IL193164A0 - Polymeric conjugates of 7-ethyl-10-hydroxycamptothecin and pharmaceutical compositions containing the same - Google Patents
Polymeric conjugates of 7-ethyl-10-hydroxycamptothecin and pharmaceutical compositions containing the sameInfo
- Publication number
- IL193164A0 IL193164A0 IL193164A IL19316408A IL193164A0 IL 193164 A0 IL193164 A0 IL 193164A0 IL 193164 A IL193164 A IL 193164A IL 19316408 A IL19316408 A IL 19316408A IL 193164 A0 IL193164 A0 IL 193164A0
- Authority
- IL
- Israel
- Prior art keywords
- hydroxycamptothecin
- ethyl
- same
- pharmaceutical compositions
- compositions containing
- Prior art date
Links
- FJHBVJOVLFPMQE-QFIPXVFZSA-N 7-Ethyl-10-Hydroxy-Camptothecin Chemical compound C1=C(O)C=C2C(CC)=C(CN3C(C4=C([C@@](C(=O)OC4)(O)CC)C=C33)=O)C3=NC2=C1 FJHBVJOVLFPMQE-QFIPXVFZSA-N 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/14—Ortho-condensed systems
- C07D491/147—Ortho-condensed systems the condensed system containing one ring with oxygen as ring hetero atom and two rings with nitrogen as ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicinal Preparation (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Polyethers (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US77246406P | 2006-02-09 | 2006-02-09 | |
| US80439106P | 2006-06-09 | 2006-06-09 | |
| US84493806P | 2006-09-15 | 2006-09-15 | |
| US86451606P | 2006-11-06 | 2006-11-06 | |
| PCT/US2007/003808 WO2007092646A2 (en) | 2006-02-09 | 2007-02-09 | Multi-arm polymeric conjugates of 7-ethyl-10-hydroxycamptothecin for treatment of breast, colorectal, pancreatic, ovarian and lung cancers |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL193164A0 true IL193164A0 (en) | 2009-08-03 |
Family
ID=38345853
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL193164A IL193164A0 (en) | 2006-02-09 | 2008-07-31 | Polymeric conjugates of 7-ethyl-10-hydroxycamptothecin and pharmaceutical compositions containing the same |
Country Status (11)
| Country | Link |
|---|---|
| EP (1) | EP1996208B1 (OSRAM) |
| JP (1) | JP5265384B2 (OSRAM) |
| KR (1) | KR20080091829A (OSRAM) |
| CN (1) | CN101420963B (OSRAM) |
| AU (1) | AU2007212201B2 (OSRAM) |
| CA (1) | CA2640013A1 (OSRAM) |
| ES (1) | ES2436109T3 (OSRAM) |
| IL (1) | IL193164A0 (OSRAM) |
| MX (1) | MX2008010303A (OSRAM) |
| TW (1) | TWI426905B (OSRAM) |
| WO (1) | WO2007092646A2 (OSRAM) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7462627B2 (en) * | 2006-02-09 | 2008-12-09 | Enzon Pharmaceuticals, Inc. | Multi-arm polymeric conjugates of 7-ethyl-10-hydroxycamptothecin for treatment of breast, colorectal, pancreatic, ovarian and lung cancers |
| US7671067B2 (en) | 2006-02-09 | 2010-03-02 | Enzon Pharmaceuticals, Inc. | Treatment of non-hodgkin's lymphomas with multi-arm polymeric conjugates of 7-ethyl-10-hydroxycamtothecin |
| KR20090108082A (ko) * | 2007-02-09 | 2009-10-14 | 엔존 파마슈티컬즈, 인코포레이티드 | 7-에틸-10-하이드록시캄토테신 다분지형 고분자 접합체를 이용한 내성 또는 불응성 암의 치료방법 |
| TW201010732A (en) * | 2008-08-29 | 2010-03-16 | Enzon Pharmaceuticals Inc | Method of treating RAS associated cancer |
| KR20110075029A (ko) * | 2008-10-21 | 2011-07-05 | 엔즌 파마슈티칼스, 인코포레이티드 | 7-에틸-10-하이드록시캄토테신의 다중-암 고분자 컨쥬게이트로 신경모세포종의 치료 |
| AU2010236453A1 (en) * | 2009-04-17 | 2011-11-03 | Enzon Pharmaceuticals, Inc. | Methods for inhibiting angiogenesis with multi-arm polymeric conjugates of 7-ethyl-10-hydroxycamptothecin |
| EP2771034B1 (en) | 2011-10-25 | 2018-08-08 | Nektar Therapeutics | Topoisomerase-i and-ii inhibitors for use in the treatment of patients suffering from cancer |
| AU2013352223B2 (en) * | 2012-11-28 | 2019-07-18 | Nektar Therapeutics | Method for assessing and predicting efficacy of breast cancer treatment with a long-acting topoisomerase I inhibitor |
| EP3004888A1 (en) | 2013-05-31 | 2016-04-13 | Nektar Therapeutics | Method for predicting and evaluating responsiveness to cancer treatment with dna-damaging chemotherapeutic agents |
| CN104650342B (zh) * | 2013-11-18 | 2018-07-10 | 江苏豪森药业集团有限公司 | 多支链聚合药物前体及其应用 |
| CA2934552C (en) | 2014-01-14 | 2021-03-30 | Nektar Therapeutics | Combination-based treatment method |
| CN110448533B (zh) * | 2014-12-05 | 2022-03-29 | 天津键凯科技有限公司 | 一种聚乙二醇修饰的喜树碱类衍生物的药物组合物及其制备方法 |
| CN106831853B (zh) * | 2017-02-15 | 2019-02-22 | 浙江海正药业股份有限公司 | 7-乙基-10-o-叔丁基二苯基硅基喜树碱-20-o-甘氨酸盐酸盐的制备工艺 |
| CN108727583B (zh) * | 2017-04-21 | 2022-03-22 | 高瑞耀业(北京)科技有限公司 | 多臂靶向抗癌偶联物 |
| CN108727584B (zh) * | 2017-04-21 | 2021-01-05 | 博瑞生物医药（苏州）股份有限公司 | 抗癌偶联物 |
| CN108164419B (zh) * | 2017-12-25 | 2021-03-16 | 武汉大学 | 单分散聚乙二醇单甲醚修饰的丙泊酚前药的制备与应用 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5880131A (en) * | 1993-10-20 | 1999-03-09 | Enzon, Inc. | High molecular weight polymer-based prodrugs |
| SI0934065T1 (sl) * | 1996-08-30 | 2007-02-28 | Univ Hawaii | Novi kriptoficinski derivati kot anti-neoplasticna sredstva |
| US20040009229A1 (en) * | 2000-01-05 | 2004-01-15 | Unger Evan Charles | Stabilized nanoparticle formulations of camptotheca derivatives |
| US6548488B2 (en) * | 2000-03-17 | 2003-04-15 | Aventis Pharma S.A. | Composition comprising camptothecin or a camptothecin derivative and an alkylating agent for the treatment of cancer |
| US7132423B2 (en) * | 2001-09-21 | 2006-11-07 | Reddy Us Therapeutics, Inc. | Methods and compositions of novel triazine compounds |
| JP2006514064A (ja) * | 2003-01-16 | 2006-04-27 | テクノ マート シーオー．，エルティーディー． | ポルフィリン誘導体 |
| DE10307787A1 (de) * | 2003-02-24 | 2004-09-02 | Ktb Tumorforschungsgesellschaft Mbh | Protein-bindende Camptothecin-Derivate |
| JP2006523237A (ja) * | 2003-04-03 | 2006-10-12 | セマフォア ファーマシューティカルズ， インコーポレイテッド | Ｐｉ−３キナーゼインヒビタープロドラッグ |
| PL2910551T3 (pl) * | 2003-04-11 | 2017-09-29 | Ptc Therapeutics, Inc. | Związki kwasu 1,2,4-oksadiazolobenzoesowego i ich zastosowanie do supresji mutacji nonsensownych i leczenia choroby |
| TWI334868B (en) * | 2003-06-03 | 2010-12-21 | Nippon Kayaku Kk | [1,2,4] triazoro [1,5-a] pyrimidine-2-ylurea derivative and use thereof |
| US20040247624A1 (en) * | 2003-06-05 | 2004-12-09 | Unger Evan Charles | Methods of making pharmaceutical formulations for the delivery of drugs having low aqueous solubility |
| KR20120073370A (ko) * | 2003-09-17 | 2012-07-04 | 넥타르 테라퓨틱스 | 다분지형 고분자 전구약물 |
| WO2005068424A1 (en) * | 2004-01-20 | 2005-07-28 | Cell Therapeutics Europe S.R.L. | Indolinone derivatives as receptor tyrosine kinase ihibitors |
| TW200530236A (en) * | 2004-02-23 | 2005-09-16 | Chugai Pharmaceutical Co Ltd | Heteroaryl phenylurea |
| ITRM20040239A1 (it) * | 2004-05-13 | 2004-08-13 | Sigma Tau Ind Farmaceuti | Derivati ciclopeptidici ad attivita' antintegrine. |
-
2007
- 2007-02-09 WO PCT/US2007/003808 patent/WO2007092646A2/en not_active Ceased
- 2007-02-09 KR KR1020087021163A patent/KR20080091829A/ko not_active Withdrawn
- 2007-02-09 AU AU2007212201A patent/AU2007212201B2/en not_active Ceased
- 2007-02-09 ES ES07763709T patent/ES2436109T3/es active Active
- 2007-02-09 TW TW096104772A patent/TWI426905B/zh not_active IP Right Cessation
- 2007-02-09 CA CA002640013A patent/CA2640013A1/en not_active Abandoned
- 2007-02-09 MX MX2008010303A patent/MX2008010303A/es unknown
- 2007-02-09 CN CN2007800127903A patent/CN101420963B/zh not_active Expired - Fee Related
- 2007-02-09 JP JP2008554430A patent/JP5265384B2/ja not_active Expired - Fee Related
- 2007-02-09 EP EP07763709.8A patent/EP1996208B1/en not_active Not-in-force
-
2008
- 2008-07-31 IL IL193164A patent/IL193164A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| KR20080091829A (ko) | 2008-10-14 |
| JP5265384B2 (ja) | 2013-08-14 |
| CN101420963A (zh) | 2009-04-29 |
| JP2009526076A (ja) | 2009-07-16 |
| EP1996208A4 (en) | 2011-04-06 |
| TW200810757A (en) | 2008-03-01 |
| TWI426905B (zh) | 2014-02-21 |
| MX2008010303A (es) | 2009-03-05 |
| EP1996208A2 (en) | 2008-12-03 |
| AU2007212201A1 (en) | 2007-08-16 |
| CN101420963B (zh) | 2012-09-05 |
| AU2007212201B2 (en) | 2012-09-13 |
| ES2436109T3 (es) | 2013-12-27 |
| WO2007092646A2 (en) | 2007-08-16 |
| CA2640013A1 (en) | 2007-08-16 |
| EP1996208B1 (en) | 2013-09-25 |
| WO2007092646A3 (en) | 2008-10-16 |
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