IL192159A0 - Nanoclusters for delivery of the therapeutics - Google Patents
Nanoclusters for delivery of the therapeuticsInfo
- Publication number
- IL192159A0 IL192159A0 IL192159A IL19215908A IL192159A0 IL 192159 A0 IL192159 A0 IL 192159A0 IL 192159 A IL192159 A IL 192159A IL 19215908 A IL19215908 A IL 19215908A IL 192159 A0 IL192159 A0 IL 192159A0
- Authority
- IL
- Israel
- Prior art keywords
- nanoclusters
- therapeutics
- delivery
- Prior art date
Links
- 239000003814 drug Substances 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5107—Excipients; Inactive ingredients
- A61K9/5115—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5107—Excipients; Inactive ingredients
- A61K9/513—Organic macromolecular compounds; Dendrimers
- A61K9/5146—Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
- A61K9/5153—Polyesters, e.g. poly(lactide-co-glycolide)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5192—Processes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
- Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
- Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
- Y10T428/2991—Coated
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
- Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
- Y10T428/2991—Coated
- Y10T428/2998—Coated including synthetic resin or polymer
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nanotechnology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Optics & Photonics (AREA)
- Biomedical Technology (AREA)
- Condensed Matter Physics & Semiconductors (AREA)
- Inorganic Chemistry (AREA)
- Composite Materials (AREA)
- Dermatology (AREA)
- General Physics & Mathematics (AREA)
- Materials Engineering (AREA)
- Crystallography & Structural Chemistry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US75117205P | 2005-12-16 | 2005-12-16 | |
| PCT/US2006/062118 WO2007076295A2 (en) | 2005-12-16 | 2006-12-14 | Nanoclusters for delivery of therapeutics |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL192159A0 true IL192159A0 (en) | 2008-12-29 |
Family
ID=37808148
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL192159A IL192159A0 (en) | 2005-12-16 | 2008-06-15 | Nanoclusters for delivery of the therapeutics |
Country Status (11)
| Country | Link |
|---|---|
| US (3) | US7651770B2 (enExample) |
| EP (1) | EP1968550A2 (enExample) |
| JP (1) | JP2009519975A (enExample) |
| CN (1) | CN101370479A (enExample) |
| AU (1) | AU2006330627A1 (enExample) |
| BR (1) | BRPI0619938A2 (enExample) |
| CA (1) | CA2633380A1 (enExample) |
| IL (1) | IL192159A0 (enExample) |
| MX (1) | MX2008007697A (enExample) |
| WO (1) | WO2007076295A2 (enExample) |
| ZA (1) | ZA200805918B (enExample) |
Families Citing this family (50)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040096515A1 (en) * | 2001-12-07 | 2004-05-20 | Bausch Andreas R. | Methods and compositions for encapsulating active agents |
| EP1861194A2 (en) * | 2005-03-04 | 2007-12-05 | The President and Fellows of Harvard College | Method and apparatus for forming multiple emulsions |
| US8906392B2 (en) * | 2005-12-16 | 2014-12-09 | University Of Kansas | Nanocluster compositions and methods |
| WO2010009146A1 (en) * | 2008-07-15 | 2010-01-21 | University Of Kansas | Nanoclusters for delivery of poorly water soluble drug nanoparticles |
| US7993749B2 (en) * | 2005-12-16 | 2011-08-09 | University Of Kansas | Nanoparticles comprising a nanoparticle template and a polymer shell having an amide side chain, and method of making thereof |
| US8445018B2 (en) | 2006-09-15 | 2013-05-21 | Cima Labs Inc. | Abuse resistant drug formulation |
| CN101668542B (zh) * | 2007-04-27 | 2012-06-27 | 国立大学法人九州大学 | 肺病治疗药 |
| JP5658031B2 (ja) | 2007-06-22 | 2015-01-21 | ボード・オブ・リージエンツ,ザ・ユニバーシテイ・オブ・テキサス・システム | 薄膜凍結による安定したサブミクロンのペプチド又はタンパク質粒子の形成 |
| US20090047318A1 (en) * | 2007-08-16 | 2009-02-19 | Abbott Cardiovascular Systems Inc. | Nanoparticle-coated medical devices and formulations for treating vascular disease |
| US20090123509A1 (en) * | 2007-11-08 | 2009-05-14 | Cory Berkland | Biodegradable Colloidal Gels as Moldable Tissue Engineering Scaffolds |
| WO2009086067A2 (en) * | 2007-12-28 | 2009-07-09 | Boston Scientific Scimed, Inc. | Particles for injection and processes fo forming the same |
| EP2287609B1 (en) * | 2008-05-09 | 2014-12-31 | ARKRAY, Inc. | Method for production of insoluble carrier particle, insoluble carrier particle, measurement reagent, sample analysis tool, and immunology turbidimetric method |
| JP5841708B2 (ja) * | 2008-07-01 | 2016-01-13 | 日東電工株式会社 | 表面被覆微粒子の医薬組成物 |
| EP2376522A4 (en) | 2008-11-16 | 2013-12-25 | Univ Texas | HIGHLY CONCENTRATED LOW VISCOSITY SUSPENSIONS |
| US8053744B2 (en) * | 2009-04-13 | 2011-11-08 | Src, Inc. | Location analysis using nucleic acid-labeled tags |
| US10952965B2 (en) * | 2009-05-15 | 2021-03-23 | Baxter International Inc. | Compositions and methods for drug delivery |
| WO2011028764A2 (en) | 2009-09-02 | 2011-03-10 | President And Fellows Of Harvard College | Multiple emulsions created using jetting and other techniques |
| WO2011044545A2 (en) | 2009-10-09 | 2011-04-14 | Sigalov Alexander B | Methods and compositions for targeted imaging |
| US12419839B2 (en) | 2009-10-09 | 2025-09-23 | Signablok, Inc. | Methods and compositions for targeted delivery of protein fragments |
| KR101878749B1 (ko) * | 2010-03-05 | 2018-07-17 | 삼성전자주식회사 | 표적 세포의 분리 방법 및 키트 |
| EP2547436A2 (en) * | 2010-03-17 | 2013-01-23 | President and Fellows of Harvard College | Melt emulsification |
| HUP1000299A2 (hu) | 2010-06-08 | 2012-02-28 | Nanoform Cardiovascular Therapeutics Ltd | Nanostrukturált Atorvastatint, gyógyszerészetileg elfogadott sóit és kokristályait tartalmazó készítmény és eljárás elõállításukra |
| US8703493B2 (en) | 2010-06-15 | 2014-04-22 | Src, Inc. | Location analysis using fire retardant-protected nucleic acid-labeled tags |
| US20120016217A1 (en) * | 2010-07-15 | 2012-01-19 | Indian Institute Of Technology Bombay | Biosensor for health monitoring and uses thereof |
| WO2012018628A1 (en) | 2010-07-26 | 2012-02-09 | Board Of Regents, The University Of Texas System | Methods for inducing an immune response via buccal and/or sublingual administration of a vaccine |
| US8716027B2 (en) | 2010-08-03 | 2014-05-06 | Src, Inc. | Nucleic acid-labeled tags associated with odorant |
| RU2013112654A (ru) * | 2010-08-30 | 2014-10-10 | Президент Энд Феллоуз Ов Харвард Колледж | Высвобождение, контролируемое сдвигом, для повреждений, вызванных стенозом, и тромболитических терапий |
| JP2014514275A (ja) * | 2011-03-10 | 2014-06-19 | ボード・オブ・リージエンツ,ザ・ユニバーシテイ・オブ・テキサス・システム | タンパク質ナノ粒子分散系 |
| US9238206B2 (en) | 2011-05-23 | 2016-01-19 | President And Fellows Of Harvard College | Control of emulsions, including multiple emulsions |
| WO2012162555A2 (en) * | 2011-05-24 | 2012-11-29 | The Regents Of The University Of California | Heparin nanoclusters |
| EP2714419B1 (en) * | 2011-06-02 | 2015-07-22 | Fábrica Nacional de Moneda Y Timbre - Real Casa de la Moneda | Use of raman markers for authenticating security documents |
| EP3120923A3 (en) | 2011-07-06 | 2017-03-01 | President and Fellows of Harvard College | Article comprising a particle having a shell and a fluid |
| CA2869849A1 (en) | 2012-04-13 | 2013-10-17 | Glaxosmithkline Intellectual Property Development Limited | Aggregate particles comprising nanoparticulate drug particles of umeclidinium bromide, vilanterol trifenatate and fluticasone furoate |
| WO2013185032A1 (en) * | 2012-06-07 | 2013-12-12 | President And Fellows Of Harvard College | Nanotherapeutics for drug targeting |
| US9757395B2 (en) | 2012-12-20 | 2017-09-12 | Otitopic Inc. | Dry powder inhaler and methods of use |
| US9757529B2 (en) | 2012-12-20 | 2017-09-12 | Otitopic Inc. | Dry powder inhaler and methods of use |
| US9974850B2 (en) | 2013-01-25 | 2018-05-22 | Board Of Regents, The University Of Texas System | Immunogenic compositions and uses thereof |
| AU2013388034B2 (en) | 2013-04-30 | 2019-08-15 | Aspeya US Inc. | Dry powder formulations and methods of use |
| HRP20192270T4 (hr) * | 2013-08-13 | 2024-03-01 | Northwestern University | Konjugirane čestice peptida |
| CA2930277A1 (en) * | 2013-11-13 | 2015-05-21 | Tillotts Pharma Ag | Multi-particulate drug delivery system |
| CN104550936B (zh) * | 2014-12-31 | 2017-05-31 | 中国科学院合肥物质科学研究院 | 纳米颗粒组装的胶状体材料及其制备方法 |
| CN108136357A (zh) | 2015-08-17 | 2018-06-08 | 国立研究开发法人科学技术振兴机构 | 纳米团簇分散液及其制造方法及其制造装置、纳米团簇膜、纳米团簇分散体 |
| WO2017083717A1 (en) * | 2015-11-11 | 2017-05-18 | Qrono, Inc. | Sustained release pharmaceutical compositions and methods of use |
| KR101803283B1 (ko) * | 2016-12-30 | 2017-12-01 | (주)아모레퍼시픽 | 항노화용 또는 주름개선용 화장료 조성물 |
| WO2019010329A1 (en) * | 2017-07-06 | 2019-01-10 | The Trustees Of The University Of Pennsylvania | AGOREGATES OF INORGANIC NANOPARTICLES COATED WITH AMPHIPHILIC COLOR |
| CA3076353A1 (en) | 2017-09-22 | 2019-03-28 | Otitopic Inc. | Dry powder compositions with magnesium stearate |
| US10786456B2 (en) | 2017-09-22 | 2020-09-29 | Otitopic Inc. | Inhaled aspirin and magnesium to treat inflammation |
| US11819488B2 (en) | 2018-02-23 | 2023-11-21 | Rhnanopharma | Nanosuspensions of salsalate and methods of using the same |
| WO2020201812A1 (en) * | 2019-04-02 | 2020-10-08 | Wutthinitikornkit Yanee | Dynamic clusters of atom particles activated in extracellular fluid |
| EP4221685A1 (en) | 2020-09-29 | 2023-08-09 | Oxford University Innovation Limited | Stroke treatment |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH09913A (ja) * | 1995-06-14 | 1997-01-07 | Res Dev Corp Of Japan | コロイド粒子クラスターとその形成方法 |
| US5814370A (en) * | 1996-06-11 | 1998-09-29 | Sandia Corporation | Encapsulation of nanoclusters in dried gel materials via an inverse micelle/sol gel synthesis |
| US7521068B2 (en) * | 1998-11-12 | 2009-04-21 | Elan Pharma International Ltd. | Dry powder aerosols of nanoparticulate drugs |
| US6656568B1 (en) * | 1999-05-28 | 2003-12-02 | The Regents Of The University Of Colorado | Ordered arrays of nanoclusters |
| GB9929919D0 (en) * | 1999-12-17 | 2000-02-09 | Hannah Research Inst The | Calcium phosphate nanoclusters and their applications |
| JP2003535063A (ja) | 2000-06-01 | 2003-11-25 | ザ・ボード・オブ・リージェンツ・フォー・オクラホマ・ステート・ユニバーシティー | 放射線医薬としてのナノ粒子のバイオコンジュゲート |
| CA2419115C (en) | 2000-08-15 | 2011-03-08 | Board Of Trustees Of The University Of Illinois | Microparticles, and method and apparatus for forming same |
| WO2003022910A1 (en) | 2001-09-08 | 2003-03-20 | Access Pharmaceuticals, Inc. | Synthesis and uses of polymer gel nanoparticle networks |
| US20030062372A1 (en) * | 2001-10-02 | 2003-04-03 | Metso Minerals (Trelleborg) Ab | Wear-resistant lining element and wear lining made thereof |
| US7563457B2 (en) * | 2001-10-02 | 2009-07-21 | The Regents Of The University Of California | Nanoparticle assembled hollow spheres |
| US6562403B2 (en) * | 2001-10-15 | 2003-05-13 | Kansas State University Research Foundation | Synthesis of substantially monodispersed colloids |
| EP1470563A2 (en) * | 2002-01-25 | 2004-10-27 | Konarka Technologies, Inc. | Photovoltaic cell components and materials |
| JP2005519129A (ja) * | 2002-03-05 | 2005-06-30 | クリーブランド ステート ユニバーシティー | エアロゾル薬物送達のための凝集粒子 |
| AU2003265229A1 (en) | 2002-03-18 | 2003-12-12 | Sciperio, Inc. | Dentritic cell nodes |
| JP4142318B2 (ja) * | 2002-03-20 | 2008-09-03 | 株式会社ホソカワ粉体技術研究所 | 薬物含有複合粒子の製造方法 |
| EP1534202B1 (en) * | 2002-06-05 | 2009-03-11 | University Of Florida Research Foundation, Inc. | Ophthalmic drug delivery system |
| AU2003257791A1 (en) * | 2002-08-15 | 2004-03-29 | Tong Liu | Soild nano pharmaceutical formulation and preparation method thereof |
| US7811605B2 (en) * | 2002-11-06 | 2010-10-12 | Uluru Inc. | Method of formation of shape-retentive aggregates of gel particles and their uses |
| US6928201B2 (en) * | 2002-11-15 | 2005-08-09 | Sunrise Telecom Incorporated | Method and apparatus for providing controllable second-order polarization mode dispersion |
| WO2004096140A2 (en) | 2003-04-25 | 2004-11-11 | The Penn State Research Foundation | Method and system for systemic delivery of growth arresting, lipid-derived bioactive compounds |
| CA2531032A1 (en) | 2003-07-09 | 2005-02-17 | Vaxdesign Corporation | Programmed immune responses using a vaccination node |
| CA2435632A1 (en) | 2003-07-21 | 2005-01-21 | Warren Hugh Finlay | Formulation of powder containing nanoparticles for aerosol delivery to the lung |
| WO2005058472A2 (en) * | 2003-12-19 | 2005-06-30 | Scf Technologies A/S | Systems for preparing fine particles and other substances |
| CN1897978B (zh) * | 2003-12-22 | 2011-11-23 | 博莱科瑞士股份有限公司 | 具有用于反差成像的活性组分的充气微囊组件 |
| US7610074B2 (en) | 2004-01-08 | 2009-10-27 | The Board Of Trustees Of The University Of Illinois | Multi-functional plasmon-resonant contrast agents for optical coherence tomography |
-
2006
- 2006-12-14 CN CN200680051564.1A patent/CN101370479A/zh active Pending
- 2006-12-14 CA CA002633380A patent/CA2633380A1/en not_active Abandoned
- 2006-12-14 AU AU2006330627A patent/AU2006330627A1/en not_active Abandoned
- 2006-12-14 JP JP2008545982A patent/JP2009519975A/ja active Pending
- 2006-12-14 MX MX2008007697A patent/MX2008007697A/es active IP Right Grant
- 2006-12-14 WO PCT/US2006/062118 patent/WO2007076295A2/en not_active Ceased
- 2006-12-14 EP EP06846628A patent/EP1968550A2/en not_active Withdrawn
- 2006-12-14 US US11/610,986 patent/US7651770B2/en active Active
- 2006-12-14 BR BRPI0619938-0A patent/BRPI0619938A2/pt not_active Application Discontinuation
-
2008
- 2008-06-15 IL IL192159A patent/IL192159A0/en unknown
- 2008-07-07 ZA ZA200805918A patent/ZA200805918B/xx unknown
- 2008-10-30 US US12/261,873 patent/US20090081295A1/en not_active Abandoned
- 2008-10-30 US US12/261,907 patent/US20090053316A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| WO2007076295A2 (en) | 2007-07-05 |
| US7651770B2 (en) | 2010-01-26 |
| WO2007076295A3 (en) | 2007-11-29 |
| US20090053316A1 (en) | 2009-02-26 |
| JP2009519975A (ja) | 2009-05-21 |
| BRPI0619938A2 (pt) | 2011-10-25 |
| US20070172653A1 (en) | 2007-07-26 |
| CN101370479A (zh) | 2009-02-18 |
| ZA200805918B (en) | 2009-05-27 |
| MX2008007697A (es) | 2008-09-26 |
| CA2633380A1 (en) | 2007-07-05 |
| AU2006330627A1 (en) | 2007-07-05 |
| EP1968550A2 (en) | 2008-09-17 |
| US20090081295A1 (en) | 2009-03-26 |
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