IL192751A0 - Thiazole compounds as protein kinase b (pkb) inhibitors - Google Patents
Thiazole compounds as protein kinase b (pkb) inhibitorsInfo
- Publication number
- IL192751A0 IL192751A0 IL192751A IL19275108A IL192751A0 IL 192751 A0 IL192751 A0 IL 192751A0 IL 192751 A IL192751 A IL 192751A IL 19275108 A IL19275108 A IL 19275108A IL 192751 A0 IL192751 A0 IL 192751A0
- Authority
- IL
- Israel
- Prior art keywords
- pkb
- inhibitors
- protein kinase
- thiazole compounds
- thiazole
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US75954606P | 2006-01-18 | 2006-01-18 | |
| PCT/US2007/000871 WO2007084391A2 (en) | 2006-01-18 | 2007-01-11 | Thiazole compounds as protein kinase b ( pkb) inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL192751A0 true IL192751A0 (en) | 2009-02-11 |
Family
ID=38180602
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL192751A IL192751A0 (en) | 2006-01-18 | 2008-07-10 | Thiazole compounds as protein kinase b (pkb) inhibitors |
Country Status (21)
Families Citing this family (56)
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| EP2326631A4 (en) * | 2008-08-18 | 2012-03-21 | Univ Yale | MODULATORS OF MIF |
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| CA2777561A1 (en) * | 2009-10-12 | 2011-04-21 | Glaxosmithkline Llc | Combination |
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| CN102933571A (zh) * | 2010-04-16 | 2013-02-13 | Abbvie公司 | 激酶的酞嗪-(2h)-酮抑制剂 |
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| CN103304468A (zh) * | 2012-03-13 | 2013-09-18 | 华东师范大学 | 一种氧化吲哚的一锅法串联合成方法 |
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| JP6417338B2 (ja) | 2013-02-19 | 2018-11-07 | アムジエン・インコーポレーテツド | 癌の治療のためのｍｄｍ２阻害剤としてのシス−モルホリノン及び他の化合物 |
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| JOP20200296A1 (ar) | 2013-06-10 | 2017-06-16 | Amgen Inc | عمليات صنع وأشكال بلورية من mdm2 مثبط |
| EA202092456A3 (ru) | 2013-11-11 | 2021-09-30 | Эмджен Инк. | Комбинированная терапия, включающая ингибитор mdm2 и один или более дополнительных фармацевтически активных агентов, для лечения различных видов рака |
| SG11201705821XA (en) * | 2015-03-02 | 2017-08-30 | Rigel Pharmaceuticals Inc | TGF-ß INHIBITORS |
| WO2017151409A1 (en) | 2016-02-29 | 2017-09-08 | University Of Florida Research Foundation, Incorporated | Chemotherapeutic methods |
| EP3426652B1 (en) * | 2016-03-10 | 2021-12-01 | Astrazeneca AB | Novel inhibitors of phosphatidylinositol 3-kinase gamma |
| TW201843139A (zh) | 2017-03-30 | 2018-12-16 | 瑞士商赫孚孟拉羅股份公司 | 作為ｈｐｋ１之抑制劑的異喹啉 |
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| US11612606B2 (en) | 2018-10-03 | 2023-03-28 | Genentech, Inc. | 8-aminoisoquinoline compounds and uses thereof |
| JP7377679B2 (ja) | 2018-11-19 | 2023-11-10 | アムジエン・インコーポレーテツド | がん治療のためのｋｒａｓｇ１２ｃ阻害剤及び１種以上の薬学的に活性な追加の薬剤を含む併用療法 |
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| CN114014787B (zh) * | 2022-01-10 | 2022-03-22 | 苏州开元民生科技股份有限公司 | 一种制备(2s,3r)-对甲砜基苯丝氨酸乙酯的不对称合成方法 |
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2007
- 2007-01-11 KR KR1020087019941A patent/KR20080091369A/ko not_active Application Discontinuation
- 2007-01-11 CN CNA2007800097081A patent/CN101421265A/zh active Pending
- 2007-01-11 US US11/652,728 patent/US7514566B2/en active Active
- 2007-01-11 CA CA2636077A patent/CA2636077C/en not_active Expired - Fee Related
- 2007-01-11 WO PCT/US2007/000871 patent/WO2007084391A2/en active Application Filing
- 2007-01-11 BR BRPI0706621-0A patent/BRPI0706621A2/pt not_active IP Right Cessation
- 2007-01-11 AU AU2007207743A patent/AU2007207743B2/en not_active Ceased
- 2007-01-11 EP EP07718125A patent/EP1981884B1/en active Active
- 2007-01-11 MY MYPI20082598A patent/MY149143A/en unknown
- 2007-01-11 EA EA200801716A patent/EA200801716A1/ru unknown
- 2007-01-11 ES ES07718125T patent/ES2389062T3/es active Active
- 2007-01-11 JP JP2008551297A patent/JP5199885B2/ja not_active Expired - Fee Related
- 2007-01-17 TW TW096101796A patent/TW200738657A/zh unknown
- 2007-01-18 PE PE2007000057A patent/PE20071114A1/es not_active Application Discontinuation
- 2007-01-18 UY UY30098A patent/UY30098A1/es not_active Application Discontinuation
- 2007-01-18 AR ARP070100212A patent/AR059064A1/es unknown
- 2007-11-01 UA UAA200810455A patent/UA91895C2/ru unknown
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2008
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- 2008-08-18 NO NO20083572A patent/NO20083572L/no not_active Application Discontinuation
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2009
- 2009-02-11 US US12/378,195 patent/US8084479B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| AU2007207743A1 (en) | 2007-07-26 |
| EP1981884B1 (en) | 2012-06-13 |
| AR059064A1 (es) | 2008-03-12 |
| EP1981884A2 (en) | 2008-10-22 |
| TW200738657A (en) | 2007-10-16 |
| US8084479B2 (en) | 2011-12-27 |
| NO20083572L (no) | 2008-10-17 |
| UA91895C2 (en) | 2010-09-10 |
| PE20071114A1 (es) | 2008-01-10 |
| MY149143A (en) | 2013-07-15 |
| BRPI0706621A2 (pt) | 2011-04-05 |
| JP5199885B2 (ja) | 2013-05-15 |
| ES2389062T3 (es) | 2012-10-22 |
| WO2007084391A3 (en) | 2008-03-20 |
| US20070173506A1 (en) | 2007-07-26 |
| CA2636077C (en) | 2012-01-03 |
| US20090270445A1 (en) | 2009-10-29 |
| CN101421265A (zh) | 2009-04-29 |
| AU2007207743B2 (en) | 2010-07-08 |
| KR20080091369A (ko) | 2008-10-10 |
| CA2636077A1 (en) | 2007-07-26 |
| CR10211A (es) | 2008-10-03 |
| UY30098A1 (es) | 2007-10-31 |
| EA200801716A1 (ru) | 2009-04-28 |
| JP2009525960A (ja) | 2009-07-16 |
| ZA200806386B (en) | 2009-11-25 |
| US7514566B2 (en) | 2009-04-07 |
| WO2007084391A2 (en) | 2007-07-26 |
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