IL165696A0 - Substituted 1,3-diphenykprop-2-en-1-one derivatives and preparation and uses thereof - Google Patents

Substituted 1,3-diphenykprop-2-en-1-one derivatives and preparation and uses thereof

Info

Publication number
IL165696A0
IL165696A0 IL16569603A IL16569603A IL165696A0 IL 165696 A0 IL165696 A0 IL 165696A0 IL 16569603 A IL16569603 A IL 16569603A IL 16569603 A IL16569603 A IL 16569603A IL 165696 A0 IL165696 A0 IL 165696A0
Authority
IL
Israel
Prior art keywords
derivatives
substituted
diphenykprop
preparation
concerns
Prior art date
Application number
IL16569603A
Other languages
English (en)
Original Assignee
Genfit
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genfit filed Critical Genfit
Publication of IL165696A0 publication Critical patent/IL165696A0/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/52Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/22Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and doubly-bound oxygen atoms bound to the same carbon skeleton
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00Preparation of carboxylic acid esters
    • C07C67/30Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00Preparation of carboxylic acid esters
    • C07C67/30Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
    • C07C67/333Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton
    • C07C67/343Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/67Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids
    • C07C69/708Ethers
    • C07C69/712Ethers the hydroxy group of the ester being etherified with a hydroxy compound having the hydroxy group bound to a carbon atom of a six-membered aromatic ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/73Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
    • C07C69/738Esters of keto-carboxylic acids or aldehydo-carboxylic acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)
IL16569603A 2002-07-08 2003-07-08 Substituted 1,3-diphenykprop-2-en-1-one derivatives and preparation and uses thereof IL165696A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0208571A FR2841900B1 (fr) 2002-07-08 2002-07-08 Nouveaux derives de 1,3-diphenylprop-2-en-1-one substitues, preparation et utilisations
PCT/FR2003/002127 WO2004005233A1 (fr) 2002-07-08 2003-07-08 Derives de 1,3-diphenylprop-2-en-1-one substitues, preparation et utilisations

Publications (1)

Publication Number Publication Date
IL165696A0 true IL165696A0 (en) 2006-01-15

Family

ID=29725283

Family Applications (2)

Application Number Title Priority Date Filing Date
IL16569603A IL165696A0 (en) 2002-07-08 2003-07-08 Substituted 1,3-diphenykprop-2-en-1-one derivatives and preparation and uses thereof
IL165696A IL165696A (en) 2002-07-08 2004-12-09 Transformed Derivatives of 3,1– DiphenylProph 2 - Ann – 1 – 1 Process of preparation and use in the preparation of pharmaceutical compositions

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL165696A IL165696A (en) 2002-07-08 2004-12-09 Transformed Derivatives of 3,1– DiphenylProph 2 - Ann – 1 – 1 Process of preparation and use in the preparation of pharmaceutical compositions

Country Status (24)

Country Link
US (3) US7943661B2 (ru)
EP (1) EP1525177B1 (ru)
JP (1) JP4575771B2 (ru)
KR (1) KR100974577B1 (ru)
CN (1) CN100548960C (ru)
AT (1) ATE365703T1 (ru)
AU (1) AU2003264698B2 (ru)
BR (1) BRPI0312398B8 (ru)
CA (1) CA2490986C (ru)
CY (1) CY1108085T1 (ru)
DE (1) DE60314633T2 (ru)
DK (1) DK1525177T3 (ru)
EA (1) EA011090B1 (ru)
ES (1) ES2287528T3 (ru)
FR (1) FR2841900B1 (ru)
IL (2) IL165696A0 (ru)
MX (1) MXPA05000427A (ru)
NO (1) NO329700B1 (ru)
NZ (1) NZ538051A (ru)
PL (1) PL207362B1 (ru)
PT (1) PT1525177E (ru)
SI (1) SI1525177T1 (ru)
WO (1) WO2004005233A1 (ru)
ZA (1) ZA200501082B (ru)

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FR2841900B1 (fr) 2002-07-08 2007-03-02 Genfit S A Nouveaux derives de 1,3-diphenylprop-2-en-1-one substitues, preparation et utilisations
FR2841784B1 (fr) * 2002-07-08 2007-03-02 Composition a base de derives de 1,3-diphenylprop-2en-1-one substitues, preparation et utilisations
AU2005209446A1 (en) * 2004-01-08 2005-08-11 Genfit 1,3-diphenylprop-2-en-1-one derivative compounds, preparation method thereof and uses of same
FR2902789A1 (fr) 2006-06-21 2007-12-28 Genfit Sa Derives de 1,3-diphenylpropane substitues, preparations et utilisations
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US9221751B2 (en) 2009-11-26 2015-12-29 Genfit Use of 1,3-diphenylprop-2-en-1-one derivatives for treating liver disorders
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US10722575B2 (en) 2009-11-26 2020-07-28 Genfit Use of 1,3-diphenylprop-2-en-1-one derivatives for treating liver disorders
WO2011080276A1 (en) 2009-12-29 2011-07-07 Genfit Pharmaceutical combinations comprising a dpp-4 inhibitor and a 1,3-diphenylprop-2-en-1-one derivative
DK2571843T3 (da) * 2010-05-17 2018-01-29 Genfit Forbedret fremstilling af chalcon-derivater
TWI415600B (zh) * 2011-08-10 2013-11-21 Univ Kaohsiung Medical 用於治療動脈粥狀硬化的組合物及其製備方法
US9115073B2 (en) 2011-12-28 2015-08-25 Genfit 1,3-diphenylpropane derivatives, preparations and uses thereof
CN102697757B (zh) * 2012-05-18 2014-06-04 广州军区广州总医院 对羟基苄叉丙酮在制备预防和/或治疗脑病药物中的应用
JP6218854B2 (ja) 2013-01-18 2017-10-25 ジェンフィGenfit 線維症及びガンの治療方法
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EP3554503B1 (en) * 2016-12-16 2023-10-04 The Board of Regents of The University of Texas System Inhibitors of bromodomain-containing protein 4 (brd4)
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CN111093705A (zh) 2017-09-13 2020-05-01 诺华股份有限公司 包含fxr激动剂的组合
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KR102603436B1 (ko) 2017-11-30 2023-11-16 쓰촨 케룬-바이오테크 바이오파마수티컬 컴퍼니 리미티드 방향족 화합물, 약학적 조성물 및 그 용도
EP3514541A1 (de) 2018-01-17 2019-07-24 Siemens Healthcare Diagnostics Products GmbH Verfahren zur quantitativen bestimmung eines therapeutischen tnf-alpha inhibitors
WO2019186410A1 (en) * 2018-03-27 2019-10-03 Lupin Limited Solid forms of elafibranor and processes thereof
US20210309608A1 (en) * 2018-08-03 2021-10-07 Genfit Elafibranor salts
WO2020039297A1 (en) * 2018-08-24 2020-02-27 Mankind Pharma Ltd. Novel compounds and their use in preparation of elafibranor and pharmaceutical acceptable salts thereof
WO2020115628A1 (en) * 2018-12-03 2020-06-11 Mankind Pharma Ltd. Solid forms of elafibranor and process of preparation thereof
CN110156648A (zh) * 2019-05-30 2019-08-23 河北科技大学 一种Elafibranor中间体的制备方法
CA3153784A1 (en) 2019-10-28 2021-05-06 Nicolas STANKOVIC-VALENTIN Combination therapy having antioxydant properties
WO2021098885A1 (zh) * 2019-11-21 2021-05-27 杭州百诚医药科技股份有限公司 α-氟代查耳酮类衍生物及其应用
CN111138264B (zh) * 2019-11-29 2023-08-04 温州医科大学 一种丁香醛衍生物及其在制备抗妇科肿瘤药物中的应用
CN113121394B (zh) * 2019-12-30 2022-11-08 中国药科大学 一种苯氧乙酸类衍生物的制备方法
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FR2841784B1 (fr) 2002-07-08 2007-03-02 Composition a base de derives de 1,3-diphenylprop-2en-1-one substitues, preparation et utilisations
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Also Published As

Publication number Publication date
CN100548960C (zh) 2009-10-14
DK1525177T3 (da) 2007-10-22
NO20045301L (no) 2005-02-04
FR2841900B1 (fr) 2007-03-02
US7943661B2 (en) 2011-05-17
SI1525177T1 (sl) 2007-10-31
PT1525177E (pt) 2007-09-06
EA011090B1 (ru) 2008-12-30
CA2490986A1 (fr) 2004-01-15
KR100974577B1 (ko) 2010-08-06
NZ538051A (en) 2007-11-30
US8058308B2 (en) 2011-11-15
DE60314633T2 (de) 2008-02-28
BRPI0312398B1 (pt) 2016-11-08
CA2490986C (fr) 2012-09-18
WO2004005233A1 (fr) 2004-01-15
JP4575771B2 (ja) 2010-11-04
PL207362B1 (pl) 2010-12-31
NO329700B1 (no) 2010-12-06
KR20050025327A (ko) 2005-03-14
US20050176808A1 (en) 2005-08-11
US7566737B2 (en) 2009-07-28
ZA200501082B (en) 2007-01-31
EP1525177B1 (fr) 2007-06-27
US20110190515A1 (en) 2011-08-04
CN1668565A (zh) 2005-09-14
CY1108085T1 (el) 2014-02-12
BRPI0312398B8 (pt) 2021-05-25
DE60314633D1 (de) 2007-08-09
EA200500169A1 (ru) 2005-06-30
FR2841900A1 (fr) 2004-01-09
AU2003264698B2 (en) 2009-09-17
JP2005532385A (ja) 2005-10-27
EP1525177A1 (fr) 2005-04-27
BR0312398A (pt) 2005-04-12
AU2003264698A1 (en) 2004-01-23
ATE365703T1 (de) 2007-07-15
PL372809A1 (en) 2005-08-08
ES2287528T3 (es) 2007-12-16
US20070032543A1 (en) 2007-02-08
IL165696A (en) 2012-09-24
MXPA05000427A (es) 2005-09-30

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