IL158420A0 - Use of follistatin to increase muscle mass - Google Patents
Use of follistatin to increase muscle massInfo
- Publication number
- IL158420A0 IL158420A0 IL15842002A IL15842002A IL158420A0 IL 158420 A0 IL158420 A0 IL 158420A0 IL 15842002 A IL15842002 A IL 15842002A IL 15842002 A IL15842002 A IL 15842002A IL 158420 A0 IL158420 A0 IL 158420A0
- Authority
- IL
- Israel
- Prior art keywords
- follistatin
- muscle mass
- increase muscle
- increase
- mass
- Prior art date
Links
- 102000016970 Follistatin Human genes 0.000 title 1
- 108010014612 Follistatin Proteins 0.000 title 1
- 210000003205 muscle Anatomy 0.000 title 1
Classifications
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- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
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Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/841,730 US6891082B2 (en) | 1997-08-01 | 2001-04-24 | Transgenic non-human animals expressing a truncated activintype II receptor |
PCT/US2002/013103 WO2002085306A2 (en) | 2001-04-24 | 2002-04-24 | Use of follistatin to increase muscle mass |
Publications (1)
Publication Number | Publication Date |
---|---|
IL158420A0 true IL158420A0 (en) | 2004-05-12 |
Family
ID=25285564
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL15842002A IL158420A0 (en) | 2001-04-24 | 2002-04-24 | Use of follistatin to increase muscle mass |
IL158420A IL158420A (en) | 2001-04-24 | 2003-10-15 | Transgenic animals have genes that contain an orange type II active receptor gene |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL158420A IL158420A (en) | 2001-04-24 | 2003-10-15 | Transgenic animals have genes that contain an orange type II active receptor gene |
Country Status (15)
Country | Link |
---|---|
US (6) | US6891082B2 (ja) |
EP (2) | EP2340709A1 (ja) |
JP (4) | JP2004537982A (ja) |
KR (3) | KR20040002927A (ja) |
CN (1) | CN1520256B (ja) |
AU (1) | AU2002307564B2 (ja) |
BR (1) | BR0209191A (ja) |
CA (2) | CA2448835C (ja) |
HU (1) | HUP0401542A2 (ja) |
IL (2) | IL158420A0 (ja) |
NO (1) | NO20034693L (ja) |
NZ (1) | NZ528963A (ja) |
PL (1) | PL367201A1 (ja) |
WO (1) | WO2002085306A2 (ja) |
ZA (1) | ZA200308021B (ja) |
Families Citing this family (93)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7566768B1 (en) | 1995-10-26 | 2009-07-28 | The Johns Hopkins University School Of Medicine | Promyostatin peptides and methods of using same |
US7393682B1 (en) * | 1993-03-19 | 2008-07-01 | The Johns Hopkins University School Of Medicine | Polynucleotides encoding promyostatin polypeptides |
US6891082B2 (en) | 1997-08-01 | 2005-05-10 | The Johns Hopkins University School Of Medicine | Transgenic non-human animals expressing a truncated activintype II receptor |
US6656475B1 (en) * | 1997-08-01 | 2003-12-02 | The Johns Hopkins University School Of Medicine | Growth differentiation factor receptors, agonists and antagonists thereof, and methods of using same |
TW200526779A (en) | 2001-02-08 | 2005-08-16 | Wyeth Corp | Modified and stabilized GDF propeptides and uses thereof |
WO2003022228A2 (en) * | 2001-09-13 | 2003-03-20 | California Institute Of Technology | Method for producing transgenic birds and fish |
US7320789B2 (en) | 2001-09-26 | 2008-01-22 | Wyeth | Antibody inhibitors of GDF-8 and uses thereof |
KR20040096592A (ko) * | 2002-02-21 | 2004-11-16 | 와이어쓰 | 폴리스타틴 도메인을 포함하는 단백질 |
US20040138118A1 (en) * | 2002-09-16 | 2004-07-15 | Neil Wolfman | Metalloprotease activation of myostatin, and methods of modulating myostatin activity |
US7261893B2 (en) | 2002-10-22 | 2007-08-28 | Wyeth | Neutralizing antibodies against GDF-8 and uses therefor |
US20040223966A1 (en) * | 2002-10-25 | 2004-11-11 | Wolfman Neil M. | ActRIIB fusion polypeptides and uses therefor |
US7511012B2 (en) | 2002-12-20 | 2009-03-31 | Amgen Inc. | Myostatin binding agents |
CA2526669A1 (en) * | 2003-06-02 | 2004-12-16 | Wyeth | Use of myostatin (gdf8) inhibitors in conjunction with corticosteroids for treating neuromuscular disorders |
WO2005025601A1 (en) * | 2003-09-15 | 2005-03-24 | Monash University | Follistatin isoforms and uses thereof |
US7246056B1 (en) * | 2003-09-26 | 2007-07-17 | The Mathworks, Inc. | Runtime parameter mapping for system simulation |
EP3006039B1 (en) | 2004-03-02 | 2021-01-06 | Acceleron Pharma Inc. | Alk7 polypeptides for use in promoting fat loss |
JP4688483B2 (ja) * | 2004-04-15 | 2011-05-25 | 株式会社テクノネットワーク四国 | フォリスタチン変異体ポリペプチド |
EP2332977B1 (en) | 2004-07-23 | 2015-11-25 | Acceleron Pharma Inc. | ActRII receptor polypeptides |
MX2007011400A (es) * | 2005-03-23 | 2007-10-11 | Wyeth Corp | Deteccion de agentes moduladores de crecimiento y la diferenciacion del factor 8 (gdf 8). |
EP2407486B1 (en) * | 2005-08-19 | 2017-11-22 | Wyeth LLC | Antagonist antibodies against GDF-8 and uses in treatment of ALS and other GDF-8-associated disorders |
CN100380118C (zh) * | 2005-09-07 | 2008-04-09 | 集美大学 | 鲍鱼种类鉴别方法 |
US8067562B2 (en) * | 2005-11-01 | 2011-11-29 | Amgen Inc. | Isolated nucleic acid molecule comprising the amino acid sequence of SEQ ID NO:1 |
KR20190006086A (ko) | 2005-11-23 | 2019-01-16 | 악셀레론 파마 인코포레이티드 | 액티빈-actrⅱa 길항제 및 골 성장을 촉진하기 위한 이들의 용도 |
US8128933B2 (en) | 2005-11-23 | 2012-03-06 | Acceleron Pharma, Inc. | Method of promoting bone growth by an anti-activin B antibody |
EP1968621A2 (en) * | 2005-12-06 | 2008-09-17 | Amgen Inc. | Uses of myostatin antagonists |
CN100347298C (zh) * | 2005-12-30 | 2007-11-07 | 中国水产科学研究院黄海水产研究所 | 鱼类肌肉生长抑素mstn基因克隆及其基因打靶载体构建 |
US20090142336A1 (en) * | 2006-02-28 | 2009-06-04 | Trustees Of Boston University | Metabolic regulators and uses thereof |
US20070275036A1 (en) * | 2006-05-18 | 2007-11-29 | Celldyne Biopharma, Llc | Avian follistatin product |
US7663019B2 (en) * | 2006-05-24 | 2010-02-16 | North Carolina State University | Transgenic snakes and methods of making |
EP2446896A1 (en) * | 2006-12-18 | 2012-05-02 | Acceleron Pharma, Inc. | Activin-ActRII Antagonists for use in Increasing Red Blood Cells, increasing reticulocyte levels, or promoting erythropoiesis |
US20100028332A1 (en) * | 2006-12-18 | 2010-02-04 | Acceleron Pharma Inc. | Antagonists of actriib and uses for increasing red blood cell levels |
US8895016B2 (en) | 2006-12-18 | 2014-11-25 | Acceleron Pharma, Inc. | Antagonists of activin-actriia and uses for increasing red blood cell levels |
RU2473362C2 (ru) * | 2007-02-01 | 2013-01-27 | Акселерон Фарма Инк. | АНТАГОНИСТЫ АКТИВИНА-ActRIIa-Fc И ИХ ПРИМЕНЕНИЕ ДЛЯ ЛЕЧЕНИЯ ИЛИ ПРОФИЛАКТИКИ РАКА МОЛОЧНОЙ ЖЕЛЕЗЫ |
TWI548647B (zh) * | 2007-02-02 | 2016-09-11 | 艾瑟勒朗法瑪公司 | 衍生自ActRIIB的變體與其用途 |
EA025371B1 (ru) * | 2007-02-09 | 2016-12-30 | Акселерон Фарма Инк. | АНТАГОНИСТЫ АКТИВИНА-ActRIIa И ПРИМЕНЕНИЕ ДЛЯ СТИМУЛЯЦИИ РОСТА КОСТИ У БОЛЬНЫХ РАКОМ |
TWI573802B (zh) | 2007-03-06 | 2017-03-11 | 安美基公司 | 變異之活動素受體多肽及其用途 |
US8501678B2 (en) | 2007-03-06 | 2013-08-06 | Atara Biotherapeutics, Inc. | Variant activin receptor polypeptides and uses thereof |
WO2008109779A2 (en) * | 2007-03-07 | 2008-09-12 | The Johns Hopkins University | Use of follistatin-like related gene (flrg) to increase muscle mass |
BRPI0811317A2 (pt) | 2007-08-03 | 2015-01-27 | Summit Corp Plc | Combinação, embalagem farmcêutica, kit ou mbalagem par apaciente, agente auxiliar, compsoto, usos de um agente auxiliar e de um composto, e, processo para a produção de uma combinação |
GB0715087D0 (en) | 2007-08-03 | 2007-09-12 | Summit Corp Plc | Drug combinations for the treatment of duchenne muscular dystrophy |
EP3243524A1 (en) | 2007-09-18 | 2017-11-15 | Acceleron Pharma Inc. | Activin-actriia antagonists and uses for decreasing or inhibiting fsh secretion |
US8461108B2 (en) | 2008-03-07 | 2013-06-11 | Myoscience, Inc. | Subdermal tissue remodeling using myostatin, methods and related systems |
EP3363453A1 (en) | 2008-06-26 | 2018-08-22 | Acceleron Pharma Inc. | Soluble actriia as activin-actriia antagonist for use in treating anemia or bone-related disorders |
US8216997B2 (en) | 2008-08-14 | 2012-07-10 | Acceleron Pharma, Inc. | Methods for increasing red blood cell levels and treating anemia using a combination of GDF traps and erythropoietin receptor activators |
LT3494986T (lt) | 2008-08-14 | 2020-07-10 | Acceleron Pharma Inc. | Gdf gaudyklės |
CN104371024A (zh) | 2008-11-26 | 2015-02-25 | 安姆根有限公司 | 激活素iib受体多肽的变异体及其用途 |
WO2010083034A1 (en) * | 2009-01-13 | 2010-07-22 | Acceleron Pharma Inc. | Methods for increasing adiponectin |
MA33279B1 (fr) * | 2009-04-27 | 2012-05-02 | Novartis Ag | Compositions et procédés pour l'augmentation de la croissance des muscles |
WO2010134686A2 (ko) * | 2009-05-20 | 2010-11-25 | 강릉원주대학교산학협력단 | 마이오스타틴 억제 활성을 갖는 가용성 마이오스타틴 프로도메인 재조합 단백질 및 그의 용도 |
US8178488B2 (en) | 2009-06-08 | 2012-05-15 | Acceleron Pharma, Inc. | Methods for increasing thermogenic adipocytes |
KR20190090049A (ko) | 2009-06-12 | 2019-07-31 | 악셀레론 파마 인코포레이티드 | 절두된 ActRIIB-FC 융합 단백질 |
IN2012DN02766A (ja) * | 2009-09-09 | 2015-09-18 | Acceleron Pharma Inc | |
JP5836961B2 (ja) * | 2009-11-03 | 2015-12-24 | アクセルロン ファーマ, インコーポレイテッド | 脂肪肝疾患を処置するための方法 |
TWI412027B (zh) | 2009-11-16 | 2013-10-11 | Sony Corp | 碟片匣 |
ES2658292T3 (es) | 2009-11-17 | 2018-03-09 | Acceleron Pharma, Inc. | Proteínas ActRIIB y variantes y usos de las mismas con respecto a la inducción de la utrofina para el tratamiento de la distrofia muscular |
WO2011102483A1 (ja) * | 2010-02-19 | 2011-08-25 | 独立行政法人理化学研究所 | ヒトTGF-βのLAPに結合する抗体 |
JP6105838B2 (ja) * | 2010-08-24 | 2017-03-29 | 国立大学法人 岡山大学 | 疼痛の治療剤 |
EP3536337A1 (en) | 2010-09-22 | 2019-09-11 | The Regents of the University of Colorado, a body corporate | Therapeutic applications of smad7 |
US20120121576A1 (en) | 2010-11-08 | 2012-05-17 | Jasbir Seehra | Actriia binding agents and uses thereof |
CN102648977B (zh) * | 2011-02-25 | 2014-12-10 | 中国科学院上海生命科学研究院 | 滤泡素抑制素样蛋白1在调节钠钾atp酶活性中的用途 |
MX358358B (es) | 2011-12-19 | 2018-08-15 | Amgen Inc | Polipeptidos de receptores de activina variantes y sus usos. |
SG10201609345QA (en) | 2012-02-07 | 2017-01-27 | Global Bio Therapeutics Inc | Compartmentalized method of nucleic acid delivery and compositions and uses thereof |
WO2013149258A2 (en) | 2012-03-30 | 2013-10-03 | Charles Drew University of Medicine and Science | Compositions and methods for treating or preventing metabolic syndrome disorders |
MX364738B (es) | 2012-06-15 | 2019-05-03 | Pfizer | Anticuerpos antagonistas mejorados contra factor-8 de crecimiento y diferenciacion y usos de los mismos. |
CA2880649C (en) | 2012-08-01 | 2023-03-14 | Elizabeth MCNALLY | Mitigating tissue damage and fibrosis via latent transforming growth factor beta binding protein (ltbp4) |
CN113604550A (zh) * | 2012-10-24 | 2021-11-05 | 细胞基因公司 | 用于治疗贫血症的生物标志物 |
CA2890217C (en) | 2012-11-02 | 2021-07-20 | Yifu FANG | Activin-actrii antagonists and uses for treating bone and other disorders |
MX2015009901A (es) | 2013-02-01 | 2016-04-06 | Santa Maria Biotherapeutics Inc | Administración de un compuesto de antiactivina a a un sujeto. |
CN105358704B (zh) | 2013-03-08 | 2020-01-03 | 科罗拉多大学董事会 | Ptd-smad7治疗剂 |
CA2911514A1 (en) | 2013-05-06 | 2014-11-13 | Scholar Rock, Inc. | Compositions and methods for growth factor modulation |
KR20210119546A (ko) | 2014-06-04 | 2021-10-05 | 악셀레론 파마 인코포레이티드 | 폴리스타틴 폴리펩티드를 이용한 장애의 치료방법 및 치료를 위한 조성물 |
US10010498B2 (en) | 2014-06-04 | 2018-07-03 | Acceleron Pharma Inc. | Methods for treatment of amyotrophic lateral sclerosis with follistatin fusion proteins |
AU2015274277B2 (en) | 2014-06-13 | 2021-03-18 | Acceleron Pharma, Inc. | Methods and compositions for treating ulcers |
MA41052A (fr) | 2014-10-09 | 2017-08-15 | Celgene Corp | Traitement d'une maladie cardiovasculaire à l'aide de pièges de ligands d'actrii |
CA3005158A1 (en) * | 2014-11-06 | 2016-05-12 | Scholar Rock, Inc. | Anti-pro/latent-myostatin antibodies and uses thereof |
DK3227675T3 (da) | 2014-12-03 | 2023-05-30 | Celgene Corp | Activin-actrii-antagonister og anvendelser til behandling af myelodysplastisk syndrom |
EP3244926A4 (en) | 2015-01-14 | 2018-06-27 | The Brigham and Women's Hospital, Inc. | Treatment of cancer with anti-lap monoclonal antibodies |
KR20170129233A (ko) | 2015-03-26 | 2017-11-24 | 악셀레론 파마 인코포레이티드 | 폴리스타틴-관련된 융합 단백질 및 이들의 용도 |
PL3286206T3 (pl) | 2015-04-22 | 2021-09-13 | Biogen Ma Inc. | Nowe hybrydowe białka pułapki na ligand actriib do leczenia chorób powodujących zanik mięśni |
CN113896789A (zh) | 2015-09-15 | 2022-01-07 | 供石公司 | 抗-原肌生长抑制素/潜伏肌生长抑制素抗体及其用途 |
CN105372276B (zh) * | 2015-11-24 | 2017-09-29 | 大连工业大学 | 一种海参加热过程中质构品质无损检测方法 |
AU2017230091B2 (en) | 2016-03-10 | 2022-04-07 | Acceleron Pharma Inc. | Activin type 2 receptor binding proteins and uses thereof |
EP4218817A3 (en) | 2017-01-06 | 2023-09-06 | Scholar Rock, Inc. | Methods for treating metabolic diseases by inhibiting myostatin activation |
ES2895382T3 (es) | 2017-04-13 | 2022-02-21 | N R Soos Tech Ltd | Dispositivos y métodos para promover la producción de embriones femeninos en huevos |
KR101822633B1 (ko) * | 2017-08-22 | 2018-01-26 | (주)진셀팜 | 폴리스타틴 유래 생리활성 펩타이드, 및 이의 용도 |
WO2019075090A1 (en) | 2017-10-10 | 2019-04-18 | Tilos Therapeutics, Inc. | ANTI-LAP ANTIBODIES AND USES THEREOF |
CA3085903A1 (en) * | 2017-12-29 | 2019-07-04 | Anagenesis Biotechnologies S.A.S. | Method for preparing bap or ba cells |
CN109006709A (zh) * | 2018-08-17 | 2018-12-18 | 孟维巍 | 一种紧凑式蜚蠊养殖系统 |
CN113164780A (zh) | 2018-10-10 | 2021-07-23 | 泰洛斯治疗公司 | 抗lap抗体变体及其用途 |
WO2020132647A1 (en) | 2018-12-21 | 2020-06-25 | Northwestern University | Use of annexins in preventing and treating muscle membrane injury |
US20220062299A1 (en) | 2018-12-26 | 2022-03-03 | Northwestern University | Use of glucocorticoid steroids in preventing and treating conditions of muscle wasting, aging and metabolic disorder |
CN110438154A (zh) * | 2019-08-10 | 2019-11-12 | 湖南文理学院 | 一种基于转基因增加鲫鱼生长速度的方法 |
CN112088804B (zh) * | 2020-10-13 | 2021-12-21 | 四川省旺达饲料有限公司 | 一种根据家禽体型自动定量出料的饲料投喂装置 |
Family Cites Families (57)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4036945A (en) | 1976-05-03 | 1977-07-19 | The Massachusetts General Hospital | Composition and method for determining the size and location of myocardial infarcts |
US4331647A (en) | 1980-03-03 | 1982-05-25 | Goldenberg Milton David | Tumor localization and therapy with labeled antibody fragments specific to tumor-associated markers |
US4873191A (en) | 1981-06-12 | 1989-10-10 | Ohio University | Genetic transformation of zygotes |
US5206347A (en) | 1985-08-06 | 1993-04-27 | La Jolla Cancer Research Foundation | Isolation and use of receptors binding to a peptide column |
US4946778A (en) | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
US5011912A (en) | 1986-12-19 | 1991-04-30 | Immunex Corporation | Hybridoma and monoclonal antibody for use in an immunoaffinity purification system |
US5162215A (en) | 1988-09-22 | 1992-11-10 | Amgen Inc. | Method of gene transfer into chickens and other avian species |
US5399346A (en) | 1989-06-14 | 1995-03-21 | The United States Of America As Represented By The Department Of Health And Human Services | Gene therapy |
US6218596B1 (en) | 1989-06-30 | 2001-04-17 | The United States Of America As Represented By The Department Of Health And Human Services | Enhancement of musculature in non-human mammals expressing c-ski |
US5225212A (en) | 1989-10-20 | 1993-07-06 | Liposome Technology, Inc. | Microreservoir liposome composition and method |
US5633076A (en) | 1989-12-01 | 1997-05-27 | Pharming Bv | Method of producing a transgenic bovine or transgenic bovine embryo |
US5283173A (en) | 1990-01-24 | 1994-02-01 | The Research Foundation Of State University Of New York | System to detect protein-protein interactions |
SG46445A1 (en) | 1990-01-26 | 1998-02-20 | Immunomedics Inc | Vaccines against cancer and infectious diseases |
US5265030A (en) | 1990-04-24 | 1993-11-23 | Scripps Clinic And Research Foundation | System and method for determining three-dimensional structures of proteins |
US5750342A (en) | 1990-06-11 | 1998-05-12 | Nexstar Pharmaceuticals, Inc. | Nucleic acid ligands of tissue target |
US5264563A (en) | 1990-08-24 | 1993-11-23 | Ixsys Inc. | Process for synthesizing oligonucleotides with random codons |
US5314695A (en) | 1990-11-13 | 1994-05-24 | Corvas International, Inc. | Tissue factor based prothrombin time reagent |
US5885794A (en) * | 1991-05-10 | 1999-03-23 | The Salk Institute For Biological Studies | Recombinant production of vertebrate activin receptor polypeptides and identification of receptor DNAs in the activin/TGF-β superfamily |
US6162896A (en) * | 1991-05-10 | 2000-12-19 | The Salk Institute For Biological Studies | Recombinant vertebrate activin receptors |
AU2408292A (en) | 1991-07-11 | 1993-02-11 | Regents Of The University Of California, The | A method to identify protein sequences that fold into a known three-dimensional structure |
US5395619A (en) | 1993-03-03 | 1995-03-07 | Liposome Technology, Inc. | Lipid-polymer conjugates and liposomes |
CA2157577C (en) * | 1993-03-19 | 2009-11-17 | Se-Jin Lee | Growth differentiation factor-8 |
US6465239B1 (en) | 1993-03-19 | 2002-10-15 | The John Hopkins University School Of Medicine | Growth differentiation factor-8 nucleic acid and polypeptides from aquatic species and non-human transgenic aquatic species |
US5994618A (en) * | 1997-02-05 | 1999-11-30 | Johns Hopkins University School Of Medicine | Growth differentiation factor-8 transgenic mice |
DK1378572T3 (da) * | 1993-05-12 | 2007-02-05 | Genetics Inst Llc | BMP-11-sammensætninger |
ATE305036T1 (de) * | 1994-07-08 | 2005-10-15 | Univ Johns Hopkins Med | Wachstums-differenzierungsfaktor-11 |
US6008434A (en) | 1994-07-08 | 1999-12-28 | Johns Hopkins University School Of Medicine | Growth differentiation factor-11 transgenic mice |
US5734039A (en) * | 1994-09-15 | 1998-03-31 | Thomas Jefferson University | Antisense oligonucleotides targeting cooperating oncogenes |
US5545616A (en) * | 1994-09-22 | 1996-08-13 | Genentech, Inc. | Method for predicting and/or preventing preterm labor |
US5998698A (en) | 1995-06-07 | 1999-12-07 | Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | Transgenic fish capable of expressing exogenous lytic peptides |
US5622699A (en) | 1995-09-11 | 1997-04-22 | La Jolla Cancer Research Foundation | Method of identifying molecules that home to a selected organ in vivo |
WO1997015319A1 (en) * | 1995-10-23 | 1997-05-01 | Queen's University At Kingston | Method and pharmaceutical composition for chondrostimulation with a prostaglandin (e.g. misoprostol) and tgf-beta, optionally in combination with igf-1 |
DE19626982C1 (de) | 1996-07-04 | 1997-09-25 | Siemens Ag | Elektromagnetisches Relais und Verfahren zu dessen Herstellung |
US5776689A (en) | 1996-07-19 | 1998-07-07 | The Regents Of The University Of California | Protein recruitment system |
WO1998023284A1 (en) * | 1996-11-27 | 1998-06-04 | Immunex Corporation | Method of regulating nitric oxide production |
AU6274298A (en) | 1997-02-05 | 1998-08-25 | Johns Hopkins University School Of Medicine, The | Growth differentiation factor-8 |
US5827533A (en) | 1997-02-06 | 1998-10-27 | Duke University | Liposomes containing active agents aggregated with lipid surfactants |
IL132922A0 (en) * | 1997-05-16 | 2001-03-19 | Procter & Gamble | The use of a bone morphogenetic protein (bmp) receptor complex for screening |
US5933819C1 (en) | 1997-05-23 | 2001-11-13 | Scripps Research Inst | Prediction of relative binding motifs of biologically active peptides and peptide mimetics |
JP2002501385A (ja) * | 1997-05-30 | 2002-01-15 | ヴァイス ステファン | 可溶性ラミニン受容体前駆体及びその相互作用を阻止するための方法 |
US6204011B1 (en) * | 1997-06-18 | 2001-03-20 | Merck & Co., Inc. | Human receptor tyrosine kinase, KDR |
US6656475B1 (en) * | 1997-08-01 | 2003-12-02 | The Johns Hopkins University School Of Medicine | Growth differentiation factor receptors, agonists and antagonists thereof, and methods of using same |
US6891082B2 (en) | 1997-08-01 | 2005-05-10 | The Johns Hopkins University School Of Medicine | Transgenic non-human animals expressing a truncated activintype II receptor |
AU8666398A (en) | 1997-08-01 | 1999-02-22 | Johns Hopkins University School Of Medicine, The | Methods to identify growth differentiation factor (gdf) receptors |
WO1999010004A2 (en) * | 1997-08-29 | 1999-03-04 | Ontogeny, Inc. | Regulation of muscle tissues by hedgehog-like polypeptides, and formulations and uses related thereto |
US6372454B2 (en) * | 1997-08-29 | 2002-04-16 | Human Genome Sciences, Inc. | Nucleic acid molecules encoding Follistatin-3 |
US5885779A (en) | 1997-09-09 | 1999-03-23 | University Of British Columbia | Repressed trans-activator system for characterization of protein-protein interactions |
AU2586199A (en) | 1998-02-05 | 1999-08-23 | Johns Hopkins University School Of Medicine, The | Growth differentiation factor-8 |
US6004937A (en) * | 1998-03-09 | 1999-12-21 | Genetics Institute, Inc. | Use of follistatin to modulate growth and differentiation factor 8 [GDF-8] and bone morphogenic protein 11 [BMP-11] |
US6156952A (en) * | 1998-04-09 | 2000-12-05 | Constituent Institution Of The University Of Maryland System | HIV transgenic animals and uses therefor |
DE69941116D1 (de) * | 1998-05-06 | 2009-08-27 | Metamorphix Inc | G von gdf-8 |
EP2009025B1 (en) * | 1998-05-14 | 2011-07-27 | Immunex Corporation | Method of inhibiting osteoclast activity |
CA2349869A1 (en) | 1998-11-13 | 2000-05-25 | Takeda Chemical Industries, Ltd. | Novel protein and utilization thereof |
JP2003517580A (ja) * | 1999-01-21 | 2003-05-27 | メタモーフイクス・インコーポレーテツド | 増殖分化因子インヒビター及びそれらの用途 |
WO2000075289A1 (en) | 1999-06-08 | 2000-12-14 | Rutgers, The State University | Compositions and methods for targeted gene insertion |
US7368534B2 (en) | 2000-01-18 | 2008-05-06 | Orico Limited | Myostatin and mimetics thereof |
TWI548647B (zh) * | 2007-02-02 | 2016-09-11 | 艾瑟勒朗法瑪公司 | 衍生自ActRIIB的變體與其用途 |
-
2001
- 2001-04-24 US US09/841,730 patent/US6891082B2/en not_active Expired - Fee Related
-
2002
- 2002-04-24 CN CN028126106A patent/CN1520256B/zh not_active Expired - Lifetime
- 2002-04-24 EP EP10183805A patent/EP2340709A1/en not_active Withdrawn
- 2002-04-24 CA CA2448835A patent/CA2448835C/en not_active Expired - Fee Related
- 2002-04-24 KR KR10-2003-7013983A patent/KR20040002927A/ko active IP Right Grant
- 2002-04-24 WO PCT/US2002/013103 patent/WO2002085306A2/en active Application Filing
- 2002-04-24 HU HU0401542A patent/HUP0401542A2/hu unknown
- 2002-04-24 BR BR0209191-7A patent/BR0209191A/pt not_active IP Right Cessation
- 2002-04-24 IL IL15842002A patent/IL158420A0/xx unknown
- 2002-04-24 CA CA2807478A patent/CA2807478A1/en not_active Abandoned
- 2002-04-24 JP JP2002582882A patent/JP2004537982A/ja active Pending
- 2002-04-24 NZ NZ528963A patent/NZ528963A/en unknown
- 2002-04-24 KR KR1020087012173A patent/KR20080051190A/ko active IP Right Grant
- 2002-04-24 AU AU2002307564A patent/AU2002307564B2/en not_active Ceased
- 2002-04-24 EP EP02764345A patent/EP1395113A4/en not_active Withdrawn
- 2002-04-24 PL PL02367201A patent/PL367201A1/xx unknown
- 2002-04-24 KR KR1020097005537A patent/KR20090032148A/ko not_active Application Discontinuation
-
2003
- 2003-10-15 IL IL158420A patent/IL158420A/en not_active IP Right Cessation
- 2003-10-15 ZA ZA200308021A patent/ZA200308021B/en unknown
- 2003-10-20 NO NO20034693A patent/NO20034693L/no not_active Application Discontinuation
-
2005
- 2005-02-03 US US11/051,267 patent/US20050257278A1/en not_active Abandoned
-
2008
- 2008-04-25 JP JP2008116224A patent/JP4361955B2/ja not_active Expired - Fee Related
- 2008-11-21 JP JP2008298119A patent/JP5004930B2/ja not_active Expired - Fee Related
-
2009
- 2009-01-26 US US12/360,093 patent/US20090186806A1/en not_active Abandoned
- 2009-01-28 US US12/361,512 patent/US8124830B2/en not_active Expired - Fee Related
- 2009-06-22 JP JP2009147316A patent/JP5425537B2/ja not_active Expired - Fee Related
-
2010
- 2010-08-23 US US12/861,738 patent/US8822411B2/en not_active Expired - Fee Related
- 2010-10-04 US US12/897,607 patent/US20120094908A1/en not_active Abandoned
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