IL157867A0 - Methods for the production of 3-o-deactivated-4'-monophosphoryl lipid a (3d-mla) - Google Patents

Methods for the production of 3-o-deactivated-4'-monophosphoryl lipid a (3d-mla)

Info

Publication number
IL157867A0
IL157867A0 IL15786702A IL15786702A IL157867A0 IL 157867 A0 IL157867 A0 IL 157867A0 IL 15786702 A IL15786702 A IL 15786702A IL 15786702 A IL15786702 A IL 15786702A IL 157867 A0 IL157867 A0 IL 157867A0
Authority
IL
Israel
Prior art keywords
mla
deactivated
production
methods
monophosphoryl lipid
Prior art date
Application number
IL15786702A
Other languages
English (en)
Original Assignee
Corixa Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Corixa Corp filed Critical Corixa Corp
Publication of IL157867A0 publication Critical patent/IL157867A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
    • C07H13/06—Fatty acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/04—Polysaccharides, i.e. compounds containing more than five saccharide radicals attached to each other by glycosidic bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55572—Lipopolysaccharides; Lipid A; Monophosphoryl lipid A

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
IL15786702A 2001-03-30 2002-03-28 Methods for the production of 3-o-deactivated-4'-monophosphoryl lipid a (3d-mla) IL157867A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US28008901P 2001-03-30 2001-03-30
PCT/US2002/009731 WO2002078637A2 (en) 2001-03-30 2002-03-28 Methods for the production of 3-o-deactivated-4'-monophosphoryl lipid a (3d-mla)

Publications (1)

Publication Number Publication Date
IL157867A0 true IL157867A0 (en) 2004-03-28

Family

ID=23071615

Family Applications (3)

Application Number Title Priority Date Filing Date
IL15786702A IL157867A0 (en) 2001-03-30 2002-03-28 Methods for the production of 3-o-deactivated-4'-monophosphoryl lipid a (3d-mla)
IL157867A IL157867A (en) 2001-03-30 2003-09-11 A method of making a lipopolisaccharide preparation (LPS and LPS produced by this method)
IL189651A IL189651A (en) 2001-03-30 2008-02-21 Preparations containing 3-O-Damascus-4 '-Monophosphoryl Lipid A (MLA - D3), Lipopolysaccharides (LPA) and Monophosphoryl Lipid A (MLA)

Family Applications After (2)

Application Number Title Priority Date Filing Date
IL157867A IL157867A (en) 2001-03-30 2003-09-11 A method of making a lipopolisaccharide preparation (LPS and LPS produced by this method)
IL189651A IL189651A (en) 2001-03-30 2008-02-21 Preparations containing 3-O-Damascus-4 '-Monophosphoryl Lipid A (MLA - D3), Lipopolysaccharides (LPA) and Monophosphoryl Lipid A (MLA)

Country Status (22)

Country Link
US (3) US20030031684A1 (de)
EP (3) EP2465937B1 (de)
JP (3) JP4233327B2 (de)
KR (2) KR100884462B1 (de)
CN (2) CN1928107B (de)
AU (1) AU2002306962B2 (de)
BR (2) BR122015016711B8 (de)
CA (1) CA2440249C (de)
CZ (2) CZ305601B6 (de)
DK (2) DK1461418T3 (de)
ES (2) ES2517391T3 (de)
HK (3) HK1075913A1 (de)
HU (1) HU228688B1 (de)
IL (3) IL157867A0 (de)
MX (1) MXPA03008856A (de)
NZ (2) NZ548595A (de)
PL (2) PL217737B1 (de)
PT (2) PT1461418E (de)
RU (2) RU2302463C2 (de)
SI (2) SI1461418T1 (de)
WO (1) WO2002078637A2 (de)
ZA (1) ZA200307238B (de)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030031684A1 (en) * 2001-03-30 2003-02-13 Corixa Corporation Methods for the production of 3-O-deactivated-4'-monophosphoryl lipid a (3D-MLA)
FR2848223B1 (fr) * 2002-12-09 2005-02-25 Centre Nat Rech Scient Nouveau procede d'isolement des endotoxines.
TWI457133B (zh) 2005-12-13 2014-10-21 Glaxosmithkline Biolog Sa 新穎組合物
GB0607088D0 (en) 2006-04-07 2006-05-17 Glaxosmithkline Biolog Sa Vaccine
EP3020411A1 (de) 2005-12-22 2016-05-18 GlaxoSmithKline Biologicals s.a. Impfstoff
WO2008134830A1 (en) * 2007-03-22 2008-11-13 Fundação Butantan Method to obtain monophosphoryl lipid a from bordetella pertussis as a by-product of the cellular pertussis vaccine production
EP2148697B1 (de) 2007-05-24 2012-10-03 GlaxoSmithKline Biologicals S.A. Lyophilisierte wt-1/cpg zusammensetzung
US20130066064A1 (en) * 2010-05-20 2013-03-14 Glaxosmithkline Biologicals S.A, Novel process
WO2012156391A1 (en) 2011-05-17 2012-11-22 Glaxosmithkline Biologicals S.A. Vaccine against streptococcus pneumoniae
GB201113570D0 (en) 2011-08-05 2011-09-21 Glaxosmithkline Biolog Sa Vaccine
US9241988B2 (en) * 2012-04-12 2016-01-26 Avanti Polar Lipids, Inc. Disaccharide synthetic lipid compounds and uses thereof
CN102746414B (zh) * 2012-07-20 2014-04-16 成都生物制品研究所有限责任公司 一种细菌脂多糖的沉降方法
GB201518684D0 (en) 2015-10-21 2015-12-02 Glaxosmithkline Biolog Sa Vaccine
EP3394109A2 (de) * 2015-12-22 2018-10-31 GlaxoSmithKline Biologicals SA Lps-extraktionsverfahren
KR101761348B1 (ko) * 2016-01-06 2017-07-26 한국과학기술연구원 헥사 아실화된 모노포스포릴 지질 a를 생산하는 세균, 및 이를 이용한 헥사 아실화된 모노포스포릴 지질 a 생산 방법
KR102019331B1 (ko) * 2017-07-05 2019-09-09 한국과학기술연구원 모노포스포릴 지질 ａ를 구성적으로 생산하는 세균, 및 이를 이용한 모노포스포릴 지질 ａ 생산 방법
EP3777884A1 (de) 2019-08-15 2021-02-17 GlaxoSmithKline Biologicals S.A. Immunogene zusammensetzung
WO2021040414A1 (ko) * 2019-08-29 2021-03-04 주식회사 유바이오로직스 모노포스포릴 지질 ａ를 생산하는 방법
US20230045642A1 (en) 2019-12-19 2023-02-09 Glaxosmithkline Biologicals Sa S. aureus antigens and compositions thereof
CN113652455B (zh) * 2021-08-09 2022-04-26 北京华诺泰生物医药科技有限公司 六酰基3d-mla的发酵方法
CN116554361B (zh) * 2023-07-11 2023-11-03 江苏瑞科生物技术股份有限公司 用于提取脂多糖的抽提液和方法

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NL8103838A (nl) * 1980-08-19 1982-03-16 Shell Int Research De bereiding van microbiologische polysacchariden.
US4436728A (en) * 1982-05-26 1984-03-13 Ribi Immunochem Research, Inc. Refined detoxified endotoxin product
US4436727A (en) 1982-05-26 1984-03-13 Ribi Immunochem Research, Inc. Refined detoxified endotoxin product
US5057598A (en) * 1983-05-06 1991-10-15 Centocor, Inc. Monoclonal antibodies reactive with endotoxin core
US4612304A (en) * 1985-06-11 1986-09-16 Ss Pharmaceutical Co., Ltd. Antitumor formulation containing lipopolysaccharide with trehalose derivatives
US5554372A (en) * 1986-09-22 1996-09-10 Emory University Methods and vaccines comprising surface-active copolymers
US4912094B1 (en) 1988-06-29 1994-02-15 Ribi Immunochem Research Inc. Modified lipopolysaccharides and process of preparation
US5068191A (en) * 1989-08-31 1991-11-26 The Biomembrane Institute Purified histo-blood group a glycosyltransferase and antibodies thereto
US5552141A (en) * 1991-10-30 1996-09-03 Ribi; Hans O. Polymeric immunological adjuvants
JP3755890B2 (ja) 1992-06-25 2006-03-15 スミスクライン・ビーチャム・バイオロジカルス（ソシエテ・アノニム） アジュバント含有ワクチン組成物
ATE204762T1 (de) 1993-03-23 2001-09-15 Smithkline Beecham Biolog 3-0-deazylierte monophosphoryl lipid a enthaltende impfstoff-zusammensetzungen
GB9326253D0 (en) 1993-12-23 1994-02-23 Smithkline Beecham Biolog Vaccines
UA56132C2 (uk) 1995-04-25 2003-05-15 Смітклайн Бічем Байолоджікалс С.А. Композиція вакцини (варіанти), спосіб стабілізації qs21 відносно гідролізу (варіанти), спосіб приготування композиції вакцини
US5985309A (en) * 1996-05-24 1999-11-16 Massachusetts Institute Of Technology Preparation of particles for inhalation
US5855913A (en) * 1997-01-16 1999-01-05 Massachusetts Instite Of Technology Particles incorporating surfactants for pulmonary drug delivery
US5846789A (en) * 1996-12-10 1998-12-08 Council Of Scientific And Industrial Research Process for preparing nontoxic lipopolysaccharides from acidiphilium species
JP3595966B2 (ja) * 1996-12-25 2004-12-02 カウンシィル オブ サイアンティフィック アンド インダストリアル リサーチ 内毒血症または敗血症の予防に有効な新規の効力のある非毒性リポ多糖体の調製方法
US6491919B2 (en) * 1997-04-01 2002-12-10 Corixa Corporation Aqueous immunologic adjuvant compostions of monophosphoryl lipid A
NZ338101A (en) 1997-04-01 2002-03-28 Corixa Corp Adjuvant compositions of Monophosphoryl Lipid A (MPL) and a phospholipid based surfactant (1,2-Dipalmitoyl-sn-glycero-3-phosphocholine (DPPC)) suitable for intranasal administration
US6630161B1 (en) * 1998-05-07 2003-10-07 Ribi Immunochem Research, Inc. Adjuvant composition and methods for its use
DE10013539B4 (de) * 2000-03-20 2006-07-13 Pharma-Zentrale Gmbh Lipopolysaccharide aus Escherichia coli, Verfahren zu deren Herstellung und deren Verwendungen
US20030031684A1 (en) * 2001-03-30 2003-02-13 Corixa Corporation Methods for the production of 3-O-deactivated-4'-monophosphoryl lipid a (3D-MLA)

Also Published As

Publication number Publication date
US20070212758A1 (en) 2007-09-13
PT1461418E (pt) 2013-07-09
CA2440249C (en) 2013-07-09
US20140243513A1 (en) 2014-08-28
BRPI0208535B1 (pt) 2016-03-29
CN1928107A (zh) 2007-03-14
KR100927099B1 (ko) 2009-11-13
RU2003131677A (ru) 2005-04-20
DK2465937T3 (da) 2014-11-10
IL189651A0 (en) 2008-06-05
HUP0304091A2 (hu) 2004-03-29
CZ20032895A3 (cs) 2004-02-18
HUP0304091A3 (en) 2011-04-28
EP1461418B1 (de) 2013-04-24
CA2440249A1 (en) 2002-10-10
CZ305601B6 (cs) 2015-12-30
SI1461418T1 (sl) 2013-08-30
AU2002306962A2 (en) 2002-10-15
IL157867A (en) 2011-07-31
PL402939A1 (pl) 2013-08-19
JP4233327B2 (ja) 2009-03-04
RU2302463C2 (ru) 2007-07-10
WO2002078637A3 (en) 2004-07-22
IL189651A (en) 2011-02-28
US9512159B2 (en) 2016-12-06
HU228688B1 (en) 2013-05-28
AU2002306962B2 (en) 2008-04-24
JP2008255335A (ja) 2008-10-23
RU2427378C2 (ru) 2011-08-27
NZ548595A (en) 2008-04-30
ZA200307238B (en) 2005-08-31
JP2004535477A (ja) 2004-11-25
CN1608127A (zh) 2005-04-20
US20030031684A1 (en) 2003-02-13
HK1165494A1 (en) 2012-10-05
CN1928107B (zh) 2010-12-22
ES2415769T3 (es) 2013-07-26
ES2517391T3 (es) 2014-11-03
NZ528204A (en) 2006-12-22
HK1075913A1 (en) 2005-12-30
PL373657A1 (en) 2005-09-05
DK1461418T3 (da) 2013-07-08
JP5730178B2 (ja) 2015-06-03
KR20080088666A (ko) 2008-10-02
PT2465937E (pt) 2014-11-03
BR122015016711B8 (pt) 2021-07-27
KR20060015704A (ko) 2006-02-20
MXPA03008856A (es) 2003-12-04
RU2006140606A (ru) 2008-05-27
WO2002078637A9 (en) 2004-01-15
BR122015016711B1 (pt) 2016-08-02
EP2465937A1 (de) 2012-06-20
SI2465937T1 (sl) 2014-11-28
BRPI0208535B8 (pt) 2021-05-25
BR0208535A (pt) 2006-02-21
EP2479280A1 (de) 2012-07-25
KR100884462B1 (ko) 2009-02-20
CZ305565B6 (cs) 2015-12-16
JP2012057170A (ja) 2012-03-22
EP1461418A4 (de) 2006-05-17
PL217737B1 (pl) 2014-08-29
WO2002078637A2 (en) 2002-10-10
EP1461418A2 (de) 2004-09-29
CN100577790C (zh) 2010-01-06
EP2465937B1 (de) 2014-08-13
HK1104319A1 (en) 2008-01-11

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