IL204192A - Inhibitors of tyrosine kinase protein activity - Google Patents

Inhibitors of tyrosine kinase protein activity

Info

Publication number
IL204192A
IL204192A IL204192A IL20419210A IL204192A IL 204192 A IL204192 A IL 204192A IL 204192 A IL204192 A IL 204192A IL 20419210 A IL20419210 A IL 20419210A IL 204192 A IL204192 A IL 204192A
Authority
IL
Israel
Prior art keywords
inhibitors
tyrosine kinase
kinase activity
protein tyrosine
protein
Prior art date
Application number
IL204192A
Other languages
English (en)
Hebrew (he)
Original Assignee
Methylgene Inc
Quebec Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Methylgene Inc, Quebec Inc filed Critical Methylgene Inc
Publication of IL204192A publication Critical patent/IL204192A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Ophthalmology & Optometry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
IL204192A 2007-08-29 2010-02-25 Inhibitors of tyrosine kinase protein activity IL204192A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US96867307P 2007-08-29 2007-08-29
PCT/CA2008/001538 WO2009026717A1 (en) 2007-08-29 2008-08-28 Inhibitors of protein tyrosine kinase activity

Publications (1)

Publication Number Publication Date
IL204192A true IL204192A (en) 2016-08-31

Family

ID=40386626

Family Applications (1)

Application Number Title Priority Date Filing Date
IL204192A IL204192A (en) 2007-08-29 2010-02-25 Inhibitors of tyrosine kinase protein activity

Country Status (19)

Country Link
US (3) US8404846B2 (OSRAM)
EP (1) EP2183254B1 (OSRAM)
JP (1) JP5656634B2 (OSRAM)
KR (1) KR101556269B1 (OSRAM)
CN (3) CN105777776B (OSRAM)
AR (1) AR068066A1 (OSRAM)
AU (1) AU2008293038B2 (OSRAM)
BR (1) BRPI0816064B8 (OSRAM)
CA (1) CA2697795C (OSRAM)
DK (1) DK2183254T3 (OSRAM)
ES (1) ES2635131T3 (OSRAM)
IL (1) IL204192A (OSRAM)
MX (1) MX2010002427A (OSRAM)
MY (1) MY156536A (OSRAM)
PL (1) PL2183254T3 (OSRAM)
RU (1) RU2495044C2 (OSRAM)
TW (1) TWI571468B (OSRAM)
WO (1) WO2009026717A1 (OSRAM)
ZA (1) ZA201001512B (OSRAM)

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AU2011307306A1 (en) * 2010-09-27 2013-05-02 Exelixis, Inc. Dual inhibitors of MET and VEGF for the treatment of castration resistant prostate cancer and osteoblastic bone metastases
US20140057943A1 (en) 2010-09-27 2014-02-27 Exelixix, Inc. Method of Treating Cancer
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CN102827186A (zh) * 2011-06-16 2012-12-19 中国科学院上海药物研究所 一类吡啶并五元杂环衍生物及其制备方法和用途
WO2013038362A1 (en) 2011-09-15 2013-03-21 Novartis Ag 6 - substituted 3 - (quinolin- 6 - ylthio) - [1,2,4] triazolo [4, 3 -a] pyradines as tyrosine kinase
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CN103626761B (zh) * 2012-08-24 2015-07-29 上海医药工业研究院 苯并吡啶氮杂卓类化合物及其作为抗肿瘤药物的应用
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US10085979B2 (en) 2014-12-02 2018-10-02 Ignyta, Inc. Combinations for the treatment of neuroblastoma
ES2764299T3 (es) 2014-12-09 2020-06-02 Inst Nat Sante Rech Med Anticuerpos monoclonales humanos contra AXL
GB201501302D0 (en) 2015-01-27 2015-03-11 Ostara Biomedical Ltd Embryo implantation
WO2016135041A1 (en) 2015-02-26 2016-09-01 INSERM (Institut National de la Santé et de la Recherche Médicale) Fusion proteins and antibodies comprising thereof for promoting apoptosis
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WO2017106492A1 (en) 2015-12-18 2017-06-22 Ignyta, Inc. Combinations for the treatment of cancer
CN108530464B (zh) * 2017-03-02 2020-10-27 深圳海王医药科技研究院有限公司 一种多靶点激酶抑制剂
JP7203083B2 (ja) 2017-07-19 2023-01-12 イグナイタ インコーポレイテッド エントレクチニブを含む薬学的組成物
US10180422B1 (en) 2017-08-22 2019-01-15 Scripps Health Methods of treating a neuroendocrine tumor
EP3697390A1 (en) 2017-10-17 2020-08-26 Ignyta, Inc. Pharmaceutical compositions and dosage forms
CN111295386B (zh) * 2018-03-08 2022-09-06 伟迈可生物有限公司 噻吩并吡啶衍生物及含有该衍生物的药物组合物
AU2019272384A1 (en) 2018-05-23 2021-01-07 Beigene, Ltd. Anti-OX40 antibodies and methods of use
CN109384799B (zh) * 2018-11-12 2020-07-14 深圳海王医药科技研究院有限公司 一种多靶点激酶抑制剂化合物的晶型a及制备方法和含有其的药物组合物
EP3819300A4 (en) 2019-09-06 2021-11-24 Wellmarker Bio Co., Ltd. THERAPEUTIC COMPOSITION BASED ON BIOMARKERS
WO2021050580A1 (en) * 2019-09-10 2021-03-18 Mirati Therapeutics, Inc. Crystalline form of a multi-tyrosine kinase inhibitor, method of preparation, and use thereof
US20230022859A1 (en) * 2019-11-21 2023-01-26 Beigene, Ltd. Treatment of cancer with anti-ox40 antibodies and multi-kinase inhibitors
US20230094146A1 (en) * 2020-01-07 2023-03-30 Medshine Discovery Inc. Deuterated thienopyridine compound
EP4213844A4 (en) 2020-09-17 2024-11-20 Mirati Therapeutics, Inc. POLYTHERAPIES
TW202302597A (zh) * 2021-03-10 2023-01-16 美商米拉蒂醫療公司 多重酪胺酸激酶抑制劑之結晶鹽、其製備方法及用途
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Also Published As

Publication number Publication date
ES2635131T3 (es) 2017-10-02
BRPI0816064B1 (pt) 2020-01-28
KR20100075873A (ko) 2010-07-05
TWI571468B (zh) 2017-02-21
CN101932586A (zh) 2010-12-29
JP5656634B2 (ja) 2015-01-21
JP2010536887A (ja) 2010-12-02
US20090264440A1 (en) 2009-10-22
US8846927B2 (en) 2014-09-30
BRPI0816064A2 (pt) 2015-03-31
DK2183254T3 (en) 2017-09-11
US8389541B2 (en) 2013-03-05
EP2183254A4 (en) 2011-09-28
KR101556269B1 (ko) 2015-09-30
TW200914458A (en) 2009-04-01
AU2008293038A1 (en) 2009-03-05
PL2183254T3 (pl) 2017-10-31
US20120108628A1 (en) 2012-05-03
CA2697795A1 (en) 2009-03-05
CN109970759A (zh) 2019-07-05
CN105777776B (zh) 2021-06-08
AU2008293038B2 (en) 2013-08-29
BRPI0816064B8 (pt) 2021-05-25
AR068066A1 (es) 2009-11-04
MY156536A (en) 2016-02-26
CA2697795C (en) 2016-08-16
ZA201001512B (en) 2010-11-24
US8404846B2 (en) 2013-03-26
RU2010111729A (ru) 2011-10-10
EP2183254A1 (en) 2010-05-12
EP2183254B1 (en) 2017-06-21
WO2009026717A1 (en) 2009-03-05
CN105777776A (zh) 2016-07-20
RU2495044C2 (ru) 2013-10-10
US20130165477A1 (en) 2013-06-27
MX2010002427A (es) 2010-03-30

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