IL162788A0 - Intermediates for lhrh antagonist synthesis, process for their production, and process for lhrh antagonist production - Google Patents

Intermediates for lhrh antagonist synthesis, process for their production, and process for lhrh antagonist production

Info

Publication number
IL162788A0
IL162788A0 IL16278802A IL16278802A IL162788A0 IL 162788 A0 IL162788 A0 IL 162788A0 IL 16278802 A IL16278802 A IL 16278802A IL 16278802 A IL16278802 A IL 16278802A IL 162788 A0 IL162788 A0 IL 162788A0
Authority
IL
Israel
Prior art keywords
production
boc
lhrh antagonist
4clphe
3pal
Prior art date
Application number
IL16278802A
Other languages
English (en)
Original Assignee
Carlbiotech Ltd As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Carlbiotech Ltd As filed Critical Carlbiotech Ltd As
Publication of IL162788A0 publication Critical patent/IL162788A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/23—Luteinising hormone-releasing hormone [LHRH]; Related peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/02—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length in solution
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0827—Tripeptides containing heteroatoms different from O, S, or N

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Endocrinology (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
IL16278802A 2001-12-29 2002-12-23 Intermediates for lhrh antagonist synthesis, process for their production, and process for lhrh antagonist production IL162788A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE0104463A SE0104463D0 (sv) 2001-12-29 2001-12-29 Mellanprodukter för syntes af LHRH-antagonister, sätt att framställa dem och sätt för framställning av LHRH-antagonister
PCT/IB2002/005583 WO2003055902A1 (en) 2001-12-29 2002-12-23 Intermediates for lhrh antagonist synthesis, process for their production, and process for lhrh antagonist production

Publications (1)

Publication Number Publication Date
IL162788A0 true IL162788A0 (en) 2005-11-20

Family

ID=20286557

Family Applications (2)

Application Number Title Priority Date Filing Date
IL16278802A IL162788A0 (en) 2001-12-29 2002-12-23 Intermediates for lhrh antagonist synthesis, process for their production, and process for lhrh antagonist production
IL162788A IL162788A (en) 2001-12-29 2004-06-29 Process for preparing a tripeptide and salt thereof

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL162788A IL162788A (en) 2001-12-29 2004-06-29 Process for preparing a tripeptide and salt thereof

Country Status (22)

Country Link
US (2) US20050124788A1 (ja)
EP (2) EP1630169B1 (ja)
JP (1) JP4272529B2 (ja)
KR (1) KR100844520B1 (ja)
CN (1) CN1304417C (ja)
AT (2) ATE342913T1 (ja)
AU (1) AU2002348749B2 (ja)
CA (1) CA2471723C (ja)
CY (2) CY1107580T1 (ja)
DE (2) DE60215544T2 (ja)
DK (2) DK1630169T3 (ja)
ES (2) ES2296050T3 (ja)
HK (1) HK1075052A1 (ja)
IL (2) IL162788A0 (ja)
NO (1) NO330129B1 (ja)
NZ (1) NZ534245A (ja)
PT (2) PT1465917E (ja)
RU (1) RU2307125C2 (ja)
SE (1) SE0104463D0 (ja)
SI (1) SI1630169T1 (ja)
WO (1) WO2003055902A1 (ja)
ZA (1) ZA200405136B (ja)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4407322B2 (ja) 2004-03-09 2010-02-03 味の素株式会社 ペプチドの製造方法
CN101037472B (zh) * 2006-03-14 2013-03-27 中国人民解放军军事医学科学院毒物药物研究所 具有低组胺释放作用的促黄体生成素释放激素拮抗剂
TWI539959B (zh) 2008-02-11 2016-07-01 菲瑞茵國際中心股份有限公司 治療轉移階段攝護腺癌的方法
SI2632934T1 (sl) 2010-10-27 2017-02-28 Ferring B.V. Proces za izdelavo degareliksa in njegovih intermediatov
EP2447276A1 (en) * 2010-10-27 2012-05-02 Ferring B.V. Process for the manufacture of Degarelix and its intermediates
MY182320A (en) 2012-06-01 2021-01-19 Ferring Bv Downstream process

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4098777A (en) * 1977-03-14 1978-07-04 Merck & Co., Inc. Process for the preparation of pyroglutamyl-Ala-Lys-Ser-Gln-Gly-Gly-Ser-Asn
US5225598A (en) * 1990-03-30 1993-07-06 Union Carbide Chemicals & Plastics Technology Corporation Selective production of linear pentaethylenehexamine and hydroxyethyldiethylenetriamine
EP0540626A1 (en) * 1990-07-24 1993-05-12 Eastman Chemical Company Process for synthesizing peptides
US5710246A (en) * 1996-03-19 1998-01-20 Abbott Laboratories Process for intermediates for the synthesis of LHRH antagonists
ES2264169T3 (es) * 1996-10-30 2006-12-16 Pfizer Inc. Derivados azabiciclicos de piridona fusionada o de citisina, su preparacion y su uso en la terapia de adiccion.
US5968895A (en) * 1996-12-11 1999-10-19 Praecis Pharmaceuticals, Inc. Pharmaceutical formulations for sustained drug delivery
DE19941248A1 (de) 1998-09-01 2000-03-02 Asta Medica Ag Peptide mit N-substituierten Glycingruppen sowie diese enthaltende Arzneimittel zur Behandlung hormonabhängiger Tumore

Also Published As

Publication number Publication date
US20050124788A1 (en) 2005-06-09
EP1630169A3 (en) 2006-03-15
ATE342913T1 (de) 2006-11-15
AU2002348749A1 (en) 2003-07-15
DE60215544T2 (de) 2007-08-30
WO2003055902A1 (en) 2003-07-10
ZA200405136B (en) 2005-07-27
NO20043047L (no) 2004-08-30
CN1304417C (zh) 2007-03-14
CY1107025T1 (el) 2012-09-26
KR100844520B1 (ko) 2008-07-08
ATE371666T1 (de) 2007-09-15
DK1465917T3 (da) 2007-02-19
PT1630169E (pt) 2007-12-06
CY1107580T1 (el) 2013-03-13
SE0104463D0 (sv) 2001-12-29
RU2307125C2 (ru) 2007-09-27
SI1630169T1 (sl) 2008-04-30
AU2002348749B2 (en) 2008-09-04
NO330129B1 (no) 2011-02-21
DE60222189T2 (de) 2008-06-19
PT1465917E (pt) 2007-01-31
US20080306242A1 (en) 2008-12-11
RU2004119964A (ru) 2006-01-10
EP1465917A1 (en) 2004-10-13
ES2275012T3 (es) 2007-06-01
DK1630169T3 (da) 2008-01-02
HK1075052A1 (en) 2005-12-02
JP2005516962A (ja) 2005-06-09
EP1630169A2 (en) 2006-03-01
NZ534245A (en) 2007-05-31
EP1630169B1 (en) 2007-08-29
DE60222189D1 (de) 2007-10-11
JP4272529B2 (ja) 2009-06-03
IL162788A (en) 2010-12-30
US8173770B2 (en) 2012-05-08
EP1465917B1 (en) 2006-10-18
CA2471723C (en) 2011-02-15
CN1622954A (zh) 2005-06-01
KR20040090965A (ko) 2004-10-27
ES2296050T3 (es) 2008-04-16
DE60215544D1 (de) 2006-11-30
CA2471723A1 (en) 2003-07-10

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