CN101675341B - 癌症的生物标志物 - Google Patents
癌症的生物标志物 Download PDFInfo
- Publication number
- CN101675341B CN101675341B CN200780051417.9A CN200780051417A CN101675341B CN 101675341 B CN101675341 B CN 101675341B CN 200780051417 A CN200780051417 A CN 200780051417A CN 101675341 B CN101675341 B CN 101675341B
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- CN
- China
- Prior art keywords
- use according
- peptide
- ser
- pro
- ala
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57407—Specifically defined cancers
- G01N33/57434—Specifically defined cancers of prostate
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6872—Intracellular protein regulatory factors and their receptors, e.g. including ion channels
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Chemical & Material Sciences (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Cell Biology (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Hospice & Palliative Care (AREA)
- Oncology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Peptides Or Proteins (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0625321.5A GB0625321D0 (en) | 2006-12-19 | 2006-12-19 | Cancer biomarker |
| GB0625321.5 | 2006-12-19 | ||
| GBGB0719792.4A GB0719792D0 (en) | 2006-12-19 | 2007-10-10 | Cancer biomarkers |
| GB0719792.4 | 2007-10-10 | ||
| PCT/GB2007/004902 WO2008075056A1 (en) | 2006-12-19 | 2007-12-19 | Cancer biomarkers |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101675341A CN101675341A (zh) | 2010-03-17 |
| CN101675341B true CN101675341B (zh) | 2017-08-08 |
Family
ID=39265269
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN200780051417.9A Expired - Fee Related CN101675341B (zh) | 2006-12-19 | 2007-12-19 | 癌症的生物标志物 |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US8460882B2 (enExample) |
| EP (1) | EP2115472B1 (enExample) |
| JP (1) | JP5683108B2 (enExample) |
| CN (1) | CN101675341B (enExample) |
| AU (1) | AU2007335999B2 (enExample) |
| BR (1) | BRPI0720371B8 (enExample) |
| CA (1) | CA2671939C (enExample) |
| CY (1) | CY1115178T1 (enExample) |
| DK (1) | DK2115472T3 (enExample) |
| ES (1) | ES2445185T3 (enExample) |
| GB (2) | GB0625321D0 (enExample) |
| IL (1) | IL199241A (enExample) |
| MX (1) | MX2009006378A (enExample) |
| NZ (1) | NZ577548A (enExample) |
| PL (1) | PL2115472T3 (enExample) |
| PT (1) | PT2115472E (enExample) |
| RU (1) | RU2460075C2 (enExample) |
| SI (1) | SI2115472T1 (enExample) |
| WO (1) | WO2008075056A1 (enExample) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8461126B2 (en) | 2005-10-14 | 2013-06-11 | Phigenix, Inc. | Targeting EN2, PAX2, and/or DEFB1 for treatment of prostate conditions |
| DE102006047617B4 (de) | 2006-10-09 | 2008-11-27 | Clariant International Limited | Verfahren zur Herstellung basischer (Meth)acrylamide |
| DE102008017216B4 (de) | 2008-04-04 | 2013-08-14 | Clariant International Ltd. | Kontinuierliches Verfahren zur Herstellung von Fettsäureamiden |
| GB0823445D0 (en) * | 2008-12-23 | 2009-01-28 | Univ Surrey | Biomarker |
| DE102009031059A1 (de) | 2009-06-30 | 2011-01-05 | Clariant International Ltd. | Vorrichtung zur kontinuierlichen Durchführung chemischer Reaktionen bei hohen Temperaturen |
| GB0912175D0 (en) * | 2009-07-13 | 2009-08-26 | Univ Surrey | Biomarker |
| GB0912190D0 (en) * | 2009-07-13 | 2009-08-26 | Univ Surrey | Biomarker |
| US20120177672A1 (en) * | 2009-07-13 | 2012-07-12 | The University Of Surrey | Therapeutic peptides, polypeptides and nucleic acid sequences |
| DE102009042522A1 (de) | 2009-09-22 | 2011-04-07 | Clariant International Ltd. | Kontinuierliches Umesterungsverfahren |
| DE102009042523B4 (de) | 2009-09-22 | 2012-02-16 | Clariant International Ltd. | Vorrichtung und Verfahren zur kontinuierlichen Durchführung heterogen katalysierter chemischer Reaktionen bei hohen Temperaturen |
| GB0921329D0 (en) * | 2009-12-04 | 2010-01-20 | Univ Surrey | Biomarker |
| DE102010056565A1 (de) | 2010-12-30 | 2012-07-05 | Clariant International Ltd. | Verfahren zur Modifizierung Hydroxylgruppen tragender Polymere |
| CA2835728A1 (en) * | 2011-05-12 | 2012-11-15 | Noviogendix Research B.V. | Molecular markers in prostate cancer |
| US20140106363A1 (en) * | 2011-05-12 | 2014-04-17 | Noviogendix Research B.V. | Molecular markers in prostate cancer |
| WO2013037118A1 (zh) * | 2011-09-16 | 2013-03-21 | 上海长海医院 | 前列腺癌的生物学标志物、治疗靶点及其用途 |
| JP5990274B2 (ja) * | 2011-12-05 | 2016-09-07 | ファイジェニクス インコーポレイテッド | 前立腺病態の処置のためのen2、pax2、および/またはdefb1の標的化 |
| US9110030B2 (en) | 2012-06-29 | 2015-08-18 | Daniel A. Kerschensteiner | Colorimetric gelatinase assay |
| US10613087B2 (en) * | 2012-08-10 | 2020-04-07 | Analiza, Inc. | Methods and devices for analyzing species to determine diseases |
| WO2014179959A1 (en) * | 2013-05-09 | 2014-11-13 | The Procter & Gamble Company | Method and system for assessing health condition |
| WO2016102560A1 (en) * | 2014-12-23 | 2016-06-30 | The University Of Surrey | Glycosylated biomarker |
| KR101698654B1 (ko) | 2014-12-24 | 2017-01-20 | 포항공과대학교 산학협력단 | En2에 특이적으로 결합하는 dna 압타머 및 이의 용도 |
| EP3303616B1 (en) * | 2015-05-29 | 2021-01-06 | Koninklijke Philips N.V. | Methods of prostate cancer prognosis |
| US20190247461A1 (en) * | 2015-09-23 | 2019-08-15 | Centre National De La Recherche Scientifique | Homeoproteins for use in the treatment of neurodegenerative disorders |
| CN106282347A (zh) * | 2016-08-17 | 2017-01-04 | 中南大学 | HoxC11作为生物标志物在制备肺腺癌的预诊断试剂中的应用 |
| WO2018119715A1 (zh) * | 2016-12-28 | 2018-07-05 | 中国科学院广州生物医药与健康研究院 | 一种获得t细胞的方法及应用 |
| KR101777085B1 (ko) | 2017-02-23 | 2017-09-11 | 주식회사 성균바이오텍 | En2 단백질의 면역원성 단편 펩타이드 또는 이를 특이적으로 인식하는 항체 조성물 |
| KR101777259B1 (ko) * | 2017-07-14 | 2017-09-13 | 주식회사 무진메디 | En2 단백질을 특이적으로 인식하는 단클론 항체 또는 이를 함유하는 전립선암 진단용 조성물 |
| KR101777254B1 (ko) | 2017-07-14 | 2017-09-13 | 주식회사 무진메디 | En2 단백질을 특이적으로 인식하는 특정 항원으로부터 얻어진 단클론 항체 또는 이를 함유하는 전립선암 진단용 조성물 |
| CN107727729A (zh) * | 2017-11-22 | 2018-02-23 | 南宁科城汇信息科技有限公司 | 一种oa候选标志物诊断模型的建立方法 |
| CN107894507A (zh) * | 2017-11-22 | 2018-04-10 | 南宁科城汇信息科技有限公司 | 一种发现和鉴定肝癌血清差异表达蛋白和验证标志物蛋白方法 |
| KR101923199B1 (ko) | 2018-04-25 | 2018-11-28 | 주식회사 무진메디 | 펩스타틴 a를 함유하는 소변 내 en2 진단용 조성물 |
| CN111363817B (zh) * | 2018-12-26 | 2024-02-02 | 广州康立明生物科技股份有限公司 | 基于hoxd12基因的肺癌诊断剂及试剂盒 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1999000498A1 (en) | 1997-06-27 | 1999-01-07 | Human Genome Sciences, Inc. | Human nk-3 related prostate specific gene-1 |
| RU2234942C2 (ru) * | 1998-07-14 | 2004-08-27 | Корикса Корпорейшн | Выделенный опухолевый полипептид предстательной железы и кодирующий его полинуклеотид |
| CA2347081A1 (en) * | 1998-10-19 | 2000-04-27 | Diadexus, Inc. | Method of diagnosing, monitoring, staging, imaging and treating prostate cancer |
| EP1290442B1 (en) | 2000-05-30 | 2013-11-13 | Aarhus Universitet | An assay method for testing plant material for exposure to herbicides using biomarkers |
| AU2001277521A1 (en) * | 2000-06-30 | 2002-01-14 | Epigenomics Ag | Diagnosis of diseases associated with cell signalling |
| US20050079492A1 (en) * | 2000-09-12 | 2005-04-14 | Burgess Jr. Robert M. | Micro-arrayed organization of transcription factor target genes |
| US20040063216A1 (en) | 2000-12-24 | 2004-04-01 | Iser Lubocki | Method for detecting biomarkers |
| AU2002249834B2 (en) | 2000-12-24 | 2008-05-22 | Iser Lubocki | A method for detecting biomarkers |
| DE60232059D1 (de) * | 2001-03-01 | 2009-06-04 | Epigenomics Ag | Verfahren zur entwicklung von gensätzen zu diagnostischen und therapeutischen zwecken auf grundlage des expressions- und methylierungsstatus der gene |
| US6949342B2 (en) * | 2001-12-21 | 2005-09-27 | Whitehead Institute For Biomedical Research | Prostate cancer diagnosis and outcome prediction by expression analysis |
| CA2469089A1 (en) * | 2003-07-08 | 2005-01-08 | Institut De Recherches Cliniques De Montreal | En-2 gene, disgnostic and therapeutic uses thereof |
| US20060014301A1 (en) | 2004-07-13 | 2006-01-19 | Power3 Medical Products, Inc. | Antibody-based system for detection of differential protein expression patterns |
| EP2284279A1 (en) * | 2004-12-02 | 2011-02-16 | Epigenomics AG | Methods and nucleic acids for the analysis of gene expression associated with the prognosis of prostate cell proliferative disorders |
| US9416422B2 (en) * | 2005-02-18 | 2016-08-16 | Sloan-Kettering Institute For Cancer Research | Methods for detecting minimum residual disease |
-
2006
- 2006-12-19 GB GBGB0625321.5A patent/GB0625321D0/en not_active Ceased
-
2007
- 2007-10-10 GB GBGB0719792.4A patent/GB0719792D0/en not_active Ceased
- 2007-12-19 ES ES07848631.3T patent/ES2445185T3/es active Active
- 2007-12-19 EP EP07848631.3A patent/EP2115472B1/en not_active Not-in-force
- 2007-12-19 US US12/518,708 patent/US8460882B2/en active Active
- 2007-12-19 RU RU2009127774/15A patent/RU2460075C2/ru not_active IP Right Cessation
- 2007-12-19 AU AU2007335999A patent/AU2007335999B2/en not_active Ceased
- 2007-12-19 PT PT78486313T patent/PT2115472E/pt unknown
- 2007-12-19 PL PL07848631T patent/PL2115472T3/pl unknown
- 2007-12-19 CN CN200780051417.9A patent/CN101675341B/zh not_active Expired - Fee Related
- 2007-12-19 BR BRPI0720371A patent/BRPI0720371B8/pt not_active IP Right Cessation
- 2007-12-19 WO PCT/GB2007/004902 patent/WO2008075056A1/en not_active Ceased
- 2007-12-19 DK DK07848631.3T patent/DK2115472T3/da active
- 2007-12-19 CA CA2671939A patent/CA2671939C/en active Active
- 2007-12-19 NZ NZ577548A patent/NZ577548A/en not_active IP Right Cessation
- 2007-12-19 SI SI200731399T patent/SI2115472T1/sl unknown
- 2007-12-19 MX MX2009006378A patent/MX2009006378A/es active IP Right Grant
- 2007-12-19 JP JP2009542216A patent/JP5683108B2/ja not_active Expired - Fee Related
-
2009
- 2009-06-08 IL IL199241A patent/IL199241A/en active IP Right Grant
-
2014
- 2014-02-05 CY CY20141100091T patent/CY1115178T1/el unknown
Non-Patent Citations (2)
| Title |
|---|
| Gary J. Miller等.Aberrant HOXC Expression Accompanies the Malignant Phenotype in Human Prostate.<CANCER RESEARCH>.2003,第63卷5879–5888. * |
| Kosaki,K.等.HOXC4 [Homo sapiens].<NCBI GenBank: AAG42145.1>.2000,全文. * |
Also Published As
| Publication number | Publication date |
|---|---|
| AU2007335999A1 (en) | 2008-06-26 |
| WO2008075056A1 (en) | 2008-06-26 |
| JP2010513901A (ja) | 2010-04-30 |
| CN101675341A (zh) | 2010-03-17 |
| IL199241A (en) | 2014-03-31 |
| BRPI0720371B8 (pt) | 2021-07-27 |
| US20100093558A1 (en) | 2010-04-15 |
| BRPI0720371A2 (pt) | 2013-12-31 |
| BRPI0720371B1 (pt) | 2019-05-28 |
| PL2115472T3 (pl) | 2014-05-30 |
| RU2009127774A (ru) | 2011-01-27 |
| CA2671939C (en) | 2017-10-03 |
| CA2671939A1 (en) | 2008-06-26 |
| MX2009006378A (es) | 2009-08-24 |
| CY1115178T1 (el) | 2016-12-14 |
| NZ577548A (en) | 2012-03-30 |
| EP2115472B1 (en) | 2013-11-06 |
| PT2115472E (pt) | 2014-02-14 |
| EP2115472A1 (en) | 2009-11-11 |
| DK2115472T3 (da) | 2014-02-10 |
| GB0719792D0 (en) | 2007-11-21 |
| AU2007335999B2 (en) | 2013-09-05 |
| JP5683108B2 (ja) | 2015-03-11 |
| SI2115472T1 (sl) | 2014-05-30 |
| US8460882B2 (en) | 2013-06-11 |
| ES2445185T3 (es) | 2014-02-28 |
| GB0625321D0 (en) | 2007-01-24 |
| RU2460075C2 (ru) | 2012-08-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20170808 |
|
| CF01 | Termination of patent right due to non-payment of annual fee |