IL195201A - Composition for use in the treatment of a disease or condition caused or associated with hyperactive cholinergic nerve of the patient or exocrine glands in the patient and a method of reducing facial lines or wrinkles or removing asymmetry of the face - Google Patents

Composition for use in the treatment of a disease or condition caused or associated with hyperactive cholinergic nerve of the patient or exocrine glands in the patient and a method of reducing facial lines or wrinkles or removing asymmetry of the face

Info

Publication number
IL195201A
IL195201A IL195201A IL19520108A IL195201A IL 195201 A IL195201 A IL 195201A IL 195201 A IL195201 A IL 195201A IL 19520108 A IL19520108 A IL 19520108A IL 195201 A IL195201 A IL 195201A
Authority
IL
Israel
Prior art keywords
wrinkles
muscles
disease
skin
patient
Prior art date
Application number
IL195201A
Other languages
English (en)
Hebrew (he)
Other versions
IL195201A0 (en
Inventor
Matthias Marx
Susanne Grafe
Reiner Benecke
Dirk Dressler
Original Assignee
Merz Pharma Gmbh & Co Kgaa
Matthias Marx
Susanne Grafe
Reiner Benecke
Dirk Dressler
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38462381&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL195201(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merz Pharma Gmbh & Co Kgaa, Matthias Marx, Susanne Grafe, Reiner Benecke, Dirk Dressler filed Critical Merz Pharma Gmbh & Co Kgaa
Publication of IL195201A0 publication Critical patent/IL195201A0/en
Publication of IL195201A publication Critical patent/IL195201A/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46Hydrolases (3)
    • A61K38/48Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/4886Metalloendopeptidases (3.4.24), e.g. collagenase
    • A61K38/4893Botulinum neurotoxin (3.4.24.69)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66Microorganisms or materials therefrom
    • A61K35/74Bacteria
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/60Sugars; Derivatives thereof
    • A61K8/606Nucleosides; Nucleotides; Nucleic acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64Proteins; Peptides; Derivatives or degradation products thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64Proteins; Peptides; Derivatives or degradation products thereof
    • A61K8/66Enzymes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02Muscle relaxants, e.g. for tetanus or cramps
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • A61Q19/08Anti-ageing preparations
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/80Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
    • A61K2800/91Injection
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Birds (AREA)
  • Dermatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Gerontology & Geriatric Medicine (AREA)
  • Biochemistry (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Pain & Pain Management (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
IL195201A 2006-06-29 2008-11-10 Composition for use in the treatment of a disease or condition caused or associated with hyperactive cholinergic nerve of the patient or exocrine glands in the patient and a method of reducing facial lines or wrinkles or removing asymmetry of the face IL195201A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US81775606P 2006-06-29 2006-06-29
PCT/EP2007/005754 WO2008000490A1 (en) 2006-06-29 2007-06-28 High frequency application of neurotoxic component of botulinum toxin

Publications (2)

Publication Number Publication Date
IL195201A0 IL195201A0 (en) 2009-08-03
IL195201A true IL195201A (en) 2015-11-30

Family

ID=38462381

Family Applications (1)

Application Number Title Priority Date Filing Date
IL195201A IL195201A (en) 2006-06-29 2008-11-10 Composition for use in the treatment of a disease or condition caused or associated with hyperactive cholinergic nerve of the patient or exocrine glands in the patient and a method of reducing facial lines or wrinkles or removing asymmetry of the face

Country Status (17)

Country Link
US (3) US8557255B2 (https=)
EP (2) EP2484373A1 (https=)
JP (2) JP5897784B2 (https=)
KR (3) KR20090027732A (https=)
CN (1) CN101460190A (https=)
AR (1) AR061669A1 (https=)
AU (1) AU2007264008B2 (https=)
BR (1) BRPI0713061A2 (https=)
CA (1) CA2654214C (https=)
CL (1) CL2007001911A1 (https=)
IL (1) IL195201A (https=)
MX (1) MX2009000253A (https=)
RU (1) RU2453333C2 (https=)
TW (1) TWI519310B (https=)
UY (1) UY30450A1 (https=)
WO (1) WO2008000490A1 (https=)
ZA (1) ZA200808491B (https=)

Families Citing this family (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10792344B2 (en) * 2006-06-29 2020-10-06 Merz Pharma Gmbh & Co. Kgaa High frequency application of botulinum toxin therapy
AR061669A1 (es) * 2006-06-29 2008-09-10 Merz Pharma Gmbh & Co Kgaa Aplicacion de alta frecuencia de terapia con toxina botulinica
EP1985276A1 (en) * 2007-04-26 2008-10-29 Merz Pharma GmbH & Co. KGaA Treatment of movement disorders by a combined use of a chemodenervating agent and automated movement therapy
RU2009149604A (ru) * 2007-06-01 2011-07-20 Мерц Фарма Гмбх Унд Ко. Кгаа (De) Способ предоставления устойчивого к температуре миорелаксанта на основе нейротоксичного компонента ботулинического токсина в твердой форме
US7473429B1 (en) * 2007-07-27 2009-01-06 Renfroe J Ben Method for treatment of laminitis in animals
US8455459B2 (en) * 2007-08-02 2013-06-04 Medicis Pharmaceutical Corporation Method of applying an injectable filler
US20090204101A1 (en) * 2007-08-20 2009-08-13 Wortzman Mitchell S Method of applying an injectable filler
US9161970B2 (en) 2007-12-12 2015-10-20 Allergan, Inc. Dermal filler
US9044477B2 (en) * 2007-12-12 2015-06-02 Allergan, Inc. Botulinum toxin formulation
EP2072057A1 (en) 2007-12-21 2009-06-24 Merz Pharma GmbH & Co.KGaA Early administration of Botulinum toxin in the treatment of cerebrovascular event and spinal cord injury
EP2072039A1 (en) * 2007-12-21 2009-06-24 Merz Pharma GmbH & Co.KGaA Use of a neurotoxic component of Clostridium botulinum toxin complex to reduce or prevent side effects
US20110033431A1 (en) * 2008-03-31 2011-02-10 The Chemo-Sero-Therapeutic Research Institute Type a2 botulinum toxin preparation
KR20110060903A (ko) 2008-08-29 2011-06-08 메르츠 파마 게엠베하 운트 코. 카가아 지속성이 변경된 클로스트리듐 신경독
EP2161033B1 (en) 2008-09-09 2013-05-01 Susanne Dr. Grafe Botulinum toxin to introduce temporal infertiliy in a vertebrate (e.g. human)
EP2248518B1 (en) * 2009-04-17 2013-01-16 Merz Pharma GmbH & Co. KGaA Formulation for stabilizing proteins, peptides or mixtures thereof.
EP2246065A1 (en) 2009-04-29 2010-11-03 Merz Pharma GmbH & Co. KGaA Intrastriatal botulinum toxin therapy
WO2011023213A1 (en) * 2009-08-28 2011-03-03 Merz Pharma Gmbh & Co. Kgaa Modified chemodenervating agents
SI2490986T1 (sl) * 2009-10-21 2018-12-31 Revance Therapeutics, Inc. Metode in sistemi za prečiščenje nekompleksiranega nevrotoksina botulina
KR101134146B1 (ko) 2010-05-31 2012-04-19 메덱스젠 주식회사 국소 근마비 효과를 갖는 비확산형 보툴리눔 독소와 그의 정제방법
EP2399601A1 (en) 2010-06-24 2011-12-28 Merz Pharma GmbH & Co. KGaA Botulinum toxin therapy
WO2012048854A2 (en) 2010-10-12 2012-04-19 Merz Pharma Gmbh & Co. Kgaa Formulation suitable for stabilizing proteins, which is free of mammalian excipients
RU2454170C1 (ru) * 2011-02-21 2012-06-27 Федеральное государственное учреждение "Нижегородский научно-исследовательский институт травматологии и ортопедии" Министерства здравоохранения и социального развития Российской Федерации Способ лечения спастичности мышц у больных с позвоночно-спинномозговой травмой
MX370929B (es) 2012-10-28 2020-01-08 Revance Therapeutics Inc Composiciones y usos de las mismas para el tratamiento seguro de la rinitis.
RU2535115C1 (ru) 2013-05-15 2014-12-10 Бости Трейдинг Лтд Фармацевтический состав, содержащий нейротоксин ботулина
HK1225744A1 (zh) * 2013-07-30 2017-09-15 Merz Pharma Gmbh & Co. Kgaa 制备高纯度的肉毒杆菌毒素神经毒性组分的方法及其应用
WO2015039206A1 (en) * 2013-09-20 2015-03-26 Mddt Inc. Diagnosing and treating movement disorders
JP6498678B2 (ja) 2013-09-20 2019-04-10 エムディディティ・インコーポレイテッドMddt Inc. 運動障害の診断および処置
WO2015188942A1 (en) * 2014-06-13 2015-12-17 Merz Pharma Gmbh & Co. Kgaa Novel uses of recombinant clostridial neurotoxins with decreased duration of effect
US20170112907A1 (en) * 2014-06-13 2017-04-27 Merz Pharma Gmbh & Co. Kgaa Novel uses of recombinant clostridial neurotoxins with decreased duration of effect
US11484580B2 (en) 2014-07-18 2022-11-01 Revance Therapeutics, Inc. Topical ocular preparation of botulinum toxin for use in ocular surface disease
EP3285800B1 (en) * 2015-04-24 2019-09-18 Consiglio Nazionale Delle Ricerche A new therapeutic use of the botulinum neurotoxin serotype a
WO2018146550A1 (en) * 2017-02-10 2018-08-16 De Maio Domingos Mauricio Methods and systems for preventing, correcting, transforming, and modifying facial, aesthetics, and consulting patients regarding the same
KR20210130711A (ko) * 2019-02-21 2021-11-01 메르츠 파마 게엠베하 운트 코. 카가아 진전의 치료를 위한 보툴리눔 신경독의 신규 용도
RU2721300C2 (ru) * 2019-10-17 2020-05-18 Федеральное государственное бюджетное учреждение "Национальный медицинский исследовательский центр радиологии" Министерства здравоохранения Российской Федерации (ФГБУ "НМИЦ радиологии" Минздрава России) Способ лечения нейрогенной дисфункции мочевого пузыря, проявляющейся функциональной инфравезикальной обструкцией у женщин
US10987411B1 (en) 2019-10-18 2021-04-27 Penland Foundation Treatment of chronic obstructive pulmonary disease using botulinum toxin
US10973873B1 (en) 2019-10-18 2021-04-13 Penland Foundation Treatment of asthma using botulinum toxin
CA3227431A1 (en) 2019-10-18 2021-04-22 Penland Foundation Use of a botulinum toxin for treating autism and/or tolerance to narcotics
US11090371B1 (en) 2019-10-18 2021-08-17 Penland Foundation Treatment of cirrhosis using botulinum toxin
US10960061B1 (en) 2019-10-18 2021-03-30 Penland Foundation Treatment of amyotrophic lateral sclerosis using botulinum toxin
US10967052B1 (en) 2019-10-18 2021-04-06 Penland Foundation Treatment of dyslexia using botulinum toxin
US11241479B2 (en) 2019-10-18 2022-02-08 Penland Foundation Treatment methods using botulinum toxins
US11738071B2 (en) 2021-07-12 2023-08-29 Penland Foundation Treatment of acute and chronic kidney disease
US10960060B1 (en) 2019-10-18 2021-03-30 Penland Foundation Treatment of cardiac arrhythmia using botulinum toxin
WO2021231666A1 (en) 2020-05-15 2021-11-18 Penland Foundation Treatment of asthma using botulinum toxin
WO2021137667A1 (ko) * 2019-12-30 2021-07-08 주식회사 에이티지씨 보툴리눔 신경독소를 포함하는 파킨슨병 치료용 조성물 및 이를 이용한 파킨슨병 치료 방법
WO2023287728A1 (en) 2021-07-12 2023-01-19 Penland Foundation Treatment of diabetes and chronic pancreatitis using botulinum toxin
USD1108809S1 (en) * 2023-08-21 2026-01-13 Taizhou Info Plastic Mould Co., Ltd. Storage box

Family Cites Families (75)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3888977A (en) * 1973-02-01 1975-06-10 Murray J Sanders Modified neurotoxin
US4932936A (en) * 1988-01-29 1990-06-12 Regents Of The University Of Minnesota Method and device for pharmacological control of spasticity
US5919665A (en) * 1989-10-31 1999-07-06 Ophidian Pharmaceuticals, Inc. Vaccine for clostridium botulinum neurotoxin
GB9120306D0 (en) * 1991-09-24 1991-11-06 Graham Herbert K Method and compositions for the treatment of cerebral palsy
US5562907A (en) * 1993-05-14 1996-10-08 Arnon; Stephen S. Method to prevent side-effects and insensitivity to the therapeutic uses of toxins
DE122009000066I2 (de) * 1993-06-10 2010-12-30 Allergan Inc Behandlung von neuromuskulären Störungen und Zuständen mit verschiedenen botulinen Serotypen
US7037680B2 (en) * 1993-09-21 2006-05-02 The United States Of America As Represented By The Secretary Of The Army Recombinant light chains of botulinum neurotoxins and light chain fusion proteins for use in research and clinical therapy
DE69428813T2 (de) * 1993-12-28 2002-04-04 Allergan Sales Inc Verwendung von Botulinustoxin zur Behandlung von Spannungs-Kopfschmerz
US8557256B2 (en) * 1993-12-28 2013-10-15 Allergan, Inc. Treatment for cervical dystonia with the neurotoxic component of a botulinum toxin
US8187612B2 (en) * 1993-12-28 2012-05-29 Allergan, Inc. Use of the neurotoxic component of a botulinum toxin for treating a spastic muscle
US6974578B1 (en) * 1993-12-28 2005-12-13 Allergan, Inc. Method for treating secretions and glands using botulinum toxin
US5670484A (en) * 1994-05-09 1997-09-23 Binder; William J. Method for treatment of skin lesions associated with cutaneous cell-proliferative disorders
KR100544060B1 (ko) * 1997-07-15 2006-01-23 더 리젠트스 오브 더 유니버시티 오브 콜로라도 비뇨기과학 및 관련 부전증을 치료하기 위한 신경독요법의 용도
WO2000001777A1 (en) * 1998-07-07 2000-01-13 Sun Chemical Corporation Low voc cationic curable lithographic printing inks
TW574036B (en) * 1998-09-11 2004-02-01 Elan Pharm Inc Stable liquid compositions of botulinum toxin
DE69943220D1 (de) 1998-09-11 2011-04-07 Gr Intellectual Reserve Llc Verfahren und system für biometrische erkennung basiert auf elektrischen und/oder magnetischen eigenschaften
DE19856897A1 (de) * 1998-12-10 2000-06-15 Biotecon Ges Fuer Biotechnologische Entwicklung & Consulting Mbh Therapeutikum zur Unterdrückung von Schnarchgeräuschen
DE19925739A1 (de) * 1999-06-07 2000-12-21 Biotecon Ges Fuer Biotechnologische Entwicklung & Consulting Mbh Therapeutikum mit einem Botulinum-Neurotoxin
US6348434B1 (en) * 1999-07-01 2002-02-19 Basf Aktiengesellschaft Herbicidal emulsifiable concentrate
US20030180289A1 (en) * 1999-09-23 2003-09-25 Foster Keith Alan Inhibition of secretion from non-neuronal cells
JP2003512603A (ja) 1999-10-05 2003-04-02 テクノロジィ ファイナンス コーポレイション(プロプライエタリー) リミテッド 回転軸におけるトルクによるねじれの測定
US6113915A (en) 1999-10-12 2000-09-05 Allergan Sales, Inc. Methods for treating pain
AU770851B2 (en) 1999-10-14 2004-03-04 Mine Safety Appliances Company Lanyard with integral fall arrest energy absorber
US6306423B1 (en) * 2000-06-02 2001-10-23 Allergan Sales, Inc. Neurotoxin implant
US20030219462A1 (en) * 2000-07-21 2003-11-27 Allergan Sales, Inc Clostridial neurotoxin compositions and modified clostridial neurotoxins
DE10043982A1 (de) * 2000-09-05 2002-03-14 Armin Maurer Verfahren zur Verbesserung des Haarwuchses menschlichen Kopfhaares
US20020086036A1 (en) * 2000-12-05 2002-07-04 Allergan Sales, Inc. Methods for treating hyperhidrosis
DK1411978T3 (da) * 2001-07-27 2009-01-05 Univ Louisiana State Botulinum-toksin ved behandlingen eller forebyggelsen af acne
US7115399B2 (en) * 2001-07-31 2006-10-03 Allergan, Inc. Pinna reflex assay
US20050106183A1 (en) * 2002-01-31 2005-05-19 Lamb Gregory B. Method of treating pain
US7022329B2 (en) * 2002-02-25 2006-04-04 Allergan, Inc. Method for treating neurogenic inflammation pain with botulinum toxin and substance P components
US7140371B2 (en) * 2002-03-14 2006-11-28 Allergan, Inc. Surface topography method for determining effects of a botulinum toxin upon a muscle and for comparing botulinum toxins
US7300412B2 (en) * 2002-05-10 2007-11-27 Hospital For Joint Diseases Methods for therapeutic treatment of carpal tunnel syndrome
US7691394B2 (en) * 2002-05-28 2010-04-06 Botulinum Toxin Research Associates, Inc. High-potency botulinum toxin formulations
US20030224020A1 (en) * 2002-05-31 2003-12-04 Zabudkin Alexander F. Pharmaceutical preparation of botulinum neurotoxin, methods of synthesis and methods of clinical use
US6776991B2 (en) * 2002-06-26 2004-08-17 Allergan, Inc. Methods for treating priapism
US20040009180A1 (en) * 2002-07-11 2004-01-15 Allergan, Inc. Transdermal botulinum toxin compositions
JPWO2004016783A1 (ja) 2002-08-06 2006-01-19 株式会社ジェノックス創薬研究所 アトピー性皮膚炎の検査方法
EP2272340B1 (en) * 2002-08-19 2018-03-14 Ira Sanders Botulinum toxin
US7824693B2 (en) * 2002-08-19 2010-11-02 Ira Sanders Treatment of fine wrinkles with clostridia neurotoxins
US20040115222A1 (en) * 2002-09-06 2004-06-17 Michael Kane Method for reduction of wrinkles
EP1398907B1 (de) * 2002-09-10 2010-12-08 Siemens Aktiengesellschaft Verfahren zur Kontrolle von Übertragungsressourcen eines paketorientierten Kommunikationsnetzes bei Topologieänderungen
US7422753B2 (en) * 2003-04-25 2008-09-09 Allergan, Inc. Methods for treating trichotillomania
US6838434B2 (en) 2003-05-02 2005-01-04 Allergan, Inc. Methods for treating sinus headache
US20050042775A1 (en) * 2003-08-21 2005-02-24 Nicholas Pomato Botulinum antitoxin compositions and methods
US7148041B2 (en) 2003-09-25 2006-12-12 Allergan, Inc. Animal product free media and processes for obtaining a botulinum toxin
US20050144029A1 (en) * 2003-12-31 2005-06-30 Rakowski Richard R. Systems and methods for aesthetic improvement
ES2338017T3 (es) * 2004-01-05 2010-05-03 Botulinum Toxin Research Associates, Inc. Metodos de utilizacion de la toxina botulinica para el tratamiento de la deformacion de los labios hipervolemica (ectropion de los labios).
US9078892B2 (en) * 2004-02-26 2015-07-14 Allergan, Inc. Methods for treating pain and for treating a medication overuse disorder
US7691381B2 (en) * 2004-04-15 2010-04-06 Allergan, Inc. Stabilized biodegradable neurotoxin implants
EP2266599B1 (en) * 2004-07-26 2014-04-16 Merz Pharma GmbH & Co. KGaA Therapeutic composition with a botulinum neurotoxin
US20060057165A1 (en) * 2004-09-10 2006-03-16 Dimitrios Dimitrakoudis Clostridium botulinum toxin formulation and method for reducing weight
AU2005288758A1 (en) * 2004-09-27 2006-04-06 Merz Pharma Gmbh & Co. Kgaa Clostridial neurotoxins for use in tissue healing
US20060073208A1 (en) * 2004-10-01 2006-04-06 Allergan, Inc. Cosmetic neurotoxin compositions and methods
GB0426394D0 (en) * 2004-12-01 2005-01-05 Health Prot Agency Fusion proteins
AU2005311086B2 (en) * 2004-12-01 2012-03-29 Allergan, Inc. Fusion proteins
FR2879462B1 (fr) * 2004-12-21 2008-12-26 Sod Conseils Rech Applic Utilisation de toxine botulique pour une insensibilisation locale prolongee
US20080220021A1 (en) * 2005-02-14 2008-09-11 Pankaj Modi Topical Botulinum Toxin Compositions for the Treatment of Hyperhidrosis
US20090232849A1 (en) * 2005-03-03 2009-09-17 Universite Catholique De Louvain Methods and compositions for the treatment of cancer
US20060269574A1 (en) * 2005-05-31 2006-11-30 De Beer Johann F Method of repairing tendons by surgery
US8105611B2 (en) * 2005-06-17 2012-01-31 Allergan, Inc. Treatment of autoimmune disorder with a neurotoxin
US20070128226A1 (en) * 2005-12-01 2007-06-07 Philip Radovic Methods of treating pain associated with abnormalities of the first metatarsophalangeal joint of the foot
US7824694B2 (en) * 2006-01-12 2010-11-02 Allergan, Inc. Methods for enhancing therapeutic effects of a neurotoxin
US8658391B2 (en) * 2006-04-27 2014-02-25 Anterios, Inc. Assessment of the effects of topical administration of chemodenervating pharmaceuticals
AR061669A1 (es) * 2006-06-29 2008-09-10 Merz Pharma Gmbh & Co Kgaa Aplicacion de alta frecuencia de terapia con toxina botulinica
EP1985276A1 (en) * 2007-04-26 2008-10-29 Merz Pharma GmbH & Co. KGaA Treatment of movement disorders by a combined use of a chemodenervating agent and automated movement therapy
RU2009149604A (ru) * 2007-06-01 2011-07-20 Мерц Фарма Гмбх Унд Ко. Кгаа (De) Способ предоставления устойчивого к температуре миорелаксанта на основе нейротоксичного компонента ботулинического токсина в твердой форме
US8586081B2 (en) * 2007-09-20 2013-11-19 University Of Massachusetts Detoxified recombinant botulinum neurotoxin
US9038912B2 (en) * 2007-12-18 2015-05-26 Microsoft Technology Licensing, Llc Trade card services
KR20110060903A (ko) * 2008-08-29 2011-06-08 메르츠 파마 게엠베하 운트 코. 카가아 지속성이 변경된 클로스트리듐 신경독
CA2751311C (en) * 2009-02-19 2019-08-06 Merz Pharma Gmbh & Co. Kgaa Means and methods for manufacturing highly pure neurotoxin
BRPI1014253A2 (pt) * 2009-07-02 2016-04-12 Merz Pharma Gmbh & Co Kgaa polinucleotídeo codificado um polipeptídeo de neurotoxina, vetor, célula hospedeira, anticorpo, uso de um polinucleotídeo, método para a fabricação de um polipeptídeo de neurotoxina e método para a fabricação de um medicamento
US9310386B2 (en) * 2010-01-22 2016-04-12 Merz Pharma Gmbh & Co. Kgaa In vitro assay for quantifying clostridial neurotoxin activity
EP2776454A1 (en) * 2011-11-09 2014-09-17 Merz Pharma GmbH & Co. KGaA Modified neurotoxins with poly-glycine and uses thereof
HK1225744A1 (zh) * 2013-07-30 2017-09-15 Merz Pharma Gmbh & Co. Kgaa 制备高纯度的肉毒杆菌毒素神经毒性组分的方法及其应用

Also Published As

Publication number Publication date
AU2007264008A1 (en) 2008-01-03
US20080003241A1 (en) 2008-01-03
AR061669A1 (es) 2008-09-10
US20150290303A1 (en) 2015-10-15
WO2008000490A1 (en) 2008-01-03
UY30450A1 (es) 2009-04-30
TWI519310B (zh) 2016-02-01
JP5897784B2 (ja) 2016-03-30
AU2007264008B2 (en) 2012-06-28
US8557255B2 (en) 2013-10-15
KR20090027732A (ko) 2009-03-17
JP2014015476A (ja) 2014-01-30
CL2007001911A1 (es) 2008-03-14
US20140010803A1 (en) 2014-01-09
RU2453333C2 (ru) 2012-06-20
CN101460190A (zh) 2009-06-17
KR20150126979A (ko) 2015-11-13
EP2032157A1 (en) 2009-03-11
RU2009102848A (ru) 2010-08-10
JP2009541396A (ja) 2009-11-26
CA2654214A1 (en) 2008-01-03
IL195201A0 (en) 2009-08-03
TW200819140A (en) 2008-05-01
MX2009000253A (es) 2009-01-22
ZA200808491B (en) 2009-11-25
US9095523B2 (en) 2015-08-04
BRPI0713061A2 (pt) 2012-04-10
EP2484373A1 (en) 2012-08-08
US9572871B2 (en) 2017-02-21
KR20140142377A (ko) 2014-12-11
CA2654214C (en) 2023-07-04

Similar Documents

Publication Publication Date Title
IL195201A (en) Composition for use in the treatment of a disease or condition caused or associated with hyperactive cholinergic nerve of the patient or exocrine glands in the patient and a method of reducing facial lines or wrinkles or removing asymmetry of the face
IL264796B (en) History of 6,23-metabolized bile acid, pharmaceutical preparations acceptable in a pharmacy and compounds for use in a method for treating or preventing a disease
ZA201007460B (en) Use of epothelone in treating tau-associated disease including alzheimer's disease
EP1998788A4 (en) COMPOSITIONS AND METHODS FOR THE TOPIC TREATMENT OF DERMATOLOGICAL DISORDERS RESPONSIBLE FOR TAR
IL207559A0 (en) Formulation and method for the prevention and treatment of skeletal manifestation of gaucher's disease
GB0624584D0 (en) Skin treatment apparatus and method
IL209546A0 (en) Method and device for characterizing the effect of a skin treatment agent on skin
ZA200806114B (en) Use of sulfonamide derivatives in the treatment of disorders of the metabolism and the nervous system
EP2244786A4 (en) SKIN TREATMENT DEVICE FOR PERSONAL USE AND USE METHOD THEREFOR
EP2323597A4 (en) HEALTHY SKIN TREATMENT APPARATUS FOR PERSONAL USE AND METHOD OF USE
IL230911A0 (en) A system for the treatment of heart tissue and its use
EP2334249A4 (en) METHOD AND DEVICE FOR SKIN CARE
GB0912941D0 (en) Methods and composition for reduction of side effects of therapeutic treatments
IL273964B (en) A cosmetic method for the treatment of skin tissue
PT2083837E (pt) Utilização terapêutica de pelo menos uma neurotoxina botulínica no tratamento da dor induzida por, pelo menos, um agente anti-cancerígeno
WO2008070859A3 (en) Treatment of skin conditions by dickkopf1 (dkk1)
EP2051732A4 (en) DIAGNOSIS AND TREATMENT OF METABOLIC DISORDERS AND METHODS THEREFOR
GB0426255D0 (en) Improvements in and relating to products for skin treatment
ZA201104743B (en) Topical herbal formulation for treatment of acne and skin disorders
ZA200900489B (en) Apparatus and methods for skin treatment
WO2008028097A3 (en) Method for skin care
GB0705566D0 (en) Method of treating learning impairment in down's syndrome subjects
GB0718918D0 (en) Compositions and methods for treating skin conditions
EP1922063A4 (en) METHOD FOR TREATING PAIN IN PATIENTS
IL201430A0 (en) Methods and compositions comprising desvenlafaxine or duloxetine for treating sleep related breathing disorders

Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
KB Patent renewed
KB Patent renewed