IL164295A0 - Tri-substituted heteroaryls and methods of making and using the same - Google Patents
Tri-substituted heteroaryls and methods of making and using the sameInfo
- Publication number
- IL164295A0 IL164295A0 IL16429503A IL16429503A IL164295A0 IL 164295 A0 IL164295 A0 IL 164295A0 IL 16429503 A IL16429503 A IL 16429503A IL 16429503 A IL16429503 A IL 16429503A IL 164295 A0 IL164295 A0 IL 164295A0
- Authority
- IL
- Israel
- Prior art keywords
- tri
- making
- methods
- same
- substituted heteroaryls
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Urology & Nephrology (AREA)
- Cardiology (AREA)
- Physical Education & Sports Medicine (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Ophthalmology & Optometry (AREA)
- Neurology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Dermatology (AREA)
- Pulmonology (AREA)
- Gastroenterology & Hepatology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US36979302P | 2002-04-04 | 2002-04-04 | |
PCT/US2003/010440 WO2003087304A2 (fr) | 2002-04-04 | 2003-04-04 | Hetero-aryles tri-substitues et procedes de fabrication |
Publications (1)
Publication Number | Publication Date |
---|---|
IL164295A0 true IL164295A0 (en) | 2005-12-18 |
Family
ID=29250467
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL16429503A IL164295A0 (en) | 2002-04-04 | 2003-04-04 | Tri-substituted heteroaryls and methods of making and using the same |
Country Status (19)
Country | Link |
---|---|
US (1) | US7612094B2 (fr) |
EP (1) | EP1499308A4 (fr) |
JP (1) | JP2005527590A (fr) |
KR (1) | KR20040094908A (fr) |
CN (1) | CN100448868C (fr) |
AR (1) | AR039241A1 (fr) |
AU (1) | AU2003228446B2 (fr) |
CA (1) | CA2480860A1 (fr) |
EA (1) | EA010418B1 (fr) |
IL (1) | IL164295A0 (fr) |
IS (1) | IS7475A (fr) |
MX (1) | MXPA04009546A (fr) |
NO (1) | NO20044779L (fr) |
NZ (1) | NZ536202A (fr) |
PL (1) | PL373502A1 (fr) |
RS (1) | RS95904A (fr) |
UA (1) | UA81624C2 (fr) |
WO (1) | WO2003087304A2 (fr) |
ZA (1) | ZA200407902B (fr) |
Families Citing this family (55)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0217787D0 (en) * | 2002-07-31 | 2002-09-11 | Glaxo Group Ltd | C ompounds |
ES2325687T3 (es) * | 2002-09-18 | 2009-09-14 | Pfizer Products Inc. | Compuestos de imidazol novedosos como inhibidores del factor de crecimiento transformante (tgf). |
AP2005003262A0 (en) | 2002-09-18 | 2005-03-31 | Pfizer Prod Inc | Novel isothiazole and isoxazole compounds as tranforming growth factor (TGF) inhibitors. |
PL375979A1 (en) | 2002-09-18 | 2005-12-12 | Pfizer Products Inc. | Pyrazole derivatives as transforming growth factor (tgf) inhibitors |
MXPA05002332A (es) | 2002-09-18 | 2005-06-08 | Pfizer Prod Inc | Nuevos compuestos de oxazol y tiazol como inhibidores del factor de crecimiento transformador (tgf). |
BR0314577A (pt) | 2002-09-18 | 2005-08-09 | Pfizer Prod Inc | Derivados de triazol como inibidores do fator de crescimento de transformação (tgf) |
PA8595001A1 (es) | 2003-03-04 | 2004-09-28 | Pfizer Prod Inc | Nuevos compuestos heteroaromaticos condensados que son inhibidores del factor de crecimiento transforante (tgf) |
MXPA06008157A (es) * | 2003-12-24 | 2007-09-07 | Johnson & Johnson | Tratamiento de gliomas malignos con inhibidores de factor de crecimiento transformante-beta. |
AU2005219737B2 (en) * | 2004-03-05 | 2009-11-19 | Taisho Pharmaceutical Co., Ltd. | Thiazole derivative |
US20080319012A1 (en) | 2004-04-21 | 2008-12-25 | In2Gen Co., Ltd. | 2-Pyridyl substituted imidazoles as ALK5 and/or ALK4 inhibitors |
WO2006026306A1 (fr) * | 2004-08-31 | 2006-03-09 | Biogen Idec Ma Inc. | Pyrimidinylimidazoles utilises comme inhibiteurs de tgf-beta |
US20070275968A1 (en) * | 2004-09-07 | 2007-11-29 | Hitoshi Kurata | Substituted Biphenyl Derivative |
AU2005289887A1 (en) | 2004-09-24 | 2006-04-06 | Janssen Pharmaceutica, N.V. | Sulfonamide compounds |
EP1804801A2 (fr) * | 2004-10-15 | 2007-07-11 | Biogen Idec MA, Inc. | Procede pour traiter des lesions vasculaires |
GB0510141D0 (en) * | 2005-05-18 | 2005-06-22 | Addex Pharmaceuticals Sa | Novel compounds B3 |
US20100166819A1 (en) | 2005-12-22 | 2010-07-01 | Biogen Idec Ma Inc. A Corporation | Transforming Growth Factor Modulators |
PL2083863T3 (pl) | 2006-10-03 | 2015-08-31 | Genzyme Corp | Przeciwciała przeciwko TGF-beta do stosowania w leczeniu niemowląt obarczonych ryzykiem rozwinięcia się dysplazji oskrzelowo-płucnej |
WO2009009059A1 (fr) * | 2007-07-09 | 2009-01-15 | Biogen Idec Ma Inc. | Composés spiro en tant qu'antagonistes du tgf-bêta |
US8138168B1 (en) | 2007-09-26 | 2012-03-20 | Takeda Pharmaceutical Company Limited | Renin inhibitors |
WO2009115572A2 (fr) * | 2008-03-21 | 2009-09-24 | Novartis Ag | Nouveaux composés hétérocycliques et leurs utilisations |
US8865732B2 (en) | 2008-03-21 | 2014-10-21 | Novartis Ag | Heterocyclic compounds and uses thereof |
CL2009000904A1 (es) * | 2008-04-21 | 2010-04-30 | Shionogi & Co | Compuestos derivados de ciclohexil sulfonamidas que tienen actividad antagonista en el receptor npy y5, composicion farmaceutica y formulacion farmaceutica que los comprende. |
UA103319C2 (en) | 2008-05-06 | 2013-10-10 | Глаксосмитклайн Ллк | Thiazole- and oxazole-benzene sulfonamide compounds |
CN102083439A (zh) * | 2008-05-30 | 2011-06-01 | 萨马保健系统有限责任公司 | 使用TGF-β受体抑制剂或活化素样激酶(ALK)5抑制剂A-83-01和SB-431542治疗眼病与伤口愈合症状的方法 |
WO2010011917A1 (fr) * | 2008-07-25 | 2010-01-28 | Glaxosmithkline Llc | Inhibiteurs doubles de seh et 11β-hsd1 |
WO2010121162A1 (fr) * | 2009-04-17 | 2010-10-21 | Summa Health Systems Llc | Utilisation de la transformation d'inhibiteurs de récepteur de facteur b de croissance pour supprimer une cicatrisation oculaire |
US8080568B1 (en) | 2010-06-29 | 2011-12-20 | Ewha University - Industry Collaboration Foundation | 2-pyridyl substituted imidazoles as therapeutic ALK5 and/or ALK4 inhibitors |
US8513222B2 (en) | 2010-06-29 | 2013-08-20 | EWHA University—Industry Collaboration Foundation | Methods of treating fibrosis, cancer and vascular injuries |
USRE47141E1 (en) | 2010-06-29 | 2018-11-27 | EWHA University—Industry Collaboration Foundation | Methods of treating fibrosis, cancer and vascular injuries |
US8871744B2 (en) | 2010-07-21 | 2014-10-28 | B & G Partyers, LLC | Compounds and methods for selectively targeting tumor-associated mucins |
PT2731949T (pt) | 2011-07-13 | 2018-06-15 | Tiumbio Co Ltd | Imidazóis substituídos com 2-piridilo como inibidores de alk5 e/ou alk4 |
US20140308275A1 (en) | 2011-07-27 | 2014-10-16 | Inserm (Institut National De La Sante Et De La Recherche Medicale | Methods for diagnosing and treating myhre syndrome |
WO2013062544A1 (fr) | 2011-10-26 | 2013-05-02 | Seattle Children's Research Institute | Cystéamine dans le traitement d'une maladie fibreuse |
US9242969B2 (en) | 2013-03-14 | 2016-01-26 | Novartis Ag | Biaryl amide compounds as kinase inhibitors |
CN105308033B (zh) | 2013-03-14 | 2018-08-24 | 特雷罗药物股份有限公司 | Jak2和alk2抑制剂及其使用方法 |
JP6723930B2 (ja) | 2014-02-07 | 2020-07-15 | エムティーエー タモガトット クタトクソポルトク イロダジャ | シグマ−1−受容体アゴニスト化合物の新規使用 |
US10842794B2 (en) | 2014-02-07 | 2020-11-24 | Támogatott Kutatócsoportok Irodája | Use of Sigma-1 receptor agonist compounds |
UY36294A (es) | 2014-09-12 | 2016-04-29 | Novartis Ag | Compuestos y composiciones como inhibidores de quinasa |
WO2017151409A1 (fr) | 2016-02-29 | 2017-09-08 | University Of Florida Research Foundation, Incorporated | Méthodes de chimiothérapie |
MX2019003095A (es) | 2016-09-19 | 2019-07-04 | Novartis Ag | Combinaciones terapeuticas que comprenden un inhibidor de raf y un inhibidor de erk. |
PT3618875T (pt) | 2017-05-02 | 2023-08-07 | Novartis Ag | Terapia de combinação que compreende um inibidor de raf e trametinib |
EP3774798A1 (fr) * | 2018-04-02 | 2021-02-17 | Silverback Therapeutics, Inc. | Inhibiteurs d'alk5, conjugués et leurs utilisations |
CN112512597A (zh) | 2018-07-26 | 2021-03-16 | 大日本住友制药肿瘤公司 | 用于治疗与acvr1表达异常相关的疾病的方法以及用于此的acvr1抑制剂 |
JP7335344B2 (ja) * | 2019-01-22 | 2023-08-29 | ビシケム カンパニー リミテッド | Alk4/5阻害剤としての縮合環ヘテロアリール化合物 |
US20220177978A1 (en) | 2019-04-02 | 2022-06-09 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods of predicting and preventing cancer in patients having premalignant lesions |
JP2023509760A (ja) | 2020-01-08 | 2023-03-09 | シンシス セラピューティクス,インコーポレイテッド | Alk5阻害剤複合体およびその使用 |
KR20230051500A (ko) | 2020-07-15 | 2023-04-18 | 키에시 파르마슈티시 엣스. 피. 에이. | Alk5 억제제로서 피리다진일 아미노 유도체 |
JP2023533850A (ja) | 2020-07-15 | 2023-08-04 | キエシ・フアルマチエウテイチ・ソチエタ・ペル・アチオニ | Alk5阻害剤としてのピリドオキサジンアミノ誘導体 |
WO2022013311A1 (fr) | 2020-07-15 | 2022-01-20 | Chiesi Farmaceutici S.P.A. | Dérivés de pyrido-oxazine en tant qu'inhibiteurs d'alk5 |
US20240116948A1 (en) | 2020-12-23 | 2024-04-11 | Chiesi Farmaceutici S.P.A. | Pyrido oxazine derivatives as alk5 inhibitors |
CN112759592A (zh) * | 2021-02-01 | 2021-05-07 | 无锡鸣鹭医药科技有限公司 | 一种6-碘[1,2,3]三唑并[1,5-a]吡啶的合成方法 |
CN114105975A (zh) * | 2021-02-25 | 2022-03-01 | 无锡海伦生物科技有限公司 | 一种[1,2,4]三氮唑[1,5-a]吡啶-6-甲醛的合成方法 |
AR127108A1 (es) | 2021-09-21 | 2023-12-20 | Chiesi Farm Spa | Derivados de amino piridazinilo como inhibidores de alk5 |
WO2023208986A1 (fr) | 2022-04-27 | 2023-11-02 | Chiesi Farmaceutici S.P.A. | Dérivés d'imidazole en tant qu'inhibiteurs d'alk5 |
WO2024111626A1 (fr) * | 2022-11-25 | 2024-05-30 | カルナバイオサイエンス株式会社 | Nouveau dérivé de thiazole |
Family Cites Families (89)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3940486A (en) | 1971-05-10 | 1976-02-24 | Ciba-Geigy Corporation | Imidazole derivatives in the treatment of pain |
US4302464A (en) | 1980-10-16 | 1981-11-24 | Pfizer Inc. | Imidazolylpyridine therapeutic agents |
IL101291A0 (en) * | 1991-03-22 | 1992-11-15 | Nippon Soda Co | 2-pyridine derivatives,their preparation and their use as fungicides |
US5656644A (en) | 1994-07-20 | 1997-08-12 | Smithkline Beecham Corporation | Pyridyl imidazoles |
US5916891A (en) | 1992-01-13 | 1999-06-29 | Smithkline Beecham Corporation | Pyrimidinyl imidazoles |
IL104369A0 (en) | 1992-01-13 | 1993-05-13 | Smithkline Beecham Corp | Novel compounds and compositions |
DK64592D0 (da) * | 1992-05-14 | 1992-05-14 | Carlbiotech Ltd As | Peptider til terapeutisk behandling |
US5593992A (en) | 1993-07-16 | 1997-01-14 | Smithkline Beecham Corporation | Compounds |
US5593991A (en) | 1993-07-16 | 1997-01-14 | Adams; Jerry L. | Imidazole compounds, use and process of making |
US5670527A (en) | 1993-07-16 | 1997-09-23 | Smithkline Beecham Corporation | Pyridyl imidazole compounds and compositions |
US5559137A (en) | 1994-05-16 | 1996-09-24 | Smithkline Beecham Corp. | Compounds |
GB9423460D0 (en) | 1994-11-21 | 1995-01-11 | Merck Sharp & Dohme | Therapeutic agents |
US5514505A (en) | 1995-05-15 | 1996-05-07 | Xerox Corporation | Method for obtaining improved image contrast in migration imaging members |
US5739143A (en) | 1995-06-07 | 1998-04-14 | Smithkline Beecham Corporation | Imidazole compounds and compositions |
IL118544A (en) | 1995-06-07 | 2001-08-08 | Smithkline Beecham Corp | History of imidazole, the process for their preparation and the pharmaceutical preparations containing them |
US6369068B1 (en) | 1995-06-07 | 2002-04-09 | Smithkline Beecham Corporation | Amino substituted pyrimidine containing compounds |
US5854276A (en) | 1995-06-29 | 1998-12-29 | Fujisawa Pharmaceutical Co., Ltd. | Substance WF16616, process for production thereof, and use thereof |
US5837719A (en) | 1995-08-10 | 1998-11-17 | Merck & Co., Inc. | 2,5-substituted aryl pyrroles, compositions containing such compounds and methods of use |
US5792778A (en) | 1995-08-10 | 1998-08-11 | Merck & Co., Inc. | 2-substituted aryl pyrroles, compositions containing such compounds and methods of use |
US5717100A (en) | 1995-10-06 | 1998-02-10 | Merck & Co., Inc. | Substituted imidazoles having anti-cancer and cytokine inhibitory activity |
US6083949A (en) | 1995-10-06 | 2000-07-04 | Merck & Co., Inc. | Substituted imidazoles having anti-cancer and cytokine inhibitory activity |
ZA9610687B (en) | 1995-12-22 | 1997-09-29 | Smithkline Beecham Corp | Novel synthesis. |
ZA97175B (en) | 1996-01-11 | 1997-11-04 | Smithkline Beecham Corp | Novel substituted imidazole compounds. |
US6046208A (en) | 1996-01-11 | 2000-04-04 | Smithkline Beecham Corporation | Substituted imidazole compounds |
CZ216498A3 (cs) | 1996-01-11 | 1999-08-11 | Smithkline Beecham Corporation | Nové substituované imidazolové sloučeniny |
JP2000504013A (ja) | 1996-02-01 | 2000-04-04 | スミスクライン・ビーチャム・コーポレイション | エンドセリンレセプターアンタゴニスト |
JP2000507224A (ja) | 1996-03-08 | 2000-06-13 | スミスクライン・ビーチャム・コーポレイション | Csaid化合物の血管形成の抑制物質としての使用 |
EP0888335A4 (fr) | 1996-03-13 | 2002-01-02 | Smithkline Beecham Corp | Nouveaux composes de pyrimidine utiles dans le traitement de maladies a mediation cytokine |
JP2000507545A (ja) | 1996-03-25 | 2000-06-20 | スミスクライン・ビーチャム・コーポレイション | Cns損傷についての新規な治療 |
EP0889888A4 (fr) | 1996-03-25 | 2003-01-08 | Smithkline Beecham Corp | Nouveau traitement des lesions du systeme nerveux central |
US5883105A (en) | 1996-04-03 | 1999-03-16 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
US5872136A (en) | 1996-04-03 | 1999-02-16 | Merck & Co., Inc. | Arylheteroaryl inhibitors of farnesyl-protein transferase |
US5880140A (en) | 1996-04-03 | 1999-03-09 | Merck & Co., Inc. | Biheteroaryl inhibitors of farnesyl-protein transferase |
US6080870A (en) | 1996-04-03 | 2000-06-27 | Merck & Co., Inc. | Biaryl substituted imidazole compounds useful as farnesyl-protein transferase inhibitors |
US5939557A (en) | 1996-04-03 | 1999-08-17 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
US5854265A (en) | 1996-04-03 | 1998-12-29 | Merck & Co., Inc. | Biheteroaryl inhibitors of farnesyl-protein transferase |
AU708883B2 (en) | 1996-06-10 | 1999-08-12 | Merck & Co., Inc. | Substituted imidazoles having cytokine inhibitory activity |
US5854264A (en) | 1996-07-24 | 1998-12-29 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
KR20000057137A (ko) | 1996-11-19 | 2000-09-15 | 스티븐 엠. 오드레 | 아릴 및 헤테로아릴로 치환된 융합 피롤 항염증제 |
US6096753A (en) | 1996-12-05 | 2000-08-01 | Amgen Inc. | Substituted pyrimidinone and pyridone compounds and methods of use |
US6410729B1 (en) | 1996-12-05 | 2002-06-25 | Amgen Inc. | Substituted pyrimidine compounds and methods of use |
US5939439A (en) | 1996-12-30 | 1999-08-17 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
EP1028954B1 (fr) | 1997-04-24 | 2003-07-02 | Ortho-McNeil Pharmaceutical, Inc. | Imidazoles substitues utilisables dans le traitement de maladies inflammatoires |
RU2249591C2 (ru) | 1997-05-22 | 2005-04-10 | Дж.Д. Серл Энд Ко. | 3(5)-гетероарилзамещенные пиразолы в качестве ингибиторов киназы p38 |
US6087496A (en) * | 1998-05-22 | 2000-07-11 | G. D. Searle & Co. | Substituted pyrazoles suitable as p38 kinase inhibitors |
US6087381A (en) | 1997-05-22 | 2000-07-11 | G. D. Searle & Company | Pyrazole derivatives as p38 kinase inhibitors |
US6514977B1 (en) | 1997-05-22 | 2003-02-04 | G.D. Searle & Company | Substituted pyrazoles as p38 kinase inhibitors |
CN100443481C (zh) * | 1997-06-12 | 2008-12-17 | 艾文蒂斯药品有限公司 | 咪唑基-环缩醛类 |
WO1998056377A1 (fr) | 1997-06-13 | 1998-12-17 | Smithkline Beecham Corporation | Nouveaux composes de pyrazole et de pyrazoline substitues |
GB9713726D0 (en) | 1997-06-30 | 1997-09-03 | Ciba Geigy Ag | Organic compounds |
JP2002515915A (ja) | 1997-06-30 | 2002-05-28 | オーソ−マクニール・フアーマシユーチカル・インコーポレーテツド | 炎症性疾患の治療で有用な2−置換イミダゾール類 |
TW517055B (en) * | 1997-07-02 | 2003-01-11 | Smithkline Beecham Corp | Novel substituted imidazole compounds |
US7301021B2 (en) * | 1997-07-02 | 2007-11-27 | Smithkline Beecham Corporation | Substituted imidazole compounds |
US6562832B1 (en) | 1997-07-02 | 2003-05-13 | Smithkline Beecham Corporation | Substituted imidazole compounds |
EP1037639A4 (fr) | 1997-12-19 | 2002-04-17 | Smithkline Beecham Corp | .0mposes d'imidazole heteroaryle substitues, leurs compositions et usages pharmaceutiques |
WO2000010563A1 (fr) | 1998-08-20 | 2000-03-02 | Smithkline Beecham Corporation | Nouveaux composes de triazole substitues |
WO2000023444A1 (fr) * | 1998-10-21 | 2000-04-27 | Abbott Laboratories | Composes de 4-aminopyrido[2,3-d]pyrimidine a disubstitution 5,7 |
JP2002528506A (ja) | 1998-11-04 | 2002-09-03 | スミスクライン・ビーチャム・コーポレイション | ピリジン−4−イルまたはピリミジン−4−イル置換ピラジン |
US6239279B1 (en) | 1998-12-16 | 2001-05-29 | Smithkline Beecham Corporation | Synthesis for 4-aryl-5-pyrimidine imidazole substituted derivatives |
US6288089B1 (en) | 1998-12-21 | 2001-09-11 | Michael Zawada | Use of kinase inhibitors for treating neurodegenerative diseases |
JP4632544B2 (ja) | 1998-12-25 | 2011-02-16 | あすか製薬株式会社 | アミノピラゾール誘導体 |
EP1175419B1 (fr) | 1999-04-02 | 2003-05-28 | Bristol-Myers Squibb Pharma Company | Sulfonyles aryles faisant office d'inhibiteurs du facteur xa |
DE60001229T2 (de) * | 1999-04-09 | 2003-10-30 | Smithkline Beecham Corp., Philadelphia | Triarylimidazole |
CO5170501A1 (es) | 1999-04-14 | 2002-06-27 | Novartis Ag | AZOLES SUSTITUIDOS UTILES PARA EL TRATAMIENTO DE ENFERMEDADES MEDIADAS POR TNFa eIL-1 Y ENFERMEDADES DEL METABOLISMO OSEO |
US6667325B1 (en) * | 1999-06-03 | 2003-12-23 | Teikoku Hormone Mfg. Co., Ltd. | Substituted pyrazole compounds |
EP1196167B1 (fr) * | 1999-07-02 | 2006-04-19 | Stuart A. Lipton | Utilisation des inhibiteurs p38 MAPK pour des maladies ophthalmiques |
US20030109428A1 (en) * | 1999-12-01 | 2003-06-12 | John Bertin | Novel molecules of the card-related protein family and uses thereof |
JP2003518123A (ja) * | 1999-12-21 | 2003-06-03 | スージェン・インコーポレーテッド | 4−置換7−アザ−インドリン−2−オンおよびその蛋白質キナーゼ阻害剤としての使用 |
WO2001091749A1 (fr) | 2000-06-01 | 2001-12-06 | Merck & Co., Inc. | Utilisation de derives de (phenyle disubstitue)-pyrimidinyl-imidazole comme inhibiteurs de jnk |
EP1296977A1 (fr) | 2000-06-23 | 2003-04-02 | Bristol-Myers Squibb Pharma Company | Inhibiteurs du facteur xa a substitution heteroaryl-phenyle |
GB0021726D0 (en) * | 2000-09-05 | 2000-10-18 | Astrazeneca Ab | Chemical compounds |
CN1471523A (zh) * | 2000-09-21 | 2004-01-28 | ʷ | 咪唑类棉子糖激酶抑制剂 |
US6755497B2 (en) * | 2000-09-26 | 2004-06-29 | Canon Kabushiki Kaisha | Ink-jet printing apparatus, control method thereof, and data processing apparatus and method |
JP2002114780A (ja) * | 2000-10-11 | 2002-04-16 | Taisho Pharmaceut Co Ltd | 4−(3−インドリル)イミダゾール誘導体 |
US6630325B1 (en) * | 2000-10-19 | 2003-10-07 | Maine Medical Center Research Institute | Compositions, methods and kits relating to remodel |
WO2002040468A1 (fr) * | 2000-11-16 | 2002-05-23 | Smithkline Beecham Corporation | Composes |
AU2002236476A1 (en) * | 2000-11-20 | 2002-05-27 | Smith Kline Beecham Corporation | Novel compounds |
GB0100762D0 (en) * | 2001-01-11 | 2001-02-21 | Smithkline Beecham Plc | Novel use |
US20040097502A1 (en) * | 2001-02-02 | 2004-05-20 | Gellibert Francoise Jeanne | Pyrazoles as tgf inhibitors |
GB0102672D0 (en) * | 2001-02-02 | 2001-03-21 | Glaxo Group Ltd | Compounds |
EP1355903B1 (fr) * | 2001-02-02 | 2005-03-16 | SmithKline Beecham Corporation | Derives pyrazole contre la surexpression du facteur tgf |
GB0102665D0 (en) * | 2001-02-02 | 2001-03-21 | Glaxo Group Ltd | Compounds |
US6787555B2 (en) | 2001-04-30 | 2004-09-07 | The Procter & Gamble Company | Triazole compounds useful in treating diseases associated with unwanted cytokine activity |
US6727364B2 (en) | 2001-04-30 | 2004-04-27 | The Procter & Gamble Company | Triazole compounds useful in treating diseases associated with unwanted cytokine activity |
AU2002345603B2 (en) * | 2001-06-07 | 2006-10-12 | Skinmedica, Inc. | Conditioned cell culture media and uses thereof |
US7300442B2 (en) * | 2001-07-11 | 2007-11-27 | Daniel Cherfas | Method of destroying formations in a body |
WO2003097615A1 (fr) * | 2002-05-17 | 2003-11-27 | Scios, Inc. | Traitement de troubles de fibro-proliferation au moyen d'inhibiteur de tgf-$g(b) |
ES2325687T3 (es) * | 2002-09-18 | 2009-09-14 | Pfizer Products Inc. | Compuestos de imidazol novedosos como inhibidores del factor de crecimiento transformante (tgf). |
MXPA05002332A (es) * | 2002-09-18 | 2005-06-08 | Pfizer Prod Inc | Nuevos compuestos de oxazol y tiazol como inhibidores del factor de crecimiento transformador (tgf). |
-
2003
- 2003-04-03 AR ARP030101166A patent/AR039241A1/es unknown
- 2003-04-04 EA EA200401309A patent/EA010418B1/ru not_active IP Right Cessation
- 2003-04-04 AU AU2003228446A patent/AU2003228446B2/en not_active Ceased
- 2003-04-04 CN CNB038126990A patent/CN100448868C/zh not_active Expired - Fee Related
- 2003-04-04 UA UA20041108993A patent/UA81624C2/ru unknown
- 2003-04-04 IL IL16429503A patent/IL164295A0/xx unknown
- 2003-04-04 PL PL03373502A patent/PL373502A1/xx not_active Application Discontinuation
- 2003-04-04 EP EP03726198A patent/EP1499308A4/fr not_active Withdrawn
- 2003-04-04 CA CA002480860A patent/CA2480860A1/fr not_active Abandoned
- 2003-04-04 JP JP2003584248A patent/JP2005527590A/ja active Pending
- 2003-04-04 WO PCT/US2003/010440 patent/WO2003087304A2/fr active Application Filing
- 2003-04-04 NZ NZ536202A patent/NZ536202A/en not_active IP Right Cessation
- 2003-04-04 MX MXPA04009546A patent/MXPA04009546A/es unknown
- 2003-04-04 US US10/510,459 patent/US7612094B2/en active Active
- 2003-04-04 RS YU95904A patent/RS95904A/sr unknown
- 2003-04-04 KR KR10-2004-7015706A patent/KR20040094908A/ko not_active Application Discontinuation
-
2004
- 2004-09-28 IS IS7475A patent/IS7475A/is unknown
- 2004-09-30 ZA ZA200407902A patent/ZA200407902B/en unknown
- 2004-11-03 NO NO20044779A patent/NO20044779L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
EA010418B1 (ru) | 2008-08-29 |
CN1658866A (zh) | 2005-08-24 |
KR20040094908A (ko) | 2004-11-10 |
EP1499308A4 (fr) | 2006-05-24 |
UA81624C2 (ru) | 2008-01-25 |
AR039241A1 (es) | 2005-02-16 |
WO2003087304A3 (fr) | 2004-07-22 |
NZ536202A (en) | 2009-08-28 |
US7612094B2 (en) | 2009-11-03 |
CN100448868C (zh) | 2009-01-07 |
EP1499308A2 (fr) | 2005-01-26 |
IS7475A (is) | 2004-09-28 |
AU2003228446A1 (en) | 2003-10-27 |
WO2003087304A2 (fr) | 2003-10-23 |
PL373502A1 (en) | 2005-09-05 |
ZA200407902B (en) | 2005-09-22 |
JP2005527590A (ja) | 2005-09-15 |
NO20044779L (no) | 2005-01-04 |
CA2480860A1 (fr) | 2003-10-23 |
EA200401309A1 (ru) | 2005-08-25 |
AU2003228446B2 (en) | 2009-08-06 |
MXPA04009546A (es) | 2005-01-25 |
RS95904A (en) | 2006-10-27 |
US20060063809A1 (en) | 2006-03-23 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
IL164295A0 (en) | Tri-substituted heteroaryls and methods of making and using the same | |
EP1546112A4 (fr) | Imidazolopyridines, procedes de fabrication et methodes d'utilisation | |
HK1117189A1 (en) | Assay cartridges and methods of using the same | |
AU2003217870A8 (en) | Pini-modulating compounds and methods of use thereof | |
AU2003286657A8 (en) | Filters and methods of making and using the same | |
HK1078088A1 (en) | Substituted phenylacetamides and their use as glucokinase activators | |
AU2003213673A8 (en) | Pin1-modulating compounds and methods of use thereof | |
AU2003275311A1 (en) | Solid micro-perforators and methods of use | |
EP1625140A4 (fr) | Composes immunomodulateurs ramifies et leur procedes d'utilisation | |
GB0229742D0 (en) | Novel compounds and uses thereof | |
AU2003236991A8 (en) | Representations of processes | |
EP1497270A4 (fr) | Composes amide et procedes d'utilisation de ceux-ci | |
AU2003243714A8 (en) | Etoposide analogs and methods of use thereof | |
EP1551398A4 (fr) | Pyrazolopyridines et leurs methodes de fabrication et d'utilisation | |
EP1476150A4 (fr) | Carboxyfullerenes et procedes d'utilisation de ceux-ci | |
AU2003303926A8 (en) | Ceramics and methods of making the same | |
SI1551805T1 (sl) | Substituirani gama-fenil-delta-laktami in njihova uporaba | |
AU2003275056A8 (en) | Novel lapacho compounds and methods of use thereof | |
EP1484622A4 (fr) | Prisme et procedure de fabrication correspondant | |
AU2003297612A8 (en) | 2-substituted-3-propenamide derivatives and methods of using the same | |
EP1545287A4 (fr) | Composes vasoregulateurs et procedes concernant leur utilisation | |
AU2003285686A8 (en) | Glycoisoforms of adiponectin and uses thereof | |
AU2003276398A8 (en) | Shearwall structure and method of making the same | |
EP1517879A4 (fr) | Aminoalkylphenols et leurs procedes d'utilisation et de fabrication | |
AU2003267944A8 (en) | Novel trifluoromethylepinephrine compounds and methods of making and using thereof |