SE0104463D0 - Mellanprodukter för syntes af LHRH-antagonister, sätt att framställa dem och sätt för framställning av LHRH-antagonister - Google Patents

Mellanprodukter för syntes af LHRH-antagonister, sätt att framställa dem och sätt för framställning av LHRH-antagonister

Info

Publication number
SE0104463D0
SE0104463D0 SE0104463A SE0104463A SE0104463D0 SE 0104463 D0 SE0104463 D0 SE 0104463D0 SE 0104463 A SE0104463 A SE 0104463A SE 0104463 A SE0104463 A SE 0104463A SE 0104463 D0 SE0104463 D0 SE 0104463D0
Authority
SE
Sweden
Prior art keywords
preparation
methods
boc
lhrh antagonists
4clphe
Prior art date
Application number
SE0104463A
Other languages
English (en)
Swedish (sv)
Inventor
Jon H Rasmussen
Palle H Rasmussen
Stefan Hansen
Wolfgang Wachs
Jens Fomsgaard
Original Assignee
Carlbiotech Ltd As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Carlbiotech Ltd As filed Critical Carlbiotech Ltd As
Priority to SE0104463A priority Critical patent/SE0104463D0/xx
Publication of SE0104463D0 publication Critical patent/SE0104463D0/xx
Priority to NZ534245A priority patent/NZ534245A/en
Priority to ES05025717T priority patent/ES2296050T3/es
Priority to ES02781699T priority patent/ES2275012T3/es
Priority to IL16278802A priority patent/IL162788A0/xx
Priority to PCT/IB2002/005583 priority patent/WO2003055902A1/en
Priority to EP02781699A priority patent/EP1465917B1/en
Priority to SI200230642T priority patent/SI1630169T1/sl
Priority to CA2471723A priority patent/CA2471723C/en
Priority to AT02781699T priority patent/ATE342913T1/de
Priority to DK02781699T priority patent/DK1465917T3/da
Priority to KR1020047010267A priority patent/KR100844520B1/ko
Priority to SI200230472T priority patent/SI1465917T1/sl
Priority to CNB028283813A priority patent/CN1304417C/zh
Priority to AU2002348749A priority patent/AU2002348749B2/en
Priority to US10/500,047 priority patent/US20050124788A1/en
Priority to DE60222189T priority patent/DE60222189T2/de
Priority to PT05025717T priority patent/PT1630169E/pt
Priority to EP05025717A priority patent/EP1630169B1/en
Priority to PT02781699T priority patent/PT1465917E/pt
Priority to JP2003556432A priority patent/JP4272529B2/ja
Priority to DE60215544T priority patent/DE60215544T2/de
Priority to RU2004119964/04A priority patent/RU2307125C2/ru
Priority to AT05025717T priority patent/ATE371666T1/de
Priority to DK05025717T priority patent/DK1630169T3/da
Priority to ZA2004/05136A priority patent/ZA200405136B/en
Priority to IL162788A priority patent/IL162788A/en
Priority to NO20043047A priority patent/NO330129B1/no
Priority to HK05107366A priority patent/HK1075052A1/xx
Priority to CY20071100070T priority patent/CY1107580T1/el
Priority to CY20071101513T priority patent/CY1107025T1/el
Priority to US12/189,925 priority patent/US8173770B2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/23—Luteinising hormone-releasing hormone [LHRH]; Related peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/02—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length in solution
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0827—Tripeptides containing heteroatoms different from O, S, or N

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Endocrinology (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
SE0104463A 2001-12-29 2001-12-29 Mellanprodukter för syntes af LHRH-antagonister, sätt att framställa dem och sätt för framställning av LHRH-antagonister SE0104463D0 (sv)

Priority Applications (32)

Application Number Priority Date Filing Date Title
SE0104463A SE0104463D0 (sv) 2001-12-29 2001-12-29 Mellanprodukter för syntes af LHRH-antagonister, sätt att framställa dem och sätt för framställning av LHRH-antagonister
ES05025717T ES2296050T3 (es) 2001-12-29 2002-12-23 Productos intermedios para sintesis de antagonistas de lhrh, procedimiento para su produccion y procedimiento para la produccion de antagonistas de lhrh.
AU2002348749A AU2002348749B2 (en) 2001-12-29 2002-12-23 Intermediates for LHRH antagonist synthesis, process for their production, and process for LHRH antagonist production
PT05025717T PT1630169E (pt) 2001-12-29 2002-12-23 Intermediários de síntese de antagonistas de lhrh, processo para a sua produção e processo de produção de antagonistas de lhrh
US10/500,047 US20050124788A1 (en) 2001-12-29 2002-12-23 Intermediates for lhrh antagonist synthesis, process for their production, and process for lhrh antagonist production
IL16278802A IL162788A0 (en) 2001-12-29 2002-12-23 Intermediates for lhrh antagonist synthesis, process for their production, and process for lhrh antagonist production
PCT/IB2002/005583 WO2003055902A1 (en) 2001-12-29 2002-12-23 Intermediates for lhrh antagonist synthesis, process for their production, and process for lhrh antagonist production
EP02781699A EP1465917B1 (en) 2001-12-29 2002-12-23 Intermediates for lhrh antagonist synthesis, process for their production, and process for lhrh antagonist production
SI200230642T SI1630169T1 (sl) 2001-12-29 2002-12-23 Intermediati za sintezo antagonistov LHRH, postopek za njihovo pripravo in postopek za pripravo antagonistov LHRH
CA2471723A CA2471723C (en) 2001-12-29 2002-12-23 Intermediates for lhrh antagonist synthesis, process for their production, and process for lhrh antagonist production
AT02781699T ATE342913T1 (de) 2001-12-29 2002-12-23 Zwischenprodukte für die synthese von lhrh- antagonisten, verfahren zu deren herstellung und verfahren zur herstellung von lhrh-antagonisten
DK02781699T DK1465917T3 (da) 2001-12-29 2002-12-23 Mellemprodukter for LHRH-antagonistsyntesen, fremgangsmåder til deres fremstilling samt fremgangsmåder til fremstilling af LHRH-antagonister
KR1020047010267A KR100844520B1 (ko) 2001-12-29 2002-12-23 Ｌｈｒｈ 길항제 합성용 중간체, 그 제조 방법 및ｌｈｒｈ 길항제의 제조 방법
SI200230472T SI1465917T1 (sl) 2001-12-29 2002-12-23 Intermediati za sintezo antagonistov LHRH, postopek za njihovo pripravo in postopek za pripravo antagonistov LHRH
CNB028283813A CN1304417C (zh) 2001-12-29 2002-12-23 用于lhrh拮抗剂合成的中间体,它们的生产方法和lhrh拮抗剂的生产方法
NZ534245A NZ534245A (en) 2001-12-29 2002-12-23 Intermediates for LHRH antagonist synthesis, process for their production, and process for LHRH antagonist production
ES02781699T ES2275012T3 (es) 2001-12-29 2002-12-23 Intermedios para la sintesis de agonista lhrh, proceso para su produccion, y proceso para la produccion del antagonista lhrh.
DK05025717T DK1630169T3 (da) 2001-12-29 2002-12-23 Mellemprodukter for LHRH-antagonist-synthesen, fremgangsmåde til deres fremstilling og fremgangsmåde til fremstilling af LHRH-antagonister
DE60222189T DE60222189T2 (de) 2001-12-29 2002-12-23 Zwischenprodukte für die Synthese von LHRH-Antagonisten, Verfahren zu deren Herstellung und Verfahren zur Herstellung von LHRH-Antagonisten
EP05025717A EP1630169B1 (en) 2001-12-29 2002-12-23 Intermediates for LHRH antagonist synthesis, process for their production, and process for LHRH antagonist production
PT02781699T PT1465917E (pt) 2001-12-29 2002-12-23 Intermediarios para a sintese de antagonistas da lhrh, processo para a sua produção e processo para a produção e processo para a produção de antagonistas da lhrh
JP2003556432A JP4272529B2 (ja) 2001-12-29 2002-12-23 Ｌｈｒｈ拮抗剤合成の中間体、その製造方法、およびｌｈｒｈ拮抗剤の製造方法
DE60215544T DE60215544T2 (de) 2001-12-29 2002-12-23 Zwischenprodukte für die synthese von lhrh-antagonisten, verfahren zu deren herstellung und verfahren zur herstellung von lhrh-antagonisten
RU2004119964/04A RU2307125C2 (ru) 2001-12-29 2002-12-23 Промежуточные соединения для синтеза антагониста рилизинг-фактора лютеинизирующего гормона (lhrh), способ их получения и способ получения антагониста lhrh
AT05025717T ATE371666T1 (de) 2001-12-29 2002-12-23 Zwischenprodukte für die synthese von lhrh- antagonisten, verfahren zu deren herstellung und verfahren zur herstellung von lhrh-antagonisten
ZA2004/05136A ZA200405136B (en) 2001-12-29 2004-06-28 Intermediates for lhrh antagonist synthesis process for their production and process for lhrh antagonist production
IL162788A IL162788A (en) 2001-12-29 2004-06-29 Process for preparing a tripeptide and salt thereof
NO20043047A NO330129B1 (no) 2001-12-29 2004-07-16 Fremgangsmater for fremstilling av et tripeptid
HK05107366A HK1075052A1 (en) 2001-12-29 2005-08-23 Intermediates for lhrh antagonist synthesis, proc ess for their production, and process for lhrh antagonist production
CY20071100070T CY1107580T1 (el) 2001-12-29 2007-01-18 Ενδιαμεσα για συνθεση ανταγωνιστων lhrh, διαδικασια για τη παραγωγη τους, και διαδικασια για παραγωγη ανταγωνιστων lhrh
CY20071101513T CY1107025T1 (el) 2001-12-29 2007-11-27 Ενδιαμεσα για συνθεση ανταγωνιστη lhrh, μεθοδος για την παρασκευη αυτου και μεθοδος για την παρασκευη ανταγωνιστη lhrh
US12/189,925 US8173770B2 (en) 2001-12-29 2008-08-12 Intermediates for LHRH antagonist synthesis, process for the production, and process for LHRH antagonist production

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE0104463A SE0104463D0 (sv) 2001-12-29 2001-12-29 Mellanprodukter för syntes af LHRH-antagonister, sätt att framställa dem och sätt för framställning av LHRH-antagonister

Publications (1)

Publication Number Publication Date
SE0104463D0 true SE0104463D0 (sv) 2001-12-29

Family

ID=20286557

Family Applications (1)

Application Number Title Priority Date Filing Date
SE0104463A SE0104463D0 (sv) 2001-12-29 2001-12-29 Mellanprodukter för syntes af LHRH-antagonister, sätt att framställa dem och sätt för framställning av LHRH-antagonister

Country Status (22)

Country Link
US (2) US20050124788A1 (ja)
EP (2) EP1630169B1 (ja)
JP (1) JP4272529B2 (ja)
KR (1) KR100844520B1 (ja)
CN (1) CN1304417C (ja)
AT (2) ATE342913T1 (ja)
AU (1) AU2002348749B2 (ja)
CA (1) CA2471723C (ja)
CY (2) CY1107580T1 (ja)
DE (2) DE60215544T2 (ja)
DK (2) DK1630169T3 (ja)
ES (2) ES2296050T3 (ja)
HK (1) HK1075052A1 (ja)
IL (2) IL162788A0 (ja)
NO (1) NO330129B1 (ja)
NZ (1) NZ534245A (ja)
PT (2) PT1465917E (ja)
RU (1) RU2307125C2 (ja)
SE (1) SE0104463D0 (ja)
SI (1) SI1630169T1 (ja)
WO (1) WO2003055902A1 (ja)
ZA (1) ZA200405136B (ja)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4407322B2 (ja) 2004-03-09 2010-02-03 味の素株式会社 ペプチドの製造方法
CN101037472B (zh) * 2006-03-14 2013-03-27 中国人民解放军军事医学科学院毒物药物研究所 具有低组胺释放作用的促黄体生成素释放激素拮抗剂
TWI539959B (zh) 2008-02-11 2016-07-01 菲瑞茵國際中心股份有限公司 治療轉移階段攝護腺癌的方法
SI2632934T1 (sl) 2010-10-27 2017-02-28 Ferring B.V. Proces za izdelavo degareliksa in njegovih intermediatov
EP2447276A1 (en) * 2010-10-27 2012-05-02 Ferring B.V. Process for the manufacture of Degarelix and its intermediates
MY182320A (en) 2012-06-01 2021-01-19 Ferring Bv Downstream process

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4098777A (en) * 1977-03-14 1978-07-04 Merck & Co., Inc. Process for the preparation of pyroglutamyl-Ala-Lys-Ser-Gln-Gly-Gly-Ser-Asn
US5225598A (en) * 1990-03-30 1993-07-06 Union Carbide Chemicals & Plastics Technology Corporation Selective production of linear pentaethylenehexamine and hydroxyethyldiethylenetriamine
EP0540626A1 (en) * 1990-07-24 1993-05-12 Eastman Chemical Company Process for synthesizing peptides
US5710246A (en) * 1996-03-19 1998-01-20 Abbott Laboratories Process for intermediates for the synthesis of LHRH antagonists
ES2264169T3 (es) * 1996-10-30 2006-12-16 Pfizer Inc. Derivados azabiciclicos de piridona fusionada o de citisina, su preparacion y su uso en la terapia de adiccion.
US5968895A (en) * 1996-12-11 1999-10-19 Praecis Pharmaceuticals, Inc. Pharmaceutical formulations for sustained drug delivery
DE19941248A1 (de) 1998-09-01 2000-03-02 Asta Medica Ag Peptide mit N-substituierten Glycingruppen sowie diese enthaltende Arzneimittel zur Behandlung hormonabhängiger Tumore

Also Published As

Publication number Publication date
US20050124788A1 (en) 2005-06-09
EP1630169A3 (en) 2006-03-15
ATE342913T1 (de) 2006-11-15
AU2002348749A1 (en) 2003-07-15
DE60215544T2 (de) 2007-08-30
WO2003055902A1 (en) 2003-07-10
ZA200405136B (en) 2005-07-27
NO20043047L (no) 2004-08-30
CN1304417C (zh) 2007-03-14
CY1107025T1 (el) 2012-09-26
KR100844520B1 (ko) 2008-07-08
ATE371666T1 (de) 2007-09-15
DK1465917T3 (da) 2007-02-19
PT1630169E (pt) 2007-12-06
CY1107580T1 (el) 2013-03-13
RU2307125C2 (ru) 2007-09-27
SI1630169T1 (sl) 2008-04-30
AU2002348749B2 (en) 2008-09-04
NO330129B1 (no) 2011-02-21
DE60222189T2 (de) 2008-06-19
PT1465917E (pt) 2007-01-31
US20080306242A1 (en) 2008-12-11
RU2004119964A (ru) 2006-01-10
EP1465917A1 (en) 2004-10-13
ES2275012T3 (es) 2007-06-01
DK1630169T3 (da) 2008-01-02
HK1075052A1 (en) 2005-12-02
JP2005516962A (ja) 2005-06-09
IL162788A0 (en) 2005-11-20
EP1630169A2 (en) 2006-03-01
NZ534245A (en) 2007-05-31
EP1630169B1 (en) 2007-08-29
DE60222189D1 (de) 2007-10-11
JP4272529B2 (ja) 2009-06-03
IL162788A (en) 2010-12-30
US8173770B2 (en) 2012-05-08
EP1465917B1 (en) 2006-10-18
CA2471723C (en) 2011-02-15
CN1622954A (zh) 2005-06-01
KR20040090965A (ko) 2004-10-27
ES2296050T3 (es) 2008-04-16
DE60215544D1 (de) 2006-11-30
CA2471723A1 (en) 2003-07-10

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