methods, e.g. for losing weight
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    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
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    • A61K8/69—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing fluorine
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    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/04—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Dermatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pediatric Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Inorganic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Cosmetics (AREA)
RU2013147629A 2011-03-28 2012-03-28 Соединения для лечения метаболического синдрома RU2615136C2 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161468163P 2011-03-28 2011-03-28
US61/468,163 2011-03-28
PCT/EP2012/055570 WO2012130912A1 (en) 2011-03-28 2012-03-28 Compounds for treatment of metabolic syndrome

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RU2013147629A RU2013147629A (ru) 2015-05-10
RU2615136C2 true RU2615136C2 (ru) 2017-04-04

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US (2) US9440966B2 (enExample)
EP (1) EP2691394B1 (enExample)
JP (1) JP6049216B2 (enExample)
KR (1) KR101784284B1 (enExample)
CN (2) CN103596949A (enExample)
AU (1) AU2012234230B2 (enExample)
BR (1) BR112013024602A2 (enExample)
CA (1) CA2831716C (enExample)
DK (1) DK2691394T3 (enExample)
ES (1) ES2635415T3 (enExample)
IL (1) IL228630A (enExample)
MX (1) MX349254B (enExample)
PL (1) PL2691394T3 (enExample)
PT (1) PT2691394T (enExample)
RU (1) RU2615136C2 (enExample)
WO (1) WO2012130912A1 (enExample)

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CN106317180B (zh) * 2015-06-24 2019-09-13 首都医科大学 β-咔啉-3-甲酰-Orn-AA-NHCH2C6H5其合成，活性和应用
WO2018142379A1 (en) 2017-02-06 2018-08-09 Joslin Diabetes Center, Inc. Methods and compositions for treating metabolic disorders
US10857136B2 (en) 2017-03-14 2020-12-08 Sjt Molecular Research, Sl Compounds for use in the prevention and/or treatment of non-alcoholic fat liver disease and non-alcoholic steatohepatitis
CN109134460B (zh) * 2018-08-02 2021-04-06 南开大学 一种β-咔啉类化合物的合成方法
CN109628358B (zh) 2019-02-20 2021-03-19 无限极（中国）有限公司 一种复合益生菌及其应用
CN109666615B (zh) 2019-02-20 2021-03-19 无限极（中国）有限公司 一种益生菌组合物及其应用
CN110585202A (zh) * 2019-10-27 2019-12-20 淮安市厚沐医疗技术咨询中心 一种β-咔啉生物碱及其葡萄糖苷用于抑制肝脏糖异生的用途
WO2021195603A1 (en) * 2020-03-27 2021-09-30 Virginia Polytechnic Institute And State University Anti-malarial compounds and uses thereof
CN111892596B (zh) * 2020-08-28 2022-07-15 南通大学 含多氟吡唑结构的β-咔啉类化合物的制备和应用
CN112047940B (zh) * 2020-08-28 2021-06-29 南通大学 含1-(3,4-二甲氧基苯基)-β-咔啉单元的吡唑化合物的制备与用途
CN116675689A (zh) * 2023-05-05 2023-09-01 五邑大学 一种β-咔啉类衍生物及其制备方法和应用
CN117700409A (zh) * 2023-05-16 2024-03-15 赣南医学院 一种用于降血脂的药物及其制备方法和应用
CN119613401B (zh) * 2024-11-04 2025-09-09 兰州大学第二医院 一种苯基哌嗪基β-咔啉类衍生物及其制备方法和应用

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BR112013024602A2 (pt) 2020-10-13
IL228630A (en) 2017-03-30
US9440966B2 (en) 2016-09-13
MX349254B (es) 2017-07-19
EP2691394A1 (en) 2014-02-05
CN103596949A (zh) 2014-02-19
AU2012234230B2 (en) 2016-12-01
EP2691394B1 (en) 2017-05-10
WO2012130912A1 (en) 2012-10-04
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CN107652283B (zh) 2021-07-06
IL228630A0 (en) 2013-12-31
MX2013011124A (es) 2014-03-31
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AU2012234230A1 (en) 2013-10-17
KR20140025401A (ko) 2014-03-04
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CA2831716A1 (en) 2012-10-04
US20150051204A1 (en) 2015-02-19
RU2013147629A (ru) 2015-05-10
KR101784284B1 (ko) 2017-10-11
US20160340355A1 (en) 2016-11-24
PT2691394T (pt) 2017-08-14
PL2691394T3 (pl) 2017-10-31

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