IL199241A - Cancer biomarkers - Google Patents
Cancer biomarkersInfo
- Publication number
- IL199241A IL199241A IL199241A IL19924109A IL199241A IL 199241 A IL199241 A IL 199241A IL 199241 A IL199241 A IL 199241A IL 19924109 A IL19924109 A IL 19924109A IL 199241 A IL199241 A IL 199241A
- Authority
- IL
- Israel
- Prior art keywords
- peptide
- fragment
- prostate cancer
- cancer
- sequence
- Prior art date
Links
- 239000000107 tumor biomarker Substances 0.000 title description 4
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 137
- 101100285412 Gallus gallus EN2 gene Proteins 0.000 claims description 99
- 206010060862 Prostate cancer Diseases 0.000 claims description 78
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims description 73
- 239000012634 fragment Substances 0.000 claims description 73
- 238000000034 method Methods 0.000 claims description 73
- 206010028980 Neoplasm Diseases 0.000 claims description 48
- 239000000090 biomarker Substances 0.000 claims description 47
- 210000004027 cell Anatomy 0.000 claims description 45
- 201000011510 cancer Diseases 0.000 claims description 38
- 210000001124 body fluid Anatomy 0.000 claims description 30
- 239000010839 body fluid Substances 0.000 claims description 30
- 238000001514 detection method Methods 0.000 claims description 29
- 239000000523 sample Substances 0.000 claims description 27
- 108091023040 Transcription factor Proteins 0.000 claims description 23
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- 238000012360 testing method Methods 0.000 claims description 17
- 239000003446 ligand Substances 0.000 claims description 16
- 238000011002 quantification Methods 0.000 claims description 12
- 238000012544 monitoring process Methods 0.000 claims description 11
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- 238000001262 western blot Methods 0.000 claims description 8
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- 108090000790 Enzymes Proteins 0.000 claims description 4
- 238000004458 analytical method Methods 0.000 claims description 4
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- 238000002560 therapeutic procedure Methods 0.000 claims description 3
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- 101000993469 Homo sapiens Beta-catenin-interacting protein 1 Proteins 0.000 claims description 2
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- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 claims description 2
- 229910052737 gold Inorganic materials 0.000 claims description 2
- 239000010931 gold Substances 0.000 claims description 2
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- 102000007066 Prostate-Specific Antigen Human genes 0.000 description 20
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- 201000005825 prostate adenocarcinoma Diseases 0.000 description 5
- 238000003753 real-time PCR Methods 0.000 description 5
- 230000009870 specific binding Effects 0.000 description 5
- 102100027695 Homeobox protein engrailed-2 Human genes 0.000 description 4
- 206010071019 Prostatic dysplasia Diseases 0.000 description 4
- 239000002246 antineoplastic agent Substances 0.000 description 4
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- 108010047041 Complementarity Determining Regions Proteins 0.000 description 3
- 108700005087 Homeobox Genes Proteins 0.000 description 3
- 238000011394 anticancer treatment Methods 0.000 description 3
- 230000008901 benefit Effects 0.000 description 3
- 210000001165 lymph node Anatomy 0.000 description 3
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- 210000000056 organ Anatomy 0.000 description 3
- 239000000047 product Substances 0.000 description 3
- 102000007469 Actins Human genes 0.000 description 2
- 108010085238 Actins Proteins 0.000 description 2
- 206010006187 Breast cancer Diseases 0.000 description 2
- 208000026310 Breast neoplasm Diseases 0.000 description 2
- 241000699666 Mus <mouse, genus> Species 0.000 description 2
- 238000012300 Sequence Analysis Methods 0.000 description 2
- 208000009956 adenocarcinoma Diseases 0.000 description 2
- 125000000539 amino acid group Chemical group 0.000 description 2
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- 238000003819 low-pressure liquid chromatography Methods 0.000 description 2
- 239000003550 marker Substances 0.000 description 2
- 108020004999 messenger RNA Proteins 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 201000001514 prostate carcinoma Diseases 0.000 description 2
- 230000028327 secretion Effects 0.000 description 2
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- 210000002536 stromal cell Anatomy 0.000 description 2
- 238000000672 surface-enhanced laser desorption--ionisation Methods 0.000 description 2
- 208000024891 symptom Diseases 0.000 description 2
- HRPVXLWXLXDGHG-UHFFFAOYSA-N Acrylamide Chemical compound NC(=O)C=C HRPVXLWXLXDGHG-UHFFFAOYSA-N 0.000 description 1
- 108091023037 Aptamer Proteins 0.000 description 1
- 206010004446 Benign prostatic hyperplasia Diseases 0.000 description 1
- 102000004506 Blood Proteins Human genes 0.000 description 1
- 108010017384 Blood Proteins Proteins 0.000 description 1
- 241000754798 Calophyllum brasiliense Species 0.000 description 1
- 241000283707 Capra Species 0.000 description 1
- 101100071835 Danio rerio hoxb1b gene Proteins 0.000 description 1
- 241000255581 Drosophila <fruit fly, genus> Species 0.000 description 1
- 101150040523 EN gene Proteins 0.000 description 1
- 241000283073 Equus caballus Species 0.000 description 1
- 102100025116 Homeobox protein Hox-A4 Human genes 0.000 description 1
- 102100022650 Homeobox protein Hox-A7 Human genes 0.000 description 1
- 102100028411 Homeobox protein Hox-B3 Human genes 0.000 description 1
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- 101001077578 Homo sapiens Homeobox protein Hox-A4 Proteins 0.000 description 1
- 101001045116 Homo sapiens Homeobox protein Hox-A7 Proteins 0.000 description 1
- 101000839775 Homo sapiens Homeobox protein Hox-B3 Proteins 0.000 description 1
- 101000989000 Homo sapiens Homeobox protein Hox-B9 Proteins 0.000 description 1
- 206010062904 Hormone-refractory prostate cancer Diseases 0.000 description 1
- 101150015534 Hoxc4 gene Proteins 0.000 description 1
- 102100034343 Integrase Human genes 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- 206010027476 Metastases Diseases 0.000 description 1
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- 101100286123 Mus musculus Hoxa1 gene Proteins 0.000 description 1
- 108091034117 Oligonucleotide Proteins 0.000 description 1
- 108700020796 Oncogene Proteins 0.000 description 1
- 206010033128 Ovarian cancer Diseases 0.000 description 1
- 206010061535 Ovarian neoplasm Diseases 0.000 description 1
- 208000004403 Prostatic Hyperplasia Diseases 0.000 description 1
- 108010076504 Protein Sorting Signals Proteins 0.000 description 1
- 238000002123 RNA extraction Methods 0.000 description 1
- 108010092799 RNA-directed DNA polymerase Proteins 0.000 description 1
- 108091030071 RNAI Proteins 0.000 description 1
- 101100348089 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) BUR6 gene Proteins 0.000 description 1
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- 238000013537 high throughput screening Methods 0.000 description 1
- 101150003074 hoxa5 gene Proteins 0.000 description 1
- 102000053283 human HOXB5 Human genes 0.000 description 1
- 102000048538 human HOXB6 Human genes 0.000 description 1
- 102000048380 human HOXC4 Human genes 0.000 description 1
- 210000004408 hybridoma Anatomy 0.000 description 1
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Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57407—Specifically defined cancers
- G01N33/57434—Specifically defined cancers of prostate
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6872—Intracellular protein regulatory factors and their receptors, e.g. including ion channels
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Urology & Nephrology (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Cell Biology (AREA)
- Pathology (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Physics & Mathematics (AREA)
- Oncology (AREA)
- Hospice & Palliative Care (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Peptides Or Proteins (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0625321.5A GB0625321D0 (en) | 2006-12-19 | 2006-12-19 | Cancer biomarker |
| GBGB0719792.4A GB0719792D0 (en) | 2006-12-19 | 2007-10-10 | Cancer biomarkers |
| PCT/GB2007/004902 WO2008075056A1 (en) | 2006-12-19 | 2007-12-19 | Cancer biomarkers |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL199241A true IL199241A (en) | 2014-03-31 |
Family
ID=39265269
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL199241A IL199241A (en) | 2006-12-19 | 2009-06-08 | Cancer biomarkers |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US8460882B2 (enExample) |
| EP (1) | EP2115472B1 (enExample) |
| JP (1) | JP5683108B2 (enExample) |
| CN (1) | CN101675341B (enExample) |
| AU (1) | AU2007335999B2 (enExample) |
| BR (1) | BRPI0720371B8 (enExample) |
| CA (1) | CA2671939C (enExample) |
| CY (1) | CY1115178T1 (enExample) |
| DK (1) | DK2115472T3 (enExample) |
| ES (1) | ES2445185T3 (enExample) |
| GB (2) | GB0625321D0 (enExample) |
| IL (1) | IL199241A (enExample) |
| MX (1) | MX2009006378A (enExample) |
| NZ (1) | NZ577548A (enExample) |
| PL (1) | PL2115472T3 (enExample) |
| PT (1) | PT2115472E (enExample) |
| RU (1) | RU2460075C2 (enExample) |
| SI (1) | SI2115472T1 (enExample) |
| WO (1) | WO2008075056A1 (enExample) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8461126B2 (en) | 2005-10-14 | 2013-06-11 | Phigenix, Inc. | Targeting EN2, PAX2, and/or DEFB1 for treatment of prostate conditions |
| DE102006047617B4 (de) | 2006-10-09 | 2008-11-27 | Clariant International Limited | Verfahren zur Herstellung basischer (Meth)acrylamide |
| DE102008017216B4 (de) | 2008-04-04 | 2013-08-14 | Clariant International Ltd. | Kontinuierliches Verfahren zur Herstellung von Fettsäureamiden |
| GB0823445D0 (en) * | 2008-12-23 | 2009-01-28 | Univ Surrey | Biomarker |
| DE102009031059A1 (de) | 2009-06-30 | 2011-01-05 | Clariant International Ltd. | Vorrichtung zur kontinuierlichen Durchführung chemischer Reaktionen bei hohen Temperaturen |
| WO2011007130A1 (en) * | 2009-07-13 | 2011-01-20 | The University Of Surrey | Therapeutic peptides, polypeptides ans nucleic acid sequences |
| GB0912190D0 (en) * | 2009-07-13 | 2009-08-26 | Univ Surrey | Biomarker |
| GB0912175D0 (en) * | 2009-07-13 | 2009-08-26 | Univ Surrey | Biomarker |
| DE102009042523B4 (de) | 2009-09-22 | 2012-02-16 | Clariant International Ltd. | Vorrichtung und Verfahren zur kontinuierlichen Durchführung heterogen katalysierter chemischer Reaktionen bei hohen Temperaturen |
| DE102009042522A1 (de) | 2009-09-22 | 2011-04-07 | Clariant International Ltd. | Kontinuierliches Umesterungsverfahren |
| GB0921329D0 (en) * | 2009-12-04 | 2010-01-20 | Univ Surrey | Biomarker |
| DE102010056565A1 (de) | 2010-12-30 | 2012-07-05 | Clariant International Ltd. | Verfahren zur Modifizierung Hydroxylgruppen tragender Polymere |
| US20140106363A1 (en) * | 2011-05-12 | 2014-04-17 | Noviogendix Research B.V. | Molecular markers in prostate cancer |
| CA2835728A1 (en) * | 2011-05-12 | 2012-11-15 | Noviogendix Research B.V. | Molecular markers in prostate cancer |
| CN103797120B (zh) * | 2011-09-16 | 2017-04-12 | 上海长海医院 | 前列腺癌的生物学标志物、治疗靶点及其用途 |
| US20140336130A1 (en) * | 2011-12-05 | 2014-11-13 | Phigenix, Inc. | Targeting en2, pax2, and/or defb1 for treatment of prostate conditions |
| WO2014005138A1 (en) * | 2012-06-29 | 2014-01-03 | Kerschensteiner Daniel A | Colorimetric gelatinase assay |
| WO2014025961A1 (en) * | 2012-08-10 | 2014-02-13 | Analiza, Inc. | Methods and devices for analyzing species to determine diseases |
| AU2013388864B2 (en) * | 2013-05-09 | 2017-06-08 | The Procter & Gamble Company | Method and system for assessing health condition |
| WO2016102560A1 (en) * | 2014-12-23 | 2016-06-30 | The University Of Surrey | Glycosylated biomarker |
| KR101698654B1 (ko) | 2014-12-24 | 2017-01-20 | 포항공과대학교 산학협력단 | En2에 특이적으로 결합하는 dna 압타머 및 이의 용도 |
| JP6745820B2 (ja) * | 2015-05-29 | 2020-08-26 | コーニンクレッカ フィリップス エヌ ヴェＫｏｎｉｎｋｌｉｊｋｅ Ｐｈｉｌｉｐｓ Ｎ．Ｖ． | 前立腺がん予後判定の方法 |
| PL3960195T3 (pl) * | 2015-09-23 | 2025-06-09 | Centre National De La Recherche Scientifique | Engrailed do zastosowania w leczeniu stwardnienia zanikowego bocznego |
| CN106282347A (zh) * | 2016-08-17 | 2017-01-04 | 中南大学 | HoxC11作为生物标志物在制备肺腺癌的预诊断试剂中的应用 |
| US10508287B2 (en) | 2016-12-28 | 2019-12-17 | Guangzhou Institutes of Biomedicine and Health Chinese Academy of Sciences | Method for regenerating T cells and applications thereof |
| KR101777085B1 (ko) | 2017-02-23 | 2017-09-11 | 주식회사 성균바이오텍 | En2 단백질의 면역원성 단편 펩타이드 또는 이를 특이적으로 인식하는 항체 조성물 |
| KR101777259B1 (ko) * | 2017-07-14 | 2017-09-13 | 주식회사 무진메디 | En2 단백질을 특이적으로 인식하는 단클론 항체 또는 이를 함유하는 전립선암 진단용 조성물 |
| KR101777254B1 (ko) * | 2017-07-14 | 2017-09-13 | 주식회사 무진메디 | En2 단백질을 특이적으로 인식하는 특정 항원으로부터 얻어진 단클론 항체 또는 이를 함유하는 전립선암 진단용 조성물 |
| CN107727729A (zh) * | 2017-11-22 | 2018-02-23 | 南宁科城汇信息科技有限公司 | 一种oa候选标志物诊断模型的建立方法 |
| CN107894507A (zh) * | 2017-11-22 | 2018-04-10 | 南宁科城汇信息科技有限公司 | 一种发现和鉴定肝癌血清差异表达蛋白和验证标志物蛋白方法 |
| KR101923199B1 (ko) | 2018-04-25 | 2018-11-28 | 주식회사 무진메디 | 펩스타틴 a를 함유하는 소변 내 en2 진단용 조성물 |
| CN111363817B (zh) * | 2018-12-26 | 2024-02-02 | 广州康立明生物科技股份有限公司 | 基于hoxd12基因的肺癌诊断剂及试剂盒 |
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| JP2002527758A (ja) * | 1998-10-19 | 2002-08-27 | ダイアデクスアス・インコーポレーテッド | 前立腺癌を診断、監視、病期分類、イメージング及び治療する方法 |
| AU2001263771A1 (en) | 2000-05-30 | 2001-12-11 | Danmarks Miljo Undersogelser | An assay method and kit for testing biological material for exposure to stress using biomarkers |
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| NZ527180A (en) | 2000-12-24 | 2007-02-23 | Iser Lubocki | A method for detecting biomarkers |
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| US6949342B2 (en) * | 2001-12-21 | 2005-09-27 | Whitehead Institute For Biomedical Research | Prostate cancer diagnosis and outcome prediction by expression analysis |
| CA2469089A1 (en) * | 2003-07-08 | 2005-01-08 | Institut De Recherches Cliniques De Montreal | En-2 gene, disgnostic and therapeutic uses thereof |
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| ES2534139T3 (es) * | 2004-12-02 | 2015-04-17 | Epigenomics Ag | Métodos y ácidos nucleicos para el análisis de la expresión génica asociada con el pronóstico de trastornos proliferativos de células de próstata |
| WO2006089091A2 (en) * | 2005-02-18 | 2006-08-24 | Memorial Sloan-Kettering Cancer Center | Methods for detecting minimum residual disease |
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| BRPI0720371B1 (pt) | 2019-05-28 |
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| AU2007335999A1 (en) | 2008-06-26 |
| GB0625321D0 (en) | 2007-01-24 |
| RU2009127774A (ru) | 2011-01-27 |
| SI2115472T1 (sl) | 2014-05-30 |
| AU2007335999B2 (en) | 2013-09-05 |
| MX2009006378A (es) | 2009-08-24 |
| CN101675341B (zh) | 2017-08-08 |
| RU2460075C2 (ru) | 2012-08-27 |
| GB0719792D0 (en) | 2007-11-21 |
| CA2671939C (en) | 2017-10-03 |
| PT2115472E (pt) | 2014-02-14 |
| DK2115472T3 (da) | 2014-02-10 |
| WO2008075056A1 (en) | 2008-06-26 |
| CY1115178T1 (el) | 2016-12-14 |
| US8460882B2 (en) | 2013-06-11 |
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| ES2445185T3 (es) | 2014-02-28 |
| EP2115472B1 (en) | 2013-11-06 |
| JP2010513901A (ja) | 2010-04-30 |
| BRPI0720371A2 (pt) | 2013-12-31 |
| US20100093558A1 (en) | 2010-04-15 |
| BRPI0720371B8 (pt) | 2021-07-27 |
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